Document
... Yuying Liang: Influenza virus-induced airway inflammation and the role of epithelial cells, and innate and adaptive immune cells (cell based assays and in vivo studies in mice). Scott O’Grady and Tamene Melkamu: Innate immune functions by epithelial cells, eosinophils, and macrophages in the lungs ( ...
... Yuying Liang: Influenza virus-induced airway inflammation and the role of epithelial cells, and innate and adaptive immune cells (cell based assays and in vivo studies in mice). Scott O’Grady and Tamene Melkamu: Innate immune functions by epithelial cells, eosinophils, and macrophages in the lungs ( ...
13. Caner Gene Therapy
... inserting gene encoding foreign antigens or cytokines (IL-2 and interferon-alfa 2b are two cytokines approved by the FDA for treatment of cancer. ) : Increase anti-tumor activity of immune system cells by, for example, inserting genes that encode cytokines : Induce normal tissues to produce anti-tum ...
... inserting gene encoding foreign antigens or cytokines (IL-2 and interferon-alfa 2b are two cytokines approved by the FDA for treatment of cancer. ) : Increase anti-tumor activity of immune system cells by, for example, inserting genes that encode cytokines : Induce normal tissues to produce anti-tum ...
Guidelines-in-Development-2015-v4
... NCEC National Clinical Guidelines in Development, 2015. Source Key: Commissioned Guidelines, Non-commissioned Guidelines, Notice of Intent *Note: final descriptions for these guidelines may change as they are early in the development process. ...
... NCEC National Clinical Guidelines in Development, 2015. Source Key: Commissioned Guidelines, Non-commissioned Guidelines, Notice of Intent *Note: final descriptions for these guidelines may change as they are early in the development process. ...
Reverse Phase Protein Lysate Microarrays
... 10,000-element lysate arrays for pathway mapping, thereby permitting detailed time-course studies to be performed of protein response to cell stimulation. The ability to quantitatively track, for example, the phosphorylation cascade down one branch of a pathway versus another can guide researchers i ...
... 10,000-element lysate arrays for pathway mapping, thereby permitting detailed time-course studies to be performed of protein response to cell stimulation. The ability to quantitatively track, for example, the phosphorylation cascade down one branch of a pathway versus another can guide researchers i ...
Cytokines PIS - STEMCELL Technologies
... Macrophage inflammatory protein-1 beta (MIP-1 beta), also known as CCL4, is a member of CC family of chemokines and is most closely related to CCL3 or MIP-1 alpha. MIP-1 beta is predominantly synthesized by activated CD8+ T cells, specifically the perforin-low memory CD8+ T cells (Kamin-Lewis et al. ...
... Macrophage inflammatory protein-1 beta (MIP-1 beta), also known as CCL4, is a member of CC family of chemokines and is most closely related to CCL3 or MIP-1 alpha. MIP-1 beta is predominantly synthesized by activated CD8+ T cells, specifically the perforin-low memory CD8+ T cells (Kamin-Lewis et al. ...
interaction of tcr with mhc and antigen
... Two distinct types of molecule are involved in the recognition of foreign antigen which leads to the initiation of adaptive immune response -- the immunoglobulins (Ig) and the T-cell antigen receptors (TCR). Characteristic features of Ig and TCR are: (1) diversity and heterogeneity, (2) gene rearran ...
... Two distinct types of molecule are involved in the recognition of foreign antigen which leads to the initiation of adaptive immune response -- the immunoglobulins (Ig) and the T-cell antigen receptors (TCR). Characteristic features of Ig and TCR are: (1) diversity and heterogeneity, (2) gene rearran ...
Open questions: A rose is a rose is a rose - or not? CO M M E NT Open Access
... Lander previously commented on this issue when discussing how hematopoietic stem cells maintain their numbers [6]. Rather than the stereotypic view that stem cell division is invariably asymmetric, giving rise to one daughter cell that differentiates and one that retains selfrenewal capacity, he and ...
... Lander previously commented on this issue when discussing how hematopoietic stem cells maintain their numbers [6]. Rather than the stereotypic view that stem cell division is invariably asymmetric, giving rise to one daughter cell that differentiates and one that retains selfrenewal capacity, he and ...
