Fentanyl Citrate Injection, USP
... Epinephrine may paradoxically decrease the blood pressure in patients treated with a neuroleptic that blocks alpha adrenergic activity. Elevated blood pressure with and without pre-existing hypertension has been reported following administration of fentanyl citrate combined with a neuroleptic. This ...
... Epinephrine may paradoxically decrease the blood pressure in patients treated with a neuroleptic that blocks alpha adrenergic activity. Elevated blood pressure with and without pre-existing hypertension has been reported following administration of fentanyl citrate combined with a neuroleptic. This ...
10 medicinal plants from pakistan - UiO
... 10 SELECTED MEDICINAL PLANTS OF PAKISTAN ................................................................................... 18 INTRODUCTION ..................................................................................................................................... 19 ISLAMIC REPUBLIC OF PA ...
... 10 SELECTED MEDICINAL PLANTS OF PAKISTAN ................................................................................... 18 INTRODUCTION ..................................................................................................................................... 19 ISLAMIC REPUBLIC OF PA ...
Why Do We Use 600 mg of Rifampicin in
... concentrations attained at the site of infection were too low [36, 37]. Recently, Gumbo and coworkers demonstrated that exposure to higher concentrations of rifampicin led to a nonlinear increase in rifampicin concentrations inside the bacteria, a phenomenon possibly related to saturation of bacteri ...
... concentrations attained at the site of infection were too low [36, 37]. Recently, Gumbo and coworkers demonstrated that exposure to higher concentrations of rifampicin led to a nonlinear increase in rifampicin concentrations inside the bacteria, a phenomenon possibly related to saturation of bacteri ...
Looking for the Edge– Dietary Supplements
... he most common reasons active duty personnel give for using DS include improving performance, increasing muscle mass, enhancing energy level, accelerating recovery, increasing alertness, boosting their immune system, and improving joint function. The best sources of information on DS are dietitians, ...
... he most common reasons active duty personnel give for using DS include improving performance, increasing muscle mass, enhancing energy level, accelerating recovery, increasing alertness, boosting their immune system, and improving joint function. The best sources of information on DS are dietitians, ...
CASSIA TORA ETHANOL INDUCED ULCER Research Article
... glycosides, tannins and saponins. Ethanol induced gastric ulceration Effect of HECT on gastric content, pH, free acidity and total acidity is shown in Table 1. Ethanol caused the accumulation of gastric secretions of 2.16±0.44 ml with pH 2.84±0.25 in Control group. Free acidity and Total acidity in ...
... glycosides, tannins and saponins. Ethanol induced gastric ulceration Effect of HECT on gastric content, pH, free acidity and total acidity is shown in Table 1. Ethanol caused the accumulation of gastric secretions of 2.16±0.44 ml with pH 2.84±0.25 in Control group. Free acidity and Total acidity in ...
The Development of Context-specific Operant Sensitization to d
... of tolerance and sensitization. These findings, in turn, may be generalizable to humans and ultimately prove to be useful in helping a person overcome drug addiction. Tolerance is a key element of drug addiction because as one continues to use a drug, the effectiveness of the drug tends to decrease, ...
... of tolerance and sensitization. These findings, in turn, may be generalizable to humans and ultimately prove to be useful in helping a person overcome drug addiction. Tolerance is a key element of drug addiction because as one continues to use a drug, the effectiveness of the drug tends to decrease, ...
Prednisone - BC Children`s Hospital
... Prednisone is a steroid which is very effective in reducing inflammation. It is used in many rheumatic diseases such Lupus, Juvenile Dermatomyositis, Linear Scleroderma, Juvenile Idiopathic Arthritis and Vasculitis. Prednisone is often used to achieve rapid improvement of a child’s disease, before o ...
... Prednisone is a steroid which is very effective in reducing inflammation. It is used in many rheumatic diseases such Lupus, Juvenile Dermatomyositis, Linear Scleroderma, Juvenile Idiopathic Arthritis and Vasculitis. Prednisone is often used to achieve rapid improvement of a child’s disease, before o ...
