confronting copd in america: executive summary
... with emphysema and nine million are diagnosed with chronic bronchitis.2 COPD is the fourth leading cause of death in the United States, accounting for more than 112,000 deaths in 1998.3 Yet surprisingly little is known about COPD beyond its clinical nature, its population prevalence, and its mortali ...
... with emphysema and nine million are diagnosed with chronic bronchitis.2 COPD is the fourth leading cause of death in the United States, accounting for more than 112,000 deaths in 1998.3 Yet surprisingly little is known about COPD beyond its clinical nature, its population prevalence, and its mortali ...
The interleukin-23 axis in intestinal inflammation
... impaired ability to transfer EAE (62). These results indicate that IL-23 may be an important factor in selecting inflammatory Th17 effector functions providing a mechanism by which the Th17 response can adapt to environmental conditions. IL-23 in models of intestinal inflammation In the last decade, ...
... impaired ability to transfer EAE (62). These results indicate that IL-23 may be an important factor in selecting inflammatory Th17 effector functions providing a mechanism by which the Th17 response can adapt to environmental conditions. IL-23 in models of intestinal inflammation In the last decade, ...
REIGN IN BLOOD IMMUNE REGULATION IN TYPE 1 DIABETES Mikael Pihl
... Kimi Räikkönen on team radio while leading the 2012 Abu Dhabi Grand Prix ...
... Kimi Räikkönen on team radio while leading the 2012 Abu Dhabi Grand Prix ...
Consequences of Sarcoidosis
... with anxiety, it is not surprising that anxiety in general and trait anxiety were found to be related to fatigue.5,24,47 One study also found that trait anxiety predicted fatigue at follow-up.47 Trait anxiety refers to the tendency of persons to react with anxiety in new situations. In contrast, sta ...
... with anxiety, it is not surprising that anxiety in general and trait anxiety were found to be related to fatigue.5,24,47 One study also found that trait anxiety predicted fatigue at follow-up.47 Trait anxiety refers to the tendency of persons to react with anxiety in new situations. In contrast, sta ...
Differential switching to IgG and IgA healthy controls
... 16106 PBMCs or lung leukocytes were stained with Alexa Fluor1 700-conjugated anti-CD20, allophycocyanin (APC)- and Cy7-conjugated anti-CD27, phycoerythrin (PE)- and Cy7conjugated anti-CD38, APC-conjugated anti-CD138, biotinylated anti-IgM followed by PE-conjugated streptavidin (BD Biosciences, San J ...
... 16106 PBMCs or lung leukocytes were stained with Alexa Fluor1 700-conjugated anti-CD20, allophycocyanin (APC)- and Cy7-conjugated anti-CD27, phycoerythrin (PE)- and Cy7conjugated anti-CD38, APC-conjugated anti-CD138, biotinylated anti-IgM followed by PE-conjugated streptavidin (BD Biosciences, San J ...
Nonalcoholic Fatty Liver Disease and Insulin Resistance: New
... Abstract: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders worldwide. It is associated with clinical states such as obesity, insulin resistance, and type 2 diabetes, and covers a wide range of liver changes, ranging from simple steatosis to non-alcoholic ste ...
... Abstract: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders worldwide. It is associated with clinical states such as obesity, insulin resistance, and type 2 diabetes, and covers a wide range of liver changes, ranging from simple steatosis to non-alcoholic ste ...
Pathophysiology and differential diagnosis of anaemia
... microcirculation or in large vessels. Finally, increased RBC destruction is observed in patients with enlarged spleen (hypersplenism). 1.2.1 Immune haemolytic anaemias These result from the presence of antibodies targeting one or more of the numerous RBC membrane antigens. This condition is frequent ...
... microcirculation or in large vessels. Finally, increased RBC destruction is observed in patients with enlarged spleen (hypersplenism). 1.2.1 Immune haemolytic anaemias These result from the presence of antibodies targeting one or more of the numerous RBC membrane antigens. This condition is frequent ...
Rheumatoid arthritis-associated lung`disease
... pattern of fibrosis. This is in contrast to IPF, in which use of immunosuppressive therapy has not demonstrated any clinical benefit. To date, there have been no randomised controlled trials comparing medications for the treatment of rheumatoid arthritis lung disease. Corticosteroids are the mainsta ...
... pattern of fibrosis. This is in contrast to IPF, in which use of immunosuppressive therapy has not demonstrated any clinical benefit. To date, there have been no randomised controlled trials comparing medications for the treatment of rheumatoid arthritis lung disease. Corticosteroids are the mainsta ...
