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Bacterial Heat Shock Proteins
Bacterial Heat Shock Proteins

... Immune responses to Hsp60 are frequently found in a wide range of microbial infections. This Hsp family has been found to elicit humoral as well as cell mediated immune responses. For example, direct involvement of Hsp60-specific T cells has been demonstrated in a murine model of Yersiniosis. In thi ...
Chapter 14 – The Lymphatic System and Immunity
Chapter 14 – The Lymphatic System and Immunity

...  Artificial – exposure to the causative agent is deliberate.  Active - injection of the agent (vaccine) results in production of your own antibodies and memory cells.  Passive – injection of protective material (antibodies) that was developed by another individual’s immune system (gamma globulins ...
Multiple Sclerosis Is an Inflammatory T-Cell–Mediated - Direct-MS
Multiple Sclerosis Is an Inflammatory T-Cell–Mediated - Direct-MS

... both the inflammatory and degenerative stages of the disease. Experimental allergic encephalomyelitis is not an exact model of MS because not all treatments that are effective in EAE are effective in MS, eg, anti–tumor necrosis factor therapy. Also, there are paradoxical effects in EAE, such as incr ...
Introduction to monoclonal antibodies
Introduction to monoclonal antibodies

PowerPoint Presentation - I. Introduction to class
PowerPoint Presentation - I. Introduction to class

... plasma, lymph, mucus, etc.) and the surface of B cells.  Defense against bacteria, bacterial toxins, and viruses that circulate freely in body fluids, before they enter ...
The primary -> secondary immune response
The primary -> secondary immune response

... Maturation cont... Selection of high affinity B cell clones leads to affinity maturation of the immune response. B cells expressing high affinity BCR are favored by clonal selection. This occurs when Ab:Ag complexes are highly compatible and possess a “good fit”. The high affinity Ab:Ag interaction ...
Chapter 17: Specific Host Defenses
Chapter 17: Specific Host Defenses

... plasma, lymph, mucus, etc.) and the surface of B cells.  Defense against bacteria, bacterial toxins, and viruses that circulate freely in body fluids, before they enter ...
Hematopoiesis Hematopoiesis Hematopoiesis Apoptosis
Hematopoiesis Hematopoiesis Hematopoiesis Apoptosis

2014 stem cell symposium - Translational Research Institute
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The Journal of Immunology, 2010
The Journal of Immunology, 2010

... GILT can facilitates the generation of MHC class II-restricted epitopes from disulfide bond containing Ags. Melanocyte differentiation Ags are melanosomal integral membrane proteins involved in melanin pigment synthesis. These Ags contain a dileucine-based sorting signal that targets them to the e ...
Hypersensitivity Ch. 18-19
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Immune
Immune

... responding strongly to antigens; foreign substances may be invisible to the immune system unless accompanied by danger signals (infection/inflammation) ...
Laudatio for Adrian Liston
Laudatio for Adrian Liston

... VIB (Vlaams Instituut voor Biotechnologie) in Leuven was the best. In the year 2009 he moved to Leuven where he has been ever since, presently as a group leader at the VIB and a professor of Leuven University. He established a vigorous and highly productive research team. His interests have remained ...
Lymphoid cells: Cells of the adaptive immune system
Lymphoid cells: Cells of the adaptive immune system

... major histocompatability complex (MHC) molecule by an antigen presenting cell (APC). The antigen presenting cell is usually a dendritic cell, although it is sometimes a B lymphocyte or macrophage. The antigenic peptide is derived from a protein, which has been endocytosed and broken down by the anti ...
Curriculum Vitae - University of Oxford
Curriculum Vitae - University of Oxford

... 3) Harnessing iNKT cells to optimize cancer vaccines. My group demonstrated for the first time that the highest frequency of tumour specific CTL can be found in tumour infiltrated lymph nodes (Romero et al., J Exp Med, 1998). We have then extended these studies to vitiligo patients and demonstrated ...
Curbing the appetites of the big eaters - MDC Repository
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... F4/80-positve macrophages from peritoneal exudates was also impaired. F4/80 is the cell surface target of a monoclonal antibody directed against mouse macrophages that was developed over 20 years ago by Austyn and Gordon [2]. The F4/80 molecule is expressed on macrophages, Kupffer cells, and microgl ...
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The components of inflammation.
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... in pain transmission. • Many receptors and enzymes in DRG cells and elsewhere are upregulated during inflammation. • Cranial nerves and CNS structures are also important. ...
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Blank Jeopardy
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... yield a positive test result as a consequence of antibody excess. ...
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... Lymphatic organs connected by the lymphatic system Lymphatic vessels circulate lymph, a fluid that contains lymphocytes (white blood cells) Bacteria are collected by the lymph and filtered out through lymph organs Bone marrow produces macrophages, special white blood cells that engulf and destroy ba ...
The Endocrine System
The Endocrine System

Rallying the troops of the immune system to fight cancer
Rallying the troops of the immune system to fight cancer

... throughout the body to kill any similar cancers. So STING activation is akin to “vaccinating” the body against the tumor. STING was discovered relatively recently, in 2008, but researchers have already uncovered many details about how it operates. It’s a transmembrane protein that bridges the innate ...
Chapter 5: Requiremnt for Infection
Chapter 5: Requiremnt for Infection

Host Parasite Relationship OBJECTIVES
Host Parasite Relationship OBJECTIVES

... which is the number of organisms or mg. of toxins that will kill 50% of susceptible lab. animal ( usually mice ) when injected into such animal. When the LD 50 is small, the microorganism is considered highly virulent and when it is high the organism is said to be of low virulence. ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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