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genetic basis of von recklinghausen disease genetyczne podstawy
genetic basis of von recklinghausen disease genetyczne podstawy

... the case of children suffering from von Recklinghausen’s disease deciduous teeth erupt earlier. Researchers explained this phenomenon with the activity of osteoclasts, which are more prone to migrate and proliferate in comparison with the cells of healthy individuals. This leads to faster alveolar p ...
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The Patterns of Evolution and Ornamental Plant Breeding
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Epigenetics - Cayetano Heredia University
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... expression of MECP2 mutations in somatic cells. MECP2 mutation in males is rare because mutations are more frequent on paternal allele. MECP2 mutation in males can cause MR. Some cases of inheritance from a female carrier have been reported, in which the phenotypically normal female carrier shows no ...
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Mutation



In biology, a mutation is a permanent change of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements. Mutations result from damage to DNA which is not repaired or to RNA genomes (typically caused by radiation or chemical mutagens), errors in the process of replication, or from the insertion or deletion of segments of DNA by mobile genetic elements. Mutations may or may not produce discernible changes in the observable characteristics (phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity.Mutation can result in several different types of change in sequences. Mutations in genes can either have no effect, alter the product of a gene, or prevent the gene from functioning properly or completely. Mutations can also occur in nongenic regions. One study on genetic variations between different species of Drosophila suggests that, if a mutation changes a protein produced by a gene, the result is likely to be harmful, with an estimated 70 percent of amino acid polymorphisms that have damaging effects, and the remainder being either neutral or weakly beneficial. Due to the damaging effects that mutations can have on genes, organisms have mechanisms such as DNA repair to prevent or correct mutations by reverting the mutated sequence back to its original state.
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