Review Article Overview of Community-Acquired Pneumonia and the Role
... have been found to have a significantly higher mortality with an increasing trend as the CD4 cell count decreases [14]. Some investigators have therefore recommended that the decision to admit HIV-infected patients with CAP to hospital should be based on both the CD4 cell count and the severity of i ...
... have been found to have a significantly higher mortality with an increasing trend as the CD4 cell count decreases [14]. Some investigators have therefore recommended that the decision to admit HIV-infected patients with CAP to hospital should be based on both the CD4 cell count and the severity of i ...
EASL Clinical Practice Guidelines: Autoimmune hepatitisq
... with human leukocyte antigens (HLA) DR3 or DR4, interface hepatitis on liver histology, and a favourable response to immunosuppression [2–5]. The disease, if untreated, often leads to cirrhosis, liver failure and death. AIH is considered relatively rare, as its prevalence ranges from 16 to 18 cases ...
... with human leukocyte antigens (HLA) DR3 or DR4, interface hepatitis on liver histology, and a favourable response to immunosuppression [2–5]. The disease, if untreated, often leads to cirrhosis, liver failure and death. AIH is considered relatively rare, as its prevalence ranges from 16 to 18 cases ...
Quantiferon (plus): what? How?
... unlikely to have M. tuberculosis infection and do not require further evaluation. • Do NOT exlude M. tuberculosis infection on a neg QFR ALONE in patients with signs or symptoms suggestive of TB‐disease (cfr casus). • Consider pre‐test probabilities. • FN possible in lymphopenia!! HIV: mantoux A ...
... unlikely to have M. tuberculosis infection and do not require further evaluation. • Do NOT exlude M. tuberculosis infection on a neg QFR ALONE in patients with signs or symptoms suggestive of TB‐disease (cfr casus). • Consider pre‐test probabilities. • FN possible in lymphopenia!! HIV: mantoux A ...
Epithelial barrier and dendritic cell function in the intestinal mucosa
... types. It has been shown that immunosuppressive DC-derived exosomes are capable to suppress inflammatory responses in rheumatic arthritis. The exact mechanism is not clear, but it is likely that DC-derived exosomes are internalised by endogenous or follicular DCs to transfer molecules like MHC class ...
... types. It has been shown that immunosuppressive DC-derived exosomes are capable to suppress inflammatory responses in rheumatic arthritis. The exact mechanism is not clear, but it is likely that DC-derived exosomes are internalised by endogenous or follicular DCs to transfer molecules like MHC class ...
Immune System Computation and the Immunological Homunculus
... existence as well as to sporadic episodes of clinical illness due to infection or injury. The immune system acts as a maintenance system; defense is only one aspect of maintenance (9). Actually, Eli Metchnikoff experimented with immune maintenance a century ago, but the discovery of antibodies to in ...
... existence as well as to sporadic episodes of clinical illness due to infection or injury. The immune system acts as a maintenance system; defense is only one aspect of maintenance (9). Actually, Eli Metchnikoff experimented with immune maintenance a century ago, but the discovery of antibodies to in ...
Guest Editorial Pinning Down Frailty
... frailty cascade is triggered by leptin deficiency or fueled by an inflammatory mediator such as tumor necrosis factor, for example, then possible treatments immediately suggest themselves. On a social level, it is crucial to shed light on what frailty entails so that elderly people, their families, ...
... frailty cascade is triggered by leptin deficiency or fueled by an inflammatory mediator such as tumor necrosis factor, for example, then possible treatments immediately suggest themselves. On a social level, it is crucial to shed light on what frailty entails so that elderly people, their families, ...
1 Phase I clinical trial of Mixed Bacterial Vaccine (Coley`s Toxins) in
... developed the mixture in the late 19th century as a treatment for cancer. This bacterial mixture was used in a large number of patients by Coley and others (1-6). Coley observed that a strong fever reaction was the key indicative aspect of a successful intervention leading to tumor regression. Howev ...
... developed the mixture in the late 19th century as a treatment for cancer. This bacterial mixture was used in a large number of patients by Coley and others (1-6). Coley observed that a strong fever reaction was the key indicative aspect of a successful intervention leading to tumor regression. Howev ...
Epidemiology of restless legs syndrome as diagnosed in UK primary
... the data from this study also suggest, however, that practicewide difficulties in recognising the condition are unlikely as almost all of the larger practices had registered at least one diagnosis in the study period. Unfortunately, it is not possible to explore the awareness of individual physician ...
