Rheumatic Heart Disease: Genes, Inflammation and Autoimmunity
... with the disease. The interleukin 1 (IL-1) gene cluster located on chromosome 2 includes the genes expressing the proinflammatory cytokines IL-1a and IL-1b and their inhibitor IL-1 receptor antagonist (IL-1RA). The ratio of IL-1RA to IL-1 is important in determining the duration and intensity of the ...
... with the disease. The interleukin 1 (IL-1) gene cluster located on chromosome 2 includes the genes expressing the proinflammatory cytokines IL-1a and IL-1b and their inhibitor IL-1 receptor antagonist (IL-1RA). The ratio of IL-1RA to IL-1 is important in determining the duration and intensity of the ...
Identification and Characterization of Genes Involved in
... has been associated with these (Altshuller et al. 1996; Kim et al. 1998; Gunther et al. 2000; Schreiber et al. 2000). Drosophila gcm-1 and gcm-2 double mutants show only a 40% reduction in presumptive plasmatocytes, and only a fraction of mature plasmatocyte markers are detected in the remaining cel ...
... has been associated with these (Altshuller et al. 1996; Kim et al. 1998; Gunther et al. 2000; Schreiber et al. 2000). Drosophila gcm-1 and gcm-2 double mutants show only a 40% reduction in presumptive plasmatocytes, and only a fraction of mature plasmatocyte markers are detected in the remaining cel ...
Document
... membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. • Glucocorticoids also stimulate the lipocortin-1 ...
... membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. • Glucocorticoids also stimulate the lipocortin-1 ...
Rethinking T cell immunity in oropharyngeal candidiasis - JEM
... a state of colonization, which evolves into a state of commensalism, except in rare cases of neonatal candidiasis (2). The state of commensalism, which does not result in damage to the host, is established as a result of host homeostasis, physiology, and development of the immune system (3, 4). Alte ...
... a state of colonization, which evolves into a state of commensalism, except in rare cases of neonatal candidiasis (2). The state of commensalism, which does not result in damage to the host, is established as a result of host homeostasis, physiology, and development of the immune system (3, 4). Alte ...
C O M M E N TA RY
... wild-type mice than of susceptible IL-17RA–deficient mice. Moreover, saliva from wild-type mice could kill the fungus in vitro, whereas the killing capacity of saliva from IL-23p19– and IL-17RA–deficient mice was impaired. These data are consistent with previous studies showing that IL-23, in concer ...
... wild-type mice than of susceptible IL-17RA–deficient mice. Moreover, saliva from wild-type mice could kill the fungus in vitro, whereas the killing capacity of saliva from IL-23p19– and IL-17RA–deficient mice was impaired. These data are consistent with previous studies showing that IL-23, in concer ...
Memory B cells, but not long-lived plasma cells, possess antigen
... serum, a substantial (9.3-fold, P < 0.01) reduction in binding to the DIII-LR epitope was observed. As an independent measure of LLPC specificity, we analyzed bone marrow cells for intracellular binding to a bivalent fusion protein composed of WNV DIII or DIII-K307E/T330I and human 1 Fc (DIII-FcHu, ...
... serum, a substantial (9.3-fold, P < 0.01) reduction in binding to the DIII-LR epitope was observed. As an independent measure of LLPC specificity, we analyzed bone marrow cells for intracellular binding to a bivalent fusion protein composed of WNV DIII or DIII-K307E/T330I and human 1 Fc (DIII-FcHu, ...
Symptomatic HIV Infection
... *one of the targets of the virus is CNS(involved in 60% of cases) leads to brain atrophy, poliosis of the cortex,, perivascular inflammation & white matter degeneration. ...
... *one of the targets of the virus is CNS(involved in 60% of cases) leads to brain atrophy, poliosis of the cortex,, perivascular inflammation & white matter degeneration. ...
Psoriatic Arthritis and the Complications of Systemic Inflammation
... reaction or other rash. Understanding the diagnostic criteria is important because the pathophysiology of PsA differs from RA. While both are inflammatory conditions and share some common cytokine pathways, there does appear to be a slightly different immune response between the two, presenting the ...
... reaction or other rash. Understanding the diagnostic criteria is important because the pathophysiology of PsA differs from RA. While both are inflammatory conditions and share some common cytokine pathways, there does appear to be a slightly different immune response between the two, presenting the ...
Skeletal System
... – Langerhans’ cells of the epidermis “present” foreign substances (antigens) to the white blood cells (lymphocytes) which in tern activate our immune system – Macrophages of the dermis dispose of viruses and bacteria that have penetrate the epidermis but they also work as presenters ...
... – Langerhans’ cells of the epidermis “present” foreign substances (antigens) to the white blood cells (lymphocytes) which in tern activate our immune system – Macrophages of the dermis dispose of viruses and bacteria that have penetrate the epidermis but they also work as presenters ...
The danger model in deciphering autoimmunity
... fulfil these criteria, and thus form the pathogenic basis of an autoimmune response. In various forms, elements of each of these scenarios have all been suggested as aetiological factors in SLE. Scenario 1: waste management and apoptotic cell antigens. MHC Class II antigen presentation is largely re ...
... fulfil these criteria, and thus form the pathogenic basis of an autoimmune response. In various forms, elements of each of these scenarios have all been suggested as aetiological factors in SLE. Scenario 1: waste management and apoptotic cell antigens. MHC Class II antigen presentation is largely re ...
