![Innate Immune Responses of the Dental Pulp to Caries](http://s1.studyres.com/store/data/016871714_1-d25cf8d3657206d49e6bac7ea99e9908-300x300.png)
Innate Immune Responses of the Dental Pulp to Caries
... nnate immunity is activated upon the initial invasion of microbes. If the innate response is unable to abolish the insult, adaptive immunity is elicited with cellular (cell-mediated immunity) and specific antibody (humoral immunity) responses to enhance the protective mechanisms of innate immunity. ...
... nnate immunity is activated upon the initial invasion of microbes. If the innate response is unable to abolish the insult, adaptive immunity is elicited with cellular (cell-mediated immunity) and specific antibody (humoral immunity) responses to enhance the protective mechanisms of innate immunity. ...
Malaria Pigment Enhances Expression of Maturation Markers on the
... present study was designed where APC (mDC and macrophages) were generated from bone marrow of BABL/c mice and subsequently the effect of both sHZ and nHz was investigated on mDC and macrophages. The model deemed suitable, as it was not reported earlier, to answer the unsettled functionality of APC a ...
... present study was designed where APC (mDC and macrophages) were generated from bone marrow of BABL/c mice and subsequently the effect of both sHZ and nHz was investigated on mDC and macrophages. The model deemed suitable, as it was not reported earlier, to answer the unsettled functionality of APC a ...
- Asian Pacific Journal of Cancer Prevention
... figure), which needs further studies. Testis is an immune privileged organ without expressing HLA molecules. CTAs are considered as ...
... figure), which needs further studies. Testis is an immune privileged organ without expressing HLA molecules. CTAs are considered as ...
B Lymphocytes in Multiple Sclerosis: Bregs and BTLA
... patients compared to HC. B cells expressing BTLA, a receptor whose binding to HVEM inhibits TcRinitiated cytokine production, as well as CD19+/BTLA+/IL-10+ cells were also significantly overall reduced in MS patients compared to HC. Analyses performed in RRMS showed that fingolimod-induced disease r ...
... patients compared to HC. B cells expressing BTLA, a receptor whose binding to HVEM inhibits TcRinitiated cytokine production, as well as CD19+/BTLA+/IL-10+ cells were also significantly overall reduced in MS patients compared to HC. Analyses performed in RRMS showed that fingolimod-induced disease r ...
- X Cell Nutri Sales
... EBV infection can lead to fatigue and impaired performance About 85% of adult Americans will test "positive" for EBV antibodies which means they have been exposed to the disease in the past • All of the diseases in the Herpes family share the common element that the infection can occur multiple time ...
... EBV infection can lead to fatigue and impaired performance About 85% of adult Americans will test "positive" for EBV antibodies which means they have been exposed to the disease in the past • All of the diseases in the Herpes family share the common element that the infection can occur multiple time ...
Phagocytosis in Teleosts. Implications of the New Cells Involved
... or membrane-bound molecules present on the host. Some effectors elaborate a response and attack the intruder in the second step. The last three decades of study greatly improved our knowledge of how the immune system initiated and developed the refined immune mechanisms actually present on invertebr ...
... or membrane-bound molecules present on the host. Some effectors elaborate a response and attack the intruder in the second step. The last three decades of study greatly improved our knowledge of how the immune system initiated and developed the refined immune mechanisms actually present on invertebr ...
Interactions of Host`s Innate and Adaptive Immune Components in
... intracellular lifecycle are capable of stimulating the host cells through both intracellular and extracellular TLRs. The viral components which are usually recognized by different TLRs include dsRNA, ssRNA and CpG-DNA [39]. It is important to note that one type of virus would not be more likely than ...
... intracellular lifecycle are capable of stimulating the host cells through both intracellular and extracellular TLRs. The viral components which are usually recognized by different TLRs include dsRNA, ssRNA and CpG-DNA [39]. It is important to note that one type of virus would not be more likely than ...
can
... boJ}e llUlJTOW transplantation, the donor mm•""~' ~ cells can attack lhe host lung. Although tl]e not normally appear to be involved in classic versus host disease (GVHD), Lhe syndrome . interstitial pneumonitis developing within allogeneic transplantation is much more patients with GVHD [7]. Chroni ...
... boJ}e llUlJTOW transplantation, the donor mm•""~' ~ cells can attack lhe host lung. Although tl]e not normally appear to be involved in classic versus host disease (GVHD), Lhe syndrome . interstitial pneumonitis developing within allogeneic transplantation is much more patients with GVHD [7]. Chroni ...
Paracrine control of tissue regeneration and cell proliferation by
... apoptosis as a trigger for tissue remodelling in response to tissue injury, identifying caspase activation as a key requirement for cell proliferation and recruitment of stem cells. In planaria, apoptotic waves have been shown to associate with tissue remodelling and regeneration.47 In Drosophila, m ...
... apoptosis as a trigger for tissue remodelling in response to tissue injury, identifying caspase activation as a key requirement for cell proliferation and recruitment of stem cells. In planaria, apoptotic waves have been shown to associate with tissue remodelling and regeneration.47 In Drosophila, m ...
Molecular Cloning, High Level Expression and Activity
... IL–25 induces the production of IL–6. Dose dependent study was carried out using the human PBMC, by treating the cells with various IL–25 concentrations to analyze the IL–6 levels. Human PBMC were isolated from the fresh human blood. 10 mL whole blood was centrifuged at 900xg for 10 min at room temp ...
... IL–25 induces the production of IL–6. Dose dependent study was carried out using the human PBMC, by treating the cells with various IL–25 concentrations to analyze the IL–6 levels. Human PBMC were isolated from the fresh human blood. 10 mL whole blood was centrifuged at 900xg for 10 min at room temp ...
