Immunological and fibrotic mechanisms in Cardiac Allograft
... But which cells are mostly responsible for the development of CAV? The human immune system contains a variety of cells. After transplantation of a solid organ, the recipient’s immune system recognizes the graft as foreign and attacks it. In this process there are many different immune cells involved ...
... But which cells are mostly responsible for the development of CAV? The human immune system contains a variety of cells. After transplantation of a solid organ, the recipient’s immune system recognizes the graft as foreign and attacks it. In this process there are many different immune cells involved ...
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... expression of ATG genes, can increase the resistance to oxidative stress, but it remains unclear if the same genes also have a role in longevity [36]. The transcription factor(s) downstream of the JNK pathway that mediate the activation of ATG genes are unknown, although FOXO may be one of them [36] ...
... expression of ATG genes, can increase the resistance to oxidative stress, but it remains unclear if the same genes also have a role in longevity [36]. The transcription factor(s) downstream of the JNK pathway that mediate the activation of ATG genes are unknown, although FOXO may be one of them [36] ...
Juno Therapeutics Adds Adenosine Receptor Antagonist Through
... mediated immunosuppression. In Phase I and II clinical trials in approximately 250 Parkinson's disease patients and healthy volunteers, vipadenant was found to reach serum levels that predict saturation of the A2a receptor and blockade of signaling through this pathway and to be well tolerated in th ...
... mediated immunosuppression. In Phase I and II clinical trials in approximately 250 Parkinson's disease patients and healthy volunteers, vipadenant was found to reach serum levels that predict saturation of the A2a receptor and blockade of signaling through this pathway and to be well tolerated in th ...
Control of Cryptosporidiosis by Probiotic Bacteria
... Abstract—Cryptosporidiosis, an opportunistic parasitic disease, has become a topic of great interest being life-threatening among immunocompromised patients worldwide. To date, there is no totally effective therapy other than a healthy intact immune system. Probiotics, widely reported to stimulate b ...
... Abstract—Cryptosporidiosis, an opportunistic parasitic disease, has become a topic of great interest being life-threatening among immunocompromised patients worldwide. To date, there is no totally effective therapy other than a healthy intact immune system. Probiotics, widely reported to stimulate b ...
A Model to Predict Cell-Mediated Immune
... have been proposed. Given the abundance of data pointing to the role of various host susceptibility and resistance genes, it seems clear that a genetic component exists (22, 23). Nonetheless, a number of theories assert that specific components of the host immune response play the primary role in de ...
... have been proposed. Given the abundance of data pointing to the role of various host susceptibility and resistance genes, it seems clear that a genetic component exists (22, 23). Nonetheless, a number of theories assert that specific components of the host immune response play the primary role in de ...
INTERPLAY BETWEEN HELICOBACTER PYLORI AND THE
... (2). The two major currently recognized groups of such receptors in humans are toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-containing proteins (3). Whereas TLRs are associated with the plasma membrane or, in some case, with lysosomal and/or endosomal vesicles, both ...
... (2). The two major currently recognized groups of such receptors in humans are toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-containing proteins (3). Whereas TLRs are associated with the plasma membrane or, in some case, with lysosomal and/or endosomal vesicles, both ...
Resolvin E1 inhibits dendritic cell migration in the skin and
... (Dyerberg et al., 1978), several clinical assessments have indicated that a diet rich in 3 polyunsaturated fatty acids (PUFAs) has beneficial effects in various inflammatory diseases, including asthma, psoriasis, inflammatory bowel diseases, and rheumatoid arthritis (Horrobin, 1987). Although it re ...
... (Dyerberg et al., 1978), several clinical assessments have indicated that a diet rich in 3 polyunsaturated fatty acids (PUFAs) has beneficial effects in various inflammatory diseases, including asthma, psoriasis, inflammatory bowel diseases, and rheumatoid arthritis (Horrobin, 1987). Although it re ...
