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DNA and the Genome - Speyside High School
DNA and the Genome - Speyside High School

... large number of cells. These are specialised to carry out specific roles in the body. Differentiation is the process by which unspecialised cells become altered and adapted to form a special function in the body. CFE Higher Biology ...
File - The Tarrytown Meetings
File - The Tarrytown Meetings

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GenomeBrowser - CBS

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LECTURE 16 – Using Genomic Variation for Identity DNA Level
LECTURE 16 – Using Genomic Variation for Identity DNA Level

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Bioinformatics
Bioinformatics

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... 8. “Southern” blotting detects sequences by hybridization. 9. Microarrays detect gene expression patterns over the genome. 10. Genes can be knocked out (deleted) or replaced in prokaryotes and eukaryotes. (N) ...
Question Report - Blue Valley Schools
Question Report - Blue Valley Schools

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Chapter 19. - Kenston Local Schools
Chapter 19. - Kenston Local Schools

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Lecture 10 Analyzing the DNA by array and deep sequencing (1)

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Mendelian and Human Genetics Standard Learning Target I can

... A) How do geneticists use the principles of probability to make predictions about inheritance? o Create a punnett square showing a cross between a tall heterozygous pea plant and a short pea plant- give the phenotype and genotype expected B) Explain the principle of independent assortment. A) Descri ...
Nature Plants - Kansas State University
Nature Plants - Kansas State University

... expansion in these genomic giants. The genomes of both species have expanded tremendously since they diverged. The majority of this expansion comes from a heterogeneous mix of low-abundance sequences, and not from a few highly repetitive elements, like in barley or cotton. The mechanism behind this ...
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Chapter 12 Test Review

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1 Forward and Reverse Genetics 1. Background What is the function

... or at non-essential amino acid positions. This method is good for fine-scale mutagenesis. b) homologous recombination - works in bacteria, yeast, mice and other mammals. It does not work well in Drosophila, although a complex experimental approach has been developed. This method has been used to kno ...
Chapter 31: Epigenetic Effects Are Inherited
Chapter 31: Epigenetic Effects Are Inherited

... base on the daughter strand. This restores the original situation, in which the site is methylated on both strands. A nonmethylated site remains nonmethylated after replication. ...
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Hands On - Gene Prediction in Prokaryotes file
Hands On - Gene Prediction in Prokaryotes file

... This step follows after the genome of a species has been sequenced. In general, the process includes identifying protein-coding regions, RNA genes, and regulatory regions. The three major categories of gene prediction algorithms are alignment-based, sequence-based, and content-based. Some algorithms ...
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Human genome



The human genome is the complete set of nucleic acid sequence for humans (Homo sapiens), encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. Human genomes include both protein-coding DNA genes and noncoding DNA. Haploid human genomes, which are contained in germ cells (the egg and sperm gamete cells created in the meiosis phase of sexual reproduction before fertilization creates a zygote) consist of three billion DNA base pairs, while diploid genomes (found in somatic cells) have twice the DNA content. While there are significant differences among the genomes of human individuals (on the order of 0.1%), these are considerably smaller than the differences between humans and their closest living relatives, the chimpanzees (approximately 4%) and bonobos. Humans share 50% of their DNA with bananas.The Human Genome Project produced the first complete sequences of individual human genomes, with the first draft sequence and initial analysis being published on February 12, 2001. The human genome was the first of all vertebrates to be completely sequenced. As of 2012, thousands of human genomes have been completely sequenced, and many more have been mapped at lower levels of resolution. The resulting data are used worldwide in biomedical science, anthropology, forensics and other branches of science. There is a widely held expectation that genomic studies will lead to advances in the diagnosis and treatment of diseases, and to new insights in many fields of biology, including human evolution.Although the sequence of the human genome has been (almost) completely determined by DNA sequencing, it is not yet fully understood. Most (though probably not all) genes have been identified by a combination of high throughput experimental and bioinformatics approaches, yet much work still needs to be done to further elucidate the biological functions of their protein and RNA products. Recent results suggest that most of the vast quantities of noncoding DNA within the genome have associated biochemical activities, including regulation of gene expression, organization of chromosome architecture, and signals controlling epigenetic inheritance.There are an estimated 20,000-25,000 human protein-coding genes. The estimate of the number of human genes has been repeatedly revised down from initial predictions of 100,000 or more as genome sequence quality and gene finding methods have improved, and could continue to drop further. Protein-coding sequences account for only a very small fraction of the genome (approximately 1.5%), and the rest is associated with non-coding RNA molecules, regulatory DNA sequences, LINEs, SINEs, introns, and sequences for which as yet no function has been elucidated.
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