The role of microRNA-1246 in the regulation of B cell activation and
... modulate the pathogenesis of autoimmune diseases such as SLE, rheumatoid arthritis, and multiple sclerosis through their effects on T cells and B cell functions [26]. Nevertheless, the mechanisms by which miRNA dysregulation contributes to the pathogenesis of autoimmune diseases such as SLE have not ...
... modulate the pathogenesis of autoimmune diseases such as SLE, rheumatoid arthritis, and multiple sclerosis through their effects on T cells and B cell functions [26]. Nevertheless, the mechanisms by which miRNA dysregulation contributes to the pathogenesis of autoimmune diseases such as SLE have not ...
Cerebral Innate Immunity in Drosophila Melanogaster
... (PRRs), which in turn has illustrated the broad variety of pathogen detection mechanisms, signaling components, immune modulating factors, and innate-adaptive immune cross-talk, which has revolutionized the field of immunology [1–3]. These initial studies in D. melanogaster, as well as subsequent in ...
... (PRRs), which in turn has illustrated the broad variety of pathogen detection mechanisms, signaling components, immune modulating factors, and innate-adaptive immune cross-talk, which has revolutionized the field of immunology [1–3]. These initial studies in D. melanogaster, as well as subsequent in ...
Licentiate thesis from the Department of Immunology, Wenner-Gren Institute,
... system that can act swiftly against all pathogens and learn to respond more efficiently against any pathogen common to a given individuals specific environment. These branches are, however, not two entirely separate systems but the adaptive is dependent on the innate components to function and the i ...
... system that can act swiftly against all pathogens and learn to respond more efficiently against any pathogen common to a given individuals specific environment. These branches are, however, not two entirely separate systems but the adaptive is dependent on the innate components to function and the i ...
Eliminating latent tuberculosis - Institute of Infectious Disease and
... progressive pre-clinical and clinical disease (Figure 2). The disease risk associated with latent TB is a combination of endogenous reactivation of an initial infection or failure to control progression of an exogenous reinfection: the relative importance of the two routes presumably depending on th ...
... progressive pre-clinical and clinical disease (Figure 2). The disease risk associated with latent TB is a combination of endogenous reactivation of an initial infection or failure to control progression of an exogenous reinfection: the relative importance of the two routes presumably depending on th ...
The machinery of programmed cell death
... Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA ...
... Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA ...
Functional Anatomy of Lymphatic System
... largest lymphatic organ located in upper left abdominal quadrant between fundus of stomach and diaphragm ...
... largest lymphatic organ located in upper left abdominal quadrant between fundus of stomach and diaphragm ...
Transplant Outcome in Mice Effects of T Cell Frequency and Graft
... (Fig. 1). Skin-derived Langerhans cells are more frequent in number and may be more immunogenic than heart-derived dendritic cells (34, 35). In addition, because skin grafts are not initially vascularized, induced ischemia-reperfusion injury is likely to be more prolonged than in vascularized heart ...
... (Fig. 1). Skin-derived Langerhans cells are more frequent in number and may be more immunogenic than heart-derived dendritic cells (34, 35). In addition, because skin grafts are not initially vascularized, induced ischemia-reperfusion injury is likely to be more prolonged than in vascularized heart ...
Molecular mechanism of the migration of neutrophils in liver
... Ischemia/reperfusion (IR) injury is comprised of two distinct phases. In the ischemic phase, insult induces oxidant stress within the liver resulting in Kupffer cells activation and oxidant mediated injury to hepatocytes [29]. The activation of Kupffer cells results in their production of the early ...
... Ischemia/reperfusion (IR) injury is comprised of two distinct phases. In the ischemic phase, insult induces oxidant stress within the liver resulting in Kupffer cells activation and oxidant mediated injury to hepatocytes [29]. The activation of Kupffer cells results in their production of the early ...
Natural Antimicrobial Peptides: Pleiotropic Molecules in Host Defense
... originally gained prominence through initial descriptions of their direct antimicrobial functions [5], not all protective cationic peptides are necessarily working through direct microbicidal action. In contrast, under such conditions, a wide range of functions have been demonstrated for these pepti ...
... originally gained prominence through initial descriptions of their direct antimicrobial functions [5], not all protective cationic peptides are necessarily working through direct microbicidal action. In contrast, under such conditions, a wide range of functions have been demonstrated for these pepti ...
Protocol S1.
... of the viral cycle and this has enabled us to develop combined drug therapy that acts on the different steps of the cycle (ie, reverse transcriptase and protease). This therapy, known as highly active antiretroviral therapy (HAART), has made it possible in approximately 70% of all treated patients t ...
... of the viral cycle and this has enabled us to develop combined drug therapy that acts on the different steps of the cycle (ie, reverse transcriptase and protease). This therapy, known as highly active antiretroviral therapy (HAART), has made it possible in approximately 70% of all treated patients t ...
Enhanced anti-tumor immune responses and delay of tumor development in human
... Introduction: Cancer vaccines have the potential to induce curative anti-tumor immune responses and better adjuvants may improve vaccine efficacy. We have previously shown that Hp91, a peptide derived from the B box domain in high-mobility group box protein 1 (HMGB1), acts as a potent immune adjuvan ...
... Introduction: Cancer vaccines have the potential to induce curative anti-tumor immune responses and better adjuvants may improve vaccine efficacy. We have previously shown that Hp91, a peptide derived from the B box domain in high-mobility group box protein 1 (HMGB1), acts as a potent immune adjuvan ...
