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Psoriasis
Psoriasis

... Clinical Pearl – Auspitz’s Sign • A patient presents with new onset of an erythematous, crusted, keratotic plaque on the left anterior thigh. Suspecting fungal disease, the PA scrapes the plaque with a #15 blade to collect scale for KOH microscopic exam. The dry, white scale is easily scraped away, ...
(ASAM) National Practice Guideline for the Use of Medications in the
(ASAM) National Practice Guideline for the Use of Medications in the

... pioid use disorder is a chronic, relapsing disease, which has significant economic, personal, and public health consequences. This ‘‘Practice Guideline’’ was developed to assist in the evaluation and treatment of opioid use disorder. Although there are existing guidelines for the treatment of opioid ...
Treatment of PTSD and comorbid symptoms in adult and elderly
Treatment of PTSD and comorbid symptoms in adult and elderly

... Resick, 2010). Research has found evidence for this model: exposure to multiple traumatic events, in contrast to a single traumatic event, exerts a greater negative impact to PTSD symptom severity, (Ogle et al., 2013b). Lonergan (2014) pointed out that having experienced multiple traumas is also as ...
Article Summaries
Article Summaries

... Cost of Uncompensated Care (Panel A), Number of Unauthorized Immigrants (Panel B), and Number of Uninsured People (Panel C) in the United States. The annual cost to U.S. hospitals of uncompensated care (charity care plus bad debt) has been rising, although the fraction of total hospital expenses rep ...
Trama Injection
Trama Injection

... Moderate to severe pain Posology and method of administration The injection is for parenteral administration either intramuscularly, by slow intravenous injection or, when diluted in solution, by infusion or patient controlled analgesia. As with all analgesic drugs the dosing of Trama Injection shou ...
Should N-acetylcysteine be administered orally or intravenously for
Should N-acetylcysteine be administered orally or intravenously for

... were identified and appraised. Results: One animal study and seven comparative clinical studies were identified and appraised. The quality of the evidence was generally poor, and there was no clear difference in outcomes between the two routes of administration. Conclusions: Without evidence of adva ...
Society for Vascular Surgery practice guidelines for atherosclerotic
Society for Vascular Surgery practice guidelines for atherosclerotic

... is placed on risk factor modification, medical therapies, and broader use of exercise programs to improve cardiovascular health and functional performance. Screening for PAD appears of unproven benefit at present. Revascularization for IC is an appropriate therapy for selected patients with disabling ...
Effectiveness and safety of leflunomide for pulmonary and extrapulmonary sarcoidosis
Effectiveness and safety of leflunomide for pulmonary and extrapulmonary sarcoidosis

... Leflunomide appears to facilitate reduction of steroid dose and can be considered as monotherapy or as add-on therapy in cases of progressive disease. KEYWORDS: Extrapulmonary, leflunomide, pulmonary, sarcoidosis, side-effects, toxicity ...
Pemphigus vulgaris - British Association of Dermatologists
Pemphigus vulgaris - British Association of Dermatologists

... existing ones - this is ‘disease control’. It usually takes about 2 to 3 weeks to stop new blisters coming up, and sometimes as long as 6 to 8 weeks for healing to be complete. Once control has been achieved, the dose of the medication will be reduced slowly to the lowest one needed to keep the pemp ...
YOUR GUIDE TO INFUSIONS WITH KANUMA™ (sebelipase alfa)
YOUR GUIDE TO INFUSIONS WITH KANUMA™ (sebelipase alfa)

... Patients with LAL-D are born with an important enzyme that is missing or not working properly. This enzyme, called lysosomal acid lipase (LAL), plays an important role in a key part of your body’s cells, called lysosomes, by breaking down fatty material. KANUMA helps to replace the LAL enzyme that i ...
Diagnosis, Prevention, and Management of Statin Adverse Effects
Diagnosis, Prevention, and Management of Statin Adverse Effects

... subtopics was identified for specific side effects and their management and a subsequent literature search was undertaken using online databases, including PubMed and Embase, to compile studies of relevance. Through the literature search, Canadian physicians who had either published in the area of s ...
Product Information for Everolimus
Product Information for Everolimus

... The overall survival results are not yet mature and no statistically significant difference in OS was noted (HR=0.99 (95% CI 0.68 to 1.43) in an updated analysis). Crossover of >74% of patients from placebo to open-label Afinitor following disease progression likely confounded the detection of any t ...
Outcomes of Direct Vision Internal Urethrotomy for Bulbar Urethral
Outcomes of Direct Vision Internal Urethrotomy for Bulbar Urethral

... In our series of patients treated with DVIU and high dose corticosteroid injections, we observed a recurrence rate of only 29% with an average follow-up of 20 month. DVIU with high dose steroids appears to be useful even in those who have had multiple prior interventions and those with longer bulbar ...
Treatment options in severe fungal asthma and allergic bronchopulmonary aspergillosis Richard B. Moss
Treatment options in severe fungal asthma and allergic bronchopulmonary aspergillosis Richard B. Moss

