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The Fourth Pan Arab Congress on Sexual Medicine
The Fourth Pan Arab Congress on Sexual Medicine

... written an evidence-based contemporary definition of lifelong PE. ISSM defines PE as a male sexual dysfunction characterized by ejaculation which always or nearly always occurs prior to or within about 1 minute of vaginal penetration, and the inability to delay ejaculation on all or nearly all vagin ...
Prescribing Information
Prescribing Information

... Life-threatening and fatal meningococcal infections have occurred in patients treated with Soliris. The use of Soliris increases a patient's susceptibility to serious meningococcal infections (septicemia and/or meningitis). Vaccinate for meningococcal disease according to the most current Advisory C ...
Fibromyalgia
Fibromyalgia

... Other Therapies. People with fibromyalgia should use non-drug treatments as well as any medicines their doctors suggest. Research shows that gentle body-based therapies including Tai Chi and yoga can ease fibromyalgia symptoms. Cognitive behavioral therapy (a type of therapy focused on behavior chan ...
Official Journal of The Kidney Cancer Association
Official Journal of The Kidney Cancer Association

... These spoke-like directions might be a metaphor for investigations into the biology of the disease itself, branching out into myriad avenues as we seek to define and redefine biomarkers and gain more of a foothold on the heteroJanice P. Dutcher, MD geneity of the gene sequence in RCC. We have known ...
J Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations
J Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations

... against current treatment. We have highlighted where this tension is greatest, but do not wish to impose specific treatment recommendations that may prove premature. ...
American Thoracic Society
American Thoracic Society

... for adverse effects of isoniazid should consist of a monthly symptom review. For persons 35 yr of age and older, hepatic enzymes should be measured prior to starting isoniazid and monitored monthly throughout treatment, in addition to monthly symptom reviews. Other factors associated with an increas ...
Variability of sputum inflammatory mediators in COPD and a -antitrypsin deficiency
Variability of sputum inflammatory mediators in COPD and a -antitrypsin deficiency

... serial collection, as it reflects airways inflammation, has no inflammatory sequalae and is acceptable to most patients (in contrast to induced sputum and bronchoalveolar lavage) [15]. With this information, phase II clinical trials can be adequately powered to detect a predetermined change in media ...
Case-Based Review of Osteonecrosis of the Jaw (ONJ) and
Case-Based Review of Osteonecrosis of the Jaw (ONJ) and

... ONJ in oncology patients receiving oncology doses of bisphosphonate (BP) or denosumab is estimated at 1%–15%, and the frequency in the osteoporosis patient population receiving much lower doses of BP or denosumab is estimated at 0.001%–0.01%. Although the diagnosis of ONJ is primarily clinical, imag ...
Prescribing Information - Gamunex-C
Prescribing Information - Gamunex-C

... Do not dilute with saline. • Content of vials may be pooled under aseptic conditions into sterile infusion bags and infused within 8 hours after pooling. • Avoid simultaneous administration of GAMUNEX-C and Heparin through a single lumen delivery device due to GAMUNEX-C, Heparin incompatibilities. ...
Acute-on-chronic liver failure: an update
Acute-on-chronic liver failure: an update

... *Acute decompensation was defined by the recent development of ascites, encephalopathy, GI haemorrhage, bacterial infection or any combination of these. †In the NACSELD study, definitions of infections were as follows: (1) spontaneous bacteraemia: positive blood cultures without a source of infectio ...
The assessment and management of adults with status asthmaticus.
The assessment and management of adults with status asthmaticus.

... in the assessment of the patient with mild to moderate asthma, they are of use in the setting ot SA. When FEV. is less than 1 L or PEFR is less than 120 L/min we recommend arterial blood gas determinations to document the degree of hypoxemia and to determine the patient's acid-base status. Patients ...
Evaluation of mild acute infectious myocarditis
Evaluation of mild acute infectious myocarditis

... and often progressive heart failure are clinically selfevident. Such a course of infectious myocarditis is rare. In contrast, mild often clinically asymptomatic myocarditis is common.2 Diagnosing even mild acute myocarditis is necessary, as these patients may be in danger of sudden cardiac death,3 o ...
Clinical Presentation and Risk Factors of Stroke
Clinical Presentation and Risk Factors of Stroke

... patients, 233 (20%) were suffering from diabetes mellitus8 which is similar to our result. This results also correlates with the study of AM Hossain et al7 (21%) and with MR Siddique et al9(11%). This result also correlates with the study in India10. Framingham study has shown that 10-14.7% of the s ...
Intense pulsed light (IPL)
Intense pulsed light (IPL)

