Bioinformatics (2011) 27
... topologically similar to site 1 in a sense that both are composed of sixhelices of the corresponding subdomains, which are arranged to form largely apolar cavities with defined polar features. In contrast to site 1, the entrance to site 2 is exposed to solvent and its inner cavity is smaller and mor ...
... topologically similar to site 1 in a sense that both are composed of sixhelices of the corresponding subdomains, which are arranged to form largely apolar cavities with defined polar features. In contrast to site 1, the entrance to site 2 is exposed to solvent and its inner cavity is smaller and mor ...
- MIT Press Journals
... the raphe that results from activation of the presynaptic 5-HT1A receptors in this region will lead to an impairment of attention. There is considerable anecdotal evidence that attentional processes are affected by psilocybin (i.e., Shulgin & Shulgin, 1997; McKenna, 1992) and formal self-rating scal ...
... the raphe that results from activation of the presynaptic 5-HT1A receptors in this region will lead to an impairment of attention. There is considerable anecdotal evidence that attentional processes are affected by psilocybin (i.e., Shulgin & Shulgin, 1997; McKenna, 1992) and formal self-rating scal ...
Serotonergic Manipulations Both Potentiate and Reduce Brain
... bens or the caudate-putamen decreased BSR (Bose et al., 1974; Redgrave, 1978; McClelland et al., 1989; Lee and Kornetsky, 1998). The above-mentioned studies used rats with stimulating electrodes in the medial forebrain bundle, including the area of the lateral hypothalamus. However, studies in subje ...
... bens or the caudate-putamen decreased BSR (Bose et al., 1974; Redgrave, 1978; McClelland et al., 1989; Lee and Kornetsky, 1998). The above-mentioned studies used rats with stimulating electrodes in the medial forebrain bundle, including the area of the lateral hypothalamus. However, studies in subje ...
STUDY OF THE NEUROMODULATORY EFFECTS OF DOPAMINE
... result of chronic cocaine self-administration. In drug naïve rats we observed that DA dosedependently decreased GABAA-inhibitory post-synaptic currents (IPSC) through the actions of pre-synaptic D2 receptors. However in rats maintaining cocaine self-administration, DA (1!M) increased the amplitude o ...
... result of chronic cocaine self-administration. In drug naïve rats we observed that DA dosedependently decreased GABAA-inhibitory post-synaptic currents (IPSC) through the actions of pre-synaptic D2 receptors. However in rats maintaining cocaine self-administration, DA (1!M) increased the amplitude o ...
morphine
... to intense sexual orgasm. These factors constitute the primary reasons for opioid abuse liability and are strongly reinforced by development of ...
... to intense sexual orgasm. These factors constitute the primary reasons for opioid abuse liability and are strongly reinforced by development of ...
Chronic Treatment with Dopamine Receptor Antagonists
... a dose-response for EEDQ was performed, in which rats received 1 mg/ kg, 2 mg/kg, or 4 mg/kg EEDQ. For protection experiments testing the specificity of flupentixol in vivo, rats were injected (s.c.) with 0.25, 0.5, 0.75, or 1 mg/kg flupentixol dissolved in saline, or the saline vehicle 40 min befor ...
... a dose-response for EEDQ was performed, in which rats received 1 mg/ kg, 2 mg/kg, or 4 mg/kg EEDQ. For protection experiments testing the specificity of flupentixol in vivo, rats were injected (s.c.) with 0.25, 0.5, 0.75, or 1 mg/kg flupentixol dissolved in saline, or the saline vehicle 40 min befor ...
cAlnOfficial Journalofthe c.AmericanHeart cjlssociation
... dopamine agonists, and compounds are now available with spectra of receptor activity different from that of dopamine. Of significance, the benzazepine derivative, fenoldopam, proved to be a selective DA, agonist.' Selective DA2 agonists have been available for several years. Examples include piribed ...
... dopamine agonists, and compounds are now available with spectra of receptor activity different from that of dopamine. Of significance, the benzazepine derivative, fenoldopam, proved to be a selective DA, agonist.' Selective DA2 agonists have been available for several years. Examples include piribed ...
Hydrophobic interactions of phenoxazine modulators with bovine
... the BSA molecules in solution. Glasser and Krieglstein 3 correlated the log10P of some phenothiazine drugs and related compounds to their log (b/a) values, b and a being the fractions of bound drug and free drug respectively. A fairly good linear correlation (r = 0⋅969) for five 10-dimethylaminoprop ...
... the BSA molecules in solution. Glasser and Krieglstein 3 correlated the log10P of some phenothiazine drugs and related compounds to their log (b/a) values, b and a being the fractions of bound drug and free drug respectively. A fairly good linear correlation (r = 0⋅969) for five 10-dimethylaminoprop ...
