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UK national guidelines on the management of syphilis 2015
UK national guidelines on the management of syphilis 2015

... rarely seen due to the use of treponemocidal antibiotics for other indications. The clinical features of symptomatic late syphilis are summarised in Table 1. ...
Sympathetic Ophthalmia
Sympathetic Ophthalmia

... to prevent synechia formation from the anterior chamber reaction. High-dose oral corticosteroids are maintained for a minimum of three months, after which the response to treatment is evaluated. The clinical criterion for response to therapy incorporates an appraisal of the inflammatory response, su ...
Your Own Perfect Medicine - Mayday
Your Own Perfect Medicine - Mayday

... After many weeks, I returned to school and struggled through the high school years with the aid of generous amounts of codeine and other strong pain killers that my doctor willingly prescribed. But by the time I left home for college, the symptoms of bleeding, exhaustion, pain and digestive problems ...
The Relationship Between Individual Ossicular Status and
The Relationship Between Individual Ossicular Status and

... Few clinical studies have carefully examined the relationship between ossicular erosion by cholesteatoma and conductive hearing loss. Studies by Jeng and Carillo found that preoperative ABG was not significantly correlated with ossicular discontinuity (2,3). In both studies, however, the status of t ...
Annual report 2015
Annual report 2015

... after three months, and 94% of hip patients and 95% of knee patients made use of what they had learned in the GLA:D® sessions on a weekly basis or more frequently after three months. ...
Product Information: Trastuzumab
Product Information: Trastuzumab

... observed values of 78.7 µg/mL (standard deviation (SD): 43.9 µg/mL) as compared to 57.8 µg/mL SD: (30.3 µg/mL). During the adjuvant phase of treatment, at the pre-dose Cycle 13 time point, the mean observed trastuzumab concentration values, were 90.4 µg/mL (SD: 41.9 µg/mL) and 62.1 µg/mL (SD: 37.1 µ ...
Page 1 of 36 012017-6 HIGHLIGHTS OF PRESCRIBING
Page 1 of 36 012017-6 HIGHLIGHTS OF PRESCRIBING

... Instruct patients that the dose will “hold” for a longer period of time as tissue stores of methadone accumulate. Use lower initial doses for patients whose tolerance is expected to be low at treatment entry. Any patient who has not taken opioids for more than 5 days may no longer be tolerant. Do n ...
GOLD for RT
GOLD for RT

... The addition of regular treatment with inhaled glucocorticosteroids to bronchodilator treatment is appropriate for symptomatic COPD patients with an FEV1 < 50% predicted (Stage III: Severe COPD and Stage IV: Very Severe COPD) and repeated exacerbations (Evidence A). ...
presentation of childhood lymphoedema
presentation of childhood lymphoedema

... these patients can be: multisegmental (type I), affecting upper and lower limb(s), face, conjunctiva and genitalia in a segmental, asymmetrical pattern, with any combination of body parts being affected; or generalised, affecting the whole body (type II) as seen in Figure 5 (Connell et al, 2009a). T ...
Treatment of Patients With Substance Use Disorders Second Edition
Treatment of Patients With Substance Use Disorders Second Edition

... the basis of all clinical data available for an individual patient and are subject to change as scientific knowledge and technology advance and practice patterns evolve. These parameters of practice should be considered guidelines only. Adherence to them will not ensure a successful outcome for ever ...
Anticholinergic therapy for acute asthma in children (Review)
Anticholinergic therapy for acute asthma in children (Review)

... authors concluded that there is not enough support for the uncritical use of anticholinergic therapy for wheezing under the age of two years. The review by Plotnick et al focused specifically on combined treatment with anticholinergics and beta2 -agonists in asthmatic children over the age of two ye ...
The Selection and Use of Essential Medicines
The Selection and Use of Essential Medicines

... authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on  maps represent approximate border lines for which there may not yet be full agreement.  The mention of specific companies or of certain manufacturers’ products does not imply that  they are endorsed or recom ...
Lawrence F. Eichenfield, Andrew C. Krakowski, Caroline Piggott, James Del... Hilary Baldwin, Sheila Fallon Friedlander, Moise Levy, Anne Lucky, Anthony... Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne
Lawrence F. Eichenfield, Andrew C. Krakowski, Caroline Piggott, James Del... Hilary Baldwin, Sheila Fallon Friedlander, Moise Levy, Anne Lucky, Anthony... Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

... testosterone, and dehydroepiandrosterone sulfate levels are recommended. No further workup is necessary for the majority of cases in the absence of hormonal abnormalities. It is also important to distinguish true infantile acne from other similar cutaneous lesions, because there is some evidence tha ...
Lupus: Deciphering the Clues
Lupus: Deciphering the Clues

