PDF - Theranostics
... tumor-associated antigens [70]. The systemic anti-tumor response is achieved by activated T cells that recognize antigens expressed by tumor cells [71]. Helper T cells are classified into Th1 and Th2 subtypes, and they possess the different anti-tumor mechanisms [72]. Th1 cells produce interferon-ga ...
... tumor-associated antigens [70]. The systemic anti-tumor response is achieved by activated T cells that recognize antigens expressed by tumor cells [71]. Helper T cells are classified into Th1 and Th2 subtypes, and they possess the different anti-tumor mechanisms [72]. Th1 cells produce interferon-ga ...
Vitiligo-Like Hypopigmentation Induced by Imiquimod Case Report Zekayi Kutlubay,
... Pigmentary changes associated with imiquimod treatment are listed as possible side effects on the package insert but have not been well described [3]. The US Food and Drug Administration records about adverse events of imiquimod in 1997 to November 2003 included 1257 reports of which 68 (5.4%) were ...
... Pigmentary changes associated with imiquimod treatment are listed as possible side effects on the package insert but have not been well described [3]. The US Food and Drug Administration records about adverse events of imiquimod in 1997 to November 2003 included 1257 reports of which 68 (5.4%) were ...
and Progression of Acute Allograft Rejection Cardiac Grafts
... The identification of early inflammatory events after transplant in solid tissue organ grafts that may direct T cell recruitment and promote acute allograft rejection remain largely unknown. To better understand temporal aspects of early inflammatory events in vascularized organ grafts, we tested th ...
... The identification of early inflammatory events after transplant in solid tissue organ grafts that may direct T cell recruitment and promote acute allograft rejection remain largely unknown. To better understand temporal aspects of early inflammatory events in vascularized organ grafts, we tested th ...
Antigen-presenting cells in the hypertrophic pharyngeal tonsils
... Summary. The antigen presenting cells (APCs) with special interest to dendritic cells (DC), were investigated in 28 hypertrophic and 10 control pharyngeal tonsils of children by histochemistry, immunohistochemistry and electron microscopy. In this study, we are trying to clarify the function and cla ...
... Summary. The antigen presenting cells (APCs) with special interest to dendritic cells (DC), were investigated in 28 hypertrophic and 10 control pharyngeal tonsils of children by histochemistry, immunohistochemistry and electron microscopy. In this study, we are trying to clarify the function and cla ...
Two-zone tumor tolerance can arise from a simple
... to avoid harm caused by their continual presence. (5) The phenomenon of anergy, in which lymphocytes such as B and T cells fail to respond to their specific antigen, might suggest additional regulatory mechanisms [24]. On the other hand, it could be argued that autoimmune diseases contradict this dy ...
... to avoid harm caused by their continual presence. (5) The phenomenon of anergy, in which lymphocytes such as B and T cells fail to respond to their specific antigen, might suggest additional regulatory mechanisms [24]. On the other hand, it could be argued that autoimmune diseases contradict this dy ...
Osteoarthritic articular chondrocytes stimulate autologous T cell
... complex would be an essential event. However, soluble factors derived from the OA chondrocytes may play additional roles which should be investigated in the future. In the case of MHC/ antigen/TCR binding, the stimulating antigens would be produced by the chondrocytes. Previously the existence of a ...
... complex would be an essential event. However, soluble factors derived from the OA chondrocytes may play additional roles which should be investigated in the future. In the case of MHC/ antigen/TCR binding, the stimulating antigens would be produced by the chondrocytes. Previously the existence of a ...
Inhibition of Normal B-Cell Function by Human
... manifested by hypergammaglobulinemia, circulating immune complexes, and spontaneous immunoglobulin-secreting cell^.'^^*'^ Concurrently, functional antibody responses in vivo and mitogen-driven B-cell differentiation responses in vitro are severely impaired.'&I8The basis for these disparate effects h ...
... manifested by hypergammaglobulinemia, circulating immune complexes, and spontaneous immunoglobulin-secreting cell^.'^^*'^ Concurrently, functional antibody responses in vivo and mitogen-driven B-cell differentiation responses in vitro are severely impaired.'&I8The basis for these disparate effects h ...
Optimal Enhancement of Immune Response
... organisms and activating B cells to produce antibodies that bind to the intruders’ antigens. The antibodies identify targets for scavenging cells (e.g. neutrophils and macrophages) that engulf and consume the microbes, reducing them to non-functioning units. They also stimulate the production of cyt ...
