![Biosteres and You](http://s1.studyres.com/store/data/008281610_1-1d3431f8108ff3b2b604e18cd968c001-300x300.png)
Biosteres and You
... They are therefore subject to rapid clearance from the body. Once absorbed they can establish strong ionic bonds with the basic amino ...
... They are therefore subject to rapid clearance from the body. Once absorbed they can establish strong ionic bonds with the basic amino ...
File
... • Many of these genetic or hereditary factors are responsible for the large differences seen in the rate of metabolism of these drugs. •Example: Isoniazid - N-acetyltransferase O ...
... • Many of these genetic or hereditary factors are responsible for the large differences seen in the rate of metabolism of these drugs. •Example: Isoniazid - N-acetyltransferase O ...
How can we use this information to improve
... area of small molecule therapeutic discovery. The goal is to create a comprehensive in silico drug discovery pipeline to increase the odds of initial preclinical hits and leads leading to significantly better outcomes downstream in the clinic. The knowledge-based drug discovery pipeline will adopt a ...
... area of small molecule therapeutic discovery. The goal is to create a comprehensive in silico drug discovery pipeline to increase the odds of initial preclinical hits and leads leading to significantly better outcomes downstream in the clinic. The knowledge-based drug discovery pipeline will adopt a ...
with HIV-neutralizing monoclonal antibodies
... PG9: conformational epitope on gp120 (Science, 2009) VRC01: CD4-binding site on gp120 (Science, 2010) PRO140: anti-CCR5 (anti-co-receptor) Ibalizumab: anti-CD4 (anti-receptor) ...
... PG9: conformational epitope on gp120 (Science, 2009) VRC01: CD4-binding site on gp120 (Science, 2010) PRO140: anti-CCR5 (anti-co-receptor) Ibalizumab: anti-CD4 (anti-receptor) ...
FinMedChem2011
... endogenous cathecolamines epinephrine and norepinephrine. In the central nervous system they modulate a wide variety of physiological functions such as arousal, attention, learning and memory. Historically, the adrenergic receptor family has been divided to α1-adrenoceptors, α2adrenoceptors and β1-a ...
... endogenous cathecolamines epinephrine and norepinephrine. In the central nervous system they modulate a wide variety of physiological functions such as arousal, attention, learning and memory. Historically, the adrenergic receptor family has been divided to α1-adrenoceptors, α2adrenoceptors and β1-a ...
Ramipril - Developing Anaesthesia
... Breast feeding: 4 There have been no reports following the use ramipril during breastfeeding, and the effects on the breastfed infant are unknown. Consider an alternative medicine where possible. Shorter acting angiotensin converting enzyme (ACE) inhibitors such as captopril or enalapril are preferr ...
... Breast feeding: 4 There have been no reports following the use ramipril during breastfeeding, and the effects on the breastfed infant are unknown. Consider an alternative medicine where possible. Shorter acting angiotensin converting enzyme (ACE) inhibitors such as captopril or enalapril are preferr ...
enzymes lecture 3
... Many enzymes depend on free sulphahydryl group for its activity. Inhibition of this group leads to loss of the enzyme activity. ...
... Many enzymes depend on free sulphahydryl group for its activity. Inhibition of this group leads to loss of the enzyme activity. ...
Respiratory Drugs 2 - Suny-perfusion
... • Headache is the most frequently reported adverse effect. There are also a few reports of liver toxicity (elevated liver enzymes) with this drug. ...
... • Headache is the most frequently reported adverse effect. There are also a few reports of liver toxicity (elevated liver enzymes) with this drug. ...
Newer Antihypertensive Drugs
... Uniquely lowers PRA in monotherapy and combination Effective and sustained monotherapy Additional BP lowering when combined with other antihypertensives Sustained 24-hour BP control with prolonged effect after withdrawal Placebo-like safety and tolerability profile Potential for improved end-organ p ...
