Medicines Management Programme: Preferred Medicines Angiotensin‐Converting Enzyme Inhibitors
... al (2005) found that ‘relative to those initiated on enalapril, no significant differences in the combined end point of readmission to the hospital for congestive heart failure or mortality were observed among users of lisinopril, ramipril, or other ACE inhibitors (included benazepril, captopri ...
... al (2005) found that ‘relative to those initiated on enalapril, no significant differences in the combined end point of readmission to the hospital for congestive heart failure or mortality were observed among users of lisinopril, ramipril, or other ACE inhibitors (included benazepril, captopri ...
1. Transport of drugs across the inner and outer blood
... mammalian cells, even though its primary and most recognized function is to promote fatty acid oxidation for energy production. Acetylcarnitine is effective in improving visual function in patients with early age-related macular degeneration. Uptake of carnitine and acetylcarnitine in TR-iBRB cells ...
... mammalian cells, even though its primary and most recognized function is to promote fatty acid oxidation for energy production. Acetylcarnitine is effective in improving visual function in patients with early age-related macular degeneration. Uptake of carnitine and acetylcarnitine in TR-iBRB cells ...
Molecules that changed our Lives Synthetic Organic
... Dr. Phani: The therapeutic action of prontosil paved the way for further investigations. In 1936 Ernest Fourneau demonstrated that in the human body Prontosil breaks down to produce sulphanilamide which is the actual agent specifically lethal to streptococci. This led to the emergence of sulpha drug ...
... Dr. Phani: The therapeutic action of prontosil paved the way for further investigations. In 1936 Ernest Fourneau demonstrated that in the human body Prontosil breaks down to produce sulphanilamide which is the actual agent specifically lethal to streptococci. This led to the emergence of sulpha drug ...
Gastroesophageal reflux disease: a review
... symptom relief and are fast-acting. The disadvantage is that they are short-acting (two to three hours) and require frequent large doses. Antacids come in single compounds such as aluminum hydroxide, calcium carbonate or magnesium hydroxide. They also come in combinations that include alginic acid. ...
... symptom relief and are fast-acting. The disadvantage is that they are short-acting (two to three hours) and require frequent large doses. Antacids come in single compounds such as aluminum hydroxide, calcium carbonate or magnesium hydroxide. They also come in combinations that include alginic acid. ...
Miconazole - Antimicrobe.org
... Miconazole Antifungal Class: Azoles (specifically imidazole) Antimifungal Spectrum: Various yeasts including Pseudoallescheria spp. and other phaeohyphomycoses Mechanism of Action: Bind to the heme moiety of the fungal cytochrome P-450 dependent enzyme lanosterol 14-αdemethlyase. Inhibits 14-α-demet ...
... Miconazole Antifungal Class: Azoles (specifically imidazole) Antimifungal Spectrum: Various yeasts including Pseudoallescheria spp. and other phaeohyphomycoses Mechanism of Action: Bind to the heme moiety of the fungal cytochrome P-450 dependent enzyme lanosterol 14-αdemethlyase. Inhibits 14-α-demet ...
Neuropharmacology of N,N-dimethyltryptamine
... and 2,5-dimethoxy-4- methylamphetamine (DOM) cause sensory distortion, depersonalization at high doses, and at least one (N,Ndiisopropyltryptamine, DiPT) causes auditory distortions, whereas some compounds such as DMT (found in ayahuasca), psilocybin (mushrooms) or mescaline (peyote) cause episodic ...
... and 2,5-dimethoxy-4- methylamphetamine (DOM) cause sensory distortion, depersonalization at high doses, and at least one (N,Ndiisopropyltryptamine, DiPT) causes auditory distortions, whereas some compounds such as DMT (found in ayahuasca), psilocybin (mushrooms) or mescaline (peyote) cause episodic ...
Drug Discovery Strategies Today
... Thirty-one drugs, for either an initial indication or a major new indication, faltered during the filing process or in Phase III trials. ...
... Thirty-one drugs, for either an initial indication or a major new indication, faltered during the filing process or in Phase III trials. ...
ASPIRIN
... prostaglandin derivative that is a potent vasoconstrictor and inducer of platelet aggregation Irreversibly inhibits platelet aggregation even at ...
