From Future Rheumatology Complications of Anti
... both infection and cancer risk the data are contradictory, but suggest a) an increased risk of serious infection (~ twofold), b) that vigilance is required for tuberculosis and other granulomatous and intracellular infection when screening patients, as well as close monitoring thereafter, c) no over ...
... both infection and cancer risk the data are contradictory, but suggest a) an increased risk of serious infection (~ twofold), b) that vigilance is required for tuberculosis and other granulomatous and intracellular infection when screening patients, as well as close monitoring thereafter, c) no over ...
The Mastocytosis Patient Experience
... We are sharing information about the rare disorder mastocytosis and related mast cell disorders, which we have derived from a number of sources in Canada and internationally. Our intention is to educate by sharing mastocytosis patient experiences. These experiences are often beyond what has been res ...
... We are sharing information about the rare disorder mastocytosis and related mast cell disorders, which we have derived from a number of sources in Canada and internationally. Our intention is to educate by sharing mastocytosis patient experiences. These experiences are often beyond what has been res ...
Evidence for specific immune response against P210 BCR
... CML is a pluripotent stem cell disease that primarily affects myeloid lineages in chronic phase. The disease almost always progresses to the blast crisis stage, which is the terminal stage. Therapy of CML with interferon (IFN) is associated with frequent hematopoietic remissions and complete cytogen ...
... CML is a pluripotent stem cell disease that primarily affects myeloid lineages in chronic phase. The disease almost always progresses to the blast crisis stage, which is the terminal stage. Therapy of CML with interferon (IFN) is associated with frequent hematopoietic remissions and complete cytogen ...
Regulatory T Cells and Viral Disease
... regulatory T cells. Recent studies have shown that multiple CD4+ T cells are actually generated in vivo, rather than distinct subsets as previously thought. The effector cells secrete large amounts of cytokines, chemokines, and other proteins that can produce cytotoxicity to host tissues, or induce ...
... regulatory T cells. Recent studies have shown that multiple CD4+ T cells are actually generated in vivo, rather than distinct subsets as previously thought. The effector cells secrete large amounts of cytokines, chemokines, and other proteins that can produce cytotoxicity to host tissues, or induce ...
Immuun nr 3 2015 - Dutch Society for Immunology
... intermediate indicators can have a beneficial or a detrimental effect, dependent on disease and context. At a certain point exercise can damage the muscles. It is all about the right time to stop training. The mechanisms to accurately determine timing are as yet uncharted. Muscles make up approximat ...
... intermediate indicators can have a beneficial or a detrimental effect, dependent on disease and context. At a certain point exercise can damage the muscles. It is all about the right time to stop training. The mechanisms to accurately determine timing are as yet uncharted. Muscles make up approximat ...
ARVO 2012 Annual Meeting Abstracts
... protecting retinal ganglion cells (RGCs) after glutamate-induced retinal insult, by locally exerting an immunoregulatory phenotype. In experimental autoimmune uveitis (EAU), macrophages are commonly associated with disease induction and progression. Appreciating the functional diversity of monocyte- ...
... protecting retinal ganglion cells (RGCs) after glutamate-induced retinal insult, by locally exerting an immunoregulatory phenotype. In experimental autoimmune uveitis (EAU), macrophages are commonly associated with disease induction and progression. Appreciating the functional diversity of monocyte- ...
Differential gene expression profiles of CAN
... CAN compared to normal transplant kidney biopsies by GeneChip technology. • Some of the upregulated genes are related to fibrosis (MMP-7, 9, and 10, laminin, fibronectin, and tenascin) or factors/cytokines, which induce fibrosis (TGF-β, thrombospondin-1, and PDGF). • Gene expression of VEGF, EGF, FG ...
... CAN compared to normal transplant kidney biopsies by GeneChip technology. • Some of the upregulated genes are related to fibrosis (MMP-7, 9, and 10, laminin, fibronectin, and tenascin) or factors/cytokines, which induce fibrosis (TGF-β, thrombospondin-1, and PDGF). • Gene expression of VEGF, EGF, FG ...
IL-23 modulated myelin-specific T cells induce - Bio
... 3.1. IL-17R-/- mice are susceptible to EAE induced by the adoptive transfer of IL-23 modulated MOG-specific T cells IL-23 deficient mice are completely resistant to EAE (Cua et al., 2003). Since IL-23 supports the accumulation of Th17 cells in vivo, it has been proposed to promote EAE through an IL-17 ...
