Pathogenesis of Dengue viral infections
... shown to be associated with milder clinical disease37. This suggests that patients with severe clinical disease possibly have impaired functional regulatory T cells responses. However IL10, which is the main regulatory T cell cytokine, has been found to be significantly higher in patients with sever ...
... shown to be associated with milder clinical disease37. This suggests that patients with severe clinical disease possibly have impaired functional regulatory T cells responses. However IL10, which is the main regulatory T cell cytokine, has been found to be significantly higher in patients with sever ...
Licentiate thesis from the Department of Immunology,
... susceptibility to malaria observed between two sympatric ethnic tribes, the Fulani and the Dogon, living in Mali. The genotypes were correlated to both ethnicity and malariometric indexes. A statistically significant inter-ethnic difference in the allele frequency and genotype inheritance pattern fo ...
... susceptibility to malaria observed between two sympatric ethnic tribes, the Fulani and the Dogon, living in Mali. The genotypes were correlated to both ethnicity and malariometric indexes. A statistically significant inter-ethnic difference in the allele frequency and genotype inheritance pattern fo ...
Liver immunology and its role in inflammation and
... immature although they can stimulate strong T-cell responses in certain situations.21 Recently a sub-population of human hepatic CD141+ DCs have been shown to be potent cytokine producers and activators of T cells.11 Myeloid-derived suppressor cells (MDSC) are also present in the healthy liver22 and ...
... immature although they can stimulate strong T-cell responses in certain situations.21 Recently a sub-population of human hepatic CD141+ DCs have been shown to be potent cytokine producers and activators of T cells.11 Myeloid-derived suppressor cells (MDSC) are also present in the healthy liver22 and ...
Expression of SpC3, the sea urchin complement component, in
... innate immunity in deuterostomes. In higher vertebrates, it is composed of four pathways; the three initiating pathways, classical, alternative, and lectin, converge to activate the terminal pathway (for a review see Volanakis 1998). The initiating pathways are activated by different mechanisms. The ...
... innate immunity in deuterostomes. In higher vertebrates, it is composed of four pathways; the three initiating pathways, classical, alternative, and lectin, converge to activate the terminal pathway (for a review see Volanakis 1998). The initiating pathways are activated by different mechanisms. The ...
Multiple Organ Dysfunction Syndrome
... Monitor CD4 count and gamma globulin levels Appropriate prophylaxis for pneumocystis, fungus, and HSV and broader empiric coverage in secondary sepsis IVIG should if hypogammaglobulinemia Prolactin is an antiapoptotic hormone for lymphocytes, but it’s unknown whether prolactin replacement is benefic ...
... Monitor CD4 count and gamma globulin levels Appropriate prophylaxis for pneumocystis, fungus, and HSV and broader empiric coverage in secondary sepsis IVIG should if hypogammaglobulinemia Prolactin is an antiapoptotic hormone for lymphocytes, but it’s unknown whether prolactin replacement is benefic ...
Cytotoxic T-Lymphocyte–Defined Human Minor
... HLA-A2 and 80% do not express HLA-B44, most recipients would not be eligible for therapy targeting any of these four minor H antigens.31 Moreover, even for donor/recipient pairs expressing HLA-A2, the clinical use of HA-2 and HA-5 as targets for GVL therapy is limited because HA-2 and HA-5 are expre ...
... HLA-A2 and 80% do not express HLA-B44, most recipients would not be eligible for therapy targeting any of these four minor H antigens.31 Moreover, even for donor/recipient pairs expressing HLA-A2, the clinical use of HA-2 and HA-5 as targets for GVL therapy is limited because HA-2 and HA-5 are expre ...
Role of the PD‐1 Pathway in the Immune Response
... The inhibitory receptor PD-1 (CD279) is a cell surface molecule with a single immunoglobulin (Ig) superfamily domain and a cytoplasmic domain containing two tyrosinebased signaling motifs: a tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) (Figure 1) (3 ...