Tight Interdigitating Developmental Processes within the
... associated with phagocytic cell defects. If PID is suspected, serum immunoglobulin and complete Box2 DiGeorge syndrome DiGeorge syndrome patients have a hemizygous deletion in chromosome 22q11.2 region (90% of patients) or in chromosome 10p13 region. This leads to defective development of the third ...
... associated with phagocytic cell defects. If PID is suspected, serum immunoglobulin and complete Box2 DiGeorge syndrome DiGeorge syndrome patients have a hemizygous deletion in chromosome 22q11.2 region (90% of patients) or in chromosome 10p13 region. This leads to defective development of the third ...
Profiling helper T cell subset gene expression in deer mice
... monoclonal antibodies to distinct epitopes for use in capture ELISAs. These assays usually require the cloning of full-length cDNAs for each cytokine, expression and production of recombinant cytokines, and production of monoclonal antibodies. This process requires substantial effort, expertise and ...
... monoclonal antibodies to distinct epitopes for use in capture ELISAs. These assays usually require the cloning of full-length cDNAs for each cytokine, expression and production of recombinant cytokines, and production of monoclonal antibodies. This process requires substantial effort, expertise and ...
NEUTROPHIL FUNCTIONAL DISORDER IN
... Elya Metchnikoff noticed that during an inflammatory reaction, leucocytes ingest microorganisms. He named this process phagocytosis and the cells capable of phagocytosis, phagocytes. He described these cells as macrophages; "big eaters"; cells "professionals"; cells that guard, protect and clean the ...
... Elya Metchnikoff noticed that during an inflammatory reaction, leucocytes ingest microorganisms. He named this process phagocytosis and the cells capable of phagocytosis, phagocytes. He described these cells as macrophages; "big eaters"; cells "professionals"; cells that guard, protect and clean the ...
21 - Dr. Jerry Cronin
... – Lectins - produced by innate system to recognize foreign invaders – When bound to foreign invaders can also bind and activate complement ...
... – Lectins - produced by innate system to recognize foreign invaders – When bound to foreign invaders can also bind and activate complement ...
Glucocorticoids and the Th1/Th2 Balance
... macrophages produce significantly less IL-12, leading to a decreased capacity of these cells to induce IFN-γ production by antigen-primed CD4+ T cells. The same treatment of monocytes/macrophages is also associated with an increased production of IL-4 by T cells, probably resulting from disinhibitio ...
... macrophages produce significantly less IL-12, leading to a decreased capacity of these cells to induce IFN-γ production by antigen-primed CD4+ T cells. The same treatment of monocytes/macrophages is also associated with an increased production of IL-4 by T cells, probably resulting from disinhibitio ...
Targeting lentiviral vectors to specific cell types in vivo
... surface ␣CD20, and FM were incubated with 293T兾CD20 cells in a low-pH buffer for half an hour, followed by culturing in regular medium. Both HAmu and SINmu induced cell–cell fusion by forming multinucleated polykaryons (Fig. 3C). The interaction between ␣CD20 and CD20 dramatically enhances the prob ...
... surface ␣CD20, and FM were incubated with 293T兾CD20 cells in a low-pH buffer for half an hour, followed by culturing in regular medium. Both HAmu and SINmu induced cell–cell fusion by forming multinucleated polykaryons (Fig. 3C). The interaction between ␣CD20 and CD20 dramatically enhances the prob ...
Innate Immune Responses
... • Few studies have examined innate responses in humans after vaccination (Querec et al., NI, 2009; Gaucher et al., JEM, 2008) • We implemented a clinical trial of an adenoviral vector HIV vaccine (Merck Ad5): 1. Which systemic innate immune responses can be measured in blood after vaccination by int ...
... • Few studies have examined innate responses in humans after vaccination (Querec et al., NI, 2009; Gaucher et al., JEM, 2008) • We implemented a clinical trial of an adenoviral vector HIV vaccine (Merck Ad5): 1. Which systemic innate immune responses can be measured in blood after vaccination by int ...
The Innate Immune Response
... invaders are dealt with using a limited set of weapons. Although the number of copies of the various weapons can be modulated in response to an invader, their mechanisms cannot be modified to enhance the reaction. The components of innate immunity have been called non-specific defenses, but recent d ...
... invaders are dealt with using a limited set of weapons. Although the number of copies of the various weapons can be modulated in response to an invader, their mechanisms cannot be modified to enhance the reaction. The components of innate immunity have been called non-specific defenses, but recent d ...
Ianello A, Thompson TW, Ardolino M, Lowe SW, Raulet DH. 2013. p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. J Experimental Medicine 210(10):2057-69.
... sensitivity to lysis by NK cells. Instead, p53 restoration caused tumor cells to secrete various chemokines with the potential to recruit NK cells. Antibody-mediated neutralization of CCL2, but not CCL3, CCL4 or CCL5, prevented NK cell recruitment to the senescent tumors and reduced their eliminatio ...
... sensitivity to lysis by NK cells. Instead, p53 restoration caused tumor cells to secrete various chemokines with the potential to recruit NK cells. Antibody-mediated neutralization of CCL2, but not CCL3, CCL4 or CCL5, prevented NK cell recruitment to the senescent tumors and reduced their eliminatio ...
Novel drug therapies in myeloid leukemia
... Rituximab [34] and ofatumumab [35] target malignancies with characteristic expression of CD20 on B-cells such as B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia (CLL) and alemtuzumab is used in the treatment of CLL and cutaneous T-cell lymphoma, where it targets CD52 on the surface of ...
... Rituximab [34] and ofatumumab [35] target malignancies with characteristic expression of CD20 on B-cells such as B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia (CLL) and alemtuzumab is used in the treatment of CLL and cutaneous T-cell lymphoma, where it targets CD52 on the surface of ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.