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The Underlying Similarity of Diversity Measures Used in
The Underlying Similarity of Diversity Measures Used in

... The simplest definition of diversity comes from the answer to the question “how different is everybody from everybody else?” If every chromosome is identical, there is no difference between any two chromosomes and hence there is no diversity in the population. If each chromosome is completely differ ...
Direct and indirect consequences of meiotic recombination
Direct and indirect consequences of meiotic recombination

Relative Paucity of Genes Causing Inviability in Hybrids
Relative Paucity of Genes Causing Inviability in Hybrids

... an experimental design different from those used previously. Second, previous studies (those of Naveira and his colleagues are an exception) examined rather large segments of introgressed foreign genome, so while there seem to be more segments causing hybrid sterility than inviability, we do not hav ...
Genome-Wide Copy Number Variation in Epilepsy: Novel
Genome-Wide Copy Number Variation in Epilepsy: Novel

Structural organization of the transfer RNA gene clusters of cholera
Structural organization of the transfer RNA gene clusters of cholera

Biophysics 101 Genomics and Computational Biology
Biophysics 101 Genomics and Computational Biology

... Analysis of estrogen response element binding by genetically selected steroid receptor DNA binding domain mutants exhibiting altered Antiprotease targeting: altered specificity of alpha 1-antitrypsin by amino acid replacement at the reactive centre. AraC proteins with altered DNA sequence specificit ...
letters - Centre for Social Evolution
letters - Centre for Social Evolution

... orders and ,300 million years (Myr) of independent evolution. We compared the coding sequences of the honeybee paralogues fem and csd with their orthologues from two related Asian honeybee species (Apis cerana, Apis dorsata), as well as fem sequences from the stingless bee (Melipona compressipes) an ...
Analysis of expressed sequence tags from the Huperzia serrata leaf
Analysis of expressed sequence tags from the Huperzia serrata leaf

... tetraketides (Morita et al. 2007, Wanibuchi et al. 2007). However, as of January 2009, there were only 10 nucleotide sequences from H . serrata available in the NCBI database. The limited information on the genetic contents of this plant triggered our efforts to construct a cDNA library from the H . ...
Triple-hit lymphoma
Triple-hit lymphoma

... estimated to be approximately 2% of all B-cell lymphomas (5). The median survival time is reported to be about 5 months, significantly shorter than for either DLBCL or BL (6). Triple-hit lymphomas have been infrequently reported, with only a small number of case reports noted. These lymphomas are rar ...
Journal Club 3
Journal Club 3

... latent period program in M. tuberculosis • High doses of NO is toxic for bacteria • NO inhibits aerobic respiration in mitochondria and bacteria • NO is an important signaling agent for eukaryotes ...
Bacterial diterpene synthases: new
Bacterial diterpene synthases: new

... epoxide ring. In both cases, the resulting carbocation undergoes a cascade of cyclization, the fate of which is determined by a combination of steric and electrostatic forces within the active site cavity. The cyclization cascade is ultimately terminated by abstraction of a proton or electrophilic a ...
Divergent selection and heterogeneous genomic
Divergent selection and heterogeneous genomic

... effects of genetic drift. These consequences of divergent selection are being reported in recently accumulating studies that identify: (i) ‘outlier loci’ with higher levels of divergence than expected under neutrality, and (ii) a positive association between the degree of adaptive phenotypic diverge ...
Natural Selection, Infectious Transfer and the Existence Conditions
Natural Selection, Infectious Transfer and the Existence Conditions

... through the population, hitchhiking to high frequency on each selective sweep. Horizontal transfer, they argue, “may be seen as an adaptation that allows a parasite [i.e., the plasmid] to move onto superior hosts that emerge.” Certainly, there can be intense selection for one or more plasmid-borne g ...
Annotation Strategy Guide - GEP Community Server
Annotation Strategy Guide - GEP Community Server

