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Enhancement of an anti-tumor immune response by transient
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Full text article
... is altered but innate immunity is enhanced. The important events of immune ageing are modifications of lymphocyte subsets with an accumulation of memory cells, a decrease in the proliferative response, and a chronic inflammatory state. (Cretel et al. 2010). Age-associated changes to immunity may als ...
... is altered but innate immunity is enhanced. The important events of immune ageing are modifications of lymphocyte subsets with an accumulation of memory cells, a decrease in the proliferative response, and a chronic inflammatory state. (Cretel et al. 2010). Age-associated changes to immunity may als ...
NAME: Clifford V. Harding, MD, PhD POSITION TITLE: Kahn
... the functional consequences of ManLAM inhibition of CD4+ T cell activation in terms of recovery of inhibition, induction of apoptosis or anergy, differential effects on CD4+ T cell subsets, synergy with inhibition of MHC-II antigen processing and effects on the activated T cell proteome; Aim 3. To d ...
... the functional consequences of ManLAM inhibition of CD4+ T cell activation in terms of recovery of inhibition, induction of apoptosis or anergy, differential effects on CD4+ T cell subsets, synergy with inhibition of MHC-II antigen processing and effects on the activated T cell proteome; Aim 3. To d ...
Organization, sequence and expression of the HLA
... clone 2.6 (Fig. 2B) w i t h different anti-H-2 and a n t i - H L A monoclonal antibodies. Fig. 2A represents the fluorescence profiles of the L D l cell line ( H - 2 ) with the mouse plasmocytoma antibody M P C - 1 1 and monoclonal antibodies W6/32 ( H L A - A , B, C) and 11-4.1 ( H - 2 ) . Fig. 2B ...
... clone 2.6 (Fig. 2B) w i t h different anti-H-2 and a n t i - H L A monoclonal antibodies. Fig. 2A represents the fluorescence profiles of the L D l cell line ( H - 2 ) with the mouse plasmocytoma antibody M P C - 1 1 and monoclonal antibodies W6/32 ( H L A - A , B, C) and 11-4.1 ( H - 2 ) . Fig. 2B ...
Commentary Fas and the Art of Lymphocyte Maintenance By
... of unrelated children with these findings revealed profound defects in lymphocyte apoptosis associated with mutations in Fas (25, 26). The mutations would be predicted to cause abnormalities of the Fas protein, including premature termination of translation, deletions of the CILDs that would abrogat ...
... of unrelated children with these findings revealed profound defects in lymphocyte apoptosis associated with mutations in Fas (25, 26). The mutations would be predicted to cause abnormalities of the Fas protein, including premature termination of translation, deletions of the CILDs that would abrogat ...
Neuroendocrine cells of nasal mucosa are a cellular source of
... the punctate staining was observed. The identity of the subcellular storage compartment for BDNF is determined by colocalisation of BDNF with ChrA, an acidic sulphated glycoprotein present in dense core granules of the regulated secretory pathway of NECs. Figure 2 shows the three-dimensional reconst ...
... the punctate staining was observed. The identity of the subcellular storage compartment for BDNF is determined by colocalisation of BDNF with ChrA, an acidic sulphated glycoprotein present in dense core granules of the regulated secretory pathway of NECs. Figure 2 shows the three-dimensional reconst ...
The Cyton Model of the adaptive immune response, part I
... are able to replicate their DNA but not undergo cell division. DNA replication is only possible for cells entering their first division. ...
... are able to replicate their DNA but not undergo cell division. DNA replication is only possible for cells entering their first division. ...
Coagulation
... Mainly in children Often associated with viral infection 1. Antigen (virus?) sticks to platelet 2. Antibody in blood sticks to antigen on platelet surface 3. Macrophages (immune cells in spleen, elsewhere) consume antibody-coated platelets 4. Platelet number in blood drops 5. Platelet count usually ...
... Mainly in children Often associated with viral infection 1. Antigen (virus?) sticks to platelet 2. Antibody in blood sticks to antigen on platelet surface 3. Macrophages (immune cells in spleen, elsewhere) consume antibody-coated platelets 4. Platelet number in blood drops 5. Platelet count usually ...
CXCR3 Ligands induce Expression of CXCL1
... Background and aim: Liver injury leads to infiltration of immune cells and a subsequent activation of hepatic stellate cells. Chemokines are ubiquitous chemotactic proteins which are involved in inflammatory pathways. It has been recently suggested that chemokines can also induce the expression of o ...
... Background and aim: Liver injury leads to infiltration of immune cells and a subsequent activation of hepatic stellate cells. Chemokines are ubiquitous chemotactic proteins which are involved in inflammatory pathways. It has been recently suggested that chemokines can also induce the expression of o ...
larreaplus - Evolving Nutrition
... herpes simplex with dried extract from Melissa officinalis. Phytomedicine. 1994;1:25-31. ...
... herpes simplex with dried extract from Melissa officinalis. Phytomedicine. 1994;1:25-31. ...
HPV and Texans: What we need to know
... http://www.oralcancerfoundation.org/people/michael_douglas.htm. ...
... http://www.oralcancerfoundation.org/people/michael_douglas.htm. ...
Indirect immunoprecipitations of labeled glycopro
... complexes, de-crossantiserum against theE19 protein were shown tobe identical linking did notreveal the presenceof components other than by peptide mapping. Likewise, radiochemical amino acid se- the class I antigen subunits and theE19 protein. quence analyses of the 19,000-Da component co-precipita ...
