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DMD Reviews 101 - Action Duchenne
DMD Reviews 101 - Action Duchenne

... the cutting edge of molecular biology and are linking these studies to finding a cure for Duchenne Muscular Dystrophy (DMD). The authors of the first paper to be reviewed from U.S.A. use the recently developed technique of CRISPRmediated Genome Editing in an attempt to restore Dystrophin expression ...
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Recombinant DNA technology

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Cell Division
Cell Division

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034 /9.00-12.00
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034 /9.00-12.00

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The National Enquirer
The National Enquirer

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4.4 Genetic engineering and biotechnology - McLain

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Study Guide: Lecture 1 1. What does “GMO” stand for and what does

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8 How Cellular Information is Altered

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Gene therapy and artificial chromosomes qu631.5 KB

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Answers to Gene technology exam 2011-10-18

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Ch. 4. Modern Genetics

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Special Topics in Heredity

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PROTEIN SYNTHESIS QUESTIONS

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

... 13. _______ inversion in which the rearrangement of genes is confined to single arm of the chromosome 14. ----------------- introns are located in the protein encoding genes of the nucleus. 15. ----------------- discovered that new species arise as a result of natural selection. IV. Answer all, each ...
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Horizontal Gene Transfer

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Gene therapy



Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.
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