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Antidepressant agents - به سامانه مديريت
... only as new enzyme is biosynthesized) Have a rapid rate of elimination, excess drug is rapidly metabolized Inhibition occurs slowly Ex: phenelzine ,tranylcypomine, isocarboxazid ...
... only as new enzyme is biosynthesized) Have a rapid rate of elimination, excess drug is rapidly metabolized Inhibition occurs slowly Ex: phenelzine ,tranylcypomine, isocarboxazid ...
eprint_1_30658_130
... The symptoms of depression are intense feelings of sadness, hopelessness, and despair, as well as the inability to experience pleasure in usual activities, changes in sleep patterns and appetite, loss of energy, and suicidal thoughts. Mechanism of Antidepressant Drugs:Most clinically useful antidepr ...
... The symptoms of depression are intense feelings of sadness, hopelessness, and despair, as well as the inability to experience pleasure in usual activities, changes in sleep patterns and appetite, loss of energy, and suicidal thoughts. Mechanism of Antidepressant Drugs:Most clinically useful antidepr ...
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... Twenty male albino rats were purchased from the Biochemistry Department of the University of Nigeria Nsukka and were transported down to Abakaliki to the Biochemistry Laboratory of Ebonyi State University. Collection of Drug Sample Orphenadol drug was bought from Chris Pharmacy, Onitsha, Anambra Sta ...
... Twenty male albino rats were purchased from the Biochemistry Department of the University of Nigeria Nsukka and were transported down to Abakaliki to the Biochemistry Laboratory of Ebonyi State University. Collection of Drug Sample Orphenadol drug was bought from Chris Pharmacy, Onitsha, Anambra Sta ...
Biological Activity of Withanolides
... above which the slope ~ the curve decreased . The ED50 was 33mglkg. Repeated administration of W A showed significant growth inhibitory and cytocidal effects on EAC. A total dose of 40 mg/kg. in 8 fraction (5 X 8mglkg. ) or a total dose of 60mg/kg. in 8 fraction (7 .5 X 8mglkg.) starting from 24 h. ...
... above which the slope ~ the curve decreased . The ED50 was 33mglkg. Repeated administration of W A showed significant growth inhibitory and cytocidal effects on EAC. A total dose of 40 mg/kg. in 8 fraction (5 X 8mglkg. ) or a total dose of 60mg/kg. in 8 fraction (7 .5 X 8mglkg.) starting from 24 h. ...
Tamsin D Tamsulosin Hydrochloride USP 0.4 mg and
... Phosphodiesterase-5 Inhibitors (PDE-5 Inhibitors): Caution is advised when alpha adrenergic antagonist-containing products, including this product, are coadministered with PDE-5 inhibitors. Alpha adrenergic antagonists and PDE-5 inhibitors are both vasodilators that can lower blood pressure. Concomi ...
... Phosphodiesterase-5 Inhibitors (PDE-5 Inhibitors): Caution is advised when alpha adrenergic antagonist-containing products, including this product, are coadministered with PDE-5 inhibitors. Alpha adrenergic antagonists and PDE-5 inhibitors are both vasodilators that can lower blood pressure. Concomi ...
Selected module tests in Pharmacology
... structure is convenient for creating computer programs. The questions in the tests and the possible answers were chosen after careful assessment. Every test module consists of 25 questions. Every question has four possible answers (and 1–3 correct answers). Correct answers should be crossed out with ...
... structure is convenient for creating computer programs. The questions in the tests and the possible answers were chosen after careful assessment. Every test module consists of 25 questions. Every question has four possible answers (and 1–3 correct answers). Correct answers should be crossed out with ...
EGFR TYROSINE KINASE TARGETED COMPOUNDS: IN VITRO
... aimed at further exploration of the SAR of this novel template, led to the discovery of highly selective compounds that target EGFR. Benzothiazoles act via competing with ATP for binding at the catalytic domain of EGFR-TK (Noolvi et al., 2012). The characteristic features of ATP binding site are; ad ...
... aimed at further exploration of the SAR of this novel template, led to the discovery of highly selective compounds that target EGFR. Benzothiazoles act via competing with ATP for binding at the catalytic domain of EGFR-TK (Noolvi et al., 2012). The characteristic features of ATP binding site are; ad ...
