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Thymus and Spleen
Thymus and Spleen

... • Composed of sinusoids and Cords of Billroth • The cords are the parenchyma of the red pulp; they are composed of reticular tissue w/ macrophages, red blood cells, and lymphocytes ...
Immunology - WordPress.com
Immunology - WordPress.com

... a) are usually only produced by one cell type b) activate a large number of immunocompetent cells because they do not require specific receptors c) have narrow ranges of action and specific effects because of the high-affinity receptors on target cells d) such as IL-Z are crucial to graft vs host re ...
To reg or not to reg: that is the question... EDITORIAL S. Baraldo and M. Saetta
To reg or not to reg: that is the question... EDITORIAL S. Baraldo and M. Saetta

... analysed markers of activation (reduced CD28) and maturation (CD45RA/CD45R0) in lymphocytes isolated from bronchoalveolar lavage (BAL) and peripheral blood of smokers with COPD. By comparing the results to the appropriate groups of smoking and nonsmoking controls, they provide new insights into the ...
Deep Insight Section Insight in inflammation and cancer in Oncology and Haematology
Deep Insight Section Insight in inflammation and cancer in Oncology and Haematology

... Inflammation starts whenever antigens trigger molecules and cells of the immune system causing them to move to the affected site. This forms part of the body's response to internal and external environmental stimuli that normally eliminate the offending organism or cells and restore the tissue physi ...
Oligoclonal expansion of TCR Vδ T cells may be a potential immune
Oligoclonal expansion of TCR Vδ T cells may be a potential immune

中文題目:微核糖核酸-17透過標的物Eos調整調節性T細胞的活性 英文
中文題目:微核糖核酸-17透過標的物Eos調整調節性T細胞的活性 英文

... sequential prcessing of primary RNA polymerase II transcripts mediated by two RNase III enzymes. We were interested in determining whether Treg differentiation and/or suppressive activity are regulated by microRNAs (miRNAs). the inflammatory cytokine IL-6 has been shown to induce miR-17-92 expressio ...
Gut associated lymphoid tissue
Gut associated lymphoid tissue

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Appearance of peripheral blood plasma cells and memory B cells in
Appearance of peripheral blood plasma cells and memory B cells in

... magnitude than the naive group, suggesting that these cells might originate from previously formed memory B cells, which have a lower threshold of activation19 and might not need to reenter GCs to differentiate into plasma cells. However, GC formation has been documented during the rapid booster res ...
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16-1

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Thymus gland Bone marrow Secondary organs of immune system

... fighting infection. ...
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Hematopoiesis

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PowerPoint Presentation - Hematopoiesis from pluripotent

... Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting. ...
Programme [2.89 Mb PDF]
Programme [2.89 Mb PDF]

... vaccine efficacy. Secondly, this genetic information will make it possible to test candidate vaccines in at-risk individuals only. Individuals naturally resistant to TB represent a major confounding factor in vaccine trials. Thirdly, the genetic dissection of TB will facilitate the detection of the ...
The Treatment of Cancer - Advanced Medicine Seminars
The Treatment of Cancer - Advanced Medicine Seminars

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Elaborate interactions between the immune and nervous systems
Elaborate interactions between the immune and nervous systems

... stimulates the temperature increase induced through the activity of preoptic neurons7. There is also evidence that afferent fibers in the vagal nerve may transport pyrogenic cytokines to the thermoregulatory centers in the hypothalamus8 (Fig. 1). Immunologists divide the physiological functions of c ...
Microbiology
Microbiology

... Immunity is defined as body’s resistance to invasion by microorganisms and damage by foreign substances vertebrate possess a sophisticated immune response that protects them from invading pathogens when a vertebrate is exposed to foreign macromolecules called antigen , the immunologic system produce ...
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B3 Topic 1 Revision tracker

Immunohematology (Blood Bank)
Immunohematology (Blood Bank)

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... A. Why are both cell types activated by DCs treated with infectious virus. B. Which antigen processing pathway would you expect to not function in cells: a. exposed to inactivated virus? _________________________ ...
Biology - WordPress.com
Biology - WordPress.com

... a harmless pathogen or antigenic material introduced b the antigens trigger an immune response which causes the production of antibodies c the antigens also trigger production of memory lymphocytes 1.22 Demonstrate an understanding of the advantages and risks associated with immunisation HSW 14 Desc ...
not currently active, names provided by Division Head
not currently active, names provided by Division Head

... born early in gestation. One main project focuses on understanding why newborns are highly susceptible to infections. This is achieved specifically by investigating mechanisms for inflammatory Toll-like receptor-mediated hypo-responses in babies born prematurely, using cell immunology, flow cytometr ...
Complement
Complement

... of cells coated with C3b is enhanced. (I.e. C3b is an opsonin) 2. C3a (and C5a) are anaphylatoxins I.e. they act on macrophages, neutrophils, basophils and mast cells to promote chemotaxis of these cells (particularly neutrophils) to the site, degranulation and the respiratory burst. This creates a ...
Jeopardy
Jeopardy

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Principles in organ transplantation
Principles in organ transplantation

... pancreatic, liver, tooth, retina, and skin tissues. Several tissueengineered products are under clinical trials for FDA approval. Engineered skin or wound dressing and cartilage are two of the most advanced areas with regards to clinical potential. For example, a skin substitute that consists of liv ...
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Document

... breast prostheses; FBR is composed of a layer of macrophages one to two cells in thickness relatively rough surfaces such as those found on the outer surfaces of vascular prosthesis; FBR composed of multiple layers of macrophages and foreign body giant cells at the surface rough surfaces such as fab ...
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Cancer immunotherapy



Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.
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