Intravenous fluid therapy in adults in hospital
... It is hoped that this guideline will lead to better fluid prescribing in hospitalised patients, reduce morbidity and mortality, and lead to better patient outcomes. Strategies for further research into the subject have also been proposed. The guideline will assume that prescribers will use a drug's ...
... It is hoped that this guideline will lead to better fluid prescribing in hospitalised patients, reduce morbidity and mortality, and lead to better patient outcomes. Strategies for further research into the subject have also been proposed. The guideline will assume that prescribers will use a drug's ...
Trichothiodystrophy: Update on the sulfur
... defective synthesis of high-sulfur matrix proteins. Abnormalities in excision repair of ultraviolet (UV)damaged DNA are recognized in about half of the patients. Three distinct autosomal recessive syndromes are associated with nucleotide excision repair (NER) defects: the photosensitive form of TTD, ...
... defective synthesis of high-sulfur matrix proteins. Abnormalities in excision repair of ultraviolet (UV)damaged DNA are recognized in about half of the patients. Three distinct autosomal recessive syndromes are associated with nucleotide excision repair (NER) defects: the photosensitive form of TTD, ...
Guidance for FDA Reviewers and Sponsors
... FDA’s primary objectives in the review of INDs are to help ensure the safety and rights of human subjects in all phases of an investigation and, in Phases 2 and 3, to help ensure that the quality of the scientific evaluation of the investigational product is adequate to permit an evaluation of its s ...
... FDA’s primary objectives in the review of INDs are to help ensure the safety and rights of human subjects in all phases of an investigation and, in Phases 2 and 3, to help ensure that the quality of the scientific evaluation of the investigational product is adequate to permit an evaluation of its s ...
Intravenous fluid therapy in adults in hospital
... It is hoped that this guideline will lead to better fluid prescribing in hospitalised patients, reduce morbidity and mortality, and lead to better patient outcomes. Strategies for further research into the subject have also been proposed. The guideline will assume that prescribers will use a drug's ...
... It is hoped that this guideline will lead to better fluid prescribing in hospitalised patients, reduce morbidity and mortality, and lead to better patient outcomes. Strategies for further research into the subject have also been proposed. The guideline will assume that prescribers will use a drug's ...
Linking Cognitive Neuroscience and Molecular Genetics: New Perspectives from Williams... Ursula Bellugi and Marie St. George (Eds.)
... Korenberg et al., 1996; Robinson et al., 1996). However, the number of expressed genes in these duplicated regions and their contribution to the WMS phenotype is unknown. The current report will illustrate the structure of the flanking duplications and suggest a possible relationship to the WMS brea ...
... Korenberg et al., 1996; Robinson et al., 1996). However, the number of expressed genes in these duplicated regions and their contribution to the WMS phenotype is unknown. The current report will illustrate the structure of the flanking duplications and suggest a possible relationship to the WMS brea ...
Conserved syntenic clusters of protein coding genes are missing in birds
... many conserved genes that could not be found in the previous assembly (for example, [20]), and yielded significant BLAT-alignments for approximately 96% of genes from a positive control search set consisting of randomly selected lizard gene models with known orthologs in birds). Lastly, this subset ...
... many conserved genes that could not be found in the previous assembly (for example, [20]), and yielded significant BLAT-alignments for approximately 96% of genes from a positive control search set consisting of randomly selected lizard gene models with known orthologs in birds). Lastly, this subset ...
Planta
... isoprene synthase gene [TG1(pQE50iso)] released 100 times more isoprene, which strongly suggests that the isolated gene indeed encodes an isoprene synthase (Table 2). Isoprene release from the strain with the plasmid carrying the gene without the sequence encoding the plastidial leader [TG1(pQE50Dis ...
... isoprene synthase gene [TG1(pQE50iso)] released 100 times more isoprene, which strongly suggests that the isolated gene indeed encodes an isoprene synthase (Table 2). Isoprene release from the strain with the plasmid carrying the gene without the sequence encoding the plastidial leader [TG1(pQE50Dis ...
Limb Girdle Muscular Dystrophy - Muscular Dystrophy Foundation of
... occur in either sex and may be transmitted from parent to child through several generations. It is usually relatively mild. In theory, this disorder may be seen in isolated cases as the result of a spontaneous "mutation" in the gene. In one large American family the gene for their condition has been ...
... occur in either sex and may be transmitted from parent to child through several generations. It is usually relatively mild. In theory, this disorder may be seen in isolated cases as the result of a spontaneous "mutation" in the gene. In one large American family the gene for their condition has been ...
Profile of Edward M. De Robertis - Howard Hughes Medical Institute
... Hamburger, as well as one by embryologist Hans Spemann (7) who taught Hamburger, sparked discussion in the club about the possibility of isolating genes involved in embryonic induction. In 1924, Spemann and a colleague had shown that a region of the amphibian embryo was able to induce the formation ...
