Schizophrenia and the supersensitive synapse
... motor symptoms (Parkinson’s disease), cognitive symptoms (Alzheimer’s disease), or mood symptoms (depression). The formulation of a supersensitive synapse (where the synaptic response is increased above normal) builds on neurochemical transmission in the nervous system, the existence of which was es ...
... motor symptoms (Parkinson’s disease), cognitive symptoms (Alzheimer’s disease), or mood symptoms (depression). The formulation of a supersensitive synapse (where the synaptic response is increased above normal) builds on neurochemical transmission in the nervous system, the existence of which was es ...
Fragment library screening against the Hepatitis C drug target
... produce a more optimal binder with higher affinity for the binding site. The fragment-based approach is particularly useful for exploring new or alternative binding sites, like allosteric binding sites. Biophysical assays are most ...
... produce a more optimal binder with higher affinity for the binding site. The fragment-based approach is particularly useful for exploring new or alternative binding sites, like allosteric binding sites. Biophysical assays are most ...
Functional assays for screening GPCR targets
... Several GPCRs clearly activate multiple G proteins [9,10]. Although multiplicity of coupling in some cases can be an artifact of receptor overexpression in recombinant expression systems, it has also been clearly estabCurrent Opinion in Biotechnology 2005, 16:655–665 ...
... Several GPCRs clearly activate multiple G proteins [9,10]. Although multiplicity of coupling in some cases can be an artifact of receptor overexpression in recombinant expression systems, it has also been clearly estabCurrent Opinion in Biotechnology 2005, 16:655–665 ...
the-serotonergic-hallucinogen-5-meo-dmt-disrupts
... dimethyltryptamine (5-MeO-DMT) which bind with high affinity to several 5-HT receptors (5-HT-R), namely phenylalkylamines such as mescaline and 2,5-dimethoxy-4- ...
... dimethyltryptamine (5-MeO-DMT) which bind with high affinity to several 5-HT receptors (5-HT-R), namely phenylalkylamines such as mescaline and 2,5-dimethoxy-4- ...
Suggestion from clinicians
... 45 received metoclopramide + 1 placebo tablet 4x daily. Nausea, vomiting, bloating/distension, and early satiety were evaluated for severity after 2 and 4 wk. Adverse central nervous system (CNS) effects of somnolence, akathisia, asthenia, anxiety, depression, and reduced mental acuity were elicited ...
... 45 received metoclopramide + 1 placebo tablet 4x daily. Nausea, vomiting, bloating/distension, and early satiety were evaluated for severity after 2 and 4 wk. Adverse central nervous system (CNS) effects of somnolence, akathisia, asthenia, anxiety, depression, and reduced mental acuity were elicited ...
A Board Preparation Study Guide
... chlorothiazide DIRUIL, SODIUM DIURIL chlorthaldone HYGROTON hydrochlorothiazide MICROZIDE indapamide LOZOL metolazone ZAROLXOLYN Loop Diuretics bumetanide BUMEX ethacrynic acid EDECRIN ...
... chlorothiazide DIRUIL, SODIUM DIURIL chlorthaldone HYGROTON hydrochlorothiazide MICROZIDE indapamide LOZOL metolazone ZAROLXOLYN Loop Diuretics bumetanide BUMEX ethacrynic acid EDECRIN ...
A molecular basis of the therapeutic and psychoactive
... receptors. The first such compound to be discovered was an eicosanoid, N-arachidonylethanolamide (AEA) (Devane et al., 1992), also named ‘‘anandamide’’ after the Sanskrit word ‘‘ananda’’ meaning bliss. Biosynthesis of AEA occurs from membrane phosphatidylethanolamine, which becomes esterified by fre ...
... receptors. The first such compound to be discovered was an eicosanoid, N-arachidonylethanolamide (AEA) (Devane et al., 1992), also named ‘‘anandamide’’ after the Sanskrit word ‘‘ananda’’ meaning bliss. Biosynthesis of AEA occurs from membrane phosphatidylethanolamine, which becomes esterified by fre ...
Minireview The Neurokinin-1 Receptor in Addictive Processes
... less alcohol in voluntary two-bottle choice drinking over a range of pharmacologically active concentrations (George et al., 2008). Decreased alcohol consumption in NK1R2/2 mice was replicated by NK1R antagonist administration in wildtype C57/BL6 mice (Thorsell et al., 2010). In this study, there ap ...
... less alcohol in voluntary two-bottle choice drinking over a range of pharmacologically active concentrations (George et al., 2008). Decreased alcohol consumption in NK1R2/2 mice was replicated by NK1R antagonist administration in wildtype C57/BL6 mice (Thorsell et al., 2010). In this study, there ap ...
hyperthermia - Calgary Emergency Medicine
... punishable for up to 3 years jail, $1000.00 fine or both. Trafficking carries jail sentence up to 10 years Legal for medical or scientific purposes ...
