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HIGHLIGHTS OF PRESCRIBING INFORMATION
HIGHLIGHTS OF PRESCRIBING INFORMATION

... weeks (Day 57) of therapy. Aminosalicylates and/or corticosteroids may be continued during treatment with HUMIRA. Azathioprine and 6-mercaptopurine (6-MP) [see Warnings and Precautions (5.2)] may be continued during treatment with HUMIRA if necessary. 2.5 Plaque Psoriasis The recommended dose of HUM ...
Vth World Congress of Behavioural and Cognitive Therapies Table
Vth World Congress of Behavioural and Cognitive Therapies Table

... Panel Debate 2: Open Papers 2: Open Papers 4: Open Papers 28: Open Papers 37: Open Papers 38: ...
study – the use of zeolite together with chemotherapy, radiation
study – the use of zeolite together with chemotherapy, radiation

... user is the reduction of free radicals; this is clearly shown in all approaches.   Since free radicals are highly unstable and are not accessible for quantitative measurement (or  are  extremely  difficult  to  access)  the  extent  of  damage  by  free  radicals  can  only  be  assessed  through th ...
clindets
clindets

... or abrasive agents. If irritancy or dermatitis occurs, clindamycin should be discontinued. Flammability Due to the flammable nature of CLINDETS®, patients should avoid smoking or being near an open flame during application and immediately after use. Use in Pregnancy The safety of CLINDETS® during pr ...
Microbiologic diagnostic tests when asymptomatic
Microbiologic diagnostic tests when asymptomatic

... infections. In the majority of these cases, the illness is not severe. However, correctly or incorrectly, a large proportion of these patients is treated with antibiotics. In the early 1990’s, I worked as a doctor at a paediatric clinic in the south western part of Sweden. Respiratory tract infectio ...
Guideline Update - American Academy of Sleep Medicine
Guideline Update - American Academy of Sleep Medicine

... divided into two papers. One discussed shift work disorder (SWD) and jet lag disorder (JLD), both of which are thought to be related to exogenously determined alterations in the timing of sleep and wakefulness rather than disturbances of the endogenous circadian system itself. A second paper discuss ...
Dual versus Single Chamber Pacemaker Therapy for
Dual versus Single Chamber Pacemaker Therapy for

... Compared with early pacemaker models, which paced at a fixed rate and could not be inhibited or synchronised with the underlying heart rhythm, modern pacemaker systems have become more sophisticated in terms of programmable modes and rate responsiveness, and they are better able to mimic the physiol ...
Donor-Derived West Nile Virus Infection in Solid Organ Transplant
Donor-Derived West Nile Virus Infection in Solid Organ Transplant

... 3, asymptomatic 1) from a common donor residing in a region of increased WNV activity. All four transplant recipients had molecular evidence of WNV infection in their serum and/or cerebrospinal fluid (CSF) by reverse transcription polymerase chain reaction (RT-PCR) testing. Serum from the organ dono ...
Obsessive compulsive disorder
Obsessive compulsive disorder

... treatments are often delivered within the context of an overall treatment programme including a range of activities, the purpose of which may be to help engage the person with OCD, and to provide an appropriate context for the delivery of specific interventions. It is important to maintain and enhan ...
AHFS Drug Information
AHFS Drug Information

... 7-day course of oral metronidazole (500 mg twice daily or 250 mg 3 times daily) or a 7day course of oral clindamycin (300 mg twice daily).341 (See Uses: Bacterial Vaginosis in Clindamycin 8:12.28.20.) Although some clinicians have recommended single-dose oral metronidazole as another alternative reg ...
British Guidelines on the management of asthma
British Guidelines on the management of asthma

... all information available from the history, examination and historical records should be undertaken. Factors to consider in an initial structured clinical assessment include: Episodic symptoms More than one of the symptoms of wheeze, breathlessness, chest tightness and cough occurring in episodes wi ...
American Gastroenterological Association Technical Review on
American Gastroenterological Association Technical Review on

... with a primary diagnosis of diabetic gastroparesis and an additional 1431 admissions for diabetic patients in which gastroparesis was a contributing factor to the need for hospitalization.21 The average hospital stay in this study was 5 days. In an unpublished study of patients with severe gastropar ...
4-080816-Gnann-Parsippany
4-080816-Gnann-Parsippany

... 1Oxman MN. Clinical manifestations of herpes zoster. In: Arvin AM, Gershon AA, eds. Varicella-Zoster Virus: Virology and Clinical Management. Cambridge, UK: Cambridge University Press; 2000:246-275; 2Rűbben A et al. Br J Dermatol. 1997;137: 256-261; 3Gershon AA et al. Varicella-zoster virus. In: Mur ...
Immediate hypersensitivity to cephalosporins
Immediate hypersensitivity to cephalosporins

