Sanquin Cellular Therapy Services
... Sanquin Research Amsterdam, Department of Experimental Immunohematology ...
... Sanquin Research Amsterdam, Department of Experimental Immunohematology ...
Viruses
... that need to live in/on another being to survive and do not benefit them in any way • Host - The organism/cell that a parasite exploits • Viruses are pathogens – something that causes disease in the host cell/organism ...
... that need to live in/on another being to survive and do not benefit them in any way • Host - The organism/cell that a parasite exploits • Viruses are pathogens – something that causes disease in the host cell/organism ...
Lecture 19
... • Regulatory T cells (TR) are vital for keeping the immune system in check, helping to avoid immune-mediated pathology and unrestricted expansion of effector T cell – Suppress other T cells when Ag no longer present – Involved in the checkpoints to prevent immune responses to self. T cells compete f ...
... • Regulatory T cells (TR) are vital for keeping the immune system in check, helping to avoid immune-mediated pathology and unrestricted expansion of effector T cell – Suppress other T cells when Ag no longer present – Involved in the checkpoints to prevent immune responses to self. T cells compete f ...
The life of a B cell - Blueprint Epigenome
... as they became fully differentiated B cells. The scientists performed a very deep and careful analysis of the changes that occur in DNA methylation during B cell differentiation. Most previous analyses paid attention to the methylation of bases called cytosines in their “canonical” context, neighbor ...
... as they became fully differentiated B cells. The scientists performed a very deep and careful analysis of the changes that occur in DNA methylation during B cell differentiation. Most previous analyses paid attention to the methylation of bases called cytosines in their “canonical” context, neighbor ...
The Immune System
... Role of the MHC Infected cells produce MHC molecules which bind to antigen fragments and then are transported to the cell surface in a process called antigen presentation. ...
... Role of the MHC Infected cells produce MHC molecules which bind to antigen fragments and then are transported to the cell surface in a process called antigen presentation. ...
the first chapter - OncologyPRO
... not require the presentation of an antigen, and does not lead to immunological memory. Its effector cells are neutrophils, macrophages, and mast cells, reacting within minutes to hours with the help of complement activation and cytokines (CK). ...
... not require the presentation of an antigen, and does not lead to immunological memory. Its effector cells are neutrophils, macrophages, and mast cells, reacting within minutes to hours with the help of complement activation and cytokines (CK). ...
Adaptive immune response
... cytoplasm. The information on the nucleic acid is incorporated into the cell’s DNA. Normal cellular mechanisms then produce viral structural components. Multiple new viral particles are produced & released from the cell (sometimes killing the cell) ...
... cytoplasm. The information on the nucleic acid is incorporated into the cell’s DNA. Normal cellular mechanisms then produce viral structural components. Multiple new viral particles are produced & released from the cell (sometimes killing the cell) ...
3.Lecture 5- Resistance of the Body to infection
... – Monocytes (blood macrophages) – Mobile and fixed tissue Macrophages – Specialiazed endothelial cells in bone marrow, lymph nodes and spleen – Reticular cells of lymph nodes spleen & bone ...
... – Monocytes (blood macrophages) – Mobile and fixed tissue Macrophages – Specialiazed endothelial cells in bone marrow, lymph nodes and spleen – Reticular cells of lymph nodes spleen & bone ...
Teaching Notes
... 2. Compare and contrast MHC I and MHC II. What is the significance of each? Which cells have MHC II? How does the presence of MHC relate to the functions of these cells? MHC I and MHC II are the two classes of the major histocompatibility complex. Both MHC I and MHC II are cell surface proteins. The ...
... 2. Compare and contrast MHC I and MHC II. What is the significance of each? Which cells have MHC II? How does the presence of MHC relate to the functions of these cells? MHC I and MHC II are the two classes of the major histocompatibility complex. Both MHC I and MHC II are cell surface proteins. The ...
STRUCTURE AND FUNCTION OF THE BLOOD AND THE IMMUNE
... functions, hemostasis and coagulation functions and the mechanisms that control the immune system, which are vital to the homeostatic maintenance of the body and its defence against external agents. ...
... functions, hemostasis and coagulation functions and the mechanisms that control the immune system, which are vital to the homeostatic maintenance of the body and its defence against external agents. ...
Unit 4 - Immunology and Public Health
... What are the two types of lymphocytes? – B and T lymphocytes Where do T lymphocytes mature? – The thymus gland Why are cytokines released at the site of infection? – To activate B lymphocytes and phagocytes What is the name of the proteins found on cell surfaces that trigger an immune response? – An ...
... What are the two types of lymphocytes? – B and T lymphocytes Where do T lymphocytes mature? – The thymus gland Why are cytokines released at the site of infection? – To activate B lymphocytes and phagocytes What is the name of the proteins found on cell surfaces that trigger an immune response? – An ...
Course Objectives - Geisel School of Medicine
... Describe and explain the key interactions during T cell and B cell interactions Describe and compare the four types of hypersensitivity Explain and compare immune processes during transplantation and tumor immunity E ...
... Describe and explain the key interactions during T cell and B cell interactions Describe and compare the four types of hypersensitivity Explain and compare immune processes during transplantation and tumor immunity E ...
Exporter la page en pdf
... double-stranded DNA genome. HAdVs cause a spectrum of pathologies in all populations regardless of health standards. Following repeat exposure to multiple HAdV types, we develop robust and long-lived humoral and cellular immune responses that provide life-long protection from de novo infections and ...