Amino Acids, Proteins, and Enzymes
... - the active site is flexible, not rigid - the shapes of the enzyme, active site, and substrate adjust to maximumize the fit, which improves catalysis - there is a greater range of substrate specificity • This model is more consistent with a wider range of enzymes ...
... - the active site is flexible, not rigid - the shapes of the enzyme, active site, and substrate adjust to maximumize the fit, which improves catalysis - there is a greater range of substrate specificity • This model is more consistent with a wider range of enzymes ...
Antidepressant_agents
... Has potential for serious side effects and potentially fatal interactions with other drugs and food MAO is one of two enzymes that break down neurotransmitters 5-HT and NE Two types MAO-A: inhibition causes antidepressant activity MAO-B: inhibition causes side effects ...
... Has potential for serious side effects and potentially fatal interactions with other drugs and food MAO is one of two enzymes that break down neurotransmitters 5-HT and NE Two types MAO-A: inhibition causes antidepressant activity MAO-B: inhibition causes side effects ...
Viral Binding and Fusion—The Next Targets in - IAS-USA
... Characteristics of HIV Binding and Fusion It has long been recognized that HIV entry into susceptible cells involves the interaction of CD4 molecules on the host cell surface with the HIV envelope glycoproteins gp120 and gp41. More recently, it was found that interaction of the virus with coreceptor ...
... Characteristics of HIV Binding and Fusion It has long been recognized that HIV entry into susceptible cells involves the interaction of CD4 molecules on the host cell surface with the HIV envelope glycoproteins gp120 and gp41. More recently, it was found that interaction of the virus with coreceptor ...
Susceptibility of coxsackievirus B3 laboratory strains and clinical
... canyon. At the base of the canyon, a surface-accessible hydrophobic pocket has been found within VP1. This pocket may be occupied by a pocket factor, which is suggested to be a lipid or a fatty acid. According to the hypothesis of Rossmann et al.,12 specific cell surface molecules, the receptors, in ...
... canyon. At the base of the canyon, a surface-accessible hydrophobic pocket has been found within VP1. This pocket may be occupied by a pocket factor, which is suggested to be a lipid or a fatty acid. According to the hypothesis of Rossmann et al.,12 specific cell surface molecules, the receptors, in ...
Non Steroidal Anti-inflammatory Drugs (NSAIDs)
... Diclofenac • Short half life (1‐2 hrs), high 1st pass metab., accumulates in synovial fluid after oral admn.. • GI S/E : in about 20% pt. Severe effects like GI distress, GI bleeding, gastric ulceration less frequent than other NSAIDs and similar to celecoxib. • High doses impairs renal functio ...
... Diclofenac • Short half life (1‐2 hrs), high 1st pass metab., accumulates in synovial fluid after oral admn.. • GI S/E : in about 20% pt. Severe effects like GI distress, GI bleeding, gastric ulceration less frequent than other NSAIDs and similar to celecoxib. • High doses impairs renal functio ...
Pore-Exposed Tyrosine Residues of P
... et al., 1999). Tyrosine residues are known to play a pivotal role for molecular recognition in biological systems, including domain interfaces and active site interactions. Tyrosines are amphipathic residues, capable of forming hydrophobic, hydrogenbonding, p-p, and p-cation interactions. They were ...
... et al., 1999). Tyrosine residues are known to play a pivotal role for molecular recognition in biological systems, including domain interfaces and active site interactions. Tyrosines are amphipathic residues, capable of forming hydrophobic, hydrogenbonding, p-p, and p-cation interactions. They were ...
Scytovirin and Ebola virus glycoprotein: possible antiviral
... effective drug and vaccine. Searching for the new antiviral drug is the hope for management of the infection. There are many ongoing researches on finding of new antiviral drugs against Ebola virus [3]. Of several potential drug candidates, scytovirin is an interesting biomolecule. The antiviral act ...
... effective drug and vaccine. Searching for the new antiviral drug is the hope for management of the infection. There are many ongoing researches on finding of new antiviral drugs against Ebola virus [3]. Of several potential drug candidates, scytovirin is an interesting biomolecule. The antiviral act ...