Nitric Oxide - chem.uwec.edu
... NO serves in the body as a neurotransmitter, but there are definite differences between other neurotransmitters used commonly in the body NO is synthesized on demand vs. constant synthesis NO diffuses out of the cells making it vs. storage in vesicles and release by exocytosis NO does not bi ...
... NO serves in the body as a neurotransmitter, but there are definite differences between other neurotransmitters used commonly in the body NO is synthesized on demand vs. constant synthesis NO diffuses out of the cells making it vs. storage in vesicles and release by exocytosis NO does not bi ...
MD Anderson Cancer Center
... Anderson Algorithm, an early success story to emerge from the Moon Shots Program. The algorithm, adopted as a standard protocol in 2013 by the center’s 21 gynecologic cancer specialists, relies on independent assessments by two surgeons via a laparoscopic exam to determine which women with advanced ...
... Anderson Algorithm, an early success story to emerge from the Moon Shots Program. The algorithm, adopted as a standard protocol in 2013 by the center’s 21 gynecologic cancer specialists, relies on independent assessments by two surgeons via a laparoscopic exam to determine which women with advanced ...
Importance of the Candida albicans cell wall during
... damage since killed fungal hyphae with no potential to cause disease can be taken up via this mechanism [7,15]. By contrast, induction of host damage is a key characteristic of pathogenesis. Damage directly caused by the fungus occurs when hyphae invade deep into or through host cells (interepithel ...
... damage since killed fungal hyphae with no potential to cause disease can be taken up via this mechanism [7,15]. By contrast, induction of host damage is a key characteristic of pathogenesis. Damage directly caused by the fungus occurs when hyphae invade deep into or through host cells (interepithel ...
Recurrent respiratory papillomatosis: pathogenesis to treatment
... The utility of this cytosine analog in the treatment of HPV-infected cells in vitro has been evaluated. Both transformed cells and cancer cells containing integrated HPV have shown preferential growth inhibition with cidofovir in comparison with non-HPV cancer cells. These studies suggest a selectiv ...
... The utility of this cytosine analog in the treatment of HPV-infected cells in vitro has been evaluated. Both transformed cells and cancer cells containing integrated HPV have shown preferential growth inhibition with cidofovir in comparison with non-HPV cancer cells. These studies suggest a selectiv ...
SOMATIC GENERATION OF IMMUNE DIVERSITY
... the carboxyl terminal regions (3). These two regions were then referred to as the variable, or V, and the constant, or C, regions. However, immunologists and geneticists were divided for many years into two schools of thought with respect to the issue of whether the genetic diversity required for th ...
... the carboxyl terminal regions (3). These two regions were then referred to as the variable, or V, and the constant, or C, regions. However, immunologists and geneticists were divided for many years into two schools of thought with respect to the issue of whether the genetic diversity required for th ...
poster template - Argos Therapeutics
... (MOA) of AGS-003 is predicated on the expansion of antigen reactive CTL having a broad multifunctional response. Multi-color flow cytometry was used to identify tumor-reactive central memory CTL subsets expanded after treatment with AGS-003. Multi-functionality of CTL responses to AGS-003 was identi ...
... (MOA) of AGS-003 is predicated on the expansion of antigen reactive CTL having a broad multifunctional response. Multi-color flow cytometry was used to identify tumor-reactive central memory CTL subsets expanded after treatment with AGS-003. Multi-functionality of CTL responses to AGS-003 was identi ...
Review Article Nuclear factor-kappaB in inflammatory bowel disease
... revealed that chronic inflammation promoted colorectal cancer by altering the composition of gut microbiota [30]. The microenvironment that contributes to tumor development is comprised of various cell types, including the infiltrating inflammatory cells, as well as a host of soluble mediators such ...
... revealed that chronic inflammation promoted colorectal cancer by altering the composition of gut microbiota [30]. The microenvironment that contributes to tumor development is comprised of various cell types, including the infiltrating inflammatory cells, as well as a host of soluble mediators such ...
Document
... Naltrexone, an opioid antagonist, has been used in clinical trials to treat alcoholism. As the opioid peptides b-endorphin and enkephalin increase splenic NK cell function in laboratory animals, it is anticipated that naltrexone treatment will cause immunosuppression. However, we report in thi ...
... Naltrexone, an opioid antagonist, has been used in clinical trials to treat alcoholism. As the opioid peptides b-endorphin and enkephalin increase splenic NK cell function in laboratory animals, it is anticipated that naltrexone treatment will cause immunosuppression. However, we report in thi ...
EVALUATION OF NEUTROPHIL FUNCTION, OPSONISING CAPACITY AND LYMPHOCYTE
... Methods: The patients were classified into three groups. Blood glucose, glycated haemoglobin (HbAlc) and ECG changes were taken into consideration when grouping. All the recruited patients had normal lipid profile and were not taking any lipid lowering drugs. The study cohort were grouped as Group 1 ...
... Methods: The patients were classified into three groups. Blood glucose, glycated haemoglobin (HbAlc) and ECG changes were taken into consideration when grouping. All the recruited patients had normal lipid profile and were not taking any lipid lowering drugs. The study cohort were grouped as Group 1 ...