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2140401 - Gujarat Technological University
2140401 - Gujarat Technological University

... To estimate DNA by DPA method. To estimate the amount of RNA by orcinol method. To perform Agarose Gel Electrophoresis. To observe the effect of Ultraviolet rays on survival of Serratia/E.coli. To isolate lactose non fermenter mutant of E.coli using physical mutage To study repair mechanism in E.col ...
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... strategies have been used to exploit maize Ac/Ds for such studies in heterologous species. First, large numbers of independent Ds insertion lines (TNPs) are generated and screened phenotypically. Alternatively, smaller numbers of transposed elements are identified, mapped and then remobilized for lo ...
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... Electroporated pollens can be germinate at 30% efficiency. However, no transgenic plant has so far been reported using this concept, even though it has been shown that pollen grains can be permeated with macromolecules such as DNA. Electroporation method is very efficient in permeating DNA into cell ...
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Cut-and-paste DNA: fixing mutations with `genome editing`

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The Genomics Resources Core Facility has at it`s disposal

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Molecular Genetics
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Chapter 7 Supplement
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Genetics 321 - Western Washington University
Genetics 321 - Western Washington University

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Unit 1: Cells - Loudoun County Public Schools
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Recombinant Plasmids

... plasmid, while those with an R. plasmid tend to multiply. As a result, an increasing number of bacteria that cause human diseases, like food poisoning and gonorrhea are becoming more resistant to antibiotics. However, R. plasmids can be useful vectors for genetic engineering. ...
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Recombinant DNA Technology Biotechnology

... Not involved in regulating growth and division of organism. Consider autonomous in that it has control over its replication Presence of plasmids in bacteria often present to protect against humans medicines by carrying antibiotic resistance genes  Prevents antibiotics from killing the bacteria ...
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Genomic library



A genomic library is a collection of the total genomic DNA from a single organism. The DNA is stored in a population of identical vectors, each containing a different insert of DNA. In order to construct a genomic library, the organism's DNA is extracted from cells and then digested with a restriction enzyme to cut the DNA into fragments of a specific size. The fragments are then inserted into the vector using DNA ligase. Next, the vector DNA can be taken up by a host organism - commonly a population of Escherichia coli or yeast - with each cell containing only one vector molecule. Using a host cell to carry the vector allows for easy amplification and retrieval of specific clones from the library for analysis.There are several kinds of vectors available with various insert capacities. Generally, libraries made from organisms with larger genomes require vectors featuring larger inserts, thereby fewer vector molecules are needed to make the library. Researchers can choose a vector also considering the ideal insert size to find a desired number of clones necessary for full genome coverage.Genomic libraries are commonly used for sequencing applications. They have played an important role in the whole genome sequencing of several organisms, including the human genome and several model organisms.
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