Prof. Kamakaka`s Lecture 6 Notes
... •Entorpy reduction- holds substrates in proper position Bringing two reactants in close proximity (reduce entropy & increase effective reactant concentrat) •Substrate is desatbilized when bound to enzyme favoring reaction-(change of solvent, chargecharge interactions strain on chemical bonds). •Deso ...
... •Entorpy reduction- holds substrates in proper position Bringing two reactants in close proximity (reduce entropy & increase effective reactant concentrat) •Substrate is desatbilized when bound to enzyme favoring reaction-(change of solvent, chargecharge interactions strain on chemical bonds). •Deso ...
Sheet#14,Dr.Alia,Rawan Majali
... If G-receptors on g-cells is activated, then gastrin is released, and it will bind to g-receptors on parietal cells and increase acid secretion. Another type of cells found in the stomach, are the D-cells, these secrete somatostatin. Somatostatin is a regulator of gastrin release; it inhibits gastri ...
... If G-receptors on g-cells is activated, then gastrin is released, and it will bind to g-receptors on parietal cells and increase acid secretion. Another type of cells found in the stomach, are the D-cells, these secrete somatostatin. Somatostatin is a regulator of gastrin release; it inhibits gastri ...
Vanadium(V) complexes in enzyme systems: aqueous chemistry
... while in LAR the arginine and aspartate locations are occupied by alanine and asparagine, respectively. The potential for use of these surface elements in the development of selective inhibitors of greatly enhanced potency can then be addressed in a systematic manner. Since the full power of organic ...
... while in LAR the arginine and aspartate locations are occupied by alanine and asparagine, respectively. The potential for use of these surface elements in the development of selective inhibitors of greatly enhanced potency can then be addressed in a systematic manner. Since the full power of organic ...
CVS 5
... Low dose: prevent incidence of MI and recurrence SE; GI disturbance, Bleeding Time prolonged. ...
... Low dose: prevent incidence of MI and recurrence SE; GI disturbance, Bleeding Time prolonged. ...
Lec 8
... • Drugs which are too polar or strongly ionized do not easily cross the cell membranes of the gut wall. Therefore, they are given by injection, but the disadvantage that they are quickly excreted. • Non-polar drugs, on the other hand, are poorly soluble in aqueous solution and are poorly absorbed. I ...
... • Drugs which are too polar or strongly ionized do not easily cross the cell membranes of the gut wall. Therefore, they are given by injection, but the disadvantage that they are quickly excreted. • Non-polar drugs, on the other hand, are poorly soluble in aqueous solution and are poorly absorbed. I ...
Lecture 2 - H2 receptors and proton pump inhibitor 1
... Acts by irreversible inhibition of proton pump (H+/ K+ ATPase) that is responsible for final step in gastric acid secretion from the parietal cell. ...
... Acts by irreversible inhibition of proton pump (H+/ K+ ATPase) that is responsible for final step in gastric acid secretion from the parietal cell. ...
Fungal Infections
... used in combination with Amphotericin B for cryptococcal and candidal infections. ...
... used in combination with Amphotericin B for cryptococcal and candidal infections. ...
4th Lecture Updated - Home - KSU Faculty Member websites
... Inhibitors of bacterial protein synthesis, Macrolides, contd. Pharmacokinetics, contd.: Clarithromycin is absorbed rapidly from the GIT after oral administration, but 1st-pass metabolism reduces its bioavailability to ~ 50%. It may be given with or without food The extended-release form, typi ...
... Inhibitors of bacterial protein synthesis, Macrolides, contd. Pharmacokinetics, contd.: Clarithromycin is absorbed rapidly from the GIT after oral administration, but 1st-pass metabolism reduces its bioavailability to ~ 50%. It may be given with or without food The extended-release form, typi ...
Heart Failure
... •Reduces both right and left ventricular afterload by reducing pulmonary and systemic vascular resistance •Results in increased cardiac output and decreased ventricular wall stress during systole •Also has moderate direct positive inotropic activity independent of its afterload reducing effects •Red ...
... •Reduces both right and left ventricular afterload by reducing pulmonary and systemic vascular resistance •Results in increased cardiac output and decreased ventricular wall stress during systole •Also has moderate direct positive inotropic activity independent of its afterload reducing effects •Red ...