Dissociable effects of monoamine reuptake inhibitors on distinct
... reuptake inhibitors (SSRIs) are not regularly prescribed as therapeutic drugs for ADHD (Biederman and Faraone 2005; Elia et al. 1999; Fone and Nutt 2005; Kutcher et al. 2004), although they are used for the treatment of other disorders associated with poor impulse control such as problem gambling, s ...
... reuptake inhibitors (SSRIs) are not regularly prescribed as therapeutic drugs for ADHD (Biederman and Faraone 2005; Elia et al. 1999; Fone and Nutt 2005; Kutcher et al. 2004), although they are used for the treatment of other disorders associated with poor impulse control such as problem gambling, s ...
Resveratrol: a focus on several neurodegenerative diseases Ester
... In vitro and in vivo experiments, RV displays a wide range of beneficial effects on human diseases but the mechanisms by which RV exerts its action is not yet been clarified. After oral administration, RV is transported to the circulatory system and is distributed to all organs where remains detecta ...
... In vitro and in vivo experiments, RV displays a wide range of beneficial effects on human diseases but the mechanisms by which RV exerts its action is not yet been clarified. After oral administration, RV is transported to the circulatory system and is distributed to all organs where remains detecta ...
5-HT1A Receptor Null Mutant Mice Responding Under a Differential
... of genetically defined mouse models of depression and other psychiatric and neurological disorders. However, it is still the case that some relevant rodent models for depression and antidepressant action have been validated experimentally in rats only and not in mice. An important example of such mo ...
... of genetically defined mouse models of depression and other psychiatric and neurological disorders. However, it is still the case that some relevant rodent models for depression and antidepressant action have been validated experimentally in rats only and not in mice. An important example of such mo ...
Guidelines for warfarin management in the community
... necessary with warfarin therapy. Obtain patient consent and document in the clinical notes. Consideration should be given to using 1 mg tablets only, particularly for patients who have difficulty with reading or with numbers. This may assist in reducing confusion until a stable dose is achieved. The ...
... necessary with warfarin therapy. Obtain patient consent and document in the clinical notes. Consideration should be given to using 1 mg tablets only, particularly for patients who have difficulty with reading or with numbers. This may assist in reducing confusion until a stable dose is achieved. The ...
Selective Suppression of Cocaine- versus Food
... One clear disadvantage of amphetamine as a candidate medication for cocaine dependence is its high abuse liability, and as with cocaine, the abuse-related effects of amphetamine are thought to be mediated by its actions as an indirect dopamine agonist (Gold et al., 1989). However, the abuserelated e ...
... One clear disadvantage of amphetamine as a candidate medication for cocaine dependence is its high abuse liability, and as with cocaine, the abuse-related effects of amphetamine are thought to be mediated by its actions as an indirect dopamine agonist (Gold et al., 1989). However, the abuserelated e ...
AusPAR: Pitavastatin - Therapeutic Goods Administration
... drying, compression and film coating. Adequate validation of the process was provided and there are appropriate in process controls. There were no changes to the product on real time storage and the stability data provided supported a shelf life of 3 years when stored below 25°C in Polyvinyl chlorid ...
... drying, compression and film coating. Adequate validation of the process was provided and there are appropriate in process controls. There were no changes to the product on real time storage and the stability data provided supported a shelf life of 3 years when stored below 25°C in Polyvinyl chlorid ...
VAGINAL BLEEDING AFTER USE OF SINGLE DOSE ORAL
... Misoprostol is a synthetic prostaglandin-E1 analogue. It can be used in both gastroenterological and gynecological conditions. In gastroenterologic use, misoprostol therapy indicated in patients who have duodenal or gastric ulcer due to use nonsteroidal anti-inflammatory drugs (NSAIDs). It acts upon ...
... Misoprostol is a synthetic prostaglandin-E1 analogue. It can be used in both gastroenterological and gynecological conditions. In gastroenterologic use, misoprostol therapy indicated in patients who have duodenal or gastric ulcer due to use nonsteroidal anti-inflammatory drugs (NSAIDs). It acts upon ...