... punishable for up to 3 years jail, $1000.00 fine or both. Trafficking carries jail sentence up to 10 years Legal for medical or scientific purposes ...
Potassium Sparing Diuretics
... ModureticR = Amiloride 5 mg + HCT 50 mg Why? because other diuretics is potassium wasting diuretics = hypokalemia to avoid that we combine these drugs with potassium sparing diuretics. ...
... ModureticR = Amiloride 5 mg + HCT 50 mg Why? because other diuretics is potassium wasting diuretics = hypokalemia to avoid that we combine these drugs with potassium sparing diuretics. ...
Management of PUD, H. pylori infection
... Because of concerns re CVS safety, COX-2 inhibitors should only be used in preference to standard NSAIDs only when specifically indicated & after assessment of CVS. Pts receiving COX-2 inhibitor & who have IHD or cerebrovascular disease should be switched to alternative asap ...
... Because of concerns re CVS safety, COX-2 inhibitors should only be used in preference to standard NSAIDs only when specifically indicated & after assessment of CVS. Pts receiving COX-2 inhibitor & who have IHD or cerebrovascular disease should be switched to alternative asap ...
Oncostatin`s LIFR sentence
... Sims’ group now needs to answer two main differentiation compared with compounds on the questions. The first, she said, is whether it’s possible to agonize OSM-LIFR signaling without a similar upregulation of market or in development. Sims said the findings published in JCI are neither patented nor ...
... Sims’ group now needs to answer two main differentiation compared with compounds on the questions. The first, she said, is whether it’s possible to agonize OSM-LIFR signaling without a similar upregulation of market or in development. Sims said the findings published in JCI are neither patented nor ...
40th Anniversary of Opioid Agonist Pharmacotherapy for
... by Dr. M. Nyswander and Dr. V.P. Dole, and joined there by Dr. J. Lowinson, including one-year follow-up studies on study subjects admitted to The Rockefeller Hospital in the first half of 1964, as well as new patients admitted to Manhattan General Hospital: Dole, V.P. and Nyswander, M.E.: A medical ...
... by Dr. M. Nyswander and Dr. V.P. Dole, and joined there by Dr. J. Lowinson, including one-year follow-up studies on study subjects admitted to The Rockefeller Hospital in the first half of 1964, as well as new patients admitted to Manhattan General Hospital: Dole, V.P. and Nyswander, M.E.: A medical ...
Association study of 37 genes related to serotonin and dopamine
... cocaine. Both environmental and genetic factors underlie this disorder. Although some studies have estimated a heritability of cocaine dependence around 60–70% (Kendler & Prescott 1998; Kendler et al . 2000), genetic susceptibility factors are not well understood. Several processes, such as reward a ...
... cocaine. Both environmental and genetic factors underlie this disorder. Although some studies have estimated a heritability of cocaine dependence around 60–70% (Kendler & Prescott 1998; Kendler et al . 2000), genetic susceptibility factors are not well understood. Several processes, such as reward a ...
Treatment of opioid-induced gut dysfunction
... effects to opioid-induced constipation is not clear [7]. Apart from affecting GI motor activity, opioids also influence GI ion and fluid transport (Figure 1). Blunted peristalsis delays GI transit and, thereby, prolongs the contact of the intestinal contents with the mucosa [1]. As a result, absorpt ...
... effects to opioid-induced constipation is not clear [7]. Apart from affecting GI motor activity, opioids also influence GI ion and fluid transport (Figure 1). Blunted peristalsis delays GI transit and, thereby, prolongs the contact of the intestinal contents with the mucosa [1]. As a result, absorpt ...
UV SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF ONDANSETRON
... A simple, rapid, precise, accurate and sensitive analytical method was developed for the UV spectrophotometric assay of ondansetron. The drug obeyed the Beer’s law and showed good correlation. It showed absorption maxima at 248 nm in saline. The linearity was observed between 5 – 25 µg mL-1. The res ...
... A simple, rapid, precise, accurate and sensitive analytical method was developed for the UV spectrophotometric assay of ondansetron. The drug obeyed the Beer’s law and showed good correlation. It showed absorption maxima at 248 nm in saline. The linearity was observed between 5 – 25 µg mL-1. The res ...
Behavioural and neurochemical changes induced by stress
... (BDNF), and also affect HPA axis hyperactivity (Duman et al. 1999 ; Kunugi et al. 2010 ; Luo et al. 2004 ; Malberg et al. 2000 ; Nibuya et al. 1996 ; Xu et al. 2003). Hence, the long-term beneficial effects of antidepressant treatment could partially be related to their delayed effect on synaptic plasti ...