... organisms and activating B cells to produce antibodies that bind to the intruders’ antigens. The antibodies identify targets for scavenging cells (e.g. neutrophils and macrophages) that engulf and consume the microbes, reducing them to non-functioning units. They also stimulate the production of cyt ...
Immune system irregularities in lysosomal storage disorders
... determining if these powerful immunomodulatory molecules contribute to the pathology seen in twitcher mice, double knockout twitcher mice that are deWcient in IL-6 protein or the TNF- receptor-1 (TNFR1) were generated [93, 94]. Surprisingly, twitcher mice that did not express IL-6 had a more severe ...
... determining if these powerful immunomodulatory molecules contribute to the pathology seen in twitcher mice, double knockout twitcher mice that are deWcient in IL-6 protein or the TNF- receptor-1 (TNFR1) were generated [93, 94]. Surprisingly, twitcher mice that did not express IL-6 had a more severe ...
Intertwined pathways of programmed cell death in immunity
... a dominant pathway of cell death, found naturally in virtually all pre- and post-developmental tissues and constitutes a default state that must be actively inhibited in most thriving cell types. Simple removal of cells from their cognate cellular interactions is sufficient to induce an apoptotic ca ...
... a dominant pathway of cell death, found naturally in virtually all pre- and post-developmental tissues and constitutes a default state that must be actively inhibited in most thriving cell types. Simple removal of cells from their cognate cellular interactions is sufficient to induce an apoptotic ca ...
Full Reviews Immunity in arterial hypertension
... diastolic BP and mean arterial pressure with levels of sICAM-1 or IL-6 [8]. In the same cohort, inflammatory biomarkers were found to be strong predictors of future risk of cardiovascular (CV) non-fatal events and death, suggesting a causal relationship between BP, inflammation and atherogenesis. Othe ...
... diastolic BP and mean arterial pressure with levels of sICAM-1 or IL-6 [8]. In the same cohort, inflammatory biomarkers were found to be strong predictors of future risk of cardiovascular (CV) non-fatal events and death, suggesting a causal relationship between BP, inflammation and atherogenesis. Othe ...
IKK / NF- B signaling in intestinal epithelial cells controls
... mice before the age of weaning, indicating that the pathology develops early after birth. Colon inflammation in NEMOIEC-KO mice was characterized by infiltration of innate immune cells such as dendritic cells, macrophages, and neutrophils during the early stages of the disease. T-cell infiltration w ...
... mice before the age of weaning, indicating that the pathology develops early after birth. Colon inflammation in NEMOIEC-KO mice was characterized by infiltration of innate immune cells such as dendritic cells, macrophages, and neutrophils during the early stages of the disease. T-cell infiltration w ...
Document
... HLA-DRAM, HLA-DRBM Paternal: 3 MHC II genes HLA-DPAP, HLA-DPBP HLA-DQAP, HLA-DQBP HLA-DRAP, HLA-DRBP ...
... HLA-DRAM, HLA-DRBM Paternal: 3 MHC II genes HLA-DPAP, HLA-DPBP HLA-DQAP, HLA-DQBP HLA-DRAP, HLA-DRBP ...
Flow Cytometric Detection of Immunophenotypically Normal Plasma
... however was uncommon target for investigations mainly due to very low counts of cir cu lating plasma cells. Nevertheless several studies were performed and results showed that presence and increased amount of circulating in peripheral blood plasma cells (CPC) are associated with more aggressive dise ...
... however was uncommon target for investigations mainly due to very low counts of cir cu lating plasma cells. Nevertheless several studies were performed and results showed that presence and increased amount of circulating in peripheral blood plasma cells (CPC) are associated with more aggressive dise ...
Testicular defense systems: immune privilege and innate
... the number of lymphocytes is significantly high,48,49 suggesting that lymphocytes are involved in testicular pathogenesis under inflammatory conditions. The rat testis also contains immunoregulatory T cells, including natural killer (NK) T cells and CD41CD251 regulatory T cells (Tregs). Tregs are po ...
... the number of lymphocytes is significantly high,48,49 suggesting that lymphocytes are involved in testicular pathogenesis under inflammatory conditions. The rat testis also contains immunoregulatory T cells, including natural killer (NK) T cells and CD41CD251 regulatory T cells (Tregs). Tregs are po ...
