• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Macrophage Morphological Changes Due to iNOS Activation by
Macrophage Morphological Changes Due to iNOS Activation by

Distinct domains of a nucleolar protein mediate protein kinase
Distinct domains of a nucleolar protein mediate protein kinase

... with transcription of rDNA, processing of pre-rRNA and formation of pre-ribosomal particles occurring within this compartment. Well-defined structural regions of the nucleolus (fibrillar center, dense fibrillar component, and granular region) that correspond to these functions have long been recogni ...
Association of Early Interferon-γ Production with Immunity to Clinical
Association of Early Interferon-γ Production with Immunity to Clinical

Amino acids - WordPress.com
Amino acids - WordPress.com

... hepatic tumors. Humans and other higher animals lack the capability to synthesize 10 of the 20 common L -α -amino acids in amounts adequate to support infant growth or to maintain health in adults . Consequently, the human diet must contain adequate quantities of these nutritionally essential amino ...
Metabolic checkpoints in activated T cells
Metabolic checkpoints in activated T cells

... potential consequences in terms of ‘metabolic checkpoints’, which we define as molecular mechanisms that sense metabolic status and, in turn, regulate cellular functions. Understanding of such checkpoints holds the promise of novel manipulation of immune responses and therapeutic intervention under ...
The `T-cell-ness` of NK cells: unexpected similarities between NK
The `T-cell-ness` of NK cells: unexpected similarities between NK

Regulatory T Cells (Tregs)- Frequently Asked
Regulatory T Cells (Tregs)- Frequently Asked

VARICELLA-ZOSTER VIRUS EPSTEIN BARR VIRUS, AND HUMAN
VARICELLA-ZOSTER VIRUS EPSTEIN BARR VIRUS, AND HUMAN

The role of the cell wall in fungal pathogenesis
The role of the cell wall in fungal pathogenesis

Identification of novel CTL epitopes of CMV-pp65
Identification of novel CTL epitopes of CMV-pp65

Histology Lymphoid system General Concepts Functions Provides
Histology Lymphoid system General Concepts Functions Provides

... a. A connective tissue capsule surrounds the thymus and extends into the thymus, dividing it into lobules. b. The stroma is formed by a network of reticular cells of endodermal, rather than the usual mesodermal, origin and are called, therefore, epithelial reticular cells. These cells do not form fi ...
Review Article The Role of Th17 in Neuroimmune
Review Article The Role of Th17 in Neuroimmune

Chapter 2 Theories of Aging
Chapter 2 Theories of Aging

... 1. Each animal (each cell?) has a specific amount of metabolic energy available to it 2. Rate at which energy is used determines lifespan 3. Experimental evidence 4. Related to Aging by Program and Accumulation of Errors theories ...
Course 19
Course 19

... Acquired, or secondary, immunodeficiencies are considerably more common than primary immunodeficiencies. Although the best-known cause of secondary immunodeficiency is HIV/AIDS, other causes are important in many patients. Malnutrition is the leading cause of secondary, or acquired, immunodeficiency ...
Review of Literature
Review of Literature

Quantitative analysis of lymphocyte differentiation and proliferation
Quantitative analysis of lymphocyte differentiation and proliferation

Implications of CTL-Mediated Killing of HIV
Implications of CTL-Mediated Killing of HIV

Ectopic lymphoid-like structures in infection, cancer and autoimmunity
Ectopic lymphoid-like structures in infection, cancer and autoimmunity

Immunotherapy and Prevention
Immunotherapy and Prevention

... Tatyana Ivakhnyuk ...
Lymphatic System These notes are intended as a comprehensive
Lymphatic System These notes are intended as a comprehensive

... special category. By themselves they are the key to recognition of self from non-self. These special proteins are called “major histocompatibility complex” or MHC in short. Now that is another mouthful. Let us explain it in brief. This term, MHC, came into being in the context of rejection of tissue ...
The challenge of multiple sclerosis: How do we cure a chronic
The challenge of multiple sclerosis: How do we cure a chronic

20 Chapter
20 Chapter

... of AIDS were documented in the United States. • At this time the disease has no known cure. • One group of medicines to help treat AIDS interferes with the way that the virus multiplies in the host cell. • Another group of medicines blocks the entrance of HIV in the host cell. ...
Slide 1
Slide 1

... of AIDS were documented in the United States. • At this time the disease has no known cure. • One group of medicines to help treat AIDS interferes with the way that the virus multiplies in the host cell. • Another group of medicines blocks the entrance of HIV in the host cell. ...
Bacterial Biofilms Resist Key Host Defenses
Bacterial Biofilms Resist Key Host Defenses

1. Inflammation
1. Inflammation

< 1 ... 153 154 155 156 157 158 159 160 161 ... 514 >

Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report