Molecular Evolution of Overlapping Genes
... Overlapping genes are defined as a pair of protein-coding genes whose coding regions overlap on either the same strand or on the opposite strand. The sequence interdependence between two overlapping coding regions adds complexity to almost all molecular evolution analyses. Here, I use a comparative- ...
... Overlapping genes are defined as a pair of protein-coding genes whose coding regions overlap on either the same strand or on the opposite strand. The sequence interdependence between two overlapping coding regions adds complexity to almost all molecular evolution analyses. Here, I use a comparative- ...
Gene Section DLX6 (distal-less homeobox 6) Atlas of Genetics and Cytogenetics
... al., 2002 ; Lo Iacono et al., 2008). However recently, two rare familial cases of SHFM1 have been demonstrated to result, with highest probability, from intragenic missense mutations of two critical glutamine residues in the third helix of the DLX5 homeodomain (Q178P reported in Shamseldin et al., 2 ...
... al., 2002 ; Lo Iacono et al., 2008). However recently, two rare familial cases of SHFM1 have been demonstrated to result, with highest probability, from intragenic missense mutations of two critical glutamine residues in the third helix of the DLX5 homeodomain (Q178P reported in Shamseldin et al., 2 ...
Gene Section MLL (myeloid/lymphoid or mixed lineage leukemia) Atlas of Genetics and Cytogenetics
... 3969 amino acids; 431 KDa; contains two DNA binding motifs: a AT hook homologous to high mobility group proteins HMGI-(Y) and HMGI(C) that binds to the minor groove of DNA, and zinc fingers, a DNA methyl transferase motif, a bromodomain, and segments of homology with trithorax, in particular in the ...
... 3969 amino acids; 431 KDa; contains two DNA binding motifs: a AT hook homologous to high mobility group proteins HMGI-(Y) and HMGI(C) that binds to the minor groove of DNA, and zinc fingers, a DNA methyl transferase motif, a bromodomain, and segments of homology with trithorax, in particular in the ...
Editorial Therapeutic approaches to familial Mediterranean fever
... failure. AAamyloid fibrils may also accumulate in other organs, including the heart,intestines and testes (3). Over the years several therapeutic approaches have been tried, some of which have proved successful. Colchicine is the main drug used to control FMF in most cases. Nevertheless, therapeutic ...
... failure. AAamyloid fibrils may also accumulate in other organs, including the heart,intestines and testes (3). Over the years several therapeutic approaches have been tried, some of which have proved successful. Colchicine is the main drug used to control FMF in most cases. Nevertheless, therapeutic ...
Host-Plasmid Interactions in Saccharomyces
... using latex beads (7.8 pm diameter; Coulter Electronics) as standards. DNA content was assayed by the diphenylamine method (Stewart, 1975), calf thymus DNA being used as standard since it has a similar G C content (i.e. 40%) to that of the S. cerevisiae genome. Mating ability was confirmed microscop ...
... using latex beads (7.8 pm diameter; Coulter Electronics) as standards. DNA content was assayed by the diphenylamine method (Stewart, 1975), calf thymus DNA being used as standard since it has a similar G C content (i.e. 40%) to that of the S. cerevisiae genome. Mating ability was confirmed microscop ...
Genetic studies of psoriasis and psoriatic arthritis
... identified with linkage analysis, 3q21 and 5q31-32, with a special emphasis on the PSORS5 region on chromosome 3q21. Another purpose was to investigate whether several autoimmuneassociating genes and genomic regions are susceptibility factors for psoriasis/psoriatic arthritis. Association studies on ...
... identified with linkage analysis, 3q21 and 5q31-32, with a special emphasis on the PSORS5 region on chromosome 3q21. Another purpose was to investigate whether several autoimmuneassociating genes and genomic regions are susceptibility factors for psoriasis/psoriatic arthritis. Association studies on ...
Gene Ontology (GO) Tutorial
... none of it is adequate to assign a term. A good example is Dab2ip. As shown by it’s annotation summary, there was literature to demonstrate that it bound a protein, but no literature to suggest what process it participated in or where in the cell it was found. In some cases, there will be unknowns a ...
... none of it is adequate to assign a term. A good example is Dab2ip. As shown by it’s annotation summary, there was literature to demonstrate that it bound a protein, but no literature to suggest what process it participated in or where in the cell it was found. In some cases, there will be unknowns a ...
