• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
The Behavioral Immune System - University of British Columbia
The Behavioral Immune System - University of British Columbia

BIO 218 F 2012 CH 23 Martini Lecture Outline
BIO 218 F 2012 CH 23 Martini Lecture Outline

... B cells will begin producing antibodies against the bacterial antigens Antibodies will bind to the bacterial antigens This antigen–antibody combination will attract an “army” of leukocytes These leukocytes will kill the bacteria ...
4 Classes of pathogens:
4 Classes of pathogens:

... Hypervariable (HV) or complementary determining region (CDR)—loops that form Ag-binding sites, 3 HV regions on both light & heavy chains Affinity—strength of sum total of all noncovalent interactions b/w single Ag-binding site & single epitope Equilibrium dialysis—used to determine affinity of Ab by ...
Lymphoma - Starpace
Lymphoma - Starpace

... -Large B-cell lymphomas (DLBCL, FLL, BL) have been shown to express Ig molecules on their surface, which bear the scars of affinity maturation; an antigen-driven process (Klein et al, 1995, Chapman et al, 1995, Kuppers et al, 1997) -The gene expression profiles of DLBCL cells resemble those of B-cel ...
CD8 Positive T Cells Influence Antigen
CD8 Positive T Cells Influence Antigen

... the humoral response. T helper cells also help cytotoxic T lymphocytes to search out and destroy infected cells in the periphery. Once engaged, humoral or cellular immunity can act independently or in concert to eradicate the pathogenic organism from the host. Although the importance of modulatory s ...
Your Amazing Immune System - how it protects your body
Your Amazing Immune System - how it protects your body

... immune system, enabling it to defend the body against germs that are yet to be encountered. Usually, vaccinations cause no more discomfort than a quick, easily-forgotten prick to your arm or thigh, but they save you from becoming seriously ill or dying from that disease. Today, many people suffer fr ...
Viral Pathogenesis - E-Learning per i corsi di Studi in Biologia
Viral Pathogenesis - E-Learning per i corsi di Studi in Biologia

... Productive infection of epithelial cells Virus infects sensory neurons Virus travels to sensory ganglion by neuronal retrograde transport Virus establishes latent infection in sensory ganglion Limited expression of viral genes, latency associated transcripts (LATs), viral genome replicates in episom ...
Transplantation - Federation of American Societies for Experimental
Transplantation - Federation of American Societies for Experimental

ENTEROBACTERIACEAE
ENTEROBACTERIACEAE

... hospital, following instrumentation, are more often caused by other bacteria such as pseudomonas and proteus. • The E.coli serotypes commonly responsible for UTI are those normally found in the feces, O ...
Outline/ Active Learning Objectives - Rose
Outline/ Active Learning Objectives - Rose

... Macrophages can circulate in lymph vessels (wandering, non-fixed macrophages), or they can reside in connective tissue, lymph nodules, along the digestive tract, in the lungs, in the spleen and other places (mature, fixed macrophages). Fixed macrophages are part of the reticuloendothelial system (RE ...
Immunomodulatory effects of Lactobacillus casei Shirota
Immunomodulatory effects of Lactobacillus casei Shirota

... system in the gut. These cells are present in tissues of the gastrointestinal tract, where the prevalence of immunogenic agents, such as food and components of the commensal bacteria, is the highest (Hill and Artis, 2010). The barrier function of mucosal surfaces in the gut involves a number of comp ...
Is Obesity One of Physiological Factors which Exert Influenza Virus
Is Obesity One of Physiological Factors which Exert Influenza Virus

... follicular region which produces antibodies with lower ...
Zonulin! The Wheat Conundrum Solved (Well, Mostly …)
Zonulin! The Wheat Conundrum Solved (Well, Mostly …)

... and still others may suffer autoimmune reactions throughout the body. Further complicating the clinical picture is that some people develop celiac disease soon after wheat is introduced into their diet as infants while others may not manifest significant symptoms and pathology until adulthood. I thi ...
A hypothesis for the initiation of COPD PERSPECTIVE
A hypothesis for the initiation of COPD PERSPECTIVE

... acquired mutations. These mutations permanently alter DNA autorepair ability, resulting in genomic instability [14]. Smoking-induced somatic mutations persist for years or decades once they are acquired [15]. In agreement with the above hypothesis, somatic genetic alterations have been detected at t ...
T cell
T cell

... • Amplitude and quality of a Tcell response is regulated by a balance of activating and inhibitory signals CTLA-4 = cytotoxic T-lymphocyte antigen-4; LAG-3 = lymphocyte activation gene-3; PD-1 = programmed death-1; PD-L1 = programmed death-ligand 1. ...
2. The immune system [7,8]
2. The immune system [7,8]

... pathogens. Key to the success of our immune system lies in its ability to develop immunity to pathogens it has never encountered before. Professional antigen-presenting cells (APCs) known as dendritic cells (DCs) are vital in directing this so called adaptive immune response. Next to their role of p ...
Evolutionary perspective on innate immune recognition
Evolutionary perspective on innate immune recognition

cancer immunology - Cell Signaling Technology
cancer immunology - Cell Signaling Technology

... Toll-like receptors (TLRs) recognize distinct pathogen-associated molecular patterns (PAMPs) and play an integral role in the innate immune response. They participate in the first line of defense against invading pathogens and play a significant role in inflammation, immune cell regulation, survival ...
SUMOylation of STAT
SUMOylation of STAT

... aminoacylates the engineered tRNA ► Only accepts unnatural amino acid into ...
IC31 and IC30, novel types of vaccine adjuvant based on peptide
IC31 and IC30, novel types of vaccine adjuvant based on peptide

... antigens into cells. Early studies indicated a potent role of polyL-arginine (IC30) in enhancing the uptake of peptide antigens into antigen-presenting cells (APCs) [6]. In addition, IC30 also exerts its adjuvant effects via the formation of a depot at the injection site, leading to a sustained prim ...
PowerPoint 프레젠테이션
PowerPoint 프레젠테이션

... • Allogrft tissue stimulates a profound cell-mediated immune response with diffuse T cell infiltrates and progressive failure of the allograft valve has been attributed to this alloreactive immune response • The role of humoral response in allograft failure is less clear, recently, evidence has been ...
Recurrent respiratory papillomatosis: pathogenesis to treatment
Recurrent respiratory papillomatosis: pathogenesis to treatment

... to represent the type of replication that occurs in nondifferentiated basal cells [18,19]. Part of the mechanism of episomal maintenance has been recently clarified. The viral gene E2 binds the viral genome to host chromosomal DNA so that it is segregated and maintained during mitosis [20••]. When k ...
The intestinal epithelium is an integral component of a
The intestinal epithelium is an integral component of a

Overview of cell shape: cytoskeletons shape bacterial cells
Overview of cell shape: cytoskeletons shape bacterial cells

... UgtP, an enzyme involved in glucolipid biosynthesis in Bacillus subtilis, also has the ability to inhibit FtsZ polymerization. Cells depleted for this enzyme (or ones upstream in the same pathway) assemble Z rings and divide at a shorter cell length than the wild type. Thus, an active UgtP reduces F ...
The Biology of Aging: An Overview
The Biology of Aging: An Overview

... (ORAC) may be more protective than other antioxidant preparations – Antioxidants may help reduce the incidence of ARMD Butler, RN et al. J. Gerontol. 57A: B333-8 (2002). ...
< 1 ... 149 150 151 152 153 154 155 156 157 ... 514 >

Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report