In Enterovirus 71 Encephalitis With Cardio
... respectively. Patients who later died or developed marked cardio-respiratory compromise are labeled on the x-axis with †or ‡ symbols, respectively. Tile color indicates relative mediator concentration: red, increased; green, decreased; black, at median concentration (for the samples); gray, concentr ...
... respectively. Patients who later died or developed marked cardio-respiratory compromise are labeled on the x-axis with †or ‡ symbols, respectively. Tile color indicates relative mediator concentration: red, increased; green, decreased; black, at median concentration (for the samples); gray, concentr ...
Chapter 15 The Lymphatic System and Immunity
... • A healthy immune system works efficiently to fight off disease. In someone with an autoimmune disorder, the immune system wrongly identifies healthy tissues as foreign and tries to destroy them. • There are over 80 known types of disorders, affecting different areas of the body – from joints and m ...
... • A healthy immune system works efficiently to fight off disease. In someone with an autoimmune disorder, the immune system wrongly identifies healthy tissues as foreign and tries to destroy them. • There are over 80 known types of disorders, affecting different areas of the body – from joints and m ...
Management Of Cold Haemolytic Syndrome
... of active complement to a patient’s serum increased haemolytic activity (Ulvestad, 1998); this suggested that haemolysis could be aggravated by increased complement production during an acute-phase reaction or by use of plasma-containing blood products. A follow-up study confirmed that the availabil ...
... of active complement to a patient’s serum increased haemolytic activity (Ulvestad, 1998); this suggested that haemolysis could be aggravated by increased complement production during an acute-phase reaction or by use of plasma-containing blood products. A follow-up study confirmed that the availabil ...
nrmicro-09-068v1 - HAL
... 3 clearance either by killing infected cells directly through the release of cytolytic mediators, e.g. 4 granzyme, or indirectly by secreting Th1-type cytokines that inhibit viral replication (Figure 1). 5 In contrast to mDCs, which may have mainly evolved to prime and activate anti-viral T-cells, 6 ...
... 3 clearance either by killing infected cells directly through the release of cytolytic mediators, e.g. 4 granzyme, or indirectly by secreting Th1-type cytokines that inhibit viral replication (Figure 1). 5 In contrast to mDCs, which may have mainly evolved to prime and activate anti-viral T-cells, 6 ...
Virus evolution within patients increases pathogenicity
... Fig. 1 illustrates the situation where two strains (strains 1 and 3) exist in the initial population, and then strain 2 invades it (a1 =b1 oa2 =b2 oa3 =b3 ). The broken curve in Fig. 1 is for the population before the invasion including strains 1 and 3 only. It consists of three arcs connected by ki ...
... Fig. 1 illustrates the situation where two strains (strains 1 and 3) exist in the initial population, and then strain 2 invades it (a1 =b1 oa2 =b2 oa3 =b3 ). The broken curve in Fig. 1 is for the population before the invasion including strains 1 and 3 only. It consists of three arcs connected by ki ...
Seroprevalence of Mycoplasma pneumoniae in HIV
... Mycoplasma pneumoniae is increasingly recognized as a common and important pathogen in community settings, and is responsible for various pulmonary and extrapulmonary conditions in the normal population. However, the seroepidemiology of acute M. pneumoniae infection in HIV-infected individuals is st ...
... Mycoplasma pneumoniae is increasingly recognized as a common and important pathogen in community settings, and is responsible for various pulmonary and extrapulmonary conditions in the normal population. However, the seroepidemiology of acute M. pneumoniae infection in HIV-infected individuals is st ...
prevention transplantation coadministered with regulatory T cells for
... Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for many hematologic malignancies and disorders. In the graft, 2 major components intervene: HSCs which durably reconstitute the hematopoietic system and mature donor T cells that are essential for (1) engraftment,1 ...
... Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for many hematologic malignancies and disorders. In the graft, 2 major components intervene: HSCs which durably reconstitute the hematopoietic system and mature donor T cells that are essential for (1) engraftment,1 ...
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... patients with nontumorous diseases. In both the glioblastoma and the nontumor group the EGF production of cultured monocytes was not influenced by medication, especially not by dexamethasone therapy. In a recently published paper10 we could demonstrate that the long-term survival of monocytes derive ...
... patients with nontumorous diseases. In both the glioblastoma and the nontumor group the EGF production of cultured monocytes was not influenced by medication, especially not by dexamethasone therapy. In a recently published paper10 we could demonstrate that the long-term survival of monocytes derive ...
A population of atypical CD56вˆ`CD16+ natural killer cells is
... (Caligiuri, 2008; Lanier et al., 1986). CD56dimCD16+ NK cells predominantly contribute to innate immunity through direct cytotoxicity, although they also influence innate and adaptive immunity through cytokine production (Campbell and Hasegawa, 2013; Camous et al., 2012). CD56brightCD16 NK cells pre ...
... (Caligiuri, 2008; Lanier et al., 1986). CD56dimCD16+ NK cells predominantly contribute to innate immunity through direct cytotoxicity, although they also influence innate and adaptive immunity through cytokine production (Campbell and Hasegawa, 2013; Camous et al., 2012). CD56brightCD16 NK cells pre ...
FVIII Immunity: Early Events and Tolerance Mechanisms to FVIII
... titer formation in hemophilic mice. Our results demonstrate that the differences in antibody formation in hemophilic mice treated with either recombinant or plasmaderived FVIII products are due to the distinct cytokine micro-environment induced by each product. ...
... titer formation in hemophilic mice. Our results demonstrate that the differences in antibody formation in hemophilic mice treated with either recombinant or plasmaderived FVIII products are due to the distinct cytokine micro-environment induced by each product. ...
The New Golden Era for Radioimmunotherapy
... rapidly internalized into the cell, leading to excellent intratumoral retention of the antibody. Some of the earliest experience used the murine IgG 125I-CO 17-1A. A phase I study of 53 patients (25 with CRC) used 125I-CO 17-1A in a fractionated approach, with up to 17 cycles of therapy and with dos ...
... rapidly internalized into the cell, leading to excellent intratumoral retention of the antibody. Some of the earliest experience used the murine IgG 125I-CO 17-1A. A phase I study of 53 patients (25 with CRC) used 125I-CO 17-1A in a fractionated approach, with up to 17 cycles of therapy and with dos ...
Neutrophils diminish T-cell immunity to foster gastric cancer
... Neutrophils are the predominant leucocytes in the blood and act as the first line of host defence against invading pathogens. Neutrophils have also been shown to play important roles in the other pathological conditions, including cancer. In the past decade, many efforts have been made to clarify the ...
... Neutrophils are the predominant leucocytes in the blood and act as the first line of host defence against invading pathogens. Neutrophils have also been shown to play important roles in the other pathological conditions, including cancer. In the past decade, many efforts have been made to clarify the ...
... Irrespective of its limitations, this approach is tested in human system, specifically in melanoma using different ganglioside preparations. An altered pattern of cell surface ganglioside (GD3, GD2, GM2 etc) expression was observed in malignant melanoma and other cancers of neuroectodermal origin 49 ...
Epitope Masking in a Murine Model Independently from Red Cell
... immunization to D+ RBCs has come from seminal studies dating back to the 1960s on human male D2 volunteers immunized with D+ RBCs. In many of these studies and others that have followed, it was noticed that the dose of anti-D that caused clearance of the D+ RBCs from the circulation was related to i ...
... immunization to D+ RBCs has come from seminal studies dating back to the 1960s on human male D2 volunteers immunized with D+ RBCs. In many of these studies and others that have followed, it was noticed that the dose of anti-D that caused clearance of the D+ RBCs from the circulation was related to i ...