... double-stranded DNA genome. HAdVs cause a spectrum of pathologies in all populations regardless of health standards. Following repeat exposure to multiple HAdV types, we develop robust and long-lived humoral and cellular immune responses that provide life-long protection from de novo infections and ...
The Generation of Diversity (GOD): How to Ensure
... in severe autoimmune disease in mice (J. Immunol. 155, 1151, 1995). The condition resembled the one described in the 1969 study. Sakaguchi called the cells regulatory T cells. • It is clear that these regulatory T cells—or Tregs—are crucial to keeping the immune system in check, although the exact m ...
... in severe autoimmune disease in mice (J. Immunol. 155, 1151, 1995). The condition resembled the one described in the 1969 study. Sakaguchi called the cells regulatory T cells. • It is clear that these regulatory T cells—or Tregs—are crucial to keeping the immune system in check, although the exact m ...
Chapter 51
... • Binding of a pathogen-associated molecule to any of the innate immune-type receptors activates signal transduction pathways that lead to a rapid response against possible pathogen • Secretion of molecules that signal to other innate cells or to adaptive cells • Production of molecules that aid in ...
... • Binding of a pathogen-associated molecule to any of the innate immune-type receptors activates signal transduction pathways that lead to a rapid response against possible pathogen • Secretion of molecules that signal to other innate cells or to adaptive cells • Production of molecules that aid in ...
Specific Cellular Defences - Smithycroft Secondary School
... I can state that each B-lymphocyte clone produces a specific antibody molecule that will recognise a specific antigen surface molecule on a pathogen or a toxin. Antigen-antibody complexes may inactivate a pathogen or toxin or render it more susceptible to phagocytosis. In other cases the antigenanti ...
... I can state that each B-lymphocyte clone produces a specific antibody molecule that will recognise a specific antigen surface molecule on a pathogen or a toxin. Antigen-antibody complexes may inactivate a pathogen or toxin or render it more susceptible to phagocytosis. In other cases the antigenanti ...
Viruses, Bacteria, and the Immune System
... fungi that are harmful to other microorganisms 2. Vaccines—substances (usually inactivated viruses or fragments of viruses or bacteria) that stimulate the production of memory cells. Passive Immunity—obtained by transferring antibodies from an individual who previously had a disease to a newly infec ...
... fungi that are harmful to other microorganisms 2. Vaccines—substances (usually inactivated viruses or fragments of viruses or bacteria) that stimulate the production of memory cells. Passive Immunity—obtained by transferring antibodies from an individual who previously had a disease to a newly infec ...
VMB 673 Comparative Immunology Syllabus 2013 Revised Cat 2
... Limit 1 page per 2 credit hours, list individually any topic given over 1hour of contact time. NOTE: Each topic below will be explored in two ways: 1. A brief introduction into the topic similar to an introductory immunology lecture to ensure students are familiarized with the appropriate immune pri ...
... Limit 1 page per 2 credit hours, list individually any topic given over 1hour of contact time. NOTE: Each topic below will be explored in two ways: 1. A brief introduction into the topic similar to an introductory immunology lecture to ensure students are familiarized with the appropriate immune pri ...
12.2 Notes - Techniques - Trimble County Schools
... happen if serum containing B antibodies is added to red blood cells containing A antigen? Explain your answer 2. What is serology and what is its most widespread application? In what other areas related to forensic science is it finding application? 3. What is the difference between monoclonal and p ...
... happen if serum containing B antibodies is added to red blood cells containing A antigen? Explain your answer 2. What is serology and what is its most widespread application? In what other areas related to forensic science is it finding application? 3. What is the difference between monoclonal and p ...
innate immunity
... An antibody is composed of two identical light (L) and two identical heavy (H) chains, and the genes specifying them are found in the 'V' (Variable) region and the 'C' (Constant) region. In the heavy-chain 'V' region there are three segments; V, D and J, which recombine randomly, in a process called ...
... An antibody is composed of two identical light (L) and two identical heavy (H) chains, and the genes specifying them are found in the 'V' (Variable) region and the 'C' (Constant) region. In the heavy-chain 'V' region there are three segments; V, D and J, which recombine randomly, in a process called ...
Congenital and Acquired Immunodeficiency Diseases (not HIV)
... • UNC-93B - essential for the normal response to signaling through TLRs that respond to viral infection (TLR3, TLR7, TLR8, and TLR9). Deficiency results in reduced production of IFNα, IFNß, IFNλ, TNFα, IL-1ß, and IL-6 in response to stimulation. • IFNγR - persistent mycobacterial infections ...
... • UNC-93B - essential for the normal response to signaling through TLRs that respond to viral infection (TLR3, TLR7, TLR8, and TLR9). Deficiency results in reduced production of IFNα, IFNß, IFNλ, TNFα, IL-1ß, and IL-6 in response to stimulation. • IFNγR - persistent mycobacterial infections ...
Airgas template
... White blood cells (granulocytes, monocytes, and lymphocytes) are formed in the bone marrow. The life span of white blood cells is relatively long, so constant renewal is not necessary to maintain normal blood levels. In neutropenia, all of the cell lines are affected, resulting in anemia, thrombocyt ...
... White blood cells (granulocytes, monocytes, and lymphocytes) are formed in the bone marrow. The life span of white blood cells is relatively long, so constant renewal is not necessary to maintain normal blood levels. In neutropenia, all of the cell lines are affected, resulting in anemia, thrombocyt ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.