(From the Medicine Branch, National Cancer Institute, Bethesda
... Research Fund, and the Immunology Division, National Institute for Medical Research, Mill Hill, London, England) PLATES 86 TO 90 (Received for publication 7 January 1966) The action of antibody and complement (C') upon red blood cells results in the formation of discrete holes in the cell membrane. ...
... Research Fund, and the Immunology Division, National Institute for Medical Research, Mill Hill, London, England) PLATES 86 TO 90 (Received for publication 7 January 1966) The action of antibody and complement (C') upon red blood cells results in the formation of discrete holes in the cell membrane. ...
GAD AS AN IMMUNOMODULATOR IN TYPE 1 DIABETES Stina Axelsson
... treatment with GAD-alum contributes to the preservation of residual insulin secretion through deviation of the GAD65-specific immune response from a destructive to a protective process, accompanied by a shift from T helper (Th) 1 towards a predominant Th2 profile. In the Phase II trial, GAD-alum-tre ...
... treatment with GAD-alum contributes to the preservation of residual insulin secretion through deviation of the GAD65-specific immune response from a destructive to a protective process, accompanied by a shift from T helper (Th) 1 towards a predominant Th2 profile. In the Phase II trial, GAD-alum-tre ...
influence of aerobic and anaerobic training on immune
... is working to raise the physical performance level of the individual athlete to the fullest extent of his abilities through give individual sports fitness. It is noteworthy (Abou El Ela, 2003)that the immunology now of the most important contemporary science as it relates to various health problems ...
... is working to raise the physical performance level of the individual athlete to the fullest extent of his abilities through give individual sports fitness. It is noteworthy (Abou El Ela, 2003)that the immunology now of the most important contemporary science as it relates to various health problems ...
Trained immunity: a new avenue for tuberculosis vaccine development
... Below we will discuss the mechanisms of latent TB and early clearance. Control of M. tuberculosis infection during latent tuberculosis Inside TB granulomas, innate immunity acts in alliance with adaptive immunity to control M. tuberculosis infection. The immunological mechanisms that contribute to t ...
... Below we will discuss the mechanisms of latent TB and early clearance. Control of M. tuberculosis infection during latent tuberculosis Inside TB granulomas, innate immunity acts in alliance with adaptive immunity to control M. tuberculosis infection. The immunological mechanisms that contribute to t ...
Immune escape from a graft-versus-leukemia effect may play a role
... (BMT) for evidence of immune escape by clonal evolution of the leukemia. Relapsed cells from four out of five patients had a reduced ability to stimulate proliferation of lymphocytes from an HLA-mismatched responder. There was decreased susceptibility to lysis by CTL in three and reduced susceptibil ...
... (BMT) for evidence of immune escape by clonal evolution of the leukemia. Relapsed cells from four out of five patients had a reduced ability to stimulate proliferation of lymphocytes from an HLA-mismatched responder. There was decreased susceptibility to lysis by CTL in three and reduced susceptibil ...
Sniðmát meistaraverkefnis HÍ
... When an APC has engulfed a pathogen in an infected tissue it travels to the draining lymph node and presents the antigen of the pathogen to naïve T-cells. So when an APC has found a lymphocyte in the draining lymph node that has a receptor that can bind to that particular antigen it activates the ly ...
... When an APC has engulfed a pathogen in an infected tissue it travels to the draining lymph node and presents the antigen of the pathogen to naïve T-cells. So when an APC has found a lymphocyte in the draining lymph node that has a receptor that can bind to that particular antigen it activates the ly ...
Lymphatic System
... • Instead, special cells of a different cell line than the fibroblasts form a stroma within the germinal center and support the B cells in it. • A similar non-fibrillar stroma is characteristic of the thymus, and will be ...
... • Instead, special cells of a different cell line than the fibroblasts form a stroma within the germinal center and support the B cells in it. • A similar non-fibrillar stroma is characteristic of the thymus, and will be ...
Update in Endocrine Autoimmunity
... tion stratification (48). The NALP1 gene, a likely regulator in the innate immune system, was also recently shown to have an association with multiple autoimmune diseases in families with vitiligo (49). In this study, families with two or more members with vitiligo and at least one with an autoimmun ...
... tion stratification (48). The NALP1 gene, a likely regulator in the innate immune system, was also recently shown to have an association with multiple autoimmune diseases in families with vitiligo (49). In this study, families with two or more members with vitiligo and at least one with an autoimmun ...