... 3.1. IL-17R-/- mice are susceptible to EAE induced by the adoptive transfer of IL-23 modulated MOG-specific T cells IL-23 deficient mice are completely resistant to EAE (Cua et al., 2003). Since IL-23 supports the accumulation of Th17 cells in vivo, it has been proposed to promote EAE through an IL-17 ...
Mayo Clinic Series - Fibrosing Mediastinitis
... ibrosing mediastinitis (FM) is a rare disorder characterized by the proliferation of locally invasive fibrous tissue within the mediastinum.11,19 Its etiology remains unknown. FM may represent a clinical-pathologic syndrome rather than a single disease.29 A number of triggers with variable geographi ...
... ibrosing mediastinitis (FM) is a rare disorder characterized by the proliferation of locally invasive fibrous tissue within the mediastinum.11,19 Its etiology remains unknown. FM may represent a clinical-pathologic syndrome rather than a single disease.29 A number of triggers with variable geographi ...
Host defence mechanisms against bacterial aggression in
... All of these findings suggest a possible role for antibodies as diagnostic indicators and markers of disease activity. However, their value in clinical practice or for patient management has not proven satisfactory. Strictly speaking, elevated levels of antibodies against a periodontal pathogen can ...
... All of these findings suggest a possible role for antibodies as diagnostic indicators and markers of disease activity. However, their value in clinical practice or for patient management has not proven satisfactory. Strictly speaking, elevated levels of antibodies against a periodontal pathogen can ...
Inflammation - UK - Tree of Light Publishing
... the body’s initial response to irritation, tissue damage or infection ...
... the body’s initial response to irritation, tissue damage or infection ...
Project Grant Application
... irreversibility of functional impairment, even if clinical activity has subsided into remission. (5,6) It is becoming increasingly clear both in and outside rheumatology that patients are crucial partners in obtaining relevant information, adding unique skills, values and experiences to research.(7) ...
... irreversibility of functional impairment, even if clinical activity has subsided into remission. (5,6) It is becoming increasingly clear both in and outside rheumatology that patients are crucial partners in obtaining relevant information, adding unique skills, values and experiences to research.(7) ...
Scleritis and episcleritis - British Journal of Ophthalmology
... lacrimation. In episcleritis when these symptoms occurred they were rarely, if ever, severe. Photophobia occurred in io per cent of the patients and lacrimation was complained of in 25 per cent. Patients with nodular disease did not have more severe symptoms than those with simple episcleritis. Phot ...
... lacrimation. In episcleritis when these symptoms occurred they were rarely, if ever, severe. Photophobia occurred in io per cent of the patients and lacrimation was complained of in 25 per cent. Patients with nodular disease did not have more severe symptoms than those with simple episcleritis. Phot ...
Nontuberculous mycobacteria in cystic fibrosis associated with allergic bronchopulmonary aspergillosis and
... expiratory volume in one second dropped 18–46%. Despite prolonged triple antibiotic therapy, M. abscessus was not eradicated, and four out of six did not return to baseline clinically. In conclusion, severe nontuberculous mycobacterial lung disease, particularly with Mycobacterium abscessus, is beco ...
... expiratory volume in one second dropped 18–46%. Despite prolonged triple antibiotic therapy, M. abscessus was not eradicated, and four out of six did not return to baseline clinically. In conclusion, severe nontuberculous mycobacterial lung disease, particularly with Mycobacterium abscessus, is beco ...
LANDREAU HID a Maquet
... Biomechanically, this is achieved by increasing the level arm of the quadriceps muscle and by increasing the angle β formed by the vectors of the quadriceps muscle and the patella tendon ...
... Biomechanically, this is achieved by increasing the level arm of the quadriceps muscle and by increasing the angle β formed by the vectors of the quadriceps muscle and the patella tendon ...
Interstitial Lung Disease Associated with the Idiopathic Inflammatory
... MA-ILD or simply a marker of disease remains to be elucidated. Animal studies in which mice were injected with murine Jo-1 antibodies demonstrate an increase in targeted B and T cells as well as a phenotype consistent with diffuse lung and muscle inflammation.64 Evidence that disease activity in hum ...
... MA-ILD or simply a marker of disease remains to be elucidated. Animal studies in which mice were injected with murine Jo-1 antibodies demonstrate an increase in targeted B and T cells as well as a phenotype consistent with diffuse lung and muscle inflammation.64 Evidence that disease activity in hum ...
Summary Introduction
... requires further investigation. Although in our series the prevalence of TTV infection was slightly higher in liver-disease patients with non-B, non-C aetiology than in healthy controls, this result does not necessarily imply a causative role for TTV. More relevant is the fact that the majority of T ...
