Efficacy of romiplostim in patients with chronic immune
... has been shown to increase platelet counts in most patients with chronic ITP. We assessed the long-term administration of romiplostim in splenectomised and non-splenectomised patients with ITP. Methods In two parallel trials, 63 splenectomised and 62 non-splenectomised patients with ITP and a mean o ...
... has been shown to increase platelet counts in most patients with chronic ITP. We assessed the long-term administration of romiplostim in splenectomised and non-splenectomised patients with ITP. Methods In two parallel trials, 63 splenectomised and 62 non-splenectomised patients with ITP and a mean o ...
Case Reports Cancer
... standard combination of 3 drugs. After 6 weeks of chemotherapy the patient felt sick. According to the child´s own words it was as if the disease had not subsided. Leukocyte values during this period were between 6- 9 g/L. After evaluating the clinical condition of the patient, chemotherapy was modi ...
... standard combination of 3 drugs. After 6 weeks of chemotherapy the patient felt sick. According to the child´s own words it was as if the disease had not subsided. Leukocyte values during this period were between 6- 9 g/L. After evaluating the clinical condition of the patient, chemotherapy was modi ...
Nortriptyline NRIM
... Patients of any age with Major Depressive Disorder may experience worsening of their depression and/or the emergence of suicidal ideation and behaviour (suicidality), whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs. Patients sho ...
... Patients of any age with Major Depressive Disorder may experience worsening of their depression and/or the emergence of suicidal ideation and behaviour (suicidality), whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs. Patients sho ...
Alternative Headache Treatments: Nutraceuticals, Behavioral and
... These results were supported by a study36 that showed low total magnesium in erythrocytes and low ionized magnesium in lymphocytes in migraine patients, both of which increased significantly after a 2-week trial of drinking mineral water containing 110 mg/L magnesium. Given its commercial availabili ...
... These results were supported by a study36 that showed low total magnesium in erythrocytes and low ionized magnesium in lymphocytes in migraine patients, both of which increased significantly after a 2-week trial of drinking mineral water containing 110 mg/L magnesium. Given its commercial availabili ...
Treatment of Hepatitis C in Patients with Renal
... Peginterferon and Ribavirin-Based Therapy in Patients with Renal Disease: Renal insufficiency, regardless of the cause, has created problems with the use of peginterferon and ribavirin therapy for HCV, since the kidney plays a role in the catabolism and filtration of both interferon and ribavirin. W ...
... Peginterferon and Ribavirin-Based Therapy in Patients with Renal Disease: Renal insufficiency, regardless of the cause, has created problems with the use of peginterferon and ribavirin therapy for HCV, since the kidney plays a role in the catabolism and filtration of both interferon and ribavirin. W ...
The Clinical Approach to Lung Disease in Patients with Cystic Fibrosis
... multicenter trial in Canada enrolled patients between 6 and 18 years of age with mild lung disease.54 In this study there was no significant impact of ibuprofen therapy on the primary end point, FEV1, although the ibuprofen-treated group spent fewer days in the hospital (1.8 vs 4.1 days/year). In ne ...
... multicenter trial in Canada enrolled patients between 6 and 18 years of age with mild lung disease.54 In this study there was no significant impact of ibuprofen therapy on the primary end point, FEV1, although the ibuprofen-treated group spent fewer days in the hospital (1.8 vs 4.1 days/year). In ne ...
Spasticity care pathway - Keep in touch with the MS Trust
... Physiotherapists can carry out specific treatments to assist an individual to manage their spasticity and can also recommend appropriate stretching, splinting and standing programmes3. ...
... Physiotherapists can carry out specific treatments to assist an individual to manage their spasticity and can also recommend appropriate stretching, splinting and standing programmes3. ...
What is Hereditary Angioedema?
... Anabolic steroids (also known as androgens) such as danazol, oxandrolone and stanozolol have, historically, been the most commonly prescribed preventive HAE therapies. While anabolic steroids have been shown to be useful, they are not well-tolerated by many women, directly linked to liver toxicity a ...
... Anabolic steroids (also known as androgens) such as danazol, oxandrolone and stanozolol have, historically, been the most commonly prescribed preventive HAE therapies. While anabolic steroids have been shown to be useful, they are not well-tolerated by many women, directly linked to liver toxicity a ...
Central Nervous System Neurodegeneration and Tinnitus
... flow to a part of the brain, results in interference in function of the involved regions in the brain. Ischemic stroke is reported to be responsible for approximately 90% of strokes. Pathophysiologically, the reduced oxygen supply to affected neurons in brain cells results in an ischemic core surrou ...