... Uniquely lowers PRA in monotherapy and combination Effective and sustained monotherapy Additional BP lowering when combined with other antihypertensives Sustained 24-hour BP control with prolonged effect after withdrawal Placebo-like safety and tolerability profile Potential for improved end-organ p ...
Antimycobacterial drugs
... Never use a single drug therapy –rifampicin combination administered for 9 months will cure 95-98% of cases . Addition of pyrazinamide for this combination for the first 2 months allows total duration to be reduced to 6 months. Isoniazid ...
... Never use a single drug therapy –rifampicin combination administered for 9 months will cure 95-98% of cases . Addition of pyrazinamide for this combination for the first 2 months allows total duration to be reduced to 6 months. Isoniazid ...
Access of the substrate to the active site of squalene and
... substrate specificity of OSCs (which transform only oxidosqualene) compared with SHCs (which transform both squalene and oxidosqualene) [3] due to the ability of the lipophilic channel of OSCs to reject the squalene nonepoxide before entrance into the active-site cavity, or does the rejection occur ...
... substrate specificity of OSCs (which transform only oxidosqualene) compared with SHCs (which transform both squalene and oxidosqualene) [3] due to the ability of the lipophilic channel of OSCs to reject the squalene nonepoxide before entrance into the active-site cavity, or does the rejection occur ...
Psychopharmacology of Mood Disorders
... – similar safety and side effect profile to SSRI’s – so-called dual action purported to be more effective – limited evidence from meta-analyses of superior efficacy vs. SSRI’s ...
... – similar safety and side effect profile to SSRI’s – so-called dual action purported to be more effective – limited evidence from meta-analyses of superior efficacy vs. SSRI’s ...
Pharmacokinetics - Christopher Hobbs
... – Inhibition of CYP3A4 is irreversible and it can last for longer than 3 days after ingestion of grape fruit juice until new enzyme has been synthesized in the gut wall (Pirmohamed 2013) ...
... – Inhibition of CYP3A4 is irreversible and it can last for longer than 3 days after ingestion of grape fruit juice until new enzyme has been synthesized in the gut wall (Pirmohamed 2013) ...
Lecture6- GENERAL PHARMACOLOGY
... Define the major phase I and phase II metabolic reactions. Describe the modulation of liver microsomal enzymes by inducers and inhibitors Mention two drugs that are known as enzyme inducers and ...
... Define the major phase I and phase II metabolic reactions. Describe the modulation of liver microsomal enzymes by inducers and inhibitors Mention two drugs that are known as enzyme inducers and ...
Poster
... • Lungs are very sensitive to radiation: doses of radiation to cancer patients are limited by the damage to the normal lung surrounding a tumor. • Radiation from a nuclear accident or terrorist event can injure sensitive lung tissue: can we find an effective treament? • Research using angiotensin co ...
... • Lungs are very sensitive to radiation: doses of radiation to cancer patients are limited by the damage to the normal lung surrounding a tumor. • Radiation from a nuclear accident or terrorist event can injure sensitive lung tissue: can we find an effective treament? • Research using angiotensin co ...
pharm 22 A [4-20
... 24. What is recombinant activated protein C (r-APC) indicated for? 4 thrombolytic agents? a. septic shock w/ evidence of organ dysfxn, shock, acidosis, etc b. streptokinase, recombinant t-PA, tenecteplase, reteplase 25. 2 limitations of streptokinase? What is it approved for? What is alteplase appro ...
... 24. What is recombinant activated protein C (r-APC) indicated for? 4 thrombolytic agents? a. septic shock w/ evidence of organ dysfxn, shock, acidosis, etc b. streptokinase, recombinant t-PA, tenecteplase, reteplase 25. 2 limitations of streptokinase? What is it approved for? What is alteplase appro ...
AntiGout and DMARDs
... 2. Uricosuric drugs act by affecting the active transports so that the net reabsorption of uric acid will be ↓ 3. This will lead to a. ↓size of urate pool b. ↑uric acid excretion c. BUT plasma concentration may not be greatly ↓ 4. Due to massive excretion of uric acid through urine, renal stone form ...