... the data from this study also suggest, however, that practicewide difficulties in recognising the condition are unlikely as almost all of the larger practices had registered at least one diagnosis in the study period. Unfortunately, it is not possible to explore the awareness of individual physician ...
Cytokine network analysis of cerebrospinal fluid in myalgic
... M Hornig1,2, G Gottschalk3, DL Peterson3, KK Knox4,5, AF Schultz1, ML Eddy1, X Che1 and WI Lipkin1,2,6 Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 ...
... M Hornig1,2, G Gottschalk3, DL Peterson3, KK Knox4,5, AF Schultz1, ML Eddy1, X Che1 and WI Lipkin1,2,6 Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 ...
A Practical Approach to Panniculitis
... exogenous or endogenous source (Table 1). After exogenous causes have been ruled-out, endogenous causes may be expanded by carefully eliciting the medical history and reviewing body systems (Table 2). On physical examination, the appearance and location of the nodules may narrow the differential dia ...
... exogenous or endogenous source (Table 1). After exogenous causes have been ruled-out, endogenous causes may be expanded by carefully eliciting the medical history and reviewing body systems (Table 2). On physical examination, the appearance and location of the nodules may narrow the differential dia ...
Treatment of Hepatitis C in Patients with Renal
... Hepatitis C Treatment Experience with Chronic Renal Disease Peginterferon and Ribavirin-Based Therapy in Patients with Renal Disease: Renal insufficiency, regardless of the cause, has created problems with the use of peginterferon and ribavirin therapy for HCV, since the kidney plays a role in the ...
... Hepatitis C Treatment Experience with Chronic Renal Disease Peginterferon and Ribavirin-Based Therapy in Patients with Renal Disease: Renal insufficiency, regardless of the cause, has created problems with the use of peginterferon and ribavirin therapy for HCV, since the kidney plays a role in the ...
Autoimmune Responses to the Brain After Stroke Are Associated
... N-methyl-D-aspartic acid receptor in individuals with a history of stroke.6,7 Cellular immune responses to myelinassociated antigens and other brain antigens are also seen in stroke survivors and are more robust than the responses seen in patients with multiple sclerosis.8 –11 In an animal model of ...
... N-methyl-D-aspartic acid receptor in individuals with a history of stroke.6,7 Cellular immune responses to myelinassociated antigens and other brain antigens are also seen in stroke survivors and are more robust than the responses seen in patients with multiple sclerosis.8 –11 In an animal model of ...
Elevated serum BAFF levels in patients with sarcoidosis: association
... Clinical and laboratory characteristics in patients with sarcoidosis showing normal and elevated serum BAFF levels Clinical and laboratory findings were compared between sarcoidosis patients with elevated BAFF levels and those with normal levels. BAFF values higher than the mean + 2 S.D. (1.40 ng/ml ...
... Clinical and laboratory characteristics in patients with sarcoidosis showing normal and elevated serum BAFF levels Clinical and laboratory findings were compared between sarcoidosis patients with elevated BAFF levels and those with normal levels. BAFF values higher than the mean + 2 S.D. (1.40 ng/ml ...
IMMUNOREGULATION OF HEPATITIS B VIRUS INFECTION
... inhibitory receptors on their surface, such as programmed death-1 (PD-1), and the interaction between PD-1 and its ligand, PD-1 ligand 1 (PD-L1) are thought to be the major inhibitory receptor pathways involved in T-cell exhaustion.66-68) Indeed, PD-1 is shown to be overexpressed on HBV-specific T-c ...
... inhibitory receptors on their surface, such as programmed death-1 (PD-1), and the interaction between PD-1 and its ligand, PD-1 ligand 1 (PD-L1) are thought to be the major inhibitory receptor pathways involved in T-cell exhaustion.66-68) Indeed, PD-1 is shown to be overexpressed on HBV-specific T-c ...
dendritic cell-based tumor vaccination for high
... CTC, Common Toxicity Criteria CTL, cytotoxic T lymphocyte CTLA-4, cytotoxic T lymphocyte-associated antigen-4 DC, dendritic cell DTH, delayed-type hypersensitivity EGFRvIII, epidermal growth factor receptor class III variant EORTC, European Organization for Research and Treatment of Cancer FACS, flu ...
... CTC, Common Toxicity Criteria CTL, cytotoxic T lymphocyte CTLA-4, cytotoxic T lymphocyte-associated antigen-4 DC, dendritic cell DTH, delayed-type hypersensitivity EGFRvIII, epidermal growth factor receptor class III variant EORTC, European Organization for Research and Treatment of Cancer FACS, flu ...