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The Principles of Balancing Diets for Amino Acids and Their Impact
The Principles of Balancing Diets for Amino Acids and Their Impact

Study of Alternative Functions of the Mitochondrial Protein Bak
Study of Alternative Functions of the Mitochondrial Protein Bak

... Molecular structures of Bax and Bak The structures of non-activated Bak and Bax resemble that of other prosurvival proteins: globular structures composed of 9 α-helices. Within a bundle of 7 amphipathic (consisting of both hydrophobic and hydrophilic parts) helices resides the hydrophobic α5 helix. ...
Preview Sample 1
Preview Sample 1

MODified™ Protein Domain Binding Kit Manual
MODified™ Protein Domain Binding Kit Manual

... (PTMs) on the N-terminal histone tails. Histone modifications can consist of acetylation, mono-, di- (symmetric or asymmetric in the case of arginine) and tri-methylation of lysine and arginine residues, phosphorylation of serine or threonine residues, citrullination and ubiquitination. These epigen ...
Meal ingestion, amino acids and brain
Meal ingestion, amino acids and brain

Automated extraction of mutation data from the literature: application
Automated extraction of mutation data from the literature: application

... heterogeneous data from across a variety of electronic and literature sources in order to draw new inferences about the target protein families. Results: We present a computational method that identifies and extracts mutation data from the scientific literature. We focused on the extraction of singl ...
paper describing HSSP
paper describing HSSP

Report of attending the international CILIA 2016 in Amsterdam
Report of attending the international CILIA 2016 in Amsterdam

... organelles in mammals, the rebirth of cilia has been driven by the discovery that cilia dysfunction was associated to severe developmental diseases. Now, this research field is very active and many aspects of cilia functions in cell physiology and development are in progress and a growing number of ...
Chapter 3 Chemical Basis of Life II. Biological Molecules
Chapter 3 Chemical Basis of Life II. Biological Molecules

... All animations will appear after viewing in Presentation Mode and playing each animation. Most animations will require the latest version of the Flash Player, which is available at http://get.adobe.com/flashplayer. ...
Phosphate Groups Modifying Myelin Basic Proteins Are
Phosphate Groups Modifying Myelin Basic Proteins Are

Changes in gene expression associated with acclimation to constant
Changes in gene expression associated with acclimation to constant

... based’ investigations of environmental effects on Small heat shock proteins appear to play an important organisms. role in response to fluctuating temperatures whereas larger molecular mass chaperones such as Hsp70 and Hsp90 respond more strongly to chronic high Supplementary material available on-l ...
Contact Area Difference (CAD): A Robust Measure to Evaluate
Contact Area Difference (CAD): A Robust Measure to Evaluate

... Each two residues i and j in a protein structure can be characterized by certain contact area Aij (Figure 1). To calculate this area one has to create a surface around isolated residue i by rolling a probe of radius R over the van der Waals surface of the residue atoms and tracing the center of the ...


... Cells infected with a rabies virus deficient in M protein were shown to lack the typical bullet­ shaped morphology of rhabdovirus particles. Instead it contained long, rod-shaped virions, thus ...
"An Introduction to Sequence Similarity ("Homology") Searching". In
"An Introduction to Sequence Similarity ("Homology") Searching". In

Chapter 2: Biochemistry Problems
Chapter 2: Biochemistry Problems

... or groups clump together to avoid contact with water. Hydrophilic groups cannot form hydrophobic interactions. Unlike an ionic or a hydrogen bond that occurs between two molecules, hydrophobic interactions are not true bonds, but involve nonpolar molecules that cluster together to avoid the water th ...
Acyl Carrier Protein (ACP) lmport into Chloroplasts Does not
Acyl Carrier Protein (ACP) lmport into Chloroplasts Does not

... chloroplasts were washed, lysed, and separated into their membrane and soluble components. As shown in Figure 2A, lane 5 , the putative transit peptide was functional and sufficient to direct ACP transport into the chloroplast. From the single precursor, there arose two products in the ...
LNBI 9043 - Lupin Allergy: Uncovering Structural Features and
LNBI 9043 - Lupin Allergy: Uncovering Structural Features and

... and antigenic propensity of polypeptide chains have been used to identify continuous epitopes (see methods section). In our analysis, antigenicity determinants were assigned by locating the positive peaks in hydrophilicity plots, and identifying the regions of maximum potential of antigenicity (data ...
LWT Food Science and Technology
LWT Food Science and Technology

... alcoholic beverages contains not only polyphenols, but also proteins and amino acids. It is common knowledge that proteins and essential amino acids of food are supplying the required building blocks for protein biosynthesis of humans (Belitz and Grosch, 1999). Now some authors suggest that these su ...
Genetic code ambiguity: an unexpected source of proteome
Genetic code ambiguity: an unexpected source of proteome

Figure 7. N-terminus sequence of the predicted
Figure 7. N-terminus sequence of the predicted

sequence-structure relationship - HAL
sequence-structure relationship - HAL

... it reduces the protein 3D complexity into one-dimensional string of characters. Based on this description, the local structure descriptions was extended to longer fragments, using an unsupervised clustering method called "Hybrid Protein Model" (HPM, (de Brevern and Hazout, 2001; de Brevern and Hazou ...
A Survey of Left-handed Helices in Protein Structures
A Survey of Left-handed Helices in Protein Structures

... Schellman motifs.10 To our knowledge, there are currently only three protein structure entries in the PDB that have a lefthanded helix assigned. Two of these are four residues long and they are found in thermolysin (PDB code 8tln)11 and neutral protease (1npc).12 The third one is a three-residue lon ...
Filip Jagodzinski - WWU Computer Science Faculty Web Pages
Filip Jagodzinski - WWU Computer Science Faculty Web Pages

... Pass Points on High Dimensional Surfaces, 2013 Symposium on University Research and Creative Expression (SOURCE), Central Washington University. Brian Orndorff*, Filip Jagodzinski, Rigidity Analysis of Protein-Ligand Conformations Generated by Molecular Dynamics, 2013 Symposium on University Researc ...
A Study of Phylogenetic Relationships and Homology of
A Study of Phylogenetic Relationships and Homology of

... The Cytochrome complex (cyt c) is a small hemeprotein loosely associated with the inner mitochondrial membrane. It belongs to the cytochrome C family of proteins and is found in all organisms. Cyt c is a highly soluble protein, unlike other cytochromes. In humans, cyt c is encoded by the CYCS gene [ ...
Kinetic Role of Helix Caps in Protein Folding Is Context
Kinetic Role of Helix Caps in Protein Folding Is Context

... described and classified (8). In this study, the N- and C-cap residues are defined as the first and last residues of the helix with CR atoms within the helical spiral (7) (see Materials and Methods for exact details). Extensive analyses by several groups have shown that helix caps at the N-terminus ...
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Interactome



In molecular biology, an interactome is the whole set of molecular interactions in a particular cell. The term specifically refers to physical interactions among molecules (such as those among proteins, also known as protein-protein interactions) but can also describe sets of indirect interactions among genes (genetic interactions). Mathematically, interactomes are generally displayed as graphs.The word ""interactome"" was originally coined in 1999 by a group of French scientists headed by Bernard Jacq. Though interactomes may be described as biological networks, they should not be confused with other networks such as neural networks or food webs.
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