... flow to a part of the brain, results in interference in function of the involved regions in the brain. Ischemic stroke is reported to be responsible for approximately 90% of strokes. Pathophysiologically, the reduced oxygen supply to affected neurons in brain cells results in an ischemic core surrou ...
Guideline on the development of new medicinal products for
... using this methodology incurs substantial complexity. Similarly, when active comparators are used, potentially nonsensical treatment regimens may be necessary to maintain study blinding in randomized withdrawal designs. We believe comparison to SOC in both induction and in maintenance may be best ac ...
... using this methodology incurs substantial complexity. Similarly, when active comparators are used, potentially nonsensical treatment regimens may be necessary to maintain study blinding in randomized withdrawal designs. We believe comparison to SOC in both induction and in maintenance may be best ac ...
Guidelines for the Management of Adult HIV Infection with
... however, monitoring should take place at 4, 8, 12 and 24 weeks after ART initiation and should subsequently be performed every 4-6 months once the patient has been stabilized on therapy. At each visit, monitoring need to be complimented by assessment of treatment side effects and adherence. Table 2 ...
... however, monitoring should take place at 4, 8, 12 and 24 weeks after ART initiation and should subsequently be performed every 4-6 months once the patient has been stabilized on therapy. At each visit, monitoring need to be complimented by assessment of treatment side effects and adherence. Table 2 ...
Press Release - American Epilepsy Society
... of another seizure is greatest within the first two years. The risk ranges from about a one-in-five chance, or 21 percent, to nearly a one-in-two chance, or 45 percent. The guideline also found strong evidence that the risk of a second seizure is greatest in people with a previous brain problem, suc ...
... of another seizure is greatest within the first two years. The risk ranges from about a one-in-five chance, or 21 percent, to nearly a one-in-two chance, or 45 percent. The guideline also found strong evidence that the risk of a second seizure is greatest in people with a previous brain problem, suc ...
AMERICAN ACADEMY OF PEDIATRICS Use of Codeine
... which may contain up to 25% alcohol by volume.3 The over-the-counter availability of numerous cough and cold preparations promotes the perception that such medications are safe and efficacious. Although codeine and dextromethorphan are efficacious for cough suppression in adults,1 similar efficacy h ...
... which may contain up to 25% alcohol by volume.3 The over-the-counter availability of numerous cough and cold preparations promotes the perception that such medications are safe and efficacious. Although codeine and dextromethorphan are efficacious for cough suppression in adults,1 similar efficacy h ...
Guidelines for the use of thyroid function tests
... of hyperthyroidism and should be interpreted in the context of clinical symptoms and signs to direct first-line therapy Assessing Response to Therapy Serum FT4 and TSH should be measured in all patients receiving thionamides. In most cases the FT4 result will be the marker of choice to guide thera ...
... of hyperthyroidism and should be interpreted in the context of clinical symptoms and signs to direct first-line therapy Assessing Response to Therapy Serum FT4 and TSH should be measured in all patients receiving thionamides. In most cases the FT4 result will be the marker of choice to guide thera ...
Bisphosphonate – Related Osteonecrois
... Your medical/dental history is very important. We must ___ 2. know the medications and drugs that you have received or taken before, before, and are receiving or taking now. A correct medical history, including including names of physicians is important. The decision to stop oral Bisphosphonate dru ...
... Your medical/dental history is very important. We must ___ 2. know the medications and drugs that you have received or taken before, before, and are receiving or taking now. A correct medical history, including including names of physicians is important. The decision to stop oral Bisphosphonate dru ...
Late Breaking Clinical Trials The Lancet - ERA
... Chronic infection with the hepatitis-C virus (HCV) can be both a cause and a potential complication of chronic kidney disease. One major problem is that only limited options are available for treating HCV infection in patients with advanced kidney disease. Medications such as Sofosbuvir can only be ...
... Chronic infection with the hepatitis-C virus (HCV) can be both a cause and a potential complication of chronic kidney disease. One major problem is that only limited options are available for treating HCV infection in patients with advanced kidney disease. Medications such as Sofosbuvir can only be ...
MTHFR 2 Mutations Indications for Ordering Clinical Background
... reductase C677T homozygosity among leukemia patients intolerant to methotrexate. Ann Oncol 2002;13:1915–8. Donnelly JG. Pharmacogenetics in cancer chemotherapy: balancing toxicity and response. Ther Drug Monit 2004; ...
