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Guided Notes – Genetic Engineering
Guided Notes – Genetic Engineering

... distinguishes the human DNA from the bacterial DNA. One way to make recombinant DNA is to insert a human gene into bacterial DNA. The new combination of genes is then returned to a bacterial cell, and the bacteria can produce the human protein. ...
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... A gene occupies a specific position on a chromosome The various specific forms of a gene are alleles Alleles differ from each other by one or only a few bases New alleles are formed by mutation The genome is the whole of the genetic information of an organism The entire base sequence of human genes ...
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Biotechnology Part 3 Outline

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6 Day 9 Biotechnology Part 3 Outline

... back into a double stranded DNA molecule. a. The “new” DNA molecule is known as cDNA. (Complimentary DNA) A copy of this cDNA molecule will be stored in a cDNA library. B. Need to then attach a promoter sequence (expression vector) at the beginning of the c DNA molecule so that a transcription compl ...
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... Sequencers provide accurate sequences for DNA segments up to 800 bp long -To reduce errors, 5-10 copies of a genome are sequenced and compared Vectors use to clone large pieces of DNA: -Yeast artificial chromosomes (YACs) -Bacterial artificial chromosomes (BACs) -Human artificial chromosomes (HACs) ...
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... Scientists are attempting to overcome this problem by Somatic Fusion. 1) Unspecialised cells of 2 different plant species are selected. 2) Their cell walls are digested away using the enzyme Cellulase. 3) Protoplasts are left. They consist of the cell's living contents (nucleus and cytoplasm) surrou ...
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Molecular Methods for Evolutionary Genetics

16.2 Biotechnology Products
16.2 Biotechnology Products

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Genomic library



A genomic library is a collection of the total genomic DNA from a single organism. The DNA is stored in a population of identical vectors, each containing a different insert of DNA. In order to construct a genomic library, the organism's DNA is extracted from cells and then digested with a restriction enzyme to cut the DNA into fragments of a specific size. The fragments are then inserted into the vector using DNA ligase. Next, the vector DNA can be taken up by a host organism - commonly a population of Escherichia coli or yeast - with each cell containing only one vector molecule. Using a host cell to carry the vector allows for easy amplification and retrieval of specific clones from the library for analysis.There are several kinds of vectors available with various insert capacities. Generally, libraries made from organisms with larger genomes require vectors featuring larger inserts, thereby fewer vector molecules are needed to make the library. Researchers can choose a vector also considering the ideal insert size to find a desired number of clones necessary for full genome coverage.Genomic libraries are commonly used for sequencing applications. They have played an important role in the whole genome sequencing of several organisms, including the human genome and several model organisms.
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