... The inhibitory receptor PD-1 (CD279) is a cell surface molecule with a single immunoglobulin (Ig) superfamily domain and a cytoplasmic domain containing two tyrosinebased signaling motifs: a tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) (Figure 1) (3 ...
the effects of thymus and other lymphoid organs enclosed in
... The possibility that the thymus produces a humoral substance with far reaching biological effects has been frequently considered. Support for the production of a hormone has been offered on morphological grounds by the description of secretory vesicles in the frog thymus (1), and colloid-containing ...
... The possibility that the thymus produces a humoral substance with far reaching biological effects has been frequently considered. Support for the production of a hormone has been offered on morphological grounds by the description of secretory vesicles in the frog thymus (1), and colloid-containing ...
Dissertation LeWi Fakultät Humboldt-Universität zu Berlin
... Analyses of the clinical and morphological picture in patients suffering from dermatomyositis showed that juvenile patients have very characteristic symptoms, like dysphagia and calcifications of skeletal muscles that are not part of the disease in adults. On the other hand, both diseases are consi ...
... Analyses of the clinical and morphological picture in patients suffering from dermatomyositis showed that juvenile patients have very characteristic symptoms, like dysphagia and calcifications of skeletal muscles that are not part of the disease in adults. On the other hand, both diseases are consi ...
Canine hemangiosarcoma: A tumor of
... a novel approach targeting IL-12 to the adhesion molecule αvβ3 integrin by molecular engineering of a fusion protein consisting of the peptide ligand for αvβ3 integrin (RGD4C) combined with IL-12 (Dickerson et al, 2004). This strategy resulted in a vastly superior anti-antiangiogenic effect against ...
... a novel approach targeting IL-12 to the adhesion molecule αvβ3 integrin by molecular engineering of a fusion protein consisting of the peptide ligand for αvβ3 integrin (RGD4C) combined with IL-12 (Dickerson et al, 2004). This strategy resulted in a vastly superior anti-antiangiogenic effect against ...
Full-text PDF - Explore Bristol Research
... younger age, smoking and alcohol use and stigma, fears and anger about the illness have been shown to reduce adherence. So too are several treatment-associated factors such as duration of treatment, frequency of dosing and requirement for storage.25 Furthermore, the ability to use Azithromycin as a ...
... younger age, smoking and alcohol use and stigma, fears and anger about the illness have been shown to reduce adherence. So too are several treatment-associated factors such as duration of treatment, frequency of dosing and requirement for storage.25 Furthermore, the ability to use Azithromycin as a ...
PDF
... CD35+ B220+ precursor cell, which is consistent with several observations of binucleate FDCs (Murakami et al., 2007; Allen and Cyster, 2008). Moreover, differentiation of FDCs as a specialized form of myofibroblasts that derive from bone marrow stromal cell progenitors has been also suggested (Munoz ...
... CD35+ B220+ precursor cell, which is consistent with several observations of binucleate FDCs (Murakami et al., 2007; Allen and Cyster, 2008). Moreover, differentiation of FDCs as a specialized form of myofibroblasts that derive from bone marrow stromal cell progenitors has been also suggested (Munoz ...
Visceral leishmaniasis: host–parasite interactions and clinical
... Asymptomatic infection has also been demonstrated in HIVinfected patients. Also in this population, the percentage of asymptomatic infection could be larger than symptomatic cases.50 Leishmania parasitemia was found to be significantly higher in patients with higher viral loads.50 A high parasitemic ...
... Asymptomatic infection has also been demonstrated in HIVinfected patients. Also in this population, the percentage of asymptomatic infection could be larger than symptomatic cases.50 Leishmania parasitemia was found to be significantly higher in patients with higher viral loads.50 A high parasitemic ...