Review: Is genetic screening for hemochromatosis worthwhile?
... detecting subjects with delayed or incomplete penetrance, allowing diagnosis at an early age and treatment to prevent clinically significant iron overload [62]. However, not all subjects with iron overload carry the C282Y mutation. This mutation is mainly found in Caucasians. This limits the applicat ...
... detecting subjects with delayed or incomplete penetrance, allowing diagnosis at an early age and treatment to prevent clinically significant iron overload [62]. However, not all subjects with iron overload carry the C282Y mutation. This mutation is mainly found in Caucasians. This limits the applicat ...
A Genetic-Based Evaluation of the Principal Tissue Reservoir for
... laboratories uncovered 12 additional cases of group A streptococcal invasive disease. In addition, isolates derived from normally sterile tissue sites of 9 patients were never sent to the state laboratory; since these 21 bacterial isolates were not available for molecular analyses, those cases were ...
... laboratories uncovered 12 additional cases of group A streptococcal invasive disease. In addition, isolates derived from normally sterile tissue sites of 9 patients were never sent to the state laboratory; since these 21 bacterial isolates were not available for molecular analyses, those cases were ...
Investigation of strategies to protect against harmful bacteria
... 5.8.2.3 Transformation of JM107 electrocompetent cells with modified plasmid DNA by electroporation of cells ...
... 5.8.2.3 Transformation of JM107 electrocompetent cells with modified plasmid DNA by electroporation of cells ...
A Pneumocystis carinii multi-gene family with
... Copies of a multi-gene family, named PRTl (protease 3,encoding a subtilisinlike serine protease were cloned from the opportunistic fungal pathogen Pneumocystis carinii. Comparison of the nucleotide sequence of a genomic clone and a cDNA clone of PRTl from P. carinii f. sp. carinii revealed the prese ...
... Copies of a multi-gene family, named PRTl (protease 3,encoding a subtilisinlike serine protease were cloned from the opportunistic fungal pathogen Pneumocystis carinii. Comparison of the nucleotide sequence of a genomic clone and a cDNA clone of PRTl from P. carinii f. sp. carinii revealed the prese ...
Disruption and aberrant expression of HMGA2 as a
... human mesenchymal tumors, resulting in fusion to diverse partner genes. In lipomas, HMGA2 has been shown to fuse to LPP at 3q27–q28, a gene encoding an LIM domain-containing protein;8,15 to LHFP at 13q12, the function of which is still unknown;16 to the G-protein-coupled receptor RDC1 at 2q35– 3717 ...
... human mesenchymal tumors, resulting in fusion to diverse partner genes. In lipomas, HMGA2 has been shown to fuse to LPP at 3q27–q28, a gene encoding an LIM domain-containing protein;8,15 to LHFP at 13q12, the function of which is still unknown;16 to the G-protein-coupled receptor RDC1 at 2q35– 3717 ...
Opsin genes, cone photopigments, color vision, and color blindness
... absorption spectra. These were determined from the cone spectral sensitivity functions, by correcting the latter for the filtering of the ocular media and the macular pigment and for the self-screening of the pigment in the outer segment (see Chapter 2, Table 2.1, for values). (C) The cone mosaic of ...
... absorption spectra. These were determined from the cone spectral sensitivity functions, by correcting the latter for the filtering of the ocular media and the macular pigment and for the self-screening of the pigment in the outer segment (see Chapter 2, Table 2.1, for values). (C) The cone mosaic of ...
Stem Cell Therapy In Pediatric Neurological Disorders
... in Cerebral Palsy and Mental Retardation - A Case Report. Case Reports in Neurological Medicine. Volume 2013, Article ID 141983, 6 pages ...
... in Cerebral Palsy and Mental Retardation - A Case Report. Case Reports in Neurological Medicine. Volume 2013, Article ID 141983, 6 pages ...
Clinical Practice Guidelines for the Management
... experience with lipid polyene formulations and drug combination studies have added to our direct anticryptococcal drug treatment insights [20, 21]. Pathobiologically, although recent studies from the cryptococcosis outbreak in Vancouver support the observation that a recombinant strain in nature bec ...
... experience with lipid polyene formulations and drug combination studies have added to our direct anticryptococcal drug treatment insights [20, 21]. Pathobiologically, although recent studies from the cryptococcosis outbreak in Vancouver support the observation that a recombinant strain in nature bec ...
