III. Pipeline
... on the results of two Phase 3 clinical trials. The studies found that while orteronel plus prednisone could extend the time patients lived before their cancer progressed, it did not extend overall survival in these patients. In February 2013, all lots of peginesatide were voluntarily recalled in the ...
... on the results of two Phase 3 clinical trials. The studies found that while orteronel plus prednisone could extend the time patients lived before their cancer progressed, it did not extend overall survival in these patients. In February 2013, all lots of peginesatide were voluntarily recalled in the ...
... minimize bone resorption. The important outcomes are the effects on bone mineral density and prevalence of vertebral fracture. In Toogood's patients there was a reduction in bone mineral density associated with an intermediate dose (1–2 mg·day-1) of inhaled corticosteroids, but the opposite was true ...
FULL Pregabalin (Lyrica) REVIEW 1
... The PBAC noted that indirect comparisons supported the conclusion that pregabalin was clinically no worse than amitriptyline and gabapentin. 21 The efficacy and safety of pregabalin and amitriptyline were demonstrated to be comparable in two head-to-head clinical trials in patients with diabetic per ...
... The PBAC noted that indirect comparisons supported the conclusion that pregabalin was clinically no worse than amitriptyline and gabapentin. 21 The efficacy and safety of pregabalin and amitriptyline were demonstrated to be comparable in two head-to-head clinical trials in patients with diabetic per ...
Nerve membrane
... A clinical example is the production of methemoglobinemia in patients receiving large doses of Prilocaine. Prilocaine, the parent compound, does not produce methemoglobinemia, but its metabolic product induces the formation of methemoglobin, which is responsible for methemoglobinemia. Another examp ...
... A clinical example is the production of methemoglobinemia in patients receiving large doses of Prilocaine. Prilocaine, the parent compound, does not produce methemoglobinemia, but its metabolic product induces the formation of methemoglobin, which is responsible for methemoglobinemia. Another examp ...
PRODUCT MONOGRAPH Frisium® (clobazam) Tablets, 10 MG
... Nevertheless, even when used as directed, FRISIUM may alter reactivity to such an extent as to impair driving performance or the ability to operate machinery, especially when it is taken in conjunction with alcohol. Therefore patients should be cautioned against driving, operating dangerous machine ...
... Nevertheless, even when used as directed, FRISIUM may alter reactivity to such an extent as to impair driving performance or the ability to operate machinery, especially when it is taken in conjunction with alcohol. Therefore patients should be cautioned against driving, operating dangerous machine ...
Cytochrome P450–mediated drug metabolism in the brain
... perfusate were higher after infusion of tranylcypromine, a monamine oxidase inhibitor, and the levels were further increased after infusion of tryptophan.100 This preparation showed potential for investigating metabolism in the brain, at least of biogenic amines such as serotonin, but unfortunately ...
... perfusate were higher after infusion of tranylcypromine, a monamine oxidase inhibitor, and the levels were further increased after infusion of tryptophan.100 This preparation showed potential for investigating metabolism in the brain, at least of biogenic amines such as serotonin, but unfortunately ...
Document
... ◦ Alleles are alternate versions of a gene ◦ *1 allele designation (CYP2C9*1) most commonly refers to the “wild type” or “normal” enzyme ◦ *2 or greater denote polymorphic alleles and are typically numbered in order of discovery-validation Homozygous designation: CYP2C9*1/*1 (two copies of wild-ty ...
... ◦ Alleles are alternate versions of a gene ◦ *1 allele designation (CYP2C9*1) most commonly refers to the “wild type” or “normal” enzyme ◦ *2 or greater denote polymorphic alleles and are typically numbered in order of discovery-validation Homozygous designation: CYP2C9*1/*1 (two copies of wild-ty ...
Pharmacological Modification of Blood
... Since Fauster et al. (1983) have shown that desipramine inhibits phospholipid degradation by lysosomes, desipramine could reduce membrane breakdown in the necrotic and adjacent area and so reduce HRP extravasation. Desipramine also reduces depression of glucose metabolism in the cortex surrounding a ...
... Since Fauster et al. (1983) have shown that desipramine inhibits phospholipid degradation by lysosomes, desipramine could reduce membrane breakdown in the necrotic and adjacent area and so reduce HRP extravasation. Desipramine also reduces depression of glucose metabolism in the cortex surrounding a ...
Routine Use of Insulin Sensitizing Agents
... Professor of Obstetrics and Gynecology, Director, Division of Reproductive Endocrinology & Infertility, Baylor College of Medicine, Houston, Texas, U.S.A. Insulin resistance is now recognized as an integral mechanism in the pathogenesis of the polycystic ovarian syndrome (PCOS).(1) (2) Compensatory ...
