Immune selection in neoplasia: towards a microevolutionary model
... It has been established that a variety of immune escape mechanisms are commonly expressed by tumours of diverse histological type. Although widely acknowledged, the scientific community has not focused on the implication for immunological involvement in tumour development. Mechanisms of immune escap ...
... It has been established that a variety of immune escape mechanisms are commonly expressed by tumours of diverse histological type. Although widely acknowledged, the scientific community has not focused on the implication for immunological involvement in tumour development. Mechanisms of immune escap ...
Homeostatic Competition Among T Cells Revealed by
... Generation and Analysis of Mouse Lines that Allow for Stagespecific Inactivation of the CD4 Gene. A conditional allele of the mouse Cd4 gene was created in ES cells by targeted mutagenesis. The targeting construct used for this purpose featured loxP sites both upstream of the initiator methionine in ...
... Generation and Analysis of Mouse Lines that Allow for Stagespecific Inactivation of the CD4 Gene. A conditional allele of the mouse Cd4 gene was created in ES cells by targeted mutagenesis. The targeting construct used for this purpose featured loxP sites both upstream of the initiator methionine in ...
61. DNA vaccines based on FMDV minigenes in a mouse model
... should provide a complete immune response: both humoral and cellular responses. In an attempt to improve the immunogenicity of these epitopes after DNA vaccination in vivo, we decided to use successful strategies previously described in our lab and in others (Boyle et al., 1997, 1998; Rodriguez & Wh ...
... should provide a complete immune response: both humoral and cellular responses. In an attempt to improve the immunogenicity of these epitopes after DNA vaccination in vivo, we decided to use successful strategies previously described in our lab and in others (Boyle et al., 1997, 1998; Rodriguez & Wh ...
Rel Induces Interferon Regulatory Factor 4 (IRF-4)
... by Rel, the expression of genes normally induced early in lymphocyte activation were examined in c-rel⫺Ⲑ⫺ B and T cells. Among those surveyed, IFN regulatory factor 4 (IRF-4), a lymphoid-restricted member of the IFN family of transcription factors, emerged as a promising candidate. IRF-4 expression ...
... by Rel, the expression of genes normally induced early in lymphocyte activation were examined in c-rel⫺Ⲑ⫺ B and T cells. Among those surveyed, IFN regulatory factor 4 (IRF-4), a lymphoid-restricted member of the IFN family of transcription factors, emerged as a promising candidate. IRF-4 expression ...
Document
... (Table 1). Even when considered separately, the scores from treat- at month 3 developed an exacerbation with left hemiparesis and ment and post-treatment phases were consistent for each patient. atypical flaccid lower extremity weakness rendering him nonUsing these criteria, patients MS501 and MS503 ...
... (Table 1). Even when considered separately, the scores from treat- at month 3 developed an exacerbation with left hemiparesis and ment and post-treatment phases were consistent for each patient. atypical flaccid lower extremity weakness rendering him nonUsing these criteria, patients MS501 and MS503 ...
Response of the Innate Immune System to Pathogens
... metabolism not subject to antigenic variability The recognized structures must be absolutely distinct from self antigens: discrimination of self vs. non-self ...
... metabolism not subject to antigenic variability The recognized structures must be absolutely distinct from self antigens: discrimination of self vs. non-self ...
Nerve growth factor: role in growth, differentiation
... models [47–49]. Although tumors have their own “cell shelter mechanisms” (immune escape, resistance to apoptosis and cell survival), a host-mediated immune response against tumors can occur and consequently two different models have been proposed. The “immunosurveillance model” suggests that tumor c ...
... models [47–49]. Although tumors have their own “cell shelter mechanisms” (immune escape, resistance to apoptosis and cell survival), a host-mediated immune response against tumors can occur and consequently two different models have been proposed. The “immunosurveillance model” suggests that tumor c ...
A c a d
... (postmenopausal/metestrus levels) did not lead to marked effects33, 34 or even exert stimulatory effects on IL-135. Particularly, the later two studies indicate that E2 at low concentrations might stimulate IL-1ß secretion, whereas it inhibits its secretion at pregnancy levels. With respect to IL-8, ...
... (postmenopausal/metestrus levels) did not lead to marked effects33, 34 or even exert stimulatory effects on IL-135. Particularly, the later two studies indicate that E2 at low concentrations might stimulate IL-1ß secretion, whereas it inhibits its secretion at pregnancy levels. With respect to IL-8, ...
Contribution of Renal Tubule Epithelial Cells in the Innate Immune
... that can lead to destruction of the epithelium. For example, the episodes of acute inflammation in inflammatory bowel diseases, such as Crohn’s disease, ulcerative colitis and necrotizing enterocolitis, are all associated with marked impairment of the integrity of the intestinal epithelium.(13) This ...
... that can lead to destruction of the epithelium. For example, the episodes of acute inflammation in inflammatory bowel diseases, such as Crohn’s disease, ulcerative colitis and necrotizing enterocolitis, are all associated with marked impairment of the integrity of the intestinal epithelium.(13) This ...
lymphatic immune - Warren County Schools
... Interferons are a family species-specific proteins synthesized by eukaryotic cells in response to viruses and a variety of natural and synthetic stimuli. There are several different interferons commonly used as therapeutics, termed alpha, beta, and gamma. These peptides are used to treat hairy cell ...
... Interferons are a family species-specific proteins synthesized by eukaryotic cells in response to viruses and a variety of natural and synthetic stimuli. There are several different interferons commonly used as therapeutics, termed alpha, beta, and gamma. These peptides are used to treat hairy cell ...