... due to pronounced host inflammatory responses to noninvasive subclinical endobronchial infection with filamentous fungi, usually Aspergillus fumigatus. These patients usually do not achieve satisfactory disease control with conventional treatment of severe asthma, i.e. high-dose inhaled corticostero ...
Product Information: Omalizumab (rch)
Product Information: Omalizumab (rch)

... beta-2-agonist. Eligible patients had experienced multiple asthma exacerbations requiring systemic corticosteroid treatment or had been hospitalised or attended an emergency room due to a severe asthma exacerbation in the past year despite continuous treatment with highdose inhaled corticosteroids a ...
Effects of deviating the Th2-response in murine mercury
Effects of deviating the Th2-response in murine mercury

... showed increasing mean levels of all PBA markers during the 3 weeks of Hg treatment (19–93%), and they were significantly different compared to Hg controls after 2 and 3 weeks (Tables 1 and 2). Treatment with Hg + a-IL-4 + rIL-12 increased the mean level of the PBA markers 40–72% during 3 weeks’ tre ...
Cystic Fibrosis Pulmonary Guidelines Chronic Medications for Maintenance of Lung Health
Cystic Fibrosis Pulmonary Guidelines Chronic Medications for Maintenance of Lung Health

- Language and Cognitive Neuroscience Laboratory
- Language and Cognitive Neuroscience Laboratory

... To account for this selectivity, Grodzinsky (1986, 1990) and others (Hickok, 1992; Mauner, Fromkin, & Cornell, 1993) have argued that the Broca's patients cannot represent traces and cannot, therefore, grammatically assign thematic roles to moved constituents. Faces with thematically unassigned phra ...
Asthma Management
Asthma Management

... – Minimal accumulation with multiple dosing • No dosage adjustments required based on: ...
1 PERCODAN® (Oxycodone and Aspirin Tablets, USP) CII Rx only
1 PERCODAN® (Oxycodone and Aspirin Tablets, USP) CII Rx only

... opioid effects include contraction of biliary tract smooth muscle, spasm of the Sphincter of Oddi, increased ureteral and bladder sphincter tone, and a reduction in uterine tone. Aspirin can produce gastrointestinal injury (lesions, ulcers) through a mechanism that is not yet completely understood, ...
A Framework for Mining Clinical Notes through
A Framework for Mining Clinical Notes through

... increase. CHF is a complex syndrome with multiple pathophysiological manifestations that frequently overlap with those of other diseases, making early diagnosis challenging. Thus it is usually diagnosed in primary care, often as a late stage disease. In order to increase the chance of early diagnosi ...
Neurological Emergencies
Neurological Emergencies

... CN AND Cerebellar deficits that affect BOTH sides of the body, with contralateral pain and temperature deficits. ...
Tinnitus Press Release About Neuromonics
Tinnitus Press Release About Neuromonics

... cases are preceded by hearing loss, neurological factors often contribute to the deterioration in symptoms. First, the brain attempts to compensate for the hearing loss by “turning up” sounds internally. Ultimately a psychological component emerges, when the sufferer develops a “fight-or-flight” str ...
Drugs 2012
Drugs 2012

... should be instituted before 2 months of age at an oral dose of 125 mg twice daily. The dose should be increased to 250 mg twice daily at age 3 years to account for physical growth of the child. Routine prophylactic penicillin coupled with immunization against Streptococcus pneumoniae, with both the ...
SAN FRANCISCO CITY CLINIC CLINICAL PROTOCOLS SEXUALLY TRANSMITTED DISEASES
SAN FRANCISCO CITY CLINIC CLINICAL PROTOCOLS SEXUALLY TRANSMITTED DISEASES

... 1. Clotrimazole 1% cream twice daily x 7-14 days 2. Miconazole 2% cream twice daily x 7-14 days 3. Tolnaftate (tinactin) 1% cream twice daily x 7-14 days All are available without prescription. Creams should be applied in a thin layer twice a day until balanitis has resolved. Most cases should resol ...
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Management of multiple sclerosis



Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS).The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable attacks (relapses) followed by periods of relative remission with no new signs of disease activity. After some years, many of the people who have this subtype begin to experience neurologic decline without acute relapses. When this happens it is called secondary progressive multiple sclerosis. Other, less common, courses of the disease are the primary progressive (decline from the beginning without attacks) and the progressive-relapsing (steady neurologic decline and superimposed attacks). Different therapies are used for patients experiencing acute attacks, for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a diagnosis of MS who have a demyelinating event, and for managing the various consequences of MS.The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. As with any medical treatment, medications used in the management of MS may have several adverse effects, and many possible therapies are still under investigation. At the same time different alternative treatments are pursued by many patients, despite the paucity of supporting, comparable, replicated scientific study.This article focuses on therapies for standard MS; borderline forms of MS have particular treatments that are excluded.
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