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Variable Autosomal and X Divergence Near and Far from Genes
Variable Autosomal and X Divergence Near and Far from Genes

... on both the autosomes and the X chromosome, we evaluated divergence in windows of increasing genetic distance from the nearest gene for ten great ape populations (fig. 1). We found that divergence in putatively neutral regions increased as the distance from genes increased on both the X and the auto ...
Genetics of Asthma – Paul E. Moore MD
Genetics of Asthma – Paul E. Moore MD

... Limitations of linkage scans • Difficult to identify candidate gene • Challenge to link specific locus or gene to asthma or asthma-related traits ...
objectives
objectives

... 35. Explain how crossing over can unlink genes 36. Map a linear sequence of genes on a chromosome using given recombination frequencies from experimental crosses 37. Explain what additional information cytological maps provide over crossover maps 38. Distinguish between heterogametic sex and homogam ...
Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting Open Access
Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting Open Access

... similarity of amino acid sequences between human and tammar PHLDA2 over this region (Figure 1B). Furthermore, we performed a genome-wide “TBLASTN” search for the published tammar genome sequence in the Ensembl database using the antigen peptide sequence for the query. It revealed the highest similar ...
Complete genome sequence of the thermophilic Thermus sp
Complete genome sequence of the thermophilic Thermus sp

... scotoductus SA-01) were selected for the comparison. The genome of strain HB27 consists of a chromosome (1.89 Mb) and a megaplasmid (0.23 Mb). On the other hand, strain HB8 has a chromosome of 1.85 Mb, a megaplasmid (0.26 Mb) and a plasmid (9.3 kb) [5]. The genome of T. scotoductus includes a 2.3 Mb ...
Maternal and paternal genomes contribute equally to the
Maternal and paternal genomes contribute equally to the

... form of imprinting in the Arabidopsis embryo. Genome-wide approaches similar to ours but looking much later after fertilization greatly expanded the list of genes with parent-of-origin-specific expression in the endosperm but did not identify such genes in embryos23,24. Thus, the imprinting-like phe ...
Mechanisms and impact of genetic recombination in the evolution of
Mechanisms and impact of genetic recombination in the evolution of

C1. Genetics, DNA and Mutations - Bioscience Bioethics Friendship
C1. Genetics, DNA and Mutations - Bioscience Bioethics Friendship

... There are also more major mutations, where large fragments of DNA can be translocated to a different chromosome. Abnormal chromosome numbers can also occur, so instead of two copies there may be three copies. Because this alters the number of alleles of genes for certain proteins, this can have majo ...
Salmonella typhi mutants defective in anaerobic respiration are
Salmonella typhi mutants defective in anaerobic respiration are

... host. There is a growing body of evidence showing that bacterial pathogens are constantly sensing their environment and adjusting to it by regulating the expression of several genes and operons. This response often involves changes in the expression of genes encoding virulence factors (Miller et al. ...
Interplay between the transcription factors acting on
Interplay between the transcription factors acting on

... Dal81 transcription factors, whereas GATA factors are responsible for NCR. Here, we show how members of the UGA regulon share the activation mechanism. Our results show that both Uga3 and Dal81 interact with UGA genes in a GABA-dependent manner, and that they depend on each other for the interaction ...
Analysis of the histone H3 gene family in Arabidopsis and
Analysis of the histone H3 gene family in Arabidopsis and

... (Chaubet et al., 1992; Robertson et al., 1996; Waterborg, 1992); however, the expression patterns of these variants have not been elucidated and the precise number of histone variants that exist remains unclear, even in the model plant Arabidopsis. This is probably because many of the histone varian ...
RNA-Mediated Programming of Developmental
RNA-Mediated Programming of Developmental

Package `tmod`
Package `tmod`

An Introduction to the Genetics and Molecular Biology of the F S
An Introduction to the Genetics and Molecular Biology of the F S

... article should be particularly useful to the uninitiated who are exposed for the first time to experimental studies of yeast. Detailed protocols are described in the primary literature and in a number of reviews in the books listed in the Bibliography. The original citations for the material covered ...
X - My Teacher Site
X - My Teacher Site

... 2) Neither Tim nor Rhoda has Duchenne muscular dystrophy, but their firstborn son does have it. What is the probability that a second child of this couple will have the disease? What is the probability if the second child is a ...
A method for finding molecular signatures from gene expression data
A method for finding molecular signatures from gene expression data

... relevant information (cancer vs. healthy, survival time, etc). Provide insight into biological mechanisms and processes and have potential diagnostic use. However, searching for molecular signatures often done using a very diverse and ad-hoc methodology. ...
Physical Mapping of a 670-kb Region of Chromosomes XVI and XVII
Physical Mapping of a 670-kb Region of Chromosomes XVI and XVII

Biomart/ GENOME ALIGNMENT III
Biomart/ GENOME ALIGNMENT III

... The comparison of the mouse and human genomes has demonstrated the power of comparative genomics in inferring the evolutionary history of species and in identifying functional regions in genomes. The possibilities for identifying regions under selection are enhanced with the addition of more sequenc ...
MAGMA manual (v0.2)
MAGMA manual (v0.2)

... location file, only SNPs with rs-ID present in both the data and the SNP location file can be used in the analysis. WARNING: when using your data .bim file as SNP location file, make sure that the SNP locations in the .bim file refer to the same human reference genome build version as the gene loca ...
letters - Lewis-Sigler Institute | for Integrative Genomics
letters - Lewis-Sigler Institute | for Integrative Genomics

Adaptive Evolution of Proteins Secreted during Sperm Maturation
Adaptive Evolution of Proteins Secreted during Sperm Maturation

... Another potential signature of adaptive evolution in reproductive genes is their preferential location on the X chromosome (Vicoso and Charlesworth 2006). Genes with male-specific benefits are expected to accumulate on the X chromosome, especially if those same genes confer a cost in females (Rice 1 ...
Transduction
Transduction

What is a biofilm?
What is a biofilm?

... • The periplasmic glucans slow the diffusion of antibiotics into the cytoplasm, giving the bacteria time to adapt to the antibiotic ...
Plant–nematode interactions
Plant–nematode interactions

... plant-parasitic nematode species, have been produced [42]. Existing EST collections from plant-parasitic nematodes are mostly derived from eggs and infective juveniles, but future projects will likely expand to include the parasitic stages [27,34,42]. DNA-sequence analyses of these ESTs have shown ...
Comparative Analysis of Parallel Gene Transfer Operators in the
Comparative Analysis of Parallel Gene Transfer Operators in the

... goes into an “auxiliary population”. The operator first fills the whole auxiliary population with A modified bacteria, and only then starts to evaluate the objective values of them simultaneously. After the evaluation the best P of P+A bacteria form the population, and the other, worse bacteria are ...
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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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