... smaller lesions, the use of a perforated plastic shield with varying aperture sizes may be helpful. An aperture matching the lesion to be treated allows a precise application of light [10]. If a melanocytic lesion is apparent within the treatment area, the nevus should be omitted from treatment or c ...
Toxicology expert questions General principles of toxicology
Toxicology expert questions General principles of toxicology

...  All patients given naloxone should be monitored for at least 2 hrs after the last dose Adverse drug effects  Nil significant in opioid naïve patients  Dose dependent withdrawal syndrome in opioid dependent patients  Reassurance, physical and chemical control of disturbed patient may be needed i ...
CMS Pulls the Trigger on COPD in 2015
CMS Pulls the Trigger on COPD in 2015

... with COPD, are unable to use their pMDIs and DPIs in an optimal manner. For such patients, nebulizers should be employed on a domiciliary basis. . . Nebulizers are more forgiving to poor inhalation technique, especially poor coordination with pMDIs and the requirement to generate adequate peak inspi ...
CHAPTER 19 - Pulmonary Rehabilitation
CHAPTER 19 - Pulmonary Rehabilitation

... Rehabilitation programs for patients with chronic obstructive pulmonary disease (COPD) have existed for more than 30 years. The American College of Chest Physicians in 1974 defined pulmonary rehabilitation and described aspects of care for patients with respiratory impairments. The American Thoracic ...
NUCLEAR MEDICINE: PET/CT in Gastrointestinal Malignancies
NUCLEAR MEDICINE: PET/CT in Gastrointestinal Malignancies

... Anal condylomata are related to infection with the human papilloma virus (HPV); patients with condylomata have an increased risk for anal cancer. Recent research suggests PET/CT alters the initial staging frequently enough that it should be used routinely in anal cancer when available. The real adva ...
Evidence for graft colonization with periodontal pathogens in lung
Evidence for graft colonization with periodontal pathogens in lung

... Abstract: Summary Bronchiolitis obliterans syndrome (BOS) is a major cause of late graft dysfunction in lung transplant recipients. There is increasing evidence that beside alloimmunologic injury also nonalloimmunologic inflammatory conditions may raise the risk of acute and chronic rejection. The o ...
Snímek 1
Snímek 1

Migraines suck
Migraines suck

... Renamed tension-type headaches by the International Headache Society in 1988, are the most common type of primary headaches.  The pain can radiate from the neck, back, eyes, or other muscle groups in the body.  Tension-type headaches account for nearly 90% of all headaches. Approximately 3% of the ...
Low Dose Naltrexone and Autoimmune Diseases: Emerging
Low Dose Naltrexone and Autoimmune Diseases: Emerging

... counteract the actions of these drugs. People on these medications after receiving an organ transplant should not take low dose naltrexone. People taking these medications for others reasons, such as rheumatoid arthritis, should weigh the benefits and risks with their doctors. ...
Regression of Nevi After Candida Injection for the Treatment of
Regression of Nevi After Candida Injection for the Treatment of

... Thus immune modulators including, Candida immunotherapy, are used to treat persistent recalcitrant and multiple verruca simultaneously. Observation: Very few serious side effects are reported with Candida immunotherapy including vitiligo and now halo nevi. Conclusions and Relevance: Physicians need ...
PDF - Charles River Associates
PDF - Charles River Associates

... Biogen asked Charles River Associates (CRA) to investigate the different factors that create barriers to patient access to multiple sclerosis (MS) treatments in Europe and to develop a set of credible recommendations to health policymakers at national and EU levels as well as national payers and cli ...
Treatment of Hepatitis B in Patients With Chronic Kidney Disease
Treatment of Hepatitis B in Patients With Chronic Kidney Disease

... It is a frequent infection in chronic kidney disease (CKD) patients. It negatively impacts long term outcomes reducing graft and patient survival. Current guidelines clearly define who will benefit from antiviral therapy; when to start; what is first-line therapy; how to monitor treatment response; ...
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Management of multiple sclerosis



Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS).The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable attacks (relapses) followed by periods of relative remission with no new signs of disease activity. After some years, many of the people who have this subtype begin to experience neurologic decline without acute relapses. When this happens it is called secondary progressive multiple sclerosis. Other, less common, courses of the disease are the primary progressive (decline from the beginning without attacks) and the progressive-relapsing (steady neurologic decline and superimposed attacks). Different therapies are used for patients experiencing acute attacks, for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a diagnosis of MS who have a demyelinating event, and for managing the various consequences of MS.The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. As with any medical treatment, medications used in the management of MS may have several adverse effects, and many possible therapies are still under investigation. At the same time different alternative treatments are pursued by many patients, despite the paucity of supporting, comparable, replicated scientific study.This article focuses on therapies for standard MS; borderline forms of MS have particular treatments that are excluded.
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