... (BDNF), and also affect HPA axis hyperactivity (Duman et al. 1999 ; Kunugi et al. 2010 ; Luo et al. 2004 ; Malberg et al. 2000 ; Nibuya et al. 1996 ; Xu et al. 2003). Hence, the long-term beneficial effects of antidepressant treatment could partially be related to their delayed effect on synaptic plasti ...
Facilitative effects of an adenosine A1/A2 receptor blockade on
... RM and WM errors in blocks of five trials given in one daily session during the acquisition phase of 10 days from saline- and theophylline-treated animals were compared using a two-way analysis of variance for repeated measures (ANOVA) with treatment and days as factors followed by a Tukey’s t-test. ...
... RM and WM errors in blocks of five trials given in one daily session during the acquisition phase of 10 days from saline- and theophylline-treated animals were compared using a two-way analysis of variance for repeated measures (ANOVA) with treatment and days as factors followed by a Tukey’s t-test. ...
Targeting the dopamine D receptor in schizophrenia
... haloperidol increased the turnover of adrenaline and dopamine, as shown by the increased production of normetanephrine and methoxytyramine, respectively. To explain the increased production of these metabolites, it was suggested that ‘the most likely [mechanism] appears to be that chlorpromazine and ...
... haloperidol increased the turnover of adrenaline and dopamine, as shown by the increased production of normetanephrine and methoxytyramine, respectively. To explain the increased production of these metabolites, it was suggested that ‘the most likely [mechanism] appears to be that chlorpromazine and ...
Histamine in Atopic Disorders: Atopic Dermatitis and
... cells (IDECs), plasmacytoid DCs (pDCs), myeloid DCs (mDCs) and Langerhans cells (LCs). The H4 receptor on murine and human LCs is expressed on the mRNA and protein levels and stimulation of the H4 receptor results in decreased expression of CCL2 in human LCs as well as enhanced the migration of LCs ...
... cells (IDECs), plasmacytoid DCs (pDCs), myeloid DCs (mDCs) and Langerhans cells (LCs). The H4 receptor on murine and human LCs is expressed on the mRNA and protein levels and stimulation of the H4 receptor results in decreased expression of CCL2 in human LCs as well as enhanced the migration of LCs ...
10 Pharmacologic Management Of Parkinsonism
... Wearing-off phenomenon/ end-of-dose akinesia: • Related to the timing of levodopa intake • Each dose of levodopa effectively improves mobility for a period of time (1–2 hrs), but rigidity and akinesia return rapidly at the end of the dosing interval • Increasing the dose and frequency of administrat ...
... Wearing-off phenomenon/ end-of-dose akinesia: • Related to the timing of levodopa intake • Each dose of levodopa effectively improves mobility for a period of time (1–2 hrs), but rigidity and akinesia return rapidly at the end of the dosing interval • Increasing the dose and frequency of administrat ...
Research advances in basic mechanisms of seizures and
... Epilepsy is a common neurological disease but the mechanism of seizure generation has been only partially unraveled. Furthermore, almost 30% of epileptic patients are resistant to pharmacological treatment. Therefore, elucidation of the basic mechanism of seizures and search for new antiepileptics i ...
... Epilepsy is a common neurological disease but the mechanism of seizure generation has been only partially unraveled. Furthermore, almost 30% of epileptic patients are resistant to pharmacological treatment. Therefore, elucidation of the basic mechanism of seizures and search for new antiepileptics i ...
Lecture 3 - Renin Angiotensin Pathway
... • A hypothetical binding model based on Zn-containing peptidases was proposed. Zinc is adjacent to the labile peptide bond ...
... • A hypothetical binding model based on Zn-containing peptidases was proposed. Zinc is adjacent to the labile peptide bond ...
SNRIs: an approach - Psychopharmacology Institute
... depression: a STAR* D report." American Journal of Psychiatry 163.9 (2006): 1531-1541. Hannan, Noel, et al. "Venlafaxine—mirtazapine combination in the treatment of persistent depressive illness." Journal of Psychopharmacology 21.2 (2007): ...
... depression: a STAR* D report." American Journal of Psychiatry 163.9 (2006): 1531-1541. Hannan, Noel, et al. "Venlafaxine—mirtazapine combination in the treatment of persistent depressive illness." Journal of Psychopharmacology 21.2 (2007): ...
5-HT3 antagonist
The 5-HT3 antagonists, informally known as ""setrons"", are a class of drugs that act as receptor antagonists at the 5-HT3 receptor, a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the brain.With the notable exception of alosetron and cilansetron, which are used in the treatment of irritable bowel syndrome, all 5-HT3 antagonists are antiemetics, used in the prevention and treatment of nausea and vomiting. They are particularly effective in controlling the nausea and vomiting produced by cancer chemotherapy and are considered the gold standard for this purpose.The 5-HT3 antagonists may be identified by the suffix –setron, and are classified under code A04AA of the WHO's Anatomical Therapeutic Chemical Classification System.