Localization of Receptors for Vasoactive Intestinal
... Further, the SP receptor-expressing structures were identified as blood vessels. Thus, all three receptors, VIP receptors, SS receptors, and SP receptors, are expressed by human lymphoid organs in different, topographically distinct structures. The CCK receptors do not appear to play a major role in ...
... Further, the SP receptor-expressing structures were identified as blood vessels. Thus, all three receptors, VIP receptors, SS receptors, and SP receptors, are expressed by human lymphoid organs in different, topographically distinct structures. The CCK receptors do not appear to play a major role in ...
CHAPTER III
... well as a barrier against bacterial and fungal infection. The inner cyst is crucial in survival of the metacercaria (Boray, 1963). When the definitive host ingests the infected plant, the metacercariae excyst in the small intestine. The newly excysted juvenile parasites immediately penetrate the int ...
... well as a barrier against bacterial and fungal infection. The inner cyst is crucial in survival of the metacercaria (Boray, 1963). When the definitive host ingests the infected plant, the metacercariae excyst in the small intestine. The newly excysted juvenile parasites immediately penetrate the int ...
Prevalence of Serum IgG and Neutralizing Factors Against
... For many viruses, studies of the IgG subclasses that arise against viral antigens can provide insight into the nature and duration of the exposure or infection. IgG subclass responses were examined in serum samples of healthy human subjects exposed to AAV2 (Murphy et al., 2009). Analysis indicated a ...
... For many viruses, studies of the IgG subclasses that arise against viral antigens can provide insight into the nature and duration of the exposure or infection. IgG subclass responses were examined in serum samples of healthy human subjects exposed to AAV2 (Murphy et al., 2009). Analysis indicated a ...
Introduction to AIS
... be evaluated by a distance or affinity measure • The choice of affinity measure is crucial: • It alters the shape-space topology • It will introduce an inductive bias into the algorithm • It needs to take into account the data-set used and the problem you are trying to solve ...
... be evaluated by a distance or affinity measure • The choice of affinity measure is crucial: • It alters the shape-space topology • It will introduce an inductive bias into the algorithm • It needs to take into account the data-set used and the problem you are trying to solve ...
The Cellular Biology of the Reed-Sternberg Cell
... a distinct entity with some pathologic features of carcinoma or histiocytosis, and usually derives from activated T cells.52 Table l contrasts the immunophenotype of ALCL with that of HD. Ki-l is one of several a n t i b ~ d i e s ~that ~ . ' ~recognize the CD30 antigen. This marker is expressed pri ...
... a distinct entity with some pathologic features of carcinoma or histiocytosis, and usually derives from activated T cells.52 Table l contrasts the immunophenotype of ALCL with that of HD. Ki-l is one of several a n t i b ~ d i e s ~that ~ . ' ~recognize the CD30 antigen. This marker is expressed pri ...
Airway smooth muscle cells respond directly to inhaled
... muscle cells of asthma patients show a predisposition to proliferate faster [24, 25] which was linked to both reduced expression of the transcription and differentiation factor C/EBP-α [26] and to an increased number of mitochrondria which were hyperactive [25]. Interestingly, many mitochondrial gen ...
... muscle cells of asthma patients show a predisposition to proliferate faster [24, 25] which was linked to both reduced expression of the transcription and differentiation factor C/EBP-α [26] and to an increased number of mitochrondria which were hyperactive [25]. Interestingly, many mitochondrial gen ...
Innate Immune Cells: Key Regulators of Homeostasis and
... in [3]). A group of intracellular PRRs known as NLRPs (NOD-like receptor family pyrin domain containing) has also been recently found to be important in maintaining gut homeostasis and in regulating inflammation severity (reviewed in [23]). NLRPs play a central role in initiating the inflammatory re ...
... in [3]). A group of intracellular PRRs known as NLRPs (NOD-like receptor family pyrin domain containing) has also been recently found to be important in maintaining gut homeostasis and in regulating inflammation severity (reviewed in [23]). NLRPs play a central role in initiating the inflammatory re ...
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... to assess. Despite the use of the same 11.4-1 antibody we are unable to repeat their finding. Of the cellular markers so far described, only one seems likely to be truly ...
... to assess. Despite the use of the same 11.4-1 antibody we are unable to repeat their finding. Of the cellular markers so far described, only one seems likely to be truly ...
Angioimmunoblastic T-cell lymphoma
... cytokines and chemokines as well as cell adhesion molecules may explain several clinicopathologic features associated with AITL. ...
... cytokines and chemokines as well as cell adhesion molecules may explain several clinicopathologic features associated with AITL. ...
roles in innate immune receptors: host - pathogen
... treatment of diseases and autoimmunity, and the development of new vaccines. Vaccines are among the greatest inventions in medical history. However traditional vaccine approaches, such as live attenuated or inactivated viruses, have failed as vaccine candidates to address certain diseases including ...
... treatment of diseases and autoimmunity, and the development of new vaccines. Vaccines are among the greatest inventions in medical history. However traditional vaccine approaches, such as live attenuated or inactivated viruses, have failed as vaccine candidates to address certain diseases including ...
Pyroptosis: A Caspase-1-Dependent Programmed Cell Death and a
... [18]. This catabolic process is essential during starvation conditions to maintain energy homeostasis and cell survival. Excessive autophagy has, however, been associated with a form of “autophagic cell death” characterized by massive accumulation of autophagic vacuoles in the cytoplasm in the absen ...
... [18]. This catabolic process is essential during starvation conditions to maintain energy homeostasis and cell survival. Excessive autophagy has, however, been associated with a form of “autophagic cell death” characterized by massive accumulation of autophagic vacuoles in the cytoplasm in the absen ...