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P D G E
P D G E

... design and rigour. While design of experiments is not a specific focus of this chapter, a good design minimises variation and has a focused objective, (Kerr and Churchill, 2001). Technical variation between microarray slides depends on numerous factors including experimental technique, instrument ac ...
Are Incomplete Denitrification Pathways a Common Trait in Thermus
Are Incomplete Denitrification Pathways a Common Trait in Thermus

... Philippot L, Piutti S, Martin-Laurent F, Hallet S, Germon JC. 2002. Molecular Analysis of the Nitrate-Reducing Community from Unplanted and Maize-Planted Soils. Applied & ...
Molecular evolution of swine vesicular disease virus
Molecular evolution of swine vesicular disease virus

... Division of Molecular Biology, Institute for Animal Health, Compton Laboratory, Compton, Newbury RG20 7NN, UK ...
Genetics
Genetics

... b. Genes are units of heredity; determines traits in offspring. c. ________ genes will mask (hide) other ...
Module 8: Horizontal Gene Transfer
Module 8: Horizontal Gene Transfer

... rather than vertical transfer by constructing phylogenetic trees, looking at gene neighborhoods and evaluating GC content of the gene under investigation compared to the genome as a whole. ...
PDF + SI - Biology Open - The Company of Biologists
PDF + SI - Biology Open - The Company of Biologists

... Over the last few decades, we have come to understand that cells cope with acute heat stress by using heat shock proteins, which help protect against protein aggregation (reviewed by Richter et al., 2010). However, despite the fact that temperature is such an important variable for the fitness and s ...
Multifractal characterisation of length sequences of coding and
Multifractal characterisation of length sequences of coding and

... quanti3cation of these correlations could give an insight into the role of the ordering of genes on the chromosome. Through detrended 7uctuation analysis (DFA) [21] and spectral analysis, the LRC was found in these length sequences [22]. The correlation dimension and Hurst exponent are parameters of ...
Genetic Evidence for a Silent SUC Gene in Yeast.
Genetic Evidence for a Silent SUC Gene in Yeast.

... 1.-Models for the structure of suco alleles. The diagrams show schematic representations (not to scale) of a chromosome carrying a SUC locus; the filled circle represents the centromere. (a) A SUC+ allele at the SUC locus is represented by an open bar. (b) A suc0 allele is depicted as a “silent” gen ...
Genomic scans for selective sweeps using SNP data
Genomic scans for selective sweeps using SNP data

... Open Access option. ...
What are major histocompatibility complex genes and why are they
What are major histocompatibility complex genes and why are they

... Rare instances of very high HLA similarity among non-mates suggest some couples may avoid extreme similarity, rather than favour dissimilarity… but too few samples to test rigorously ...
From Molecular Systems to Simple Cells: a - TBI
From Molecular Systems to Simple Cells: a - TBI

A locus in Pristionchus pacificus that is responsible for the ability to
A locus in Pristionchus pacificus that is responsible for the ability to

Caenorhabditis elegans chromosome arms are anchored to the
Caenorhabditis elegans chromosome arms are anchored to the

... found to be associated with large domains up to several megabases in length, which cover about 40% of the genome in mouse and human cells [6,7]. In flies, however, the size and the coverage of lamin-associated regions were not determined precisely because the cDNA microarrays used for detection cont ...
The Evolutionary History of Human and Chimpanzee Y
The Evolutionary History of Human and Chimpanzee Y

Harnessing gene expression to identify the genetic basis of drug
Harnessing gene expression to identify the genetic basis of drug

... credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission. ...
Update on Staphylococcal Infections and MRSA/MRSI
Update on Staphylococcal Infections and MRSA/MRSI

... penicillin-resistant staphylococcal infections. Methicillin-resistance was reported by 1961. Today, more than 90% of human isolates produce penicillinase. Although this low-level resistance can be overcome by administration of a “protector” (i.e. clavulanic acid), high-level resistance involves prod ...
A Complex Suite of Forces Drives Gene Traffic from Drosophila X
A Complex Suite of Forces Drives Gene Traffic from Drosophila X

How to report IG sequence data in clinical Richard Rosenquist Uppsala, Sweden
How to report IG sequence data in clinical Richard Rosenquist Uppsala, Sweden

... to investigate the clinical association. • The ERIC database has been created to facilitate an internationell collaborative ...
Agilent Whole Human Genome Oligo Microarray Kit
Agilent Whole Human Genome Oligo Microarray Kit

... its whole genome microarray to represent the best possible view of the human genome as we know it today. The vast majority of highly-sensitive 60-mer oligo probes on this microarray have been empirically and experimentally validated to provide you with added confidence in its content. Moreover, thes ...
Solid Tumour Section Mesothelioma: t(14;22)(q32;q12) in mesothelioma Atlas of Genetics and Cytogenetics
Solid Tumour Section Mesothelioma: t(14;22)(q32;q12) in mesothelioma Atlas of Genetics and Cytogenetics

... Mesothelioma is strongly associated with exposure to asbestos which can be documented in about 5080% of pleural cases and 30% of peritoneal mesothelioma in men (Bianchi and Bianchi, 2007). Genetic predisposition, smoking, radiation, and viral infection can also contribute to mesothelioma. The onset ...
Harnessing gene expression to identify the genetic basis of drug
Harnessing gene expression to identify the genetic basis of drug

... credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission. ...
Genes, Environment and Sport Performance
Genes, Environment and Sport Performance

SNaPshot® Multiplex System for SNP genotyping
SNaPshot® Multiplex System for SNP genotyping

... automatically by the software using a sample or an artificial extension product created using the SNaPshot® Primer Focus® Kit. Each bin defines the minimum and maximum allowable size for each allele. GeneMapper ® Software identifies each peak and assigns the corresponding allele. In this example, th ...
Gene overexpression reveals alternative
Gene overexpression reveals alternative

... increase in GCN4 mRNA translation, coupled with an extensive protein synthesis shut down. However, both phenomena are independent of Gcn2 function (Tzamarias et al., 1989). In addition, the assimilation of GCN4 mRNA translational derepression in vitro, does not require the Gcn2 kinase (Krupitza and ...
Neutral and Non-Neutral Evolution of Duplicated Genes with Gene
Neutral and Non-Neutral Evolution of Duplicated Genes with Gene

... maintain AA when B is not beneficial and to create BB when B is beneficial. Theoretically speaking, the model would be similar to Kimura’s compensatory mutation model [27]. One important evolutionary advantage of gene duplication is increased gene dosage, and the retention of sequence similarity is ...
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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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