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... Sjögren’s syndrome (SS) is a rheumatic autoimmune disease, with focal lymphocyte infiltration and inflammation in exocrine glands, resulting in destruction of glandular tissue. B cells have an important role in the humoral part of the adaptive immune response where they carry out several functions; ...
Immunology Stack - U
Immunology Stack - U

... synovial overgrowth (fronding) onto articular cartilage causing irreversible joint destruction and malformation. ...
March 24 (PP)
March 24 (PP)

... Negative selection eliminates self reactive lymphocytes Autoimmune diseases caused by body responding to self antigens MHC genes involved; genetically based ...
Spectrum of Autoimmune Diseases
Spectrum of Autoimmune Diseases

... Autoimmune Diseases 2008 C.K.Shieh Spectrum of Autoimmune Diseases HLA Association of Autoimmune Diseases Depletion of Autoreactive T Cells in the Thymus How does autoantibody cause diseases • Direct binding to target cells thyrotoxicosis Myasthenia gravis Goodpasture’s syndrome ...
Autoimmune Disorders
Autoimmune Disorders

... Normal process Promotes inflammation  Fights off invasion ...
Autoimmune Disease
Autoimmune Disease

... antibodies have not been identified Autoantibodies that have been found have not been shown to have any direct pathogenic effects on exocrine tissues There is substantial circumstantial evidence that tissue damage is the result of autoimmunity ...
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Sjögren syndrome

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