... complexes, de-crossantiserum against theE19 protein were shown tobe identical linking did notreveal the presenceof components other than by peptide mapping. Likewise, radiochemical amino acid se- the class I antigen subunits and theE19 protein. quence analyses of the 19,000-Da component co-precipita ...
Immune Cell Repertoire and Their Mediators in Patients with Acute
... as a key component of adaptive immune system, eliminate the pathogenic microorganisms and malignant cells. The significant decline of T cell function suggests that the pathogenesis of acute thrombosis in AMI patients may be associated with the depletion of immune cells. However, less is known about ...
... as a key component of adaptive immune system, eliminate the pathogenic microorganisms and malignant cells. The significant decline of T cell function suggests that the pathogenesis of acute thrombosis in AMI patients may be associated with the depletion of immune cells. However, less is known about ...
Vaccines: A Molecular View
... response against the real pathogen(s) • Various types of vaccines are available – in all cases the pathogens or parts of them are modified so that they do not cause infection but do generate an immune response • Herd Immunity provides protection to individuals who have immature or weak immune system ...
... response against the real pathogen(s) • Various types of vaccines are available – in all cases the pathogens or parts of them are modified so that they do not cause infection but do generate an immune response • Herd Immunity provides protection to individuals who have immature or weak immune system ...
Autoimmune Disorders: an Overview of Molecular and Cellular
... for the development of AD. It should also be noted that in many cases during disease propagation, immunoregulatory pathways are also activated, which may result in natural inhibition of clinical disease over time. Such immunoregulation is likely absent or fails in a susceptible host. ...
... for the development of AD. It should also be noted that in many cases during disease propagation, immunoregulatory pathways are also activated, which may result in natural inhibition of clinical disease over time. Such immunoregulation is likely absent or fails in a susceptible host. ...
Cell proliferation in human epiretinal membranes:
... Purpose: To quantify the extent of cellular proliferation and immunohistochemically characterize the proliferating cell types in epiretinal membranes (ERMs) from four different conditions: proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy, post–retinal detachment, and idiopat ...
... Purpose: To quantify the extent of cellular proliferation and immunohistochemically characterize the proliferating cell types in epiretinal membranes (ERMs) from four different conditions: proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy, post–retinal detachment, and idiopat ...
blood cells are produced in the bone marrow.
... can sometimes appear milky after a very fatty meal or when people have a high level of lipids in their blood. • Plasma is 90-percent water. The other 10 percent dissolved in plasma is essential for life. These dissolved substances are circulated throughout the body and diffuse into tissues and cells ...
... can sometimes appear milky after a very fatty meal or when people have a high level of lipids in their blood. • Plasma is 90-percent water. The other 10 percent dissolved in plasma is essential for life. These dissolved substances are circulated throughout the body and diffuse into tissues and cells ...
Innate immunity in the lung: how epithelial cells fight
... inflammatory reaction. This inflammatory reaction includes the recruitment of phagocytes, that serve to remove microorganisms that are not cleared by the epithelium itself, and dendritic cells and lymphocytes that may aid to mount an adaptive immune response. Mechanisms to recognise pathogens by the ...
... inflammatory reaction. This inflammatory reaction includes the recruitment of phagocytes, that serve to remove microorganisms that are not cleared by the epithelium itself, and dendritic cells and lymphocytes that may aid to mount an adaptive immune response. Mechanisms to recognise pathogens by the ...
Mycobacterium tuberculosis-induced neutrophil - Arca
... shown to have functional activity and can modulate other cells.20,27e29 Ectosomes were recently shown to only be secreted by living cells and they are clearly distinct from the microvesicles produced by apoptotic cells.27 In addition to their generation kinetics, ectosomes and apoptotic bodies diffe ...
... shown to have functional activity and can modulate other cells.20,27e29 Ectosomes were recently shown to only be secreted by living cells and they are clearly distinct from the microvesicles produced by apoptotic cells.27 In addition to their generation kinetics, ectosomes and apoptotic bodies diffe ...
Cotton, Sarah, Final Thesis.
... motif (ITAM) phosphorylation by the folding of the domains into an inhibited conformation that blocks the catalytic domains.19 The specific roles of Syk in specific signaling pathways will be discussed in later sections. Characteristics of Syk in the LFA-1 Integrin Pathway Syk is in multiple immune ...
... motif (ITAM) phosphorylation by the folding of the domains into an inhibited conformation that blocks the catalytic domains.19 The specific roles of Syk in specific signaling pathways will be discussed in later sections. Characteristics of Syk in the LFA-1 Integrin Pathway Syk is in multiple immune ...
The Population of CD40L-expressing Cells was Slightly but not
... useful experimental model for studying the pathological mechanisms of therapeutic agents for human rheumatoid arthritis (RA). The development of CIA is known to depend on the presence of activated CD4+ T cells and the disease is associated with both cell-mediated and humoral immunity to collagen.1,2 ...
... useful experimental model for studying the pathological mechanisms of therapeutic agents for human rheumatoid arthritis (RA). The development of CIA is known to depend on the presence of activated CD4+ T cells and the disease is associated with both cell-mediated and humoral immunity to collagen.1,2 ...
Immune Stimulating Additives - Are They Worth the
... heifers than controls, which indicates that they were better able to mount an immune response during the stresses associated with calving, a time when the immune system is usually suppressed. White blood cells collected from supplemented heifers were more active in engulfing bacteria such as E. coli ...
... heifers than controls, which indicates that they were better able to mount an immune response during the stresses associated with calving, a time when the immune system is usually suppressed. White blood cells collected from supplemented heifers were more active in engulfing bacteria such as E. coli ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.