... Hamburger, as well as one by embryologist Hans Spemann (7) who taught Hamburger, sparked discussion in the club about the possibility of isolating genes involved in embryonic induction. In 1924, Spemann and a colleague had shown that a region of the amphibian embryo was able to induce the formation ...
Endpoints in respiratory diseases
... highlighting the need of robust endpoints for clinical trials in such field.3 A wide range of outcome measures or endpoints have been used in clinical trials to assess the effects of treatments in paediatric respiratory diseases. This can make difficult to compare treatment outcomes from different t ...
... highlighting the need of robust endpoints for clinical trials in such field.3 A wide range of outcome measures or endpoints have been used in clinical trials to assess the effects of treatments in paediatric respiratory diseases. This can make difficult to compare treatment outcomes from different t ...
New and Redesigned pRS Plasmid Shuttle Vectors for Genetic
... 1993; Lorenz et al. 1995; Wach 1996). The simplicity and utility of PCR-mediated gene replacement has led to its usage in other fungal model organisms as well (Kaur et al. 1997; Walther and Wendland 2008; Wendland et al. 2000). Due to the standardized design of the pRS series, a single pair of oligo ...
... 1993; Lorenz et al. 1995; Wach 1996). The simplicity and utility of PCR-mediated gene replacement has led to its usage in other fungal model organisms as well (Kaur et al. 1997; Walther and Wendland 2008; Wendland et al. 2000). Due to the standardized design of the pRS series, a single pair of oligo ...
Guidelines for Antiretroviral Therapy for the Prevention and
... Services, MOHCC, P.O. Box CY 1122, Causeway, Harare, Zimbabwe. Comments can be forwarded to the AIDS and TB Directorate (atp.director@ ymail.com) or the Directorate of Pharmacy Services ([email protected]). The information presented in these guidelines conforms to current medical, nursing, and pharma ...
... Services, MOHCC, P.O. Box CY 1122, Causeway, Harare, Zimbabwe. Comments can be forwarded to the AIDS and TB Directorate (atp.director@ ymail.com) or the Directorate of Pharmacy Services ([email protected]). The information presented in these guidelines conforms to current medical, nursing, and pharma ...
National Conference to Assess Antibody
... The detection and treatment of allograft rejection has historically focused upon T-cell-mediated processes. The existence of vascular or humoral rejection was suspected, as antibodies reactive to donor HLA antigens were regularly found in the sera of recipients undergoing rejection (1). However, unt ...
... The detection and treatment of allograft rejection has historically focused upon T-cell-mediated processes. The existence of vascular or humoral rejection was suspected, as antibodies reactive to donor HLA antigens were regularly found in the sera of recipients undergoing rejection (1). However, unt ...
EASL Clinical Practice Guidelines: Management of hepatitis C virus infection ⇑
... Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease worldwide. The long-term impact of HCV infection is highly variable, from minimal changes to extensive fibrosis and cirrhosis with or without hepatocellular carcinoma (HCC). The number of chronically infected persons ...
... Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease worldwide. The long-term impact of HCV infection is highly variable, from minimal changes to extensive fibrosis and cirrhosis with or without hepatocellular carcinoma (HCC). The number of chronically infected persons ...
Progress in the Understanding of the Genetic Etiology of Vertebral
... Figure 3. (A) Schematic representation of the caudal part of the chick embryo. The major steps leading to somite formation are indicated. (B) Dynamic and periodic expression of the cyclic genes in the PSM identifies a molecular clock linked to segmentation. Top panel: Sequence of expression of the l ...
... Figure 3. (A) Schematic representation of the caudal part of the chick embryo. The major steps leading to somite formation are indicated. (B) Dynamic and periodic expression of the cyclic genes in the PSM identifies a molecular clock linked to segmentation. Top panel: Sequence of expression of the l ...
Interferon Gamma Gene Polymorphism as a Biochemical Marker in
... The development of atopy depends on several genes, and disease expression is influenced by exposure to environmental factors. Several genome-wide searches have linked the development of atopy to different autosomal chromosomal regions, many of which directly or indirectly regulate IgE production and ...
... The development of atopy depends on several genes, and disease expression is influenced by exposure to environmental factors. Several genome-wide searches have linked the development of atopy to different autosomal chromosomal regions, many of which directly or indirectly regulate IgE production and ...
Dohner H 2017 ENL guidelines.full
... *Other recurring translocations involving RARA should be reported accordingly: for example, AML with t(11;17)(q23;q12); ZBTB16-RARA; AML with t(11;17)(q13;q12); NUMA1-RARA; AML with t(5;17)(q35;q12); NPM1-RARA; or AML with STAT5B-RARA (the latter having a normal chromosome 17 on conventional cytogen ...