... Figure 5: addition of 5 amino acids to the 3’ end of CDS 5_9975_0  Selecting a better supported splice site: While extension of an open reading frame is important for conserving the length of the coding exon, it is also important to consider selecting the best-supported splice site. For example, le ...
Karyotype Polymorphism in Hybrid Populations of Drosophila
Karyotype Polymorphism in Hybrid Populations of Drosophila

... strains were established. Each strain was initiated by crossing one D. nasuta male and one D. alborn/cans female. Their hybrid offsprings were maintained with the non-overlapping generation method for 2.5 y (i.e., 45 generations) and then subjected to karyotype analysis. The origins of the 3rd, 4th, ...
View PDF - G3: Genes | Genomes | Genetics
View PDF - G3: Genes | Genomes | Genetics

... Raw reads (50 bp) were aligned separately to the reference genome (Dmel r5) using the default settings of BWA 0.6.2. Three different methods were used to analyze the sequences: split-read mapping, paired-end mapping, and depth of coverage. The split-read mapping was performed by Pindel (Ye et al. 20 ...
Algorithms for Finding Gene Clusters
Algorithms for Finding Gene Clusters

... associated genes of a gene cluster lie on the same DNA strand [20,12]. We take this into account by constructing signed permutations where the sign of a gene indicates the strand it lies on. We then determine all common intervals with the additional restriction that within each permutation, the elem ...
GO and Annotation
GO and Annotation

... GO tools • Most of these tools work in a similar way: – input a gene list and a subset of ‘interesting’ genes – tool shows which GO categories have most interesting genes associated with them i.e. which categories are ‘enriched’ for interesting genes – tool provides a statistical measure to determi ...
Dynamic Changes in Aromatic Hydrocarbon Associated Catabolic
Dynamic Changes in Aromatic Hydrocarbon Associated Catabolic

... pure cultures from environmental samples and allow studies of complex communities and their interactions with specific substrates to be performed. Previous studies have focused upon qualitative PCR approaches using catabolic genes as indicators of microbial degradation of compounds [9] or qPCR looki ...
Genetics of Male Infertility - the Infertility Center of St. Louis
Genetics of Male Infertility - the Infertility Center of St. Louis

... Y (NRY), there are many “Y deletions” that are of no consequence. Only if these deletions in the infertile male are not present in his fertile male relatives, nor in hundreds of normal controls, could they be implicated as a cause of the infertility. The fertile fathers of the Y-deleted, infertile m ...
Similarity Searches on Sequence Databases: BLAST
Similarity Searches on Sequence Databases: BLAST

... compositions, e.g. many proteins contain patches known as low-complexity regions: such as segments that contain many prolines or glutamic acid residues. • If BLAST aligns two proline-rich domains, this alignment gets a very good E-value because of the high number of identical amino acids it contains ...
American College of Medical Genetics standards
American College of Medical Genetics standards

... guidelines attempt to cover common issues encountered during evaluation of CNVs, there are many CNVs with unique characteristics, and no algorithm will be applicable to all findings. ...
American College of Medical Genetics standards and guidelines for
American College of Medical Genetics standards and guidelines for

... guidelines attempt to cover common issues encountered during evaluation of CNVs, there are many CNVs with unique characteristics, and no algorithm will be applicable to all findings. ...
29th International Conference on Animal Genetics ISAG2004/TOKYO
29th International Conference on Animal Genetics ISAG2004/TOKYO

... Comparative sequencing in the porcine MHC region. Patrick Chardon (INRA-LREG) The mouse Genome Informatics Database as a resource for mammalian phenotype and gene expression data. David Shaw (The Jackson Laboratory) ...
Plant Functional Genomics Plant Functional Genomics
Plant Functional Genomics Plant Functional Genomics

... The BAC cloning uses a derivative of the Escherichia coli F-factor as vector and E. coli as the host, making library construction and subsequent downstream procedures efficient and easy to perform. Recombinant DNA inserts up to 200 kb can be efficiently cloned and stably maintained in E. coli. Altho ...
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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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