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Topamax SPC
... smaller increments or longer intervals between increments can be used. Dose and titration rate should be guided by clinical outcome. The recommended initial target dose for topiramate monotherapy in adults with newly diagnosed epilepsy is 100 mg/day and the maximum recommended daily dose is 400 mg. ...
... smaller increments or longer intervals between increments can be used. Dose and titration rate should be guided by clinical outcome. The recommended initial target dose for topiramate monotherapy in adults with newly diagnosed epilepsy is 100 mg/day and the maximum recommended daily dose is 400 mg. ...
Drug Metabolism Test Results
... to harboring untested phenotypically important polymorphisms, drug-drug interactions, co-morbidities, lifestyle habits or other non-genetic factors. This report does not address drug allergies or drug-drug interactions. Laboratory Accreditation This test was developed and its performance charact ...
... to harboring untested phenotypically important polymorphisms, drug-drug interactions, co-morbidities, lifestyle habits or other non-genetic factors. This report does not address drug allergies or drug-drug interactions. Laboratory Accreditation This test was developed and its performance charact ...
PRIAPISM INDUCED WITH SINGLE ORAL DOSE OF SILDENAFIL: A RARE CASE REPORT Research Article
... use of sildenafil have been with self‐administration of very large doses or in conditions predisposing to priapism or had used drug for prolonged period.. The first case report of priapism induced by oral sildenafil was due to a high dose (200mg)15. Priapism may also follow s ...
... use of sildenafil have been with self‐administration of very large doses or in conditions predisposing to priapism or had used drug for prolonged period.. The first case report of priapism induced by oral sildenafil was due to a high dose (200mg)15. Priapism may also follow s ...
Isosorbide Mononitrate Extended-Release Tablets, USP Rx only
... Pharmacokinetics and Metabolism After oral administration of ISMN as a solution or immediate-release tablets, maximum plasma concentrations of ISMN are achieved in 30 to 60 minutes, with an absolute bioavailability of approximately 100%. After intravenous administration, ISMN is distributed into tot ...
... Pharmacokinetics and Metabolism After oral administration of ISMN as a solution or immediate-release tablets, maximum plasma concentrations of ISMN are achieved in 30 to 60 minutes, with an absolute bioavailability of approximately 100%. After intravenous administration, ISMN is distributed into tot ...
Vol 1 Pg 2 EXECUTIVE SUMMARY
... injury can occur following substantial acetaminophen overdose, but does not show a risk of hepatic injury with the maximum labeled daily dose of acetaminophen, regardless of population. While there exists retrospective case reports of serious hepatic events reported to involve acetaminophen-containi ...
... injury can occur following substantial acetaminophen overdose, but does not show a risk of hepatic injury with the maximum labeled daily dose of acetaminophen, regardless of population. While there exists retrospective case reports of serious hepatic events reported to involve acetaminophen-containi ...
Newer Antihistamines
... rhinoconjunctivitis and chronic urticaria Their use can be justified mainly on the basis of a more favorable risk-benefit ratio, because they are less toxic to the central nervous system ...
... rhinoconjunctivitis and chronic urticaria Their use can be justified mainly on the basis of a more favorable risk-benefit ratio, because they are less toxic to the central nervous system ...
Advicor® (niacin extended-release/lovastatin tablets)
... molecule of Apo B, and since little Apo B is found in other lipoproteins, this strongly suggests that lovastatin does not merely cause cholesterol to be lost from LDL-C, but also reduces the concentration of circulating LDL particles. In addition, lovastatin can produce increases of variable magnitu ...
... molecule of Apo B, and since little Apo B is found in other lipoproteins, this strongly suggests that lovastatin does not merely cause cholesterol to be lost from LDL-C, but also reduces the concentration of circulating LDL particles. In addition, lovastatin can produce increases of variable magnitu ...
JATEORHIZA MACRANTHA EXTRACT ON ETHANOL-INDUCED HYPERTENSION IN WISTAR Research Article
... macrantha (AEJM) on ethanol-induced hypertension in rats. Five groups of male albinos rats were respectively treated for 3 weeks with distilled water (10 mL/kg), ethanol 40° (6 g/kg), ethanol and captopril (20 mg/kg), ethanol and the AEJM (150 or 300 mg/kg). After 3 weeks, the hemodynamic parameters ...
... macrantha (AEJM) on ethanol-induced hypertension in rats. Five groups of male albinos rats were respectively treated for 3 weeks with distilled water (10 mL/kg), ethanol 40° (6 g/kg), ethanol and captopril (20 mg/kg), ethanol and the AEJM (150 or 300 mg/kg). After 3 weeks, the hemodynamic parameters ...
