... Drugs of abuse, such as amphetamine, share the ability to activate the mesolimbic dopamine (DA) system. The behavioral effects of amphetamine are mediated in large part by increasing DA neurotransmission in the nucleus accumbens. However, there is evidence that serotonin (5-HT) systems may regulate ...
Adrenergic Drugs
... vasoconstriction caused by α1 and α 2 adrenoceptors). Coronary arteries have only β2 receptors. Relaxation of Bronchioles ...
... vasoconstriction caused by α1 and α 2 adrenoceptors). Coronary arteries have only β2 receptors. Relaxation of Bronchioles ...
FOUR MAJOR TARGETS FOR DRUGS
... LIGAND-GATED CHANNELS Extracellular ligands NMDA (N-methyl-D-aspartate) receptor glutamate receptor ...
... LIGAND-GATED CHANNELS Extracellular ligands NMDA (N-methyl-D-aspartate) receptor glutamate receptor ...
Opiates and Respiratory Depression - index
... while connected to the Abbott Lifecare 4100 PCA Plus II machine. This machine is easily misprogrammed by caregivers, who must manually enter the PCA parameters, and it needs a more sensible and forgiving user interface. A number of patients have received opiate overdoses as a result of PCA errors: i ...
... while connected to the Abbott Lifecare 4100 PCA Plus II machine. This machine is easily misprogrammed by caregivers, who must manually enter the PCA parameters, and it needs a more sensible and forgiving user interface. A number of patients have received opiate overdoses as a result of PCA errors: i ...
Background PLASMA PROTEIN BINDING Protocol
... drug, given that only the free drug in plasma is available to elicit a pharmacological effect and only free drug is available to be ...
... drug, given that only the free drug in plasma is available to elicit a pharmacological effect and only free drug is available to be ...
Indirect cholinergic agonists
... Short acting (Alcohols) edrophonium Intermediate acting (Carbamates esters) Physostigmine, Neostigmine Pyridostigmine, Ambenonium Irreversible anticholinesterases Phosphates esters (very stable covalent bond) e.g. Ecothiophate & Isoflurophate ...
... Short acting (Alcohols) edrophonium Intermediate acting (Carbamates esters) Physostigmine, Neostigmine Pyridostigmine, Ambenonium Irreversible anticholinesterases Phosphates esters (very stable covalent bond) e.g. Ecothiophate & Isoflurophate ...
Slide 1
... another one of man’s oldest drugs! medicinal uses documented back to ancient times….. Cannabis sativa ...
... another one of man’s oldest drugs! medicinal uses documented back to ancient times….. Cannabis sativa ...
Page Selective D3 receptor antagonist The dopamine D3
... although no effect was observed on reducing alcohol consumption in rats (data on file). GSK598809 dose dependently reduced the expression of nicotine-induced CPP in rats, with an effect proportional to the exposure and occupancy of brain D3Rs at every time point, and 100% effect at occupancy of brai ...
... although no effect was observed on reducing alcohol consumption in rats (data on file). GSK598809 dose dependently reduced the expression of nicotine-induced CPP in rats, with an effect proportional to the exposure and occupancy of brain D3Rs at every time point, and 100% effect at occupancy of brai ...
24 slides
... Van Dolah, F.M. Marine algal toxins: Origins, health effects, and their increased occurrence. Environ. Hlth. Perspect. 108 (suppl. 1): 133-141, 2000. Vortherms T.A. and B.L. Roth. Salvinorin A: From natural product to human therapeutics. Molecular Interventions 6: 257-265, 2006. ...
... Van Dolah, F.M. Marine algal toxins: Origins, health effects, and their increased occurrence. Environ. Hlth. Perspect. 108 (suppl. 1): 133-141, 2000. Vortherms T.A. and B.L. Roth. Salvinorin A: From natural product to human therapeutics. Molecular Interventions 6: 257-265, 2006. ...
Cross-Regional Webinar on Synthetic Cannabinoids
... found in a “fertiliser” product called “Forest Humus”, along with another synthetic cannabinoid (C8)CP 47,497. These claims were confirmed in July 2009 when tests of Spice product, seized after the legal ban on JWH-018 had gone into effect in Germany, were shown to contain the unregulated compound J ...
... found in a “fertiliser” product called “Forest Humus”, along with another synthetic cannabinoid (C8)CP 47,497. These claims were confirmed in July 2009 when tests of Spice product, seized after the legal ban on JWH-018 had gone into effect in Germany, were shown to contain the unregulated compound J ...
Pharmacology and Pharmacokinetics of Alcohol and Opioids
... NMDA receptors potentially leading to increased withdrawal symptoms of both alcohol and opiates. ...
... NMDA receptors potentially leading to increased withdrawal symptoms of both alcohol and opiates. ...
Sedative- Hypnotic Drugs
... As a partial agonist at brain 5-HT1A receptors, No rebound anxiety or withdrawal signs on abrupt discontinuance. The anxiolytic effects of buspirone may take more than a week to become established The drug is used in generalized anxiety states but is less effective in panic disorders. The ...
... As a partial agonist at brain 5-HT1A receptors, No rebound anxiety or withdrawal signs on abrupt discontinuance. The anxiolytic effects of buspirone may take more than a week to become established The drug is used in generalized anxiety states but is less effective in panic disorders. The ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.