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Microbiology 204: Cellular and Molecular Immunology
Microbiology 204: Cellular and Molecular Immunology

IMMUNE SYSTEM - Roslyn School
IMMUNE SYSTEM - Roslyn School

... Bacteria cause disease • Heterotrophic bacteria – obtain nutrients by secreting enzymes that break down complex organic structures and absorbing them ...
immune system-struct and func
immune system-struct and func

...  is broken into non-infective pieces  & attached to the cell’s MHC when processed through the cell’s machinery  MHC-antigen complex is placed on the cell membrane surface  where it is recognized by the T Helper cell ...
Immune System
Immune System

Immune System
Immune System

... viral antigens displayed by infected cells Cytotoxic T cells (TC) punch a hole in the cell’s membrane Your body produces many cytotoxic T cells (TC) - each specific to a particular antigen ...
dipaimmunesystem - Dr. Brahmbhatt`s Class Handouts
dipaimmunesystem - Dr. Brahmbhatt`s Class Handouts

... • T-cell lymphocytes carry out cell-mediated immunity by directly combining with the foreign cell and destroying it or rendering it incapable of causing disease – Macrophages help present antigen – antigen presenting cells – Faster response ...
7.5 Immune response – questions and answers Q1. Bk Ch7 S7.6 Q1
7.5 Immune response – questions and answers Q1. Bk Ch7 S7.6 Q1

... into a person rather than the person producing the antibodies. Active immunity is long lasting because the body has produced the antibodies itself and therefore retains a ‘memory’ of the pathogen. However, when a person is immunised against a particular pathogen, for example the measles virus, they ...
Immune System Notes: Part I
Immune System Notes: Part I

... (occurs before birth and is completed a few months after birth)  Immature B cells produce antibodies while still in the bone marrow and insert these antibodies into their cell membranes (genes determine this)  Antibody bearing B cells enter the blood stream and travel to the lymph nodes, spleen an ...
Understanding the Immune System
Understanding the Immune System

... – T-Cells (Thymus derived) Natural Killer Cells (Innate Immunity)  CD4+ T-Cells (helper cells)  CD8+ T-Cells (cytotoxic cells) ...
March 2016, Anti-inflammatory role of a natural
March 2016, Anti-inflammatory role of a natural

... International Conference of the European Association of Fish Pathologists (EAFP) in Gran Canaria, Las Palmas in September 2015, where TargetFish highlights and achievements were discussed, was a great success. The significance of these developments for the aquatic animal health industry and ...
Stem cells from fat outperform those from bone marrow Singapore
Stem cells from fat outperform those from bone marrow Singapore

... although it took a smaller dose for the adipose tissue-derived stem cells (AT-SCs) to achieve the same effect on the immune cells. When it came to secreting cytokines, the cell signaling molecules that regulate the immune system, the AT-SCs also outperformed the bone marrow-derived cells. The findin ...
Another person Direct contact: shaking hands 1. 2. Contaminated
Another person Direct contact: shaking hands 1. 2. Contaminated

... 7. What are four major groups of human pathogens? ...
The Immune system - Locust Trace Veterinary Assistant Program
The Immune system - Locust Trace Veterinary Assistant Program

The Immune System
The Immune System

... the following terminology and others that you may have learned: immune system, lymphatic vessels, lymph nodes, filter, lymph, B cells, lymphocytes, epitopes, Class II MHC receptor, phagocytes, spleen, ...
03-Chapter-8-supplement
03-Chapter-8-supplement

... Viruses that disable the type I IFN pathway frequently disable iNOS activity as well Some viruses turn iNOS on to induce inflammation, which can help in viral dissemination (e.g., Ebola Zaire) ...
CIRCULATORY SYSTEM:
CIRCULATORY SYSTEM:

... 3. Immune System ...
(non-specific) immune system
(non-specific) immune system

... The immune system and its importance for homeostasis of organism • The immune system = a system of non-specific and specific mechanisms protecting the organism from damage caused by infectious factors of environment and providing surveillance of own structures (elimination of damaged and death cell ...
Body Defenses
Body Defenses

...   Plasma cells produce IgE antibodies which attach to mast cells   Mast cells release histamine – which causes inflammation and itching   Also releases a leukotriene called slow reactive substance – causes smooth muscle contraction in ...
File
File

... cell’s membrane 3. The pores allow a “signal” molecule from the NK cell to enter the target cell and trigger a genetically controlled series of events 4. The target cell then switches on a “suicide” gene, and “suicide” proteins are released 5. “Suicide” proteins function as self-destructive (degrada ...
Week 9: Today`s Program
Week 9: Today`s Program

... Vertebrate lymphocytes take on specialized roles Circulate through blood & lymph, concentrated in spleen & lymph nodes B & T cells bear ~100K antigen receptors (all the same) Antigenbinding sites ...
Chapter 31 Immune System and Diseases
Chapter 31 Immune System and Diseases

... • Fever goes away when the chemicals are no longer being made by the mast cells ...
Chapter 31 Immune System and Diseases
Chapter 31 Immune System and Diseases

... • Fever goes away when the chemicals are no longer being made by the mast cells ...
Chapter 15
Chapter 15

... benefits and the other (host) is unharmed • May be opportunistic pathogens ...
Transcriptional noise in CD4+ cells
Transcriptional noise in CD4+ cells

... Project description: The numbers of mRNAs and proteins that are found in a cell are usually low, amounting to less than one hundred for most types of mRNA. The statistical distributions of these among the cells of an otherwise identical population feature high variances. Yet, cells function reliably ...
B cells
B cells

...  no memory cell  no secondary response  fight against invading substances in a fast fashion ...
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Adaptive immune system



The adaptive immune system, also known as the acquired immune or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. The adaptive immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Adaptive immunity creates immunological memory after an initial response to a specific pathogen, leads to an enhanced response to subsequent encounters with that pathogen. This process of acquired immunity is the basis of vaccination. Like the innate system, the adaptive system includes both humoral immunity components and cell-mediated immunity components.Unlike the innate immune system, the adaptive immune system is highly specific to a specific pathogen. Adaptive immunity can also provide long-lasting protection: for example; someone who recovers from measles is now protected against measles for their lifetime but in other cases it does not provide lifetime protection: for example; chickenpox. The adaptive system response destroys invading pathogens and any toxic molecules they produce. Sometimes the adaptive system is unable to distinguish foreign molecules, the effects of this may be hayfever, asthma or any other allergies. Antigens are any substances that elicit the adaptive immune response. The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. Two main broad classes—antibody responses and cell mediated immune response—are also carried by two different lymphocytes (B cells and T cells). In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host.In acquired immunity, pathogen-specific receptors are ""acquired"" during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is called ""adaptive"" because it prepares the body's immune system for future challenges (though it can actually also be maladaptive when it results in autoimmunity).The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all progeny (offspring) of that cell inherit genes that encode the same receptor specificity, including the memory B cells and memory T cells that are the keys to long-lived specific immunity.A theoretical framework explaining the workings of the acquired immune system is provided by immune network theory. This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine.
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