RAYMOND GEORGE RESEARCH SYNOPSIS
... Drug Discovery and Development for Neuropsychiatric Disorders The laboratory is on track to an Investigational New Drug (IND) Application regarding novel drug(s) that target brain serotonin receptors for treatment of neuropsychiatric disorders, including, autism spectrum disorder, obsessive-compulsi ...
... Drug Discovery and Development for Neuropsychiatric Disorders The laboratory is on track to an Investigational New Drug (IND) Application regarding novel drug(s) that target brain serotonin receptors for treatment of neuropsychiatric disorders, including, autism spectrum disorder, obsessive-compulsi ...
Inhibition of platelet aggregability by losartan in essential hypertension
... because it occurs at doses 1,000-fold higher than those required for binding to vascular AT1 receptors 8, 9, 13. Although the argument has been posed that chronic therapy with losartan (80 to 120 mg oral dose) may expose platelets to circulating drug concentrations amounting to 1 µmol/L 8, 13 this s ...
... because it occurs at doses 1,000-fold higher than those required for binding to vascular AT1 receptors 8, 9, 13. Although the argument has been posed that chronic therapy with losartan (80 to 120 mg oral dose) may expose platelets to circulating drug concentrations amounting to 1 µmol/L 8, 13 this s ...
Mirtazapine in combination - Actas Españolas de Psiquiatría
... Mirtazapine is an antidepressant with the primary mechanism of action of antagonizing α2 noradrenergic autoreceptors. This maximally reduces the role of these synaptic structures in delaying antidepressive response. In addition, mirtazapine also has serotoninergic effects that are mediated by the α2 ...
... Mirtazapine is an antidepressant with the primary mechanism of action of antagonizing α2 noradrenergic autoreceptors. This maximally reduces the role of these synaptic structures in delaying antidepressive response. In addition, mirtazapine also has serotoninergic effects that are mediated by the α2 ...
Drugs for Parkinsonism
... dopaminergic cells of substantia nigra. • D3 receptors are also important, since one of the newer agents is D3 receptor selective (pramipexole). ...
... dopaminergic cells of substantia nigra. • D3 receptors are also important, since one of the newer agents is D3 receptor selective (pramipexole). ...
Using Psilocybin to Investigate the Relationship between Attention
... the raphe that results from activation of the presynaptic 5-HT1A receptors in this region will lead to an impairment of attention. There is considerable anecdotal evidence that attentional processes are affected by psilocybin (i.e., Shulgin & Shulgin, 1997; McKenna, 1992) and formal self-rating scal ...
... the raphe that results from activation of the presynaptic 5-HT1A receptors in this region will lead to an impairment of attention. There is considerable anecdotal evidence that attentional processes are affected by psilocybin (i.e., Shulgin & Shulgin, 1997; McKenna, 1992) and formal self-rating scal ...
In vivo imaging of dopamine and serotonin release Udo de
... predetermined standard region of interest (ROI) template localized in stereotactic MNI space was applied to determine the ROIs including left and right dorsal, middle and ventral caudate nucleus, dorsal and ventral putamen, cerebellum and occipital cortex. For further analyses we defined the followi ...
... predetermined standard region of interest (ROI) template localized in stereotactic MNI space was applied to determine the ROIs including left and right dorsal, middle and ventral caudate nucleus, dorsal and ventral putamen, cerebellum and occipital cortex. For further analyses we defined the followi ...
Antineoplastic Action of Growth Hormone
... have been developed for the treatment of various cancers [39]. The clinical need for anticancer applications of GHRH antagonists was supported by Pollak et al. on the grounds that somatostatin analogs do not adequately suppress GH and IGF-I levels in patients with neoplasms potentially dependent on ...
... have been developed for the treatment of various cancers [39]. The clinical need for anticancer applications of GHRH antagonists was supported by Pollak et al. on the grounds that somatostatin analogs do not adequately suppress GH and IGF-I levels in patients with neoplasms potentially dependent on ...
The Role of The A2A Receptor in Cell Apoptosis Caused by MDMA
... MDMA use. MDMA causes apoptosis in neurons of the central nervous system (CNS). Withdrawal signs are attenuated by treatment with the adenosine receptor (A2A receptor). This study reports the effects of glutamyl cysteine synthetase (GCS), as an A2A receptor agonist, and succinylcholine (SCH), as an ...
... MDMA use. MDMA causes apoptosis in neurons of the central nervous system (CNS). Withdrawal signs are attenuated by treatment with the adenosine receptor (A2A receptor). This study reports the effects of glutamyl cysteine synthetase (GCS), as an A2A receptor agonist, and succinylcholine (SCH), as an ...