... caregivers and health providers across the United States. Sarah has two Bachelors of Science degrees, one from New York University College of Nursing and another from Skidmore College. She has had several clinical experiences in a variety of hospitals in the New York metropolitan area. She previousl ...
1-05-b NL 103 - Budesonide Art. 45
1-05-b NL 103 - Budesonide Art. 45

... Article 45 of the Regulation (EC)No 1901/2006, as amended on medicinal products for paediatric use. A fourth MAH, Alcon, informed the rapporteur that they did not sponsor any studies relevant for this procedure, but submitted 26 articles concerning the use of budesonide. AstraZeneca submitted 22 com ...
Thesis - Archive ouverte UNIGE
Thesis - Archive ouverte UNIGE

... the plasma membrane and is then cleaved in the extracellular domain to release the mature monomer through the actions of matrix metalloproteases, the TNF-alpha converting enzyme (TACE) toward a soluble 17-kDa protein made up of three subunits [2]. This molecule stands at the beginning of a proinflam ...
MAJOR REVIEW Central Serous Chorioretinopathy: Update on Pathophysiology and Treatment Benjamin Nicholson, MD,
MAJOR REVIEW Central Serous Chorioretinopathy: Update on Pathophysiology and Treatment Benjamin Nicholson, MD,

... among their 312 cases (versus just 2/312 age and sex-matched controls, p ! 0.0001) and calculated an odds ratio of 9.3 (95% CI, 2.1--40.6).73 Chumbley and Frank describe an otherwise healthy young woman who developed active CSC during each of four successive pregnancies, with spontaneous resolution ...
Neonatal Seizures
Neonatal Seizures

... 1.Volpe JJ.Neonatal seizures. In:Neurology of the newborn.4th ed.Philadelphia,Pa:WB Saunders's Co;2001:178-214 2.Hahn J,Olson D.Etiology of neonatal seizures.NeoReviews.2004;5:327-335 3.Riviello,J.Drug therapy for neonatal seizures:Part ...
Product Monograph
Product Monograph

... Since bone loss can be anticipated as part of natural menopause, it may also be expected to occur during the medically induced hypoestrogenic state caused by the long-term use of LUPRON DEPOT®. For a period of up to six months, this bone loss should not be important. Clinical studies indicate that c ...
Neonatal Seizures
Neonatal Seizures

Guidelines for the management of adult lower respiratory tract
Guidelines for the management of adult lower respiratory tract

Numbness matters: A clinical review of trigeminal neuropathy
Numbness matters: A clinical review of trigeminal neuropathy

... identified radiographically on coronal MRI as the fascial space enclosing the muscles of mastication: masseter, medial and lateral pterygoids, and temporalis. In the brainstem, cranial nerve V has three sensory nuclei: a principle sensory nucleus, which mediates tactile sensation, a spinal trigeminal ...
The Neuropathology of Manganese
The Neuropathology of Manganese

... presence of intracellular Lewy bodies (13Y16). Neurodegeneration can also occur in other brain areas including the olfactory region, locus coeruleus, nucleus basalis of Meynert, dorsal motor nucleus of the vagus, pedunculopontine nucleus, and the cerebral cortex (17, 18). In contrast, quantitative s ...
HERCEPTIN Product Monograph
HERCEPTIN Product Monograph

Martindale: The Complete Drug Reference
Martindale: The Complete Drug Reference

... Insomnia, with or without daytime drowsiness, has also been reported in patients taking metoclopramide 40 mg daily.5 Hypersensitivity psychosis has also been reported, shortly after stopping metoclopramide.6 Symptoms included hallucinations, delusional experiences, anxiety, restlessness, and sleep d ...
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Management of multiple sclerosis



Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS).The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable attacks (relapses) followed by periods of relative remission with no new signs of disease activity. After some years, many of the people who have this subtype begin to experience neurologic decline without acute relapses. When this happens it is called secondary progressive multiple sclerosis. Other, less common, courses of the disease are the primary progressive (decline from the beginning without attacks) and the progressive-relapsing (steady neurologic decline and superimposed attacks). Different therapies are used for patients experiencing acute attacks, for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a diagnosis of MS who have a demyelinating event, and for managing the various consequences of MS.The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. As with any medical treatment, medications used in the management of MS may have several adverse effects, and many possible therapies are still under investigation. At the same time different alternative treatments are pursued by many patients, despite the paucity of supporting, comparable, replicated scientific study.This article focuses on therapies for standard MS; borderline forms of MS have particular treatments that are excluded.
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