February 14, 2017 - Theratechnologies
... or Protease Inhibitors (PI) and more than 60% of patients had resistance to at least one Integrase Inhibitor (INI). Patients enrolled in the trial were infected with HIV-1 resistant to more than 75% of all drugs in the NRTI, NNRTI and PI classes and to 1-2 drugs from the INI class, on average. Final ...
... or Protease Inhibitors (PI) and more than 60% of patients had resistance to at least one Integrase Inhibitor (INI). Patients enrolled in the trial were infected with HIV-1 resistant to more than 75% of all drugs in the NRTI, NNRTI and PI classes and to 1-2 drugs from the INI class, on average. Final ...
Chapter 43 – The Immune System
... While microorganisms are under assault by phagocytic cells, the inflammatory response, and antimicrobial proteins, they inevitably encounter lymphocytes, the key cells of acquired immunity, the body’s second major kind of defense. ...
... While microorganisms are under assault by phagocytic cells, the inflammatory response, and antimicrobial proteins, they inevitably encounter lymphocytes, the key cells of acquired immunity, the body’s second major kind of defense. ...
Glycolipid Immunology: NKT cells
... utilization of receptors that recognizes structures common to pathogens (i.e., pattern recognition receptors). Once the innate immune system is activated, the adaptive immune system is induced by T as well as B cells bearing receptors that have higher specificity and affinity for antigens. Natural k ...
... utilization of receptors that recognizes structures common to pathogens (i.e., pattern recognition receptors). Once the innate immune system is activated, the adaptive immune system is induced by T as well as B cells bearing receptors that have higher specificity and affinity for antigens. Natural k ...
Cerebellum - Austin Community College
... • T cells are activated when they detect and bind to small fragments of antigens that are combined with to cell-surface glycoproteins called major histocompatability complex (MHC) molecules • Lymphocytes respond to antigens bound to either class I or class II MHC proteins depending on the source of ...
... • T cells are activated when they detect and bind to small fragments of antigens that are combined with to cell-surface glycoproteins called major histocompatability complex (MHC) molecules • Lymphocytes respond to antigens bound to either class I or class II MHC proteins depending on the source of ...
Pulmonary defence mechanisms and inflammatory pathways in
... (see [28] for a more detailed review on the biology of lung DC function). The general function of lung DCs is to recognise and pick up foreign antigens at the periphery of the body, and subsequently migrate to the draining mediastinal lymph nodes where the antigen is processed into immunogenic pepti ...
... (see [28] for a more detailed review on the biology of lung DC function). The general function of lung DCs is to recognise and pick up foreign antigens at the periphery of the body, and subsequently migrate to the draining mediastinal lymph nodes where the antigen is processed into immunogenic pepti ...
Primary lymphoma of the central nervous system
... receptors on tumor cells and resident cell populations may facilitate recruitment of B cells to the CNS, their intracerebral dissemination, and the specific interaction of tumor cells with CNS structures. The investigation of the interaction of tumor cells with braincell populations is still largely ...
... receptors on tumor cells and resident cell populations may facilitate recruitment of B cells to the CNS, their intracerebral dissemination, and the specific interaction of tumor cells with CNS structures. The investigation of the interaction of tumor cells with braincell populations is still largely ...
B cell characterization and reactivity analysis in multiple sclerosis
... (CSF) but not in the serum of more than 90% of patients with MS, indicating an intrathecal immunoglobulin (Ig) production [1,2]. The presence of B cells, plasma cells, complement and myelin-specific antibodies in chronic MS lesions [2–4] and the restricted Ig gene usage pattern in the variable region ...
... (CSF) but not in the serum of more than 90% of patients with MS, indicating an intrathecal immunoglobulin (Ig) production [1,2]. The presence of B cells, plasma cells, complement and myelin-specific antibodies in chronic MS lesions [2–4] and the restricted Ig gene usage pattern in the variable region ...
MCB 4211 Syllabus F2016
... 1914 Little: genetic theory of tumor transplantation f. 1936 Gorer: identification of MHC antigens g. 1939 Kabat and Tselius: Antibodies as gamma globulins ...
... 1914 Little: genetic theory of tumor transplantation f. 1936 Gorer: identification of MHC antigens g. 1939 Kabat and Tselius: Antibodies as gamma globulins ...