... prostaglandin derivative that is a potent vasoconstrictor and inducer of platelet aggregation Irreversibly inhibits platelet aggregation even at ...
Neuro-Oncology Practice - Oxford Academic
... that seizures can lie on a spectrum from brief focal, unilateral sensory symptoms without impairment of awareness to prolonged bilateral motor involvement and loss of consciousness with a gradation of risk to the patient between these. Generalized seizures, in which patients lose consciousness and f ...
... that seizures can lie on a spectrum from brief focal, unilateral sensory symptoms without impairment of awareness to prolonged bilateral motor involvement and loss of consciousness with a gradation of risk to the patient between these. Generalized seizures, in which patients lose consciousness and f ...
International Journal Of Pharma Professional`s Research RECENT
... Transdermal administration of drugs is an another way of administration that can significantly deliver larger molecules in potent quantities that overcome the problem with the oral administration such as poor bioavailability due to first pass metabolism and sometimes responsible for rapid blood leve ...
... Transdermal administration of drugs is an another way of administration that can significantly deliver larger molecules in potent quantities that overcome the problem with the oral administration such as poor bioavailability due to first pass metabolism and sometimes responsible for rapid blood leve ...
Structure-based design of enzyme inhibitors and receptor ligands
... All major drug companies currently apply structure-based design as an important technique in their search for new drugs. Some start-up companies, such as Agouron Pharmaceuticals, Vertex [7••], and several others, exclusively select biological targets where structure-based and computeraided drug desi ...
... All major drug companies currently apply structure-based design as an important technique in their search for new drugs. Some start-up companies, such as Agouron Pharmaceuticals, Vertex [7••], and several others, exclusively select biological targets where structure-based and computeraided drug desi ...
nsaids
... or enolic acids. They are central and peripheral analgesics, antipyretics, and have peripheral and central anti-inflammatory activity. Most act primarily by inhibiting cyclo-oxygenase leading to reduced synthesis of prostaglandins and related compounds. This mechanism probably underlies their princi ...
... or enolic acids. They are central and peripheral analgesics, antipyretics, and have peripheral and central anti-inflammatory activity. Most act primarily by inhibiting cyclo-oxygenase leading to reduced synthesis of prostaglandins and related compounds. This mechanism probably underlies their princi ...
Anesthetics-3
... may impair ventilation and post operative respiratory depression may occur requiring assisted ventilation and administration of Opioid antagonistic (e.g., Naloxane). ...
... may impair ventilation and post operative respiratory depression may occur requiring assisted ventilation and administration of Opioid antagonistic (e.g., Naloxane). ...
The Effect of Chronic Morphine or Methadone Exposure and
... 2000, Meijer et al. 2000, Vansteensel et al. 2005). This effect might be mediated by changes in signaling cascades within the SCN neurons represented by time of day-dependent modifications of extracellular signalregulated kinase 1/2 (ERK1/2) and glycogen synthase kinase-3β (GSK-3β) activity (Pačesov ...
... 2000, Meijer et al. 2000, Vansteensel et al. 2005). This effect might be mediated by changes in signaling cascades within the SCN neurons represented by time of day-dependent modifications of extracellular signalregulated kinase 1/2 (ERK1/2) and glycogen synthase kinase-3β (GSK-3β) activity (Pačesov ...
letters to nature - Department of Biology
... behaviours. Five genes have been identified that, when mutated, cause defects in these behaviours3. However, the phenotype of only one of these mutants, unc-47, is consistent with a loss of GABA transport into synaptic vesicles. First, the defect in unc-47 is global, affecting all of the behaviours ...
... behaviours. Five genes have been identified that, when mutated, cause defects in these behaviours3. However, the phenotype of only one of these mutants, unc-47, is consistent with a loss of GABA transport into synaptic vesicles. First, the defect in unc-47 is global, affecting all of the behaviours ...
RATIONALIZATION OF TWO DOSAGE FORMS OF A MODEL COMPOUND ALPRAZOLAM,
... effects are influenced by environmental factors such as age, disease, drug interactions due to co-administration etc [3,4,11]. Based on these pharmaco-metabonomic phenotyping has been used in the individualization of drug dosages [5]and metabolic signatures have been used for prediction of efficacie ...