Uptake of Methotrexate, Aminopterin, and
... keeping with fmdings that, in rats, the urinary and biiary excretion of MQ appeared less rapid than that ofMtx (14). All 3 agents, however, reach negligible concentrations in mouse serum within 1 to 2 hr after injection of0.l mg/kg, an amount are in fair agreement with previous estimates of minimal ...
... keeping with fmdings that, in rats, the urinary and biiary excretion of MQ appeared less rapid than that ofMtx (14). All 3 agents, however, reach negligible concentrations in mouse serum within 1 to 2 hr after injection of0.l mg/kg, an amount are in fair agreement with previous estimates of minimal ...
IMITREX® Tablets Tear Sheet
... equipped facility unless the patient has previously received sumatriptan. Because cardiac ischemia can occur in the absence of clinical symptoms, consideration should be given to obtaining on the first occasion of use an electrocardiogram (ECG) during the interval immediately following IMITREX Table ...
... equipped facility unless the patient has previously received sumatriptan. Because cardiac ischemia can occur in the absence of clinical symptoms, consideration should be given to obtaining on the first occasion of use an electrocardiogram (ECG) during the interval immediately following IMITREX Table ...
Document
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
Chemotherapy-Induced Nausea and Vomiting
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
Life Sciences, Vol. 32, pp. 971{-978 /_ Pergamo n Press
... drugs is separate from the site mediating tolerance, then it may be possible to develop drugs which produce the primary therapeutic effect, without producing tolerance. Therefore, it would be possible to conduct long-termtherapy without the onset of tolerance, and the concomitant need to increase dr ...
... drugs is separate from the site mediating tolerance, then it may be possible to develop drugs which produce the primary therapeutic effect, without producing tolerance. Therefore, it would be possible to conduct long-termtherapy without the onset of tolerance, and the concomitant need to increase dr ...
Translational Pharmacokinetic Modeling of Fingolimod
... An overview of the studies used to characterize the PK of fingolimod(-P) in rat and human can be found in Table 1. Ex Vivo Studies. Three ex vivo experiments were performed in isolated blood from male albino rats of strain Hanover Wistar and human blood obtained from healthy male volunteers (Blutspe ...
... An overview of the studies used to characterize the PK of fingolimod(-P) in rat and human can be found in Table 1. Ex Vivo Studies. Three ex vivo experiments were performed in isolated blood from male albino rats of strain Hanover Wistar and human blood obtained from healthy male volunteers (Blutspe ...
Product Monograph Template - Standard
... The dosage should be individualised, and the patient's response should be monitored by the prescribing physician on an ongoing basis. In patients with asthma, if salbutamol is required more than three times a week (not including its use to prevent exercise-induced bronchospasm), antiinflammatory the ...
... The dosage should be individualised, and the patient's response should be monitored by the prescribing physician on an ongoing basis. In patients with asthma, if salbutamol is required more than three times a week (not including its use to prevent exercise-induced bronchospasm), antiinflammatory the ...
Motivating Clients for Treatment and Addressing Resistance
... Relapse is extremely common. It is part of the process of resolving the dependence – much like giving up tobacco. A principle health care objective is to get the patient into treatment, help keep them in treatment, and return them to treatment when relapse occurs. ...
... Relapse is extremely common. It is part of the process of resolving the dependence – much like giving up tobacco. A principle health care objective is to get the patient into treatment, help keep them in treatment, and return them to treatment when relapse occurs. ...
A Comparison of Oral Azithromycin with Topical Oxytetracycline
... of age (table 2). Although case selection was not population based, this age distribution of active cases was similar to that noted in our previous studies in Egypt. This group does not include three children whose family did not want them to participate in the study; another child was excluded beca ...
... of age (table 2). Although case selection was not population based, this age distribution of active cases was similar to that noted in our previous studies in Egypt. This group does not include three children whose family did not want them to participate in the study; another child was excluded beca ...
Topamax tablet - PIO Nas - Badan Pengawas Obat dan Makanan
... is excreted in the milk of lactating rats. The excretion of topiramate in human milk has not been evaluated in controlled studies. Limited observations in patients suggests an extensive excretion of topiramate into breast milk. Since many drugs are excreted in human milk, a decision should be made w ...
... is excreted in the milk of lactating rats. The excretion of topiramate in human milk has not been evaluated in controlled studies. Limited observations in patients suggests an extensive excretion of topiramate into breast milk. Since many drugs are excreted in human milk, a decision should be made w ...
ASPIRIN 75 mg, WHICH FORMULATION?
... incurs a lower risk of GI injury compared with dispersible or plain formulations. However, endoscopy studies are poor predictors of serious upper GI complications e.g. bleeds. Three well conducted epidemiological studies and two meta-analyses contradict this, suggesting that the risk of serious uppe ...