43_DetailLectOut_jkAR
... cell receptor undergo similar rearrangements, but we will consider only the gene coding for the light chain of the B cell receptor. The immunoglobulin light-chain gene contains a series of 40 variable (V) gene segments separated by a long stretch of DNA from 5 joining (J) gene segments. Beyond t ...
... cell receptor undergo similar rearrangements, but we will consider only the gene coding for the light chain of the B cell receptor. The immunoglobulin light-chain gene contains a series of 40 variable (V) gene segments separated by a long stretch of DNA from 5 joining (J) gene segments. Beyond t ...
Clearance mechanism of a mannosylated antibody–enzyme fusion
... This study investigates the clearance mechanism of a recombinant glycoprotein therapeutic used in experimental cancer therapy. The glycoprotein, MFECP1, is a fusion of a bacterial enzyme and an scFv antibody and would not be glycosylated in native form. However, expression in P. pastoris X33 strain ...
... This study investigates the clearance mechanism of a recombinant glycoprotein therapeutic used in experimental cancer therapy. The glycoprotein, MFECP1, is a fusion of a bacterial enzyme and an scFv antibody and would not be glycosylated in native form. However, expression in P. pastoris X33 strain ...
Challenging the theory of Artificial Immunity
... Natural (and lasting) immunity occurs only after actually recovering from the actual disease. When naturally exposed to pathogens, the organism has to pass through the body’s natural defense systems in the body before it ever reaches the bloodstream. A tremendous amount of biological events are trig ...
... Natural (and lasting) immunity occurs only after actually recovering from the actual disease. When naturally exposed to pathogens, the organism has to pass through the body’s natural defense systems in the body before it ever reaches the bloodstream. A tremendous amount of biological events are trig ...
DETERMINATION OF ANTI-MALIGNIN ANTIBODY AND MALIGNIN
... gens rather than a potentially more constant level of specific anti· body had to be measured in serum. Malignin is produced in tissue culture of malignant cells. is of known composition. and its anti· body can be isolated from the serum of patients with cancer (Bo goch and Bogoch. 1979. 1980>. The ...
... gens rather than a potentially more constant level of specific anti· body had to be measured in serum. Malignin is produced in tissue culture of malignant cells. is of known composition. and its anti· body can be isolated from the serum of patients with cancer (Bo goch and Bogoch. 1979. 1980>. The ...
Autoimmune disease I
... b) Non-HLA genes (cont.) Recent examples: 1- Polymorphisms in a gene called PTPN-22 (most frequently implicated with AD, a\w RA & type 1 DM. Mechanism : defect in encoded phosphatase > defect in control of tyrosine kinases activity>defect of lymphocyte responses>> excessive activation 2- Polymorphis ...
... b) Non-HLA genes (cont.) Recent examples: 1- Polymorphisms in a gene called PTPN-22 (most frequently implicated with AD, a\w RA & type 1 DM. Mechanism : defect in encoded phosphatase > defect in control of tyrosine kinases activity>defect of lymphocyte responses>> excessive activation 2- Polymorphis ...
Bulletin 1345.qxd - Bio-Rad
... option. Our laboratory has been trying to maximize genetic transfer into non-adherent, murine bone marrow cells using electroporation. We have used the Gene Pulser® apparatus to electro-transfect either a murine MHC class II gene, ABb, or a plasmid encoding a mutant dihydrofolate reductase enzyme (d ...
... option. Our laboratory has been trying to maximize genetic transfer into non-adherent, murine bone marrow cells using electroporation. We have used the Gene Pulser® apparatus to electro-transfect either a murine MHC class II gene, ABb, or a plasmid encoding a mutant dihydrofolate reductase enzyme (d ...
X-linked hyper IgM syndrome = CD40 ligand deficiency
... endosome, FcRn binds to maternal IgG and transcytoses it to the fetal circulation where it is released at physiological pH. ...
... endosome, FcRn binds to maternal IgG and transcytoses it to the fetal circulation where it is released at physiological pH. ...
Nutritional Supplementation in HIV-Infected
... Department of Public Health and Community Medicine, Tufts University School of Medicine; Department of Clinical Research, Tuberculosis Research Centre, Chennai, India; United Nations’ World Food Programme, Italy ...
... Department of Public Health and Community Medicine, Tufts University School of Medicine; Department of Clinical Research, Tuberculosis Research Centre, Chennai, India; United Nations’ World Food Programme, Italy ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.