... requires further investigation. Although in our series the prevalence of TTV infection was slightly higher in liver-disease patients with non-B, non-C aetiology than in healthy controls, this result does not necessarily imply a causative role for TTV. More relevant is the fact that the majority of T ...
... the predominant cell population expressing human immunodeficiency virus-1 (HIV-1) in most tissues. Unlike CD4+ T-lymphocytes, monocytes and macrophages are relatively resistant to the cytopathic effect of HIV-1 and, thus, serve as a reservoir for the virus [1]. In the lung, alveolar macrophages (AMs ...
oral graft versus host disease
... Management of oral aGVHD consists of systemic treatment, pain control, and local, usually palliative, measures. In general, oral lesions of aGVHD will respond to systemic immunosuppression, and patients need opiates for pain control. For local comfort and symptomatic relief, saline rinses, topical a ...
... Management of oral aGVHD consists of systemic treatment, pain control, and local, usually palliative, measures. In general, oral lesions of aGVHD will respond to systemic immunosuppression, and patients need opiates for pain control. For local comfort and symptomatic relief, saline rinses, topical a ...
SWALLOWING DISORDERS AND DYSPHAGIA
... muscle disorders are also well known etiologies. Structural disorders are seen in less than 20% of elderly patients with dysphagia. 10. Why is a brainstem stroke more likely to cause severe oropharyngeal dysphagia than a hemispheric stroke? The swallowing center is situated bilaterally, in the ret ...
... muscle disorders are also well known etiologies. Structural disorders are seen in less than 20% of elderly patients with dysphagia. 10. Why is a brainstem stroke more likely to cause severe oropharyngeal dysphagia than a hemispheric stroke? The swallowing center is situated bilaterally, in the ret ...
Exogenous Cushing`s Syndrome and Glucocorticoid
... Several forms of injectable steroid therapy have been associated with signs and symptoms of Cushing’s syndrome. Intravenous therapy is used almost exclusively for short-term treatment in emergency room or hospital settings. Therefore, this form of therapy is unlikely to result in Cushing’s syndrome, ...
... Several forms of injectable steroid therapy have been associated with signs and symptoms of Cushing’s syndrome. Intravenous therapy is used almost exclusively for short-term treatment in emergency room or hospital settings. Therefore, this form of therapy is unlikely to result in Cushing’s syndrome, ...
Natural killer cell deficiency - Journal of Allergy and Clinical
... some of which are rather specific in their expression. These include receptors capable of inducing either activation or inhibitory signals. NK cell activities are accessed after a favorable balance of activation over inhibitory signals is achieved in their recognition of a target.7 Regarding their r ...
... some of which are rather specific in their expression. These include receptors capable of inducing either activation or inhibitory signals. NK cell activities are accessed after a favorable balance of activation over inhibitory signals is achieved in their recognition of a target.7 Regarding their r ...
Diagnostic Tools for Dry Eye Disease
... this objective test does not distinguish the type of dry eye. Increased osmolarity is a critical component of dry eye disease pathology. The TearLab test (TearLab Inc., San Diego, CA, US) is easy and readily available for use in clinic. It is performed by obtaining 50 nanolitres of tears, applied to ...
... this objective test does not distinguish the type of dry eye. Increased osmolarity is a critical component of dry eye disease pathology. The TearLab test (TearLab Inc., San Diego, CA, US) is easy and readily available for use in clinic. It is performed by obtaining 50 nanolitres of tears, applied to ...
Toxic Epidermal Necrolysis-Like Cutaneous Lupus in
... progressive mucocutaneous reaction usually associated with medication use. Differentiating between classic drug-induced TEN and TEN-like cutaneous LE is important but difficult. We report a series of 3 patients with pediatric systemic LE who were admitted with severe worsening of skin disease resemb ...
... progressive mucocutaneous reaction usually associated with medication use. Differentiating between classic drug-induced TEN and TEN-like cutaneous LE is important but difficult. We report a series of 3 patients with pediatric systemic LE who were admitted with severe worsening of skin disease resemb ...
Dr. Vet. Med. Jaroslav Renda, in memoriam, Czech
... At present, intensive research into Chlamydiae is taking place in almost all medically-developed countries in the world, and there is a great deal of information about the connection between Chlamydiae and specific diseases and also about various methods of Chlamydial diagnosis. Bazala and Renda (19 ...
... At present, intensive research into Chlamydiae is taking place in almost all medically-developed countries in the world, and there is a great deal of information about the connection between Chlamydiae and specific diseases and also about various methods of Chlamydial diagnosis. Bazala and Renda (19 ...