... Professor of Obstetrics and Gynecology, Director, Division of Reproductive Endocrinology & Infertility, Baylor College of Medicine, Houston, Texas, U.S.A. Insulin resistance is now recognized as an integral mechanism in the pathogenesis of the polycystic ovarian syndrome (PCOS).(1) (2) Compensatory ...
Behavioural analysis of the acute and chronic effects of MDMA
... Both clinical depression and age-related cognitive impairments (Fischer et al. 1995) are associated with reductions in 5-HT markers and may be amenable to treatment with drugs acting through the 5-HT system. Therefore, an improved understanding of the long-term consequences of MDMA exposure is of si ...
... Both clinical depression and age-related cognitive impairments (Fischer et al. 1995) are associated with reductions in 5-HT markers and may be amenable to treatment with drugs acting through the 5-HT system. Therefore, an improved understanding of the long-term consequences of MDMA exposure is of si ...
J=” m -1- w
... experiences with IGF-I. IGF-I is a recombinant biological product; however, this approval process was taken by CDER that requires two independent clinical trials. All other neurotrophic factors, such as CNTF, BDNF, or GDNF, were to be evaluated by CBER that requires only one clinical trial. I do not ...
... experiences with IGF-I. IGF-I is a recombinant biological product; however, this approval process was taken by CDER that requires two independent clinical trials. All other neurotrophic factors, such as CNTF, BDNF, or GDNF, were to be evaluated by CBER that requires only one clinical trial. I do not ...
RSA WHITE PAPER - March, 2015 - Research Society on Alcoholism
... with the alcohol use disorder becomes abstinent, health care costs for the family decrease over time to the same level as other families. Alcohol use disorders are costly to families in time and money.45 Treatment makes a difference in terms of family expenditures, with at least one study finding th ...
... with the alcohol use disorder becomes abstinent, health care costs for the family decrease over time to the same level as other families. Alcohol use disorders are costly to families in time and money.45 Treatment makes a difference in terms of family expenditures, with at least one study finding th ...
Gastroretentive Drug Delivery Systems As A Potential Tool For
... dripping method using a polymer mixture of sodium alginate and hydroxyl propyl methyl cellulose. Sodium bicarbonate was used as a gas forming agent. The prepared floating microspheres were evaluated for particle size distribution, floating behavior, drug content and in-vitro release. The prepared mi ...
... dripping method using a polymer mixture of sodium alginate and hydroxyl propyl methyl cellulose. Sodium bicarbonate was used as a gas forming agent. The prepared floating microspheres were evaluated for particle size distribution, floating behavior, drug content and in-vitro release. The prepared mi ...
Similar rewarding effects of testosterone in individuals RESEARCH ARTICLE
... could be this area.15 Additionally, this CPP can be blocked by the treatment with a -flupenthixol, a dopaminergic antagonist. 14,16,17 Although further investigation is needed, the present results suggest that this mechanism also occurs in male mice. Until now, very few studies have focused on the r ...
... could be this area.15 Additionally, this CPP can be blocked by the treatment with a -flupenthixol, a dopaminergic antagonist. 14,16,17 Although further investigation is needed, the present results suggest that this mechanism also occurs in male mice. Until now, very few studies have focused on the r ...
Medications for the Acute and Chronic Management of Asthma
... – Systemic not inhaled in this case – Give oral if they can tolerate but IV if not – High dose Beta agonists can impair gut absorption – Early administration improves outcomes – 2mg/kg/day of prednisone or methylprednisolone – No evidence that higher doses are better ...
... – Systemic not inhaled in this case – Give oral if they can tolerate but IV if not – High dose Beta agonists can impair gut absorption – Early administration improves outcomes – 2mg/kg/day of prednisone or methylprednisolone – No evidence that higher doses are better ...
Department of Health Care Policy
... determined according to 10 C.C.R. 2505-10, Section 8.754. Medical Director means the physician or physicians who advise the Department. Medicare Part D means the drug benefit provided to Part D Eligible Individuals pursuant to the Medicare Prescription Drug, Improvement and Modernization Act of 2003 ...
... determined according to 10 C.C.R. 2505-10, Section 8.754. Medical Director means the physician or physicians who advise the Department. Medicare Part D means the drug benefit provided to Part D Eligible Individuals pursuant to the Medicare Prescription Drug, Improvement and Modernization Act of 2003 ...