... *Other recurring translocations involving RARA should be reported accordingly: for example, AML with t(11;17)(q23;q12); ZBTB16-RARA; AML with t(11;17)(q13;q12); NUMA1-RARA; AML with t(5;17)(q35;q12); NPM1-RARA; or AML with STAT5B-RARA (the latter having a normal chromosome 17 on conventional cytogen ...
Diagnosis and management of AML in adults: 2017
... *Other recurring translocations involving RARA should be reported accordingly: for example, AML with t(11;17)(q23;q12); ZBTB16-RARA; AML with t(11;17)(q13;q12); NUMA1-RARA; AML with t(5;17)(q35;q12); NPM1-RARA; or AML with STAT5B-RARA (the latter having a normal chromosome 17 on conventional cytogen ...
... *Other recurring translocations involving RARA should be reported accordingly: for example, AML with t(11;17)(q23;q12); ZBTB16-RARA; AML with t(11;17)(q13;q12); NUMA1-RARA; AML with t(5;17)(q35;q12); NPM1-RARA; or AML with STAT5B-RARA (the latter having a normal chromosome 17 on conventional cytogen ...
An Update on the Hereditary Spastic Paraplegias: New Genes and
... candidate genes have been subsequently confirmed in independent studies, including REEP2,33 DDHD2,34,35 and KIF1C.36 The investigators also used the network to examine the similarity of HSP genes (seed plus candidate) to other common neurological disorders. They found that there was a significant ov ...
... candidate genes have been subsequently confirmed in independent studies, including REEP2,33 DDHD2,34,35 and KIF1C.36 The investigators also used the network to examine the similarity of HSP genes (seed plus candidate) to other common neurological disorders. They found that there was a significant ov ...
The purpose of this summary is exclusively educational, to provide
... sensitization → development of other allergies); (ii) it usually occurs in childhood; (iii) appearance of diseases may not follow the same order (e.g. asthma can precede AD); (iv) all diseases do not always occur (e.g. some patients do not develop food allergy or asthma); (v) environmental factors c ...
... sensitization → development of other allergies); (ii) it usually occurs in childhood; (iii) appearance of diseases may not follow the same order (e.g. asthma can precede AD); (iv) all diseases do not always occur (e.g. some patients do not develop food allergy or asthma); (v) environmental factors c ...
Help Me Understand Genetics
... The information in DNA is stored as a code made up of four chemical bases: adenine (A), guanine (G), cytosine (C), and thymine (T). Human DNA consists of about 3 billion bases, and more than 99 percent of those bases are the same in all people. The order, or sequence, of these bases determines the i ...
... The information in DNA is stored as a code made up of four chemical bases: adenine (A), guanine (G), cytosine (C), and thymine (T). Human DNA consists of about 3 billion bases, and more than 99 percent of those bases are the same in all people. The order, or sequence, of these bases determines the i ...
PDF
... complement the homoeotic phenotype of trx1, as well as each others lethality. Genetic analysis suggests that all three alleles abolish most, if not all, of the wildtype function of the trx locus (Ingham, 1981); in addition, there is some evidence that trx3 may have an antimorphic component (unpublis ...
... complement the homoeotic phenotype of trx1, as well as each others lethality. Genetic analysis suggests that all three alleles abolish most, if not all, of the wildtype function of the trx locus (Ingham, 1981); in addition, there is some evidence that trx3 may have an antimorphic component (unpublis ...
Management of Patients with Histoplasmosis
... have occurred within the Ohio and Mississippi River valleys. Precise reasons for this distribution pattern of endemicity are unknown but are thought to include moderate climate, humidity, and soil characteristics. Bird and bat excrement enhances the growth of the organism in soil by accelerating spo ...
... have occurred within the Ohio and Mississippi River valleys. Precise reasons for this distribution pattern of endemicity are unknown but are thought to include moderate climate, humidity, and soil characteristics. Bird and bat excrement enhances the growth of the organism in soil by accelerating spo ...
Gene therapy
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy could be a way to fix a genetic problem at its source. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations.The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a ""vector"", which carries the molecule inside cells.Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. By the late 1980s the technology had already been extensively used on animals, and the first genetic modification of a living human occurred on a trial basis in May 1989 , and the first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred on September 14, 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.Early clinical failures led to dismissals of gene therapy. Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. These include treatment of retinal disease Leber's congenital amaurosis, X-linked SCID, ADA-SCID, adrenoleukodystrophy, chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), multiple myeloma, haemophilia and Parkinson's disease. Between 2013 and April 2014, US companies invested over $600 million in the field.The first commercial gene therapy, Gendicine, was approved in China in 2003 for the treatment of certain cancers. In 2011 Neovasculgen was registered in Russia as the first-in-class gene-therapy drug for treatment of peripheral artery disease, including critical limb ischemia.In 2012 Glybera, a treatment for a rare inherited disorder, became the first treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.