- Salford Royal NHS Foundation Trust
... increase in CD8 cells. ICL patients have higher proportion of activated (HLADR) CD4, but not CD8 T cells. The studies of patients with ICL showed that among CD4 T-cells, naıve CD45RA T-cells are more severely diminished than the memory CD45RO population. Some reports described a high percentage of g ...
... increase in CD8 cells. ICL patients have higher proportion of activated (HLADR) CD4, but not CD8 T cells. The studies of patients with ICL showed that among CD4 T-cells, naıve CD45RA T-cells are more severely diminished than the memory CD45RO population. Some reports described a high percentage of g ...
Thymus gland Bone marrow Secondary organs of immune system
... of antibiotics for an infection… •as well as killing off the harmful bacteria causing the infection, •some of the good resident microbes will die, leaving an opportunity for others to grow. ...
... of antibiotics for an infection… •as well as killing off the harmful bacteria causing the infection, •some of the good resident microbes will die, leaving an opportunity for others to grow. ...
Biology
... Plasmodium antigen but the person is not suffering the symptoms of malaria then the drugs work. ...
... Plasmodium antigen but the person is not suffering the symptoms of malaria then the drugs work. ...
Innate and adaptive immune responses subsequent to
... cytokines. Recently, it has been shown that administration of the selective A2aR agonist ATL313 attenuated renal IRI via tolerizing effects on DCs [77]. Similarly, ATL313 treatment at the time of reperfusion protected mice from liver IRI via effects on bone marrow derived cells [78]. Furthermore, AT ...
... cytokines. Recently, it has been shown that administration of the selective A2aR agonist ATL313 attenuated renal IRI via tolerizing effects on DCs [77]. Similarly, ATL313 treatment at the time of reperfusion protected mice from liver IRI via effects on bone marrow derived cells [78]. Furthermore, AT ...
Preliminary evidence that the novel host-derived immunostimulant EP67 can act as a mucosal adjuvant
... Mucosal vaccines composed of killed (bacteria) or inactivated (virus) pathogens (killed/inactivated vaccines) or protective fragments of the pathogen (subunit vaccines) can potentially overcome problems associated with live attenuated vaccines but require the addition of an adjuvant because they are ...
... Mucosal vaccines composed of killed (bacteria) or inactivated (virus) pathogens (killed/inactivated vaccines) or protective fragments of the pathogen (subunit vaccines) can potentially overcome problems associated with live attenuated vaccines but require the addition of an adjuvant because they are ...
CureVac Collaborates with the Cancer Research Institute and
... biopharmaceutical company that has pioneered the development of a new class of therapies and vaccines based on messenger RNA (mRNA), today announced that they will collaborate to enable clinical testing of novel cancer immunotherapy treatment options. Amplifying the immune system’s ability to recogn ...
... biopharmaceutical company that has pioneered the development of a new class of therapies and vaccines based on messenger RNA (mRNA), today announced that they will collaborate to enable clinical testing of novel cancer immunotherapy treatment options. Amplifying the immune system’s ability to recogn ...
Human Pancreatic Cancer Cells Induce a MyD88
... tolerance (5). Although innate immunity is generally beneficial to the host, an overexuberant or persistent response can result in tissue injury (6). To minimize this possibility, the immune system is equipped with negative regulatory mechanisms that suppress inflammation and downregulate adaptive imm ...
... tolerance (5). Although innate immunity is generally beneficial to the host, an overexuberant or persistent response can result in tissue injury (6). To minimize this possibility, the immune system is equipped with negative regulatory mechanisms that suppress inflammation and downregulate adaptive imm ...
Sphingolipids and the Balancing of Immune Cell Function: Lessons
... and S1P (following activation of sphingosine kinase (SphK)). Each of these lipid metabolites can directly bind proteins, activate signaling pathways, and affect cellular responses; moreover, in combination, the sphingolipid mediators can finely tune cellular function. Cer binds to a number of signal ...
... and S1P (following activation of sphingosine kinase (SphK)). Each of these lipid metabolites can directly bind proteins, activate signaling pathways, and affect cellular responses; moreover, in combination, the sphingolipid mediators can finely tune cellular function. Cer binds to a number of signal ...
Thesis - KI Open Archive
... In addition, infections with enteroviruses belonging to the group B Coxsackieviruses have been implicated in the etiology of type 1 diabetes. Enterovirus infections are also commonly observed in patients with cystic fibrosis, resulting in lung exacerbations and morbidity. Proper antiviral response m ...
... In addition, infections with enteroviruses belonging to the group B Coxsackieviruses have been implicated in the etiology of type 1 diabetes. Enterovirus infections are also commonly observed in patients with cystic fibrosis, resulting in lung exacerbations and morbidity. Proper antiviral response m ...
Phagocytosis and comparative innate immunity
... Phagocytosis is initiated by the ligation of cell-surface receptors that either directly bind to the particle or to opsonins that are deposited on the particle’s surface. Both forward and reverse genetics, as well as RNAi screens, in D. melanogaster cells have been successfully used to identify pote ...
... Phagocytosis is initiated by the ligation of cell-surface receptors that either directly bind to the particle or to opsonins that are deposited on the particle’s surface. Both forward and reverse genetics, as well as RNAi screens, in D. melanogaster cells have been successfully used to identify pote ...
The role of the thymus in allogeneic hematopoietic stem cell
... plants are now performed annually, the majority to treat leukaemias and bone marrow failure syndromes [3]. Patients eligible for allogeneic HSCT first receive preparative cytoreductive conditioning which is followed by the transfer of a donor haematopoietic cell graft. The stem cells contained in th ...
... plants are now performed annually, the majority to treat leukaemias and bone marrow failure syndromes [3]. Patients eligible for allogeneic HSCT first receive preparative cytoreductive conditioning which is followed by the transfer of a donor haematopoietic cell graft. The stem cells contained in th ...