1. dia
... and mucous membranes. The most common type is pemphigus vulgaris, which involves painful sores and blisters on the skin and in mouth. Autoantibodies attack desmosomes. Antigen: Desmoglein 3 ...
... and mucous membranes. The most common type is pemphigus vulgaris, which involves painful sores and blisters on the skin and in mouth. Autoantibodies attack desmosomes. Antigen: Desmoglein 3 ...
misdirected reactions of the immune system autoimmunity
... diseases with genetic predisposition and environmental modulation * Prevalence of 5% to 8% in US * Prevalence is greater for females than males • 75% of cases • 4th largest disease class in women ...
... diseases with genetic predisposition and environmental modulation * Prevalence of 5% to 8% in US * Prevalence is greater for females than males • 75% of cases • 4th largest disease class in women ...
abstract
... Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9148 The presence of DNA and aberrant RNA in the cytoplasm is a danger signal that alerts the host immune system to eliminate microbial infections and malignant cells, but inappropriate activation of these pathways can also lead to ...
... Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9148 The presence of DNA and aberrant RNA in the cytoplasm is a danger signal that alerts the host immune system to eliminate microbial infections and malignant cells, but inappropriate activation of these pathways can also lead to ...
Snímek 1
... Genes assiciated with antigen clearance (complement proteins) Genes associated with tolerance induction (CTLA-4, Fas-FasL) ...
... Genes assiciated with antigen clearance (complement proteins) Genes associated with tolerance induction (CTLA-4, Fas-FasL) ...
Autoimmune Diseases
... Autoimmune disorders are caused by the immune system attacking healthy cells in the body Examples of rheumatoid arthritis, multiple sclerosis, type 1diabetes, vitiligo and systemic lupus erythematosus MiRNA’s are able to repress targeted gene expression by interfering with translation of mRNA or deg ...
... Autoimmune disorders are caused by the immune system attacking healthy cells in the body Examples of rheumatoid arthritis, multiple sclerosis, type 1diabetes, vitiligo and systemic lupus erythematosus MiRNA’s are able to repress targeted gene expression by interfering with translation of mRNA or deg ...
chapter 19 autoimmunity: breakdown of self-tolerance
... particular. It is important to remember that the presence of circulating immune complexes is a common feature of many autoimmune diseases, most notably the non-organ specific ones such as RA and SLE; these autoimmune complexes exhibit the same sequelae as those formed with heterologous antigens, i.e ...
... particular. It is important to remember that the presence of circulating immune complexes is a common feature of many autoimmune diseases, most notably the non-organ specific ones such as RA and SLE; these autoimmune complexes exhibit the same sequelae as those formed with heterologous antigens, i.e ...
PowerPoint Presentation - Atypical Cutaneous Leishmaniasis
... damage by infection may allow access of T cells and B cells to sequestered antigens. Antigenic (molecular) mimicry is when ...
... damage by infection may allow access of T cells and B cells to sequestered antigens. Antigenic (molecular) mimicry is when ...
241.Autoimmunity
... Occurs when a virus or a bacterium posses antigenic determinants that are very similar or identical to normal host cell components Molecular mimicry may be the initiating step in a variety of autoimmune diseases. E.g. Rheumatoid fever occurs after streptococcal infection ...
... Occurs when a virus or a bacterium posses antigenic determinants that are very similar or identical to normal host cell components Molecular mimicry may be the initiating step in a variety of autoimmune diseases. E.g. Rheumatoid fever occurs after streptococcal infection ...
6_Autoimmune_2013
... and mucous membranes. The most common type is pemphigus vulgaris, which involves painful sores and blisters on the skin and in mouth. Autoantibodies attack desmosomes. Antigen: Desmoglein 3 ...
... and mucous membranes. The most common type is pemphigus vulgaris, which involves painful sores and blisters on the skin and in mouth. Autoantibodies attack desmosomes. Antigen: Desmoglein 3 ...
Autoimmune diseases
... Juvenile diabetes or Type I DM (attacks insulin-producing cells) 3. Systemic autoimmune diseases or Non-organ specific autoimmune diseases Immune complexes accumulate in many tissues and cause inflammation and damage. They affect many organs or the whole body ...
... Juvenile diabetes or Type I DM (attacks insulin-producing cells) 3. Systemic autoimmune diseases or Non-organ specific autoimmune diseases Immune complexes accumulate in many tissues and cause inflammation and damage. They affect many organs or the whole body ...
Autoimmunity and immune- mediated inflammatory diseases FOCiS
... Immune-mediated diseases • Immunological diseases tend to be chronic and self-perpetuating, because -– The initiating trigger can often not be eliminated (self antigen, commensal microbes) – The immune system contains many built-in amplification mechanisms whose normal function is to optimize our ab ...
