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... Autoimmune disease occurs when an immune response attacks our own tissues. Like all adaptive immune responses, it is focused on specific antigens by T-cell receptors and B cell receptors. In contrast to infection, the antigens that these cells recognise are processed from proteins within the target ...
AUTOIMMUNE DISEASES
AUTOIMMUNE DISEASES

... Cartilage loss ...
Spectrum of Autoimmune Diseases
Spectrum of Autoimmune Diseases

... HLA Association of Autoimmune Diseases Depletion of Autoreactive T Cells in the Thymus How does autoantibody cause diseases • Direct binding to target cells thyrotoxicosis Myasthenia gravis Goodpasture’s syndrome ...
4.-autoimmunity-and
4.-autoimmunity-and

... • T-lymphocytes have specific surface proteins that should be able to read the surface antigens of a cell and tell if it is self or non-self. • However, sometimes T-lymphocyte regulation can fail • T-lymphocytes fail to distinguish between the surface proteins of the body’s own cells and surface pro ...
79th WPI-IIIS Seminar - International Institute for Integrative Sleep
79th WPI-IIIS Seminar - International Institute for Integrative Sleep

... The presence of DNA and aberrant RNA in the cytoplasm is a danger signal that alerts the host immune system to eliminate microbial infections, but inappropriate activation of these pathways can also lead to autoimmune diseases such as lupus. My talk will focus on our recent work on the discovery of ...
March 24 (PP)
March 24 (PP)

... Negative selection eliminates self reactive lymphocytes Autoimmune diseases caused by body responding to self antigens MHC genes involved; genetically based ...
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Autoimmunity

Autoimmunity is the system of immune responses of an organism against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease. Prominent examples include Celiac disease, diabetes mellitus type 1, Sarcoidosis, systemic lupus erythematosus (SLE), Sjögren's syndrome, Churg-Strauss Syndrome, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's Disease, rheumatoid arthritis (RA), Polymyositis (PM), and Dermatomyositis (DM). Autoimmune diseases are very often treated with steroids.The misconception that an individual's immune system is totally incapable of recognizing self antigens is not new. Paul Ehrlich, at the beginning of the twentieth century, proposed the concept of horror autotoxicus, wherein a ""normal"" body does not mount an immune response against its own tissues. Thus, any autoimmune response was perceived to be abnormal and postulated to be connected with human disease. Now, it is accepted that autoimmune responses are an integral part of vertebrate immune systems (sometimes termed ""natural autoimmunity""), normally prevented from causing disease by the phenomenon of immunological tolerance to self-antigens. Autoimmunity should not be confused with alloimmunity.
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