Atropine
... Mandragora (mandrake) was described by Theophrastus in the fourth century B.C. for treatment of wounds, gout, and sleeplessness, and as a love potion. By the first century A.D. Dioscorides recognized wine of mandrake as an anaesthetic for treatment of pain or sleeplessness, to be given prior to surg ...
... Mandragora (mandrake) was described by Theophrastus in the fourth century B.C. for treatment of wounds, gout, and sleeplessness, and as a love potion. By the first century A.D. Dioscorides recognized wine of mandrake as an anaesthetic for treatment of pain or sleeplessness, to be given prior to surg ...
Muscarinic antagonist
... Mandragora (mandrake) was described by Theophrastus in the fourth century B.C. for treatment of wounds, gout, and sleeplessness, and as a love potion. By the first century A.D. Dioscorides recognized wine of mandrake as an anaesthetic for treatment of pain or sleeplessness, to be given prior to surg ...
... Mandragora (mandrake) was described by Theophrastus in the fourth century B.C. for treatment of wounds, gout, and sleeplessness, and as a love potion. By the first century A.D. Dioscorides recognized wine of mandrake as an anaesthetic for treatment of pain or sleeplessness, to be given prior to surg ...
... may occur [7]. Mediators may act on target cells within the airways to induce features typical of asthma, such as bronchoconstriction, mucus plugging, airway wall oedema through microvascular leakage, eosinophil infiltration and bronchial hyperresponsiveness [8]. Although many mediators are likely t ...
Desensitization of Cannabinoid-Mediated Presynaptic Inhibition of
... MARIA KOUZNETSOVA, BROOKE KELLEY, MAOXING SHEN, and STANLEY A. THAYER Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota Received August 8, 2001; accepted November 26, 2001 ...
... MARIA KOUZNETSOVA, BROOKE KELLEY, MAOXING SHEN, and STANLEY A. THAYER Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota Received August 8, 2001; accepted November 26, 2001 ...
Buspirone and Pindolol Effects on the EEG Frequency Spectrum in
... 2. Smith C.E., Ware C.J., & Cowen P.J. (1991) Pindolol decreases prolactin and growth hormone responses to intravenous L-tryptophan. Psychopharm. 103, 140-142. 3. Blier P., Seletti B., Young S.N., Benkelfat C., & de Montigny C. (1994) Serotonin 1A receptor activation and hypothermia: Evidence for a ...
... 2. Smith C.E., Ware C.J., & Cowen P.J. (1991) Pindolol decreases prolactin and growth hormone responses to intravenous L-tryptophan. Psychopharm. 103, 140-142. 3. Blier P., Seletti B., Young S.N., Benkelfat C., & de Montigny C. (1994) Serotonin 1A receptor activation and hypothermia: Evidence for a ...
5 - WordPress.com
... emetics were administered to the participants, the group then split into two groups. One group received one gram of ginger root powder in a capsule for five days, while the other group received a placebo on the first day, but was switched to metoclopramide for three days. Following the completion of ...
... emetics were administered to the participants, the group then split into two groups. One group received one gram of ginger root powder in a capsule for five days, while the other group received a placebo on the first day, but was switched to metoclopramide for three days. Following the completion of ...
The thesis
... The sensation of pain is fundamental in the maintenance of the biological integrity of the body, but chronic pain status cause severe somatic and psychic impairment, which give rise to considerable social and economic burden not only on the individual but also on the society. The International Assoc ...
... The sensation of pain is fundamental in the maintenance of the biological integrity of the body, but chronic pain status cause severe somatic and psychic impairment, which give rise to considerable social and economic burden not only on the individual but also on the society. The International Assoc ...
Tutorial Planner - Collegiate Medical Centre
... outpatients who are unable to absorb oral agents because of gastric atony or vomiting. Injectables are used in the emergency room or inpatient settings. The new agents are used when all else fails. Some antihistamines commonly used as vestibular suppressants have significant antiemetic properties (e ...
... outpatients who are unable to absorb oral agents because of gastric atony or vomiting. Injectables are used in the emergency room or inpatient settings. The new agents are used when all else fails. Some antihistamines commonly used as vestibular suppressants have significant antiemetic properties (e ...
5-HT3 antagonist
The 5-HT3 antagonists, informally known as ""setrons"", are a class of drugs that act as receptor antagonists at the 5-HT3 receptor, a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the brain.With the notable exception of alosetron and cilansetron, which are used in the treatment of irritable bowel syndrome, all 5-HT3 antagonists are antiemetics, used in the prevention and treatment of nausea and vomiting. They are particularly effective in controlling the nausea and vomiting produced by cancer chemotherapy and are considered the gold standard for this purpose.The 5-HT3 antagonists may be identified by the suffix –setron, and are classified under code A04AA of the WHO's Anatomical Therapeutic Chemical Classification System.