A retrospective study to identify risk factors for somnolence and
... during the first week of pregabalin treatment. The remaining 168 patients did not regularly receive strong opioids, and 25 (14.9 %) had an adverse event. In multivariate analysis, age (≧65 years, adjusted odds ratio: 2.507, 95 % CI: 1.164-5.397, p = 0.019) and regular co-administration of strong opi ...
... during the first week of pregabalin treatment. The remaining 168 patients did not regularly receive strong opioids, and 25 (14.9 %) had an adverse event. In multivariate analysis, age (≧65 years, adjusted odds ratio: 2.507, 95 % CI: 1.164-5.397, p = 0.019) and regular co-administration of strong opi ...
The practice of digoxin therapeutic drug monitoring - BN6Team-10
... in which TDM is performed is often inappropriate, as highlighted in the article by Sidwell et al in this issue.1 In publications from other countries in the past 15 years, similar conclusions have been drawn, and show that inappropriate use of TDM with digoxin is quite common and not restricted to N ...
... in which TDM is performed is often inappropriate, as highlighted in the article by Sidwell et al in this issue.1 In publications from other countries in the past 15 years, similar conclusions have been drawn, and show that inappropriate use of TDM with digoxin is quite common and not restricted to N ...
John Salamone: Dopamine, Motivation and Schizophrenia
... antipsychotics based upon their mesolimbic actions; perhaps antipsychotic effects are due to actions on other systems (e.g. mesocortical DA). • They are related; the core antipsychotic effect could be directly dependent upon the fundamental motivational effects of D2 antagonists, which can be studie ...
... antipsychotics based upon their mesolimbic actions; perhaps antipsychotic effects are due to actions on other systems (e.g. mesocortical DA). • They are related; the core antipsychotic effect could be directly dependent upon the fundamental motivational effects of D2 antagonists, which can be studie ...
Nitro-Dur - Merck.com
... Nitrate ions liberated during metabolism of nitroglycerin can oxidize hemoglobin into methemoglobin. Even in patients totally without cytochrome b5 reductase activity, however, and even assuming that the nitrate moieties of nitroglycerin are quantitatively applied to oxidation of hemoglobin, about 1 ...
... Nitrate ions liberated during metabolism of nitroglycerin can oxidize hemoglobin into methemoglobin. Even in patients totally without cytochrome b5 reductase activity, however, and even assuming that the nitrate moieties of nitroglycerin are quantitatively applied to oxidation of hemoglobin, about 1 ...
Part I: Summary of Product Information
... The optimal regimen and treatment duration have not been established. Such regimens should only be used for patients that are intolerant to or ineligible for interferon therapy, and are in urgent need of treatment. Co-administration with other direct-acting antivirals against HCV Gratisovir should o ...
... The optimal regimen and treatment duration have not been established. Such regimens should only be used for patients that are intolerant to or ineligible for interferon therapy, and are in urgent need of treatment. Co-administration with other direct-acting antivirals against HCV Gratisovir should o ...
Anti-Inflammatory Activity of Aqueous Extract of Ipomoea Carnea
... guideline dose of 2000mg/kg showed the toxic symptoms, so according to OECD guideline 420, it is considered as a LD50 cutoff value. Doses selected for pharmacological studies by fixed dose methods are 250mg/kg and 500mg/kg17. Evaluation of anti-inflammatory activity: Carrageenan-induced paw edema in ...
... guideline dose of 2000mg/kg showed the toxic symptoms, so according to OECD guideline 420, it is considered as a LD50 cutoff value. Doses selected for pharmacological studies by fixed dose methods are 250mg/kg and 500mg/kg17. Evaluation of anti-inflammatory activity: Carrageenan-induced paw edema in ...
Effects of IV and ICV Hypocretin-1 (Orexin A)
... in a canine model of the disorder and in preprohypocretin (preproorexin) knockout mice. Null mutations in the hypocretin receptor-2 gene (Hcrtr2) cause narcolepsy in a genetically defined model of narcolepsy in dogs (Dobermans and Labradors).4 In addition, the phenotype of the hypocretin-ligand gene ...