Tumor necrosis factor antagonist mechanisms of action: A
... organs or tissues, they appear to share some common underlying mechanisms involving TNF. All 3 TNF antagonists are parenterally administered protein therapeutics (biologics); infliximab and adalimumab are monoclonal antibodies (mAbs) that specifically bind TNF; and etanercept is a TNF-receptor Fc-fu ...
... organs or tissues, they appear to share some common underlying mechanisms involving TNF. All 3 TNF antagonists are parenterally administered protein therapeutics (biologics); infliximab and adalimumab are monoclonal antibodies (mAbs) that specifically bind TNF; and etanercept is a TNF-receptor Fc-fu ...
Allergic conjunctivitis: a comprehensive review of the literature
... Combination treatments using decongestants with antihistamines have been shown to be more effective, and are administered to the eye as drops up to 4 times daily [37]. Decongestants act primarily as vasoconstrictors and are effective in reducing erythema, however, adverse effects include burning and ...
... Combination treatments using decongestants with antihistamines have been shown to be more effective, and are administered to the eye as drops up to 4 times daily [37]. Decongestants act primarily as vasoconstrictors and are effective in reducing erythema, however, adverse effects include burning and ...
Allergic conjunctivitis: a comprehensive review of the literature Open Access
... Combination treatments using decongestants with antihistamines have been shown to be more effective, and are administered to the eye as drops up to 4 times daily [37]. Decongestants act primarily as vasoconstrictors and are effective in reducing erythema, however, adverse effects include burning and ...
... Combination treatments using decongestants with antihistamines have been shown to be more effective, and are administered to the eye as drops up to 4 times daily [37]. Decongestants act primarily as vasoconstrictors and are effective in reducing erythema, however, adverse effects include burning and ...
Candida
... changes locally following inoculation. The exception was an increase in IL-1a levels in wild-type and IL-222/2 mice (p,0.05 and p,0.0001, respectively) and IL-1b in IL-222/2 mice (p,0.05) following inoculation. When analyzed comparatively between lavages from mice with high PMNs and low PMNs, the cy ...
... changes locally following inoculation. The exception was an increase in IL-1a levels in wild-type and IL-222/2 mice (p,0.05 and p,0.0001, respectively) and IL-1b in IL-222/2 mice (p,0.05) following inoculation. When analyzed comparatively between lavages from mice with high PMNs and low PMNs, the cy ...
SG Palsule Common Diseases and their
... indigestible things like cheese may be retained. It has no connection with the quantity or quality of food. Migraine or bilious head-ache : In this trouble, the patient awakens with a head-ache and vomits only bile indicating that the vomiting is urgent or that the stomach is empty. Tumour, meningit ...
... indigestible things like cheese may be retained. It has no connection with the quantity or quality of food. Migraine or bilious head-ache : In this trouble, the patient awakens with a head-ache and vomits only bile indicating that the vomiting is urgent or that the stomach is empty. Tumour, meningit ...
dependent regulation of intestinal immunity and homeostasis
... activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory disorders, such as food allergy or inflammatory bowel disease (IBD). A complex networ ...
... activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory disorders, such as food allergy or inflammatory bowel disease (IBD). A complex networ ...
HIC1 links retinoic acid signalling to group 3 innate
... activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory disorders, such as food allergy or inflammatory bowel disease (IBD). A complex networ ...
... activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory disorders, such as food allergy or inflammatory bowel disease (IBD). A complex networ ...
Human complement control and complement evasion by pathogenic
... cells and bacteria. 1.1.2 Effector Level I - C3 convertase circuit. This first complement effector level forms an active enzyme, the C3 convertase. The alternative pathway and the classical/lectin pathway form separate C3 convertases. Once assembled, the C3 convertase of either the alternative (C3bB ...
... cells and bacteria. 1.1.2 Effector Level I - C3 convertase circuit. This first complement effector level forms an active enzyme, the C3 convertase. The alternative pathway and the classical/lectin pathway form separate C3 convertases. Once assembled, the C3 convertase of either the alternative (C3bB ...