Kinetics of a nucleoside release from lactide
... In order to select polymers suitable for further development as carriers capable of delivering high and sustained concentrations of cytostatic or radiosensitizing nucleosides it was, therefore, necessary to assessment the rate of release of a nucleoside in appropriate conditions. As far, as the rate ...
... In order to select polymers suitable for further development as carriers capable of delivering high and sustained concentrations of cytostatic or radiosensitizing nucleosides it was, therefore, necessary to assessment the rate of release of a nucleoside in appropriate conditions. As far, as the rate ...
ARTHRITIS MEDICAL CANNABIS
... considerable analgesic effects in animals. In some cases, the dose-dependent effect of THC was equivalent to morphine, but with a much greater duration of action and far less toxicity.34-35 In contrast to the NSAIDs commonly prescribed arthritis sufferers, CT3 did not cause ulcers at therapeutically ...
... considerable analgesic effects in animals. In some cases, the dose-dependent effect of THC was equivalent to morphine, but with a much greater duration of action and far less toxicity.34-35 In contrast to the NSAIDs commonly prescribed arthritis sufferers, CT3 did not cause ulcers at therapeutically ...
Vasopressin Axis in Shock States
... appear to play a major role in the vascular regulation of blood pressure and abnormally high endogenous vasopressin levels (syndrome of IADH secretion) do not produce hypertension. ...
... appear to play a major role in the vascular regulation of blood pressure and abnormally high endogenous vasopressin levels (syndrome of IADH secretion) do not produce hypertension. ...
Marijuana
... bloodstream and distributed from the lungs to other parts of the body including nerve cells in the brain. In the nerve cells, THC binds to cannabinoid receptors, affecting activities and functions of the cells. Majority of these receptors are concentrated in the brain regions responsible for control ...
... bloodstream and distributed from the lungs to other parts of the body including nerve cells in the brain. In the nerve cells, THC binds to cannabinoid receptors, affecting activities and functions of the cells. Majority of these receptors are concentrated in the brain regions responsible for control ...
Frequency
... (suicide-related events). This risk persists until significant remission occurs. As improvement may not occur during the first few weeks or more of treatment, patients should be closely monitored until such improvement occurs. It is general clinical experience that the risk of suicide may increase i ...
... (suicide-related events). This risk persists until significant remission occurs. As improvement may not occur during the first few weeks or more of treatment, patients should be closely monitored until such improvement occurs. It is general clinical experience that the risk of suicide may increase i ...
Module 10 – Anaesthesia
... Most anaesthetic agents do more than produce unconsciousness and pain relief. They are potent drugs that may affect every system in the body. The effects on the respiratory and cardiovascular systems may be particularly significant during the anaesthetic period; however effects on other organ system ...
... Most anaesthetic agents do more than produce unconsciousness and pain relief. They are potent drugs that may affect every system in the body. The effects on the respiratory and cardiovascular systems may be particularly significant during the anaesthetic period; however effects on other organ system ...
Antiseizure drugs
... frequency of GABAA channel openings, may interfere with glutamate binding to AMPA/KA receptor • Half-life: 20-30 hours (long) • Adverse effects: CNS sedative • Drug interactions: Stimulates CYP3A and inhibits CYP2C19, can lessen effectiveness of birth control pills ...
... frequency of GABAA channel openings, may interfere with glutamate binding to AMPA/KA receptor • Half-life: 20-30 hours (long) • Adverse effects: CNS sedative • Drug interactions: Stimulates CYP3A and inhibits CYP2C19, can lessen effectiveness of birth control pills ...
m5zn_776561dda50e649
... – The partition ratio of a given drug will determine its solubility in plasma, its ability to traverse cell membranes, and which tissues it will reach. – Drugs must have some aqueous solubility since this is essential for absorption through membranes, and for the production of an adequate concentra ...
... – The partition ratio of a given drug will determine its solubility in plasma, its ability to traverse cell membranes, and which tissues it will reach. – Drugs must have some aqueous solubility since this is essential for absorption through membranes, and for the production of an adequate concentra ...
Microinfusion of nefazodone into the basolateral nucleus
... Previous results from our laboratory revealed that neurotoxic lesions of central nucleus of the amygdala (CNA) increases the thresholds of aversive responses elicited by electric stimulation in IC, whereas lesion of BLA decreases the threshold of these responses [15]. These results indicate that the ...
... Previous results from our laboratory revealed that neurotoxic lesions of central nucleus of the amygdala (CNA) increases the thresholds of aversive responses elicited by electric stimulation in IC, whereas lesion of BLA decreases the threshold of these responses [15]. These results indicate that the ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.