... in a canine model of the disorder and in preprohypocretin (preproorexin) knockout mice. Null mutations in the hypocretin receptor-2 gene (Hcrtr2) cause narcolepsy in a genetically defined model of narcolepsy in dogs (Dobermans and Labradors).4 In addition, the phenotype of the hypocretin-ligand gene ...
Exercise and Neural Function Take Home Messages
... 2. Exercise (voluntary wheel running) stimulates cell proliferation in dentate gyrus (DG) a. Not seen in rats in and enriched environment, or swimmers b. Cell survival is increased in both exercising animals and those in an enriched environment c. % of surviving cells is greatest in an enriched envi ...
... 2. Exercise (voluntary wheel running) stimulates cell proliferation in dentate gyrus (DG) a. Not seen in rats in and enriched environment, or swimmers b. Cell survival is increased in both exercising animals and those in an enriched environment c. % of surviving cells is greatest in an enriched envi ...
Effect of `Mentat` on the pharmacokinetics of single and multiple
... fast, the rabbits were given 60 mg/kg of phenytoin alongwith 3 ml/kg of water, p.o once daily at 0800 hour for 7 days. On day 7, blood samples of 1 ml each were collected at 0, 1, 2, 3, 4, 5, 6, 9, 12 and 24 hours after drug treatment in heparinized tubes. Plasma was separated and kept at -20oC unti ...
... fast, the rabbits were given 60 mg/kg of phenytoin alongwith 3 ml/kg of water, p.o once daily at 0800 hour for 7 days. On day 7, blood samples of 1 ml each were collected at 0, 1, 2, 3, 4, 5, 6, 9, 12 and 24 hours after drug treatment in heparinized tubes. Plasma was separated and kept at -20oC unti ...
Photobiological Aspects of the Mutualistic Association Between
... developed among different forms of life to obtain protection and to repair damage, solar UVR has been an important selective factor during evolution of life on Earth, particularly for photosynthetic organisms (Cockell 1998). However, physiological and ecological work on Chlorella-bearing ciliates ha ...
... developed among different forms of life to obtain protection and to repair damage, solar UVR has been an important selective factor during evolution of life on Earth, particularly for photosynthetic organisms (Cockell 1998). However, physiological and ecological work on Chlorella-bearing ciliates ha ...
TIMOPTIC® in OCUDOSE
... Beta-adrenergic receptor blockade in the bronchi and bronchioles results in increased airway resistance from unopposed parasympathetic activity. Such an effect in patients with asthma or other bronchospastic conditions is potentially dangerous. TIMOPTIC (timolol maleate ophthalmic solution), when ap ...
... Beta-adrenergic receptor blockade in the bronchi and bronchioles results in increased airway resistance from unopposed parasympathetic activity. Such an effect in patients with asthma or other bronchospastic conditions is potentially dangerous. TIMOPTIC (timolol maleate ophthalmic solution), when ap ...
Hormesis
Hormesis (from Greek hórmēsis ""rapid motion, eagerness,"" from ancient Greek hormáein ""to set in motion, impel, urge on"") is the term for generally favorable biological responses to low exposures to toxins and other stressors. A pollutant or toxin showing hormesis thus has the opposite effect in small doses as in large doses. A related concept is Mithridatism, which refers to the willful exposure to toxins in an attempt to develop immunity against them. Hormetics is the term proposed for the study and science of hormesis.In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an inverted U-shaped dose response. Such environmental factors that would seem to produce positive responses have also been termed ""eustress.""The hormesis model of dose response is vigorously debated. The notion that hormesis is important for chemical risks regulations is not widely accepted.The biochemical mechanisms by which hormesis works are not well understood. It is conjectured that low doses of toxins or other stressors might activate the repair mechanisms of the body. The repair process fixes not only the damage caused by the toxin, but also other low-level damage that might have accumulated before without triggering the repair mechanism.