... reductase C677T homozygosity among leukemia patients intolerant to methotrexate. Ann Oncol 2002;13:1915–8. Donnelly JG. Pharmacogenetics in cancer chemotherapy: balancing toxicity and response. Ther Drug Monit 2004; ...
Review Nicola Petrosillo , Maddalena
... selecting resistant subpopulations that later breakthrough in the patient with untreatable levels of resistance. These risks are magnified in patients who do not receive timely (early) effective treatment for CR-KP, allowing progression to a higher inoculum. Consequently, contemporary dosing strateg ...
... selecting resistant subpopulations that later breakthrough in the patient with untreatable levels of resistance. These risks are magnified in patients who do not receive timely (early) effective treatment for CR-KP, allowing progression to a higher inoculum. Consequently, contemporary dosing strateg ...
Management of Difficult-to-Treat Atopic Dermatitis
... incorporated into topical medication,18 and even some halogenated corticosteroids (hydrocortisone-17-butyrate and betamethasone-17-valerate).19 Patients who report that the ointment or more often cream makes their AD flare should be considered for a period of avoidance and patch testing. Patch testin ...
... incorporated into topical medication,18 and even some halogenated corticosteroids (hydrocortisone-17-butyrate and betamethasone-17-valerate).19 Patients who report that the ointment or more often cream makes their AD flare should be considered for a period of avoidance and patch testing. Patch testin ...
Consensus guidelines for the safe prescription and administration of
... available in the UK are summarised in online appendix 2. Polyethylene glycols (also known as PEG or macrogols) are nonabsorbable iso-osmotic solutions, which pass through the bowel without net absorption or secretion. Significant fluid and electrolyte shifts are therefore attenuated. Moviprep contains ...
... available in the UK are summarised in online appendix 2. Polyethylene glycols (also known as PEG or macrogols) are nonabsorbable iso-osmotic solutions, which pass through the bowel without net absorption or secretion. Significant fluid and electrolyte shifts are therefore attenuated. Moviprep contains ...
Adult antiretroviral therapy guidelines 2014
... These goals are achieved by suppressing viral replication completely for as long as possible, using well-tolerated and sustainable treatment taken with good adherence. With prolonged viral suppression, the CD4+ lymphocyte count usually increases, which is accompanied by a restoration of pathogen-spe ...
... These goals are achieved by suppressing viral replication completely for as long as possible, using well-tolerated and sustainable treatment taken with good adherence. With prolonged viral suppression, the CD4+ lymphocyte count usually increases, which is accompanied by a restoration of pathogen-spe ...
Peptic Ulcer Disease: Introduction
... the upper abdomen and may descend into the lower abdomen or pelvis on standing. The duodenum extends from the pylorus to the ligament of Treitz in a sharp curve that almost completes a circle. It is so named because it is about equal in length to the breadth of 12 fingers, or about 25 cm. It is larg ...
... the upper abdomen and may descend into the lower abdomen or pelvis on standing. The duodenum extends from the pylorus to the ligament of Treitz in a sharp curve that almost completes a circle. It is so named because it is about equal in length to the breadth of 12 fingers, or about 25 cm. It is larg ...
26.2.16 download.xml - James Lind Alliance
... Uncertainties identified from 22 patients, 9 carers and 9 clinicians This is an indicative uncertainty and several submissions were merged to form this one. Uncertainties identified from 2 carers and 2 ...
... Uncertainties identified from 22 patients, 9 carers and 9 clinicians This is an indicative uncertainty and several submissions were merged to form this one. Uncertainties identified from 2 carers and 2 ...
Management of multiple sclerosis
Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS).The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable attacks (relapses) followed by periods of relative remission with no new signs of disease activity. After some years, many of the people who have this subtype begin to experience neurologic decline without acute relapses. When this happens it is called secondary progressive multiple sclerosis. Other, less common, courses of the disease are the primary progressive (decline from the beginning without attacks) and the progressive-relapsing (steady neurologic decline and superimposed attacks). Different therapies are used for patients experiencing acute attacks, for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a diagnosis of MS who have a demyelinating event, and for managing the various consequences of MS.The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. As with any medical treatment, medications used in the management of MS may have several adverse effects, and many possible therapies are still under investigation. At the same time different alternative treatments are pursued by many patients, despite the paucity of supporting, comparable, replicated scientific study.This article focuses on therapies for standard MS; borderline forms of MS have particular treatments that are excluded.