... 2. Uricosuric drugs act by affecting the active transports so that the net reabsorption of uric acid will be ↓ 3. This will lead to a. ↓size of urate pool b. ↑uric acid excretion c. BUT plasma concentration may not be greatly ↓ 4. Due to massive excretion of uric acid through urine, renal stone form ...
Peptidomimetic Therapeutic Agents Targeting the
... to mutations conferring viral resistance to treatment. The predominant mutations raised by compound 10 are on residue Val-82, which interacts primarily with the P3 moiety. A strategy that was employed by Abbott in designing their second generation drug was to select compounds with a smaller P3 than ...
... to mutations conferring viral resistance to treatment. The predominant mutations raised by compound 10 are on residue Val-82, which interacts primarily with the P3 moiety. A strategy that was employed by Abbott in designing their second generation drug was to select compounds with a smaller P3 than ...
L04 Cannabinoids Part 1 Medicinal Plants
... more than 500 million people worldwide, it was spread in Vietnam War in 1970s and before, it was widely used because of its euphoric characteristics. It’s not legitimate to use Cannabis sativa in the majority of countries with the exception of some European countries where it’s not illegal to have C ...
... more than 500 million people worldwide, it was spread in Vietnam War in 1970s and before, it was widely used because of its euphoric characteristics. It’s not legitimate to use Cannabis sativa in the majority of countries with the exception of some European countries where it’s not illegal to have C ...
Characterization of Membrane Components of the Erythrocyte
... analysis of these molecules showed that phosphatidylinositol, phosphatidylserine and GM3 ganglioside were responsible for the inhibitory activity and could therefore represent VSV binding sites on goose erythrocyte membranes. Removal of negatively charged groups from these molecules by enzymic treat ...
... analysis of these molecules showed that phosphatidylinositol, phosphatidylserine and GM3 ganglioside were responsible for the inhibitory activity and could therefore represent VSV binding sites on goose erythrocyte membranes. Removal of negatively charged groups from these molecules by enzymic treat ...
11.02 Community Acquired Pneumonia
... ▪ Newer macrolides (clarithromycin, azithromycin) have a better coverage of H. influenzae. But there are wide spread resistance among the common Gram-positive bacteria including MSSA, Pneumococcus, Group A Streptococcus. ▪ not be used as single empirical treatment of CAP and soft tissue infections t ...
... ▪ Newer macrolides (clarithromycin, azithromycin) have a better coverage of H. influenzae. But there are wide spread resistance among the common Gram-positive bacteria including MSSA, Pneumococcus, Group A Streptococcus. ▪ not be used as single empirical treatment of CAP and soft tissue infections t ...
Slide 1
... Reduce LDL cholesterol by 18-55% Decrease TG by 7-30% Raise HDL cholesterol by 5-15% Statins are the most effective in lowering LDL cholesterol Statins are the most effective in patient who has low HDL and high LDL ...
... Reduce LDL cholesterol by 18-55% Decrease TG by 7-30% Raise HDL cholesterol by 5-15% Statins are the most effective in lowering LDL cholesterol Statins are the most effective in patient who has low HDL and high LDL ...
R-Lipoic Acid (stabilized)
... its absorption significantly. In real-time stability tests, sodium R-lipoic remained stable for 12 months. The natural R isomer of alpha-lipoic acid may provide enhanced antioxidant activity, energy production, and general metabolic function.* ...
... its absorption significantly. In real-time stability tests, sodium R-lipoic remained stable for 12 months. The natural R isomer of alpha-lipoic acid may provide enhanced antioxidant activity, energy production, and general metabolic function.* ...
Pharmacology PowerPoint
... Cox-1 & Cox-2, with a slightly greater inhibition of Cox-1 enzyme – Slight anti-coagulant ...
... Cox-1 & Cox-2, with a slightly greater inhibition of Cox-1 enzyme – Slight anti-coagulant ...