... effects are influenced by environmental factors such as age, disease, drug interactions due to co-administration etc [3,4,11]. Based on these pharmaco-metabonomic phenotyping has been used in the individualization of drug dosages [5]and metabolic signatures have been used for prediction of efficacie ...
1: gastro-intestinal system
... At least five different types of muscarinic receptors have been identified,2 and newer drugs tend to be more selective in their actions. Thus, oxybutynin and tolterodine are relatively selective for muscarinic receptors in the urinary tract (see p.551). At toxic doses, all the tertiary amines, includi ...
... At least five different types of muscarinic receptors have been identified,2 and newer drugs tend to be more selective in their actions. Thus, oxybutynin and tolterodine are relatively selective for muscarinic receptors in the urinary tract (see p.551). At toxic doses, all the tertiary amines, includi ...
EpilEpsy BoARD REviEw MAnuAl Antiepilepsy Drugs: Mechanisms
... be estimated with a variety of formulas using serum creatinine levels, including the Modification of Diet in Renal Disease study equation (MDRD), the Cockcroft-Gault equation, and most recently, the Chronic Kidney Disease Epidemiology Collaboration equation (CKD-Epi).10 The MDRD and CKD-Epi are used ...
... be estimated with a variety of formulas using serum creatinine levels, including the Modification of Diet in Renal Disease study equation (MDRD), the Cockcroft-Gault equation, and most recently, the Chronic Kidney Disease Epidemiology Collaboration equation (CKD-Epi).10 The MDRD and CKD-Epi are used ...
International Narcotics Control Board
... The regular analysis of consumption data, particularly regarding narcotic drugs, convinced the Board that the level of consumption of narcotic drugs was very low in a number of countries. Therefore, in 1989, the Board, in cooperation with WHO, assessed the medical need for opiates in the world. They ...
... The regular analysis of consumption data, particularly regarding narcotic drugs, convinced the Board that the level of consumption of narcotic drugs was very low in a number of countries. Therefore, in 1989, the Board, in cooperation with WHO, assessed the medical need for opiates in the world. They ...
- Journal of SOPI
... professional protectionism is a good example of the process. The maintenance of disabling power differentials compromises the growth and maturity of those who are kept in dependence; it is a very real form of oppression. Inequality and injustice are also rooted in differentials in knowledge and acce ...
... professional protectionism is a good example of the process. The maintenance of disabling power differentials compromises the growth and maturity of those who are kept in dependence; it is a very real form of oppression. Inequality and injustice are also rooted in differentials in knowledge and acce ...
the laboratory`s role in opioid pain medication monitoring
... properties. Overdose by these opioids results in stupor, coma, severe respiratory depression, pinpoint pupils and decreased body temperature. Death can result from respiratory depression. Morphine can be administered orally or via s.c., i.m. or i.v. injections. The bioavailability of oral morphine i ...
... properties. Overdose by these opioids results in stupor, coma, severe respiratory depression, pinpoint pupils and decreased body temperature. Death can result from respiratory depression. Morphine can be administered orally or via s.c., i.m. or i.v. injections. The bioavailability of oral morphine i ...
Cl = Vd x 0T693
... comparison of beta-adrenergic blocking drugs, but suffers the disadvantage that there is no fixed end point because there is no limit to the amount of isoproterenol that can be given. Thus, with isoproterenol as the stimulus, the dose ratio becomes a continuous variable within the limits of toxicity ...
... comparison of beta-adrenergic blocking drugs, but suffers the disadvantage that there is no fixed end point because there is no limit to the amount of isoproterenol that can be given. Thus, with isoproterenol as the stimulus, the dose ratio becomes a continuous variable within the limits of toxicity ...
ADULTERATION OF HERBAL MEDICINES AND DIETARY SUPPLEMENTS WITH UNDECLARED
... which are illegal. Several studies reported to contain hidden synthetic medicines, metals, or other toxic substances in high concentrations [2] which may put the health of patients at risk. Analysis of 2600 Chinese herbal medicines found that 24% of total samples contained at least one synthetic med ...
... which are illegal. Several studies reported to contain hidden synthetic medicines, metals, or other toxic substances in high concentrations [2] which may put the health of patients at risk. Analysis of 2600 Chinese herbal medicines found that 24% of total samples contained at least one synthetic med ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.