... Immune-mediated diseases • Immunological diseases tend to be chronic and self-perpetuating, because -– The initiating trigger can often not be eliminated (self antigen, commensal microbes) – The immune system contains many built-in amplification mechanisms whose normal function is to optimize our ab ...
Theories of Autoimmunity
... - blockage of preferred TCRs with monoclonal antibodies - monoclonal antibody against an MHC molecule that is associated with autoimmunity while sparing the others • Oral antigens - tend to induce tolerance - still in early clinical trials ...
... - blockage of preferred TCRs with monoclonal antibodies - monoclonal antibody against an MHC molecule that is associated with autoimmunity while sparing the others • Oral antigens - tend to induce tolerance - still in early clinical trials ...
What Happens When the Immune System Attacks Itself?
... When the immune system malfunctions, it can affect the skin, heart, central nervous system, and almost any structure in the body. There are two types of autoimmune diseases: localized and systemic. Localized diseases slowly destroy a specific type of organ or tissue, make an organ grow excessively, ...
... When the immune system malfunctions, it can affect the skin, heart, central nervous system, and almost any structure in the body. There are two types of autoimmune diseases: localized and systemic. Localized diseases slowly destroy a specific type of organ or tissue, make an organ grow excessively, ...
Crabtree_DOM_ResearchDay_Abstract
... predisposes to autoimmune and infectious disease, and confers altered signaling through antigen receptors and PRRs. We tested the hypothesis that LypWbearing humans would have diminished immune response to trivalent influenza vaccine (TIV). LypW carriers exhibited decreased induction of influenza-sp ...
... predisposes to autoimmune and infectious disease, and confers altered signaling through antigen receptors and PRRs. We tested the hypothesis that LypWbearing humans would have diminished immune response to trivalent influenza vaccine (TIV). LypW carriers exhibited decreased induction of influenza-sp ...
Malaria in Pregnancy & Anaemia in Pregnancy
... instead of reacting only against foreign antigens, could focus its attack on SELF ANTIGENS ...
... instead of reacting only against foreign antigens, could focus its attack on SELF ANTIGENS ...
Autoimmune Disease
... MHC-related diseases occur more commonly in women, eg, rheumatoid arthritis, Graves’s disease (hyperthyroidism), and systemic lupus erythematosus, whereas class I MHC-related diseases occur more commonly in men, eg, ankylosing spondylitis and Reither’s syndrome. In summary, the current model is that ...
... MHC-related diseases occur more commonly in women, eg, rheumatoid arthritis, Graves’s disease (hyperthyroidism), and systemic lupus erythematosus, whereas class I MHC-related diseases occur more commonly in men, eg, ankylosing spondylitis and Reither’s syndrome. In summary, the current model is that ...
Overview Of Autoimmune Disease - American Proficiency Institute
... In some people, something triggers the immune response to begin attacking self cells or tissues. Immune tolerance to self is impaired, and antibodies and T cytotoxic lymphocytes cause damage to self. Inflammation is produced and leads to tissue damage. The result is an autoimmune disease. The cause ...
... In some people, something triggers the immune response to begin attacking self cells or tissues. Immune tolerance to self is impaired, and antibodies and T cytotoxic lymphocytes cause damage to self. Inflammation is produced and leads to tissue damage. The result is an autoimmune disease. The cause ...
Autoimmune Disorders
... What is an autoimmune disorder? • More than 80 types of autoimmune disorders affect 5% of the population • Immune system turns its defense against body’s own tissues → B and T cells react against ‘self’ ...
... What is an autoimmune disorder? • More than 80 types of autoimmune disorders affect 5% of the population • Immune system turns its defense against body’s own tissues → B and T cells react against ‘self’ ...
Drugs to Treat Autoimmune Diseases
... capable of neutralizing self reactive antibodies exist naturally within the body ...
... capable of neutralizing self reactive antibodies exist naturally within the body ...
Autoimmunity Autoimmunity Targets of Autoimmunity
... • Some show increased prevalence in families ...
... • Some show increased prevalence in families ...
Helminth derived Immunodmodulator A therapeutic for immune-related diseases Overview
... The technology relates to novel compositions and methods for modulating an immune response in order to prevent or treat disease and/or conditions where T lymphocyte cells have a pathogenic role, such as Th1 or ThIL-17 mediated inflammatory conditions, chronic inflammatory conditions and autoimmune d ...
... The technology relates to novel compositions and methods for modulating an immune response in order to prevent or treat disease and/or conditions where T lymphocyte cells have a pathogenic role, such as Th1 or ThIL-17 mediated inflammatory conditions, chronic inflammatory conditions and autoimmune d ...