... incurs a lower risk of GI injury compared with dispersible or plain formulations. However, endoscopy studies are poor predictors of serious upper GI complications e.g. bleeds. Three well conducted epidemiological studies and two meta-analyses contradict this, suggesting that the risk of serious uppe ...
Renal Analgesic Brochure
... itchiness); irritation/erythema, pruritus at application site. Risk of accidental overdose when used in acute pain, nontolerant individuals, or through careless disposal. Might precipitate opioid withdrawal symptoms if administered before other opioid agonist effects have subsided (within 4 hours of ...
... itchiness); irritation/erythema, pruritus at application site. Risk of accidental overdose when used in acute pain, nontolerant individuals, or through careless disposal. Might precipitate opioid withdrawal symptoms if administered before other opioid agonist effects have subsided (within 4 hours of ...
anti-inflammatory, analgesic and antipyretic activities of the aqueous
... written evidence for the use of natural sources for curing various diseases (6). The plant derived drugs are considered to be associated with less adverse effects as compared to synthetic compounds. These are still being used in several countries as alternative medicines. Many plants like roots of G ...
... written evidence for the use of natural sources for curing various diseases (6). The plant derived drugs are considered to be associated with less adverse effects as compared to synthetic compounds. These are still being used in several countries as alternative medicines. Many plants like roots of G ...
Prescribing Information - PI
... not been studied in the relief of acute symptoms and extra doses should not be used for that purpose. Acute symptoms should be treated with an inhaled short-acting beta2-agonist. When beginning BEVESPI AEROSPHERE, patients who have been taking inhaled, shortacting beta2-agonists on a regular basis ...
... not been studied in the relief of acute symptoms and extra doses should not be used for that purpose. Acute symptoms should be treated with an inhaled short-acting beta2-agonist. When beginning BEVESPI AEROSPHERE, patients who have been taking inhaled, shortacting beta2-agonists on a regular basis ...
Piracetam (NootropilIV)
... Piracetam exerts its haemorrheological effects on the platelets, red blood cells, and vessel walls by increasing erythrocyte deformability and by decreasing platelet aggregation, erythrocyte adhesion to vessel walls and capillary vasospasm. Effects on the red blood cells: In patients with sickle cel ...
... Piracetam exerts its haemorrheological effects on the platelets, red blood cells, and vessel walls by increasing erythrocyte deformability and by decreasing platelet aggregation, erythrocyte adhesion to vessel walls and capillary vasospasm. Effects on the red blood cells: In patients with sickle cel ...
Platelet inhibitory activity and pharmacokinetics of prasugrel
... We assessed the tolerability, pharmacodynamics as measured by inhibition of platelet aggregation (IPA), and pharmacokinetics of prasugrel (CS-747, LY640315), a novel thienopyridine antiplatelet agent in healthy volunteers. Twenty-four subjects were randomized into four groups of six in a double-blin ...
... We assessed the tolerability, pharmacodynamics as measured by inhibition of platelet aggregation (IPA), and pharmacokinetics of prasugrel (CS-747, LY640315), a novel thienopyridine antiplatelet agent in healthy volunteers. Twenty-four subjects were randomized into four groups of six in a double-blin ...
(Avinza): prescribing information
... extraction of talc along with morphine sulfate. (see DRUG ABUSE AND ADDICTION) Concerns about abuse, addiction, and diversion should not prevent the proper management of pain. Healthcare professionals should contact their State Professional Licensing Board, or State Controlled Substances Authority f ...
... extraction of talc along with morphine sulfate. (see DRUG ABUSE AND ADDICTION) Concerns about abuse, addiction, and diversion should not prevent the proper management of pain. Healthcare professionals should contact their State Professional Licensing Board, or State Controlled Substances Authority f ...
Hormesis
Hormesis (from Greek hórmēsis ""rapid motion, eagerness,"" from ancient Greek hormáein ""to set in motion, impel, urge on"") is the term for generally favorable biological responses to low exposures to toxins and other stressors. A pollutant or toxin showing hormesis thus has the opposite effect in small doses as in large doses. A related concept is Mithridatism, which refers to the willful exposure to toxins in an attempt to develop immunity against them. Hormetics is the term proposed for the study and science of hormesis.In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an inverted U-shaped dose response. Such environmental factors that would seem to produce positive responses have also been termed ""eustress.""The hormesis model of dose response is vigorously debated. The notion that hormesis is important for chemical risks regulations is not widely accepted.The biochemical mechanisms by which hormesis works are not well understood. It is conjectured that low doses of toxins or other stressors might activate the repair mechanisms of the body. The repair process fixes not only the damage caused by the toxin, but also other low-level damage that might have accumulated before without triggering the repair mechanism.