ULTRATHERM 1008 short-wave therapy unit
... therapy unit become aware of the potential dangers of the unit and its external components before beginning work. Please read and observe all safety instructions in this operating manual. ...
... therapy unit become aware of the potential dangers of the unit and its external components before beginning work. Please read and observe all safety instructions in this operating manual. ...
pdf
... was filtered onto Sterivex capsules (0.2 µm pore size, Millipore, Inc., Bedford, MA, USA) with a peristaltic pump, quick frozen in liquid nitrogen and stored at −80°C until the DNA could be extracted. DNA analyses are reported for samples from the SNM for the open-ocean locations. The sampling depth ...
... was filtered onto Sterivex capsules (0.2 µm pore size, Millipore, Inc., Bedford, MA, USA) with a peristaltic pump, quick frozen in liquid nitrogen and stored at −80°C until the DNA could be extracted. DNA analyses are reported for samples from the SNM for the open-ocean locations. The sampling depth ...
Quarterly Report March 2009 - Office of the Gene Technology
... containment facilities that are designed to prevent release of the GMO(s) into the environment. These licence applications have a statutory timeframe of 90 working days for making a decision. Accreditations of organisations DIR and DNIR licences require organisations which conduct work with GMOs t ...
... containment facilities that are designed to prevent release of the GMO(s) into the environment. These licence applications have a statutory timeframe of 90 working days for making a decision. Accreditations of organisations DIR and DNIR licences require organisations which conduct work with GMOs t ...
hereditary plasma clotting factor disorders and their
... father. Alternatively, the origin could have been a mutant ovum in her mother. Or, a mutation could have arisen in one cell in either of her parents when they were embryos, and the mutant cell developed into a gonad or part of a gonad. Some mothers of sporadic cases can be shown to have the mutation ...
... father. Alternatively, the origin could have been a mutant ovum in her mother. Or, a mutation could have arisen in one cell in either of her parents when they were embryos, and the mutant cell developed into a gonad or part of a gonad. Some mothers of sporadic cases can be shown to have the mutation ...
Proviral amplification of the Gypsy endogenous retrovirus of
... of intracellular retrotransposition. This mechanism might indeed be a default pathway, since both an endogenous (intracisternal A particle, IAP) and an exogenous (Moloney murine leukemia virus, Mo-MuLV) mouse retrovirus were actually shown to be able to transpose, although at very low frequencies, i ...
... of intracellular retrotransposition. This mechanism might indeed be a default pathway, since both an endogenous (intracisternal A particle, IAP) and an exogenous (Moloney murine leukemia virus, Mo-MuLV) mouse retrovirus were actually shown to be able to transpose, although at very low frequencies, i ...
Conjugative plasmids: vessels of the communal gene pool
... turn means that apart from direct mutational changes, variation is not automatically introduced by virtue of self-proliferation (vertical transfer), which corresponds to binary fission in prokaryotes. Their genomes are modified by gene loss and by gene addition through duplication and the acquisitio ...
... turn means that apart from direct mutational changes, variation is not automatically introduced by virtue of self-proliferation (vertical transfer), which corresponds to binary fission in prokaryotes. Their genomes are modified by gene loss and by gene addition through duplication and the acquisitio ...
Conjugative plasmids: vessels of the communal gene pool
... turn means that apart from direct mutational changes, variation is not automatically introduced by virtue of self-proliferation (vertical transfer), which corresponds to binary fission in prokaryotes. Their genomes are modified by gene loss and by gene addition through duplication and the acquisitio ...
... turn means that apart from direct mutational changes, variation is not automatically introduced by virtue of self-proliferation (vertical transfer), which corresponds to binary fission in prokaryotes. Their genomes are modified by gene loss and by gene addition through duplication and the acquisitio ...
the genetics of the budgerigar
... directly responsible for the appearance of those variations from the wild type which, when they first appear, are popularly termed "sports." But it is probably truer to say that domestication is merely responsible for their recognition and perpetuation. It is not uncommon to find that a "sport" is n ...
... directly responsible for the appearance of those variations from the wild type which, when they first appear, are popularly termed "sports." But it is probably truer to say that domestication is merely responsible for their recognition and perpetuation. It is not uncommon to find that a "sport" is n ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.