positive selection - immunology.unideb.hu
... Migration of naive T lymphocytes to normal tissues is limited Antigen presenting cells are not activated in normal tissues NO SIGNAL 3. for CD4+ Th activation PERIPHERAL TISSUES TOLERIZE THEMSELVES ...
... Migration of naive T lymphocytes to normal tissues is limited Antigen presenting cells are not activated in normal tissues NO SIGNAL 3. for CD4+ Th activation PERIPHERAL TISSUES TOLERIZE THEMSELVES ...
Chapter 21b revised
... • Play a central role in the adaptive immune response • Once primed by APC presentation of antigen, they • Help activate T and B cells • Induce T and B cell proliferation • Activate macrophages and recruit other immune cells ...
... • Play a central role in the adaptive immune response • Once primed by APC presentation of antigen, they • Help activate T and B cells • Induce T and B cell proliferation • Activate macrophages and recruit other immune cells ...
Allergy and Immune Disorders
... Chronic connective tissue disease (autoimmune)-exact cause unknown Organ-specific disease! Not contagious or cancerous; most common in middle-aged women Not directly inherited, possibly a family hx of rheumatic diseases S/S: chronic hardening and thickening of the skin caused by new collagen formati ...
... Chronic connective tissue disease (autoimmune)-exact cause unknown Organ-specific disease! Not contagious or cancerous; most common in middle-aged women Not directly inherited, possibly a family hx of rheumatic diseases S/S: chronic hardening and thickening of the skin caused by new collagen formati ...
Biomaterials_Lecture 7
... 3.0 Immune Response to Biomaterial Both innate and adaptive immunity depend on the ability of the immune system to distinguish between self and non-self molecules. In immunology, self molecules are those components of an organism's body that can be distinguished from foreign substances by the i ...
... 3.0 Immune Response to Biomaterial Both innate and adaptive immunity depend on the ability of the immune system to distinguish between self and non-self molecules. In immunology, self molecules are those components of an organism's body that can be distinguished from foreign substances by the i ...
Blood and Immunity - Calgary Christian School
... Non-specific defenses Second line of defense Cell-mediated immunity from three types of WBC’s – macrophages, neutrophils and monocytes ...
... Non-specific defenses Second line of defense Cell-mediated immunity from three types of WBC’s – macrophages, neutrophils and monocytes ...
White Blood Cells Morphology and Counts
... • This release occurs when antigens complex with IgE is located on the cellular surface. ...
... • This release occurs when antigens complex with IgE is located on the cellular surface. ...
Cell Mediated Immunity
... Killing of microbes & tumor cells; stimulation of inflammation; production of growth factors & cytokines Lysis of cells that are virally infected or associated with allografts and tumors Non-specific killing of tumor cells & some infected cells ...
... Killing of microbes & tumor cells; stimulation of inflammation; production of growth factors & cytokines Lysis of cells that are virally infected or associated with allografts and tumors Non-specific killing of tumor cells & some infected cells ...
The effectors of innate immunity: DAMPs, DAMEs, or DIMEs
... I think that such a situation is occurring right now in the field of innate immunity since the essence of many things is not fully known. As research progresses rapidly, new cells, molecules, and pathways are discovered and receive names, often an acronym or an abbreviation or sometimes a brand new ...
... I think that such a situation is occurring right now in the field of innate immunity since the essence of many things is not fully known. As research progresses rapidly, new cells, molecules, and pathways are discovered and receive names, often an acronym or an abbreviation or sometimes a brand new ...
Classification of allergens
... Cytotoxic type of allergic reactions • Immunological stage. It is called cytotoxic because the antibodies that developed to antigen of the cell bind to cells and cause their damage or even lysis (cytolytic action). For swithing of this mechanism cells have to acquire autoallergen properties. Than t ...
... Cytotoxic type of allergic reactions • Immunological stage. It is called cytotoxic because the antibodies that developed to antigen of the cell bind to cells and cause their damage or even lysis (cytolytic action). For swithing of this mechanism cells have to acquire autoallergen properties. Than t ...
Haemolytic anaemias
... Immunoglobulin binding occurs at all temps Fc receptors/C3b recognized by macrophages. Hemolysis primarily extravascular 70% associated with other illnesses Responsive to steroids/splenectomy ...
... Immunoglobulin binding occurs at all temps Fc receptors/C3b recognized by macrophages. Hemolysis primarily extravascular 70% associated with other illnesses Responsive to steroids/splenectomy ...
Introduction to Immunoassays
... immunogen, because it can stimulate an immune response. Over time, and in some cases with multiple injections, the immune system of the animal produces antibodies to the antigen that was injected. Blood is collected from the animal, and serum is isolated from the blood. This serum is usually rich in ...
... immunogen, because it can stimulate an immune response. Over time, and in some cases with multiple injections, the immune system of the animal produces antibodies to the antigen that was injected. Blood is collected from the animal, and serum is isolated from the blood. This serum is usually rich in ...
... in class II presentation showed in multiple independent experiments. Some PEPGRS family members have been implicated in the intracellular replication capability of Mtb and are up-regulated under low iron conditions. This PE_PGRS gene has been showed to be non-essential for in-vitro growth but its de ...
Immunology Basics Biology Lecture PowerPoint
... • Images used on this resource, and on the SPO website are, wherever possible, credited and linked to their source. Any words underlined and appearing in blue are links that can be clicked on for more information. PowerPoints must be viewed in slide show mode to use the hyperlinks directly. • Severa ...
... • Images used on this resource, and on the SPO website are, wherever possible, credited and linked to their source. Any words underlined and appearing in blue are links that can be clicked on for more information. PowerPoints must be viewed in slide show mode to use the hyperlinks directly. • Severa ...
Tolerance, Immune Regulation, and Autoimmunity
... Bovine myelin basic protein in MS Type II collagen in RA Retinal S-antigen in posterior uveitis Insulin in type I diabetes mellitus Oral feeding of HLA molecules to prevent graft rejection Crohn’s and Ulcerative Colitis patients may have deficient oral tolerance mechanisms. ...
... Bovine myelin basic protein in MS Type II collagen in RA Retinal S-antigen in posterior uveitis Insulin in type I diabetes mellitus Oral feeding of HLA molecules to prevent graft rejection Crohn’s and Ulcerative Colitis patients may have deficient oral tolerance mechanisms. ...
Characterization and protein engineering of L
... Characterization and protein engineering of Lasparaginase 1 from Saccharomyces cerevisiae to evaluate its use as biopharmaceutical ...
... Characterization and protein engineering of Lasparaginase 1 from Saccharomyces cerevisiae to evaluate its use as biopharmaceutical ...
Inducing and expanding regulatory T cell populations by foreign
... The extrathymic generation and proliferation of regulatory T cells may contribute to self-tolerance as well as the poor immunogenicity of tumors and may be exploited clinically to prevent or reverse unwanted immunity. The contributions of thymically and extrathymically generated suppressor T cells t ...
... The extrathymic generation and proliferation of regulatory T cells may contribute to self-tolerance as well as the poor immunogenicity of tumors and may be exploited clinically to prevent or reverse unwanted immunity. The contributions of thymically and extrathymically generated suppressor T cells t ...
MALARIAL VACCINES
... IMMUNE RESPONSE TO MALARIAL PARASITE PfMEP1-expressed on infected erythrocytic surface and mediates binding of parasite to receptors(CD36, chondoitin sulfate A(CSA) ...
... IMMUNE RESPONSE TO MALARIAL PARASITE PfMEP1-expressed on infected erythrocytic surface and mediates binding of parasite to receptors(CD36, chondoitin sulfate A(CSA) ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.