... share the same side chain with the culprit penicillin. Few studies have been carried out to evaluate crossreactivity between cephalosporins and penicillins or among cephalosporins in samples of at least 10 subjects with primary hypersensitivity to the latter (23, 24). The principles of allergenic cr ...
Invest in ME
Invest in ME

... It is a sad failing of NICE, however, that these guidelines fail to grasp this opportunity and instead deliver a weak and ineffectual document that seemingly attempts to retain much of the ignorance and prejudice existing within healthcare provision for ME/CFS. We believe these guidelines provide li ...
Fentanyl Takeda transdermal patch ENG SmPC
Fentanyl Takeda transdermal patch ENG SmPC

... Previous analgesic therapy should be phased out gradually from the time of the first patch application until analgesic efficacy with Fentanyl Takeda is attained. For both strong opioid-naïve and opioid tolerant patients, the initial evaluation of the analgesic effect of Fentanyl Takeda should not be ...
Spasticity
Spasticity

... Patients with upper motor neuron lesions often exhibit abnormal cocontraction of agonist and antagonist muscle pairs during active movement, which clearly interferes with movement. For example, active extension of the elbow is impaired by simultaneous cocontraction of elbow flexors. It could be argu ...
Diagnosis and Treatment of Leishmaniasis: Clinical Practice
Diagnosis and Treatment of Leishmaniasis: Clinical Practice

... leishmaniasis, which includes a spectrum of diseases caused by >20 Leishmania species found in many areas of the world, many of the recommendations are based on observational studies, anecdotal data, or expert opinion. Although there may be disagreement with some of our recommendations and suggestio ...
Multiple Sclerosis Outcome Measures Taskforce Compendium of
Multiple Sclerosis Outcome Measures Taskforce Compendium of

...  Minute walk tests have been used in various patient populations (e.g., neuromuscular,  cardiopulmonary, peripheral vascular disease, cancer, amputation)  ...
Network effects of deep brain stimulation
Network effects of deep brain stimulation

... extensive review of functional imaging in STN DBS. Nonetheless, initial fMRI studies of DBS effects at rest essentially have corroborated earlier metabolic imaging findings. In addition, Kahan and colleagues studied the effects of DBS on the motor network directly by using dynamic causal modeling in ...
Non-Hodgkin Lymphoma What is cancer?
Non-Hodgkin Lymphoma What is cancer?

... also be found in the spinal cord and in tissues around the spinal cord and the eye. Over time, it tends to become widespread in the central nervous system. Primary CNS lymphoma is rare overall, but it’s more common in people with immune system problems, such as those infected with HIV, the virus tha ...
What could a change in score mean to her?
What could a change in score mean to her?

... treatment. Although patients may experience a resistance in the effect of BOTOX® treatment over time (in clinical trials, 1.2% [n = 326] of cervical dystonia patients developed neutralizing antibodies, which could result in resistance to treatment),9 there are other factors such as injection-site se ...
Critical Evaluation of Bacteriophage to Prevent and Treat
Critical Evaluation of Bacteriophage to Prevent and Treat

... in this area. With a better understanding of the significance of the microbiota of the intestine it may even be possible to use bacteriophage to alter the microbiota to improve the growth of production animals such as sub-therapeutic antibiotics currently do, and this application of bacteriophage ha ...
Briefing Document Treatment of Pneumonic Plague:  Medical Utility of Ciprofloxacin
Briefing Document Treatment of Pneumonic Plague: Medical Utility of Ciprofloxacin

... but when they present clinically, they are typically prostrate and lethargic and may also be restless or agitated. Such patients usually have fever in the range of 38.5 to 40.0ºC, but may have higher fever with delirium or, in children, seizures. The pulse rate is typically increased to 110 to 140 b ...
The use of docetaxel, paclitaxel, gemcitabine and vinorelbine
The use of docetaxel, paclitaxel, gemcitabine and vinorelbine

... The incidence of lung cancer is declining following a drop in smoking rates, but is still the leading cause of death from cancer in England and Wales, with about 30,000 deaths a year. Survival rates for lung cancer are poor everywhere, but they appear to be better in the rest of the European Communi ...
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Management of multiple sclerosis



Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS).The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable attacks (relapses) followed by periods of relative remission with no new signs of disease activity. After some years, many of the people who have this subtype begin to experience neurologic decline without acute relapses. When this happens it is called secondary progressive multiple sclerosis. Other, less common, courses of the disease are the primary progressive (decline from the beginning without attacks) and the progressive-relapsing (steady neurologic decline and superimposed attacks). Different therapies are used for patients experiencing acute attacks, for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a diagnosis of MS who have a demyelinating event, and for managing the various consequences of MS.The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. As with any medical treatment, medications used in the management of MS may have several adverse effects, and many possible therapies are still under investigation. At the same time different alternative treatments are pursued by many patients, despite the paucity of supporting, comparable, replicated scientific study.This article focuses on therapies for standard MS; borderline forms of MS have particular treatments that are excluded.
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