Serotonin Transporter Occupancy of Five Selective Serotonin
... subjects therapeutic doses for 4 weeks. (The antidepressants are proven therapeutic agents, and it was unnecessary to administer them to healthy subjects; see the following.) This led to three dosing groups. The first group (N=37) were primarily healthy subjects, and they received no more than half ...
... subjects therapeutic doses for 4 weeks. (The antidepressants are proven therapeutic agents, and it was unnecessary to administer them to healthy subjects; see the following.) This led to three dosing groups. The first group (N=37) were primarily healthy subjects, and they received no more than half ...
Prevention, Diagnosis, and Management of Serotonin Syndrome
... cognitive changes require hospitalization.3,8 Benzodiazepines may be used for control of agitation and tremor. Patients may also benefit from cyproheptadine, olanzapine (Zyprexa), or chlorpromazine. Chlorpromazine and olanzapine are not routinely used because of the potential for adverse effects and ...
... cognitive changes require hospitalization.3,8 Benzodiazepines may be used for control of agitation and tremor. Patients may also benefit from cyproheptadine, olanzapine (Zyprexa), or chlorpromazine. Chlorpromazine and olanzapine are not routinely used because of the potential for adverse effects and ...
LONG-TERM USE OF INTRATHECAL DROPERIDOL AS AN EXCELLENT ANTIEMETIC IN NONMALIGNANT
... we hoped for the lowest effective dose, with the least number of negative side effects, no toxicity and as close to the nausea centers as possible. The chemoreceptor trigger zone (CTZ) has been known, so far, to have at least five kinds of receptors that may activate nausea. It would be very interes ...
... we hoped for the lowest effective dose, with the least number of negative side effects, no toxicity and as close to the nausea centers as possible. The chemoreceptor trigger zone (CTZ) has been known, so far, to have at least five kinds of receptors that may activate nausea. It would be very interes ...
... Basel, Switzerland), using the "MacroModel" Modelling System analysis software supported on a VAX mainframe computer [17]. The side-chain does, however, profoundly affect the lipophilicity of salmeterol, which is at least an order of magnitude more lipid soluble than the moderately lipophilic formot ...
Dopamine Receptor Antagonists Reverse Amphetamine
... Previous studies have shown that amphetamine significantly alters operant responding on the behavior maintained on a schedule of differential reinforcement of low-rate (DRL). As such, behavioral deficiency of DRL responding has been observed by the drug-induced increase of non-reinforced responses a ...
... Previous studies have shown that amphetamine significantly alters operant responding on the behavior maintained on a schedule of differential reinforcement of low-rate (DRL). As such, behavioral deficiency of DRL responding has been observed by the drug-induced increase of non-reinforced responses a ...
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces
... et al., 2012). Human studies have also shown that treatment with cannabinoids enhances the analgesic effects of opioids in ...
... et al., 2012). Human studies have also shown that treatment with cannabinoids enhances the analgesic effects of opioids in ...
Ergot Alkaloids: A Review on Therapeutic Applications (PDF
... Ergot of Rye is a plant disease caused by the fungus Claviceps purpurea which infects the grains of cereals and grasses. "Ergot" is the French word for “spur” named after the similarity between sclerotia of fungus and spurs on rooster legs. In Ayurveda it is known as “Annaamaya”, or “Sraavikaa” and ...
... Ergot of Rye is a plant disease caused by the fungus Claviceps purpurea which infects the grains of cereals and grasses. "Ergot" is the French word for “spur” named after the similarity between sclerotia of fungus and spurs on rooster legs. In Ayurveda it is known as “Annaamaya”, or “Sraavikaa” and ...
- University of Mississippi
... antidepressants. There are two distinct subtypes of sigma receptors. Sigma-1 receptors are expressed more dominantly over sigma-2 and are slightly larger in size. Sigma-1 receptors are also known to translocate during signaling and are associated with regulating intracellular secondary messengers. S ...
... antidepressants. There are two distinct subtypes of sigma receptors. Sigma-1 receptors are expressed more dominantly over sigma-2 and are slightly larger in size. Sigma-1 receptors are also known to translocate during signaling and are associated with regulating intracellular secondary messengers. S ...
Biphasic effects of 7-OH-DPAT on the acquisition of responding for
... Previous studies have shown that dopamine (DA) receptor subtype-specific agonists differentially affect responding for conditioned reward D1-like agonists impair, whereas D2-like agonists enhance responding. The present study compared the effects of the D2-like agonists bromocriptine and 7-hydroxy-N ...
... Previous studies have shown that dopamine (DA) receptor subtype-specific agonists differentially affect responding for conditioned reward D1-like agonists impair, whereas D2-like agonists enhance responding. The present study compared the effects of the D2-like agonists bromocriptine and 7-hydroxy-N ...
PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT
... fatal cases. These reports include toxic skin eruptions such as Stevens-Johnson syndrome and toxic epidermal necrolysis, and have occurred in patients taking other medications that can be associated with bullous skin and mucosal reactions. ...
... fatal cases. These reports include toxic skin eruptions such as Stevens-Johnson syndrome and toxic epidermal necrolysis, and have occurred in patients taking other medications that can be associated with bullous skin and mucosal reactions. ...
http://www.utdallas.edu/~tres/papers/thompson&disterhoft.97a.pdf
... trials to criterion by =50%. Dose-response curves were right-shifted by aging (twice the dose was required to achieve the same enhancement compared with controls). DCS did not affect nonassociative performance but sharpened the conditioned stimulus tone intensity discrimination. DCS thus can functio ...
... trials to criterion by =50%. Dose-response curves were right-shifted by aging (twice the dose was required to achieve the same enhancement compared with controls). DCS did not affect nonassociative performance but sharpened the conditioned stimulus tone intensity discrimination. DCS thus can functio ...
ZOFRAN Tablets, Oral Solution and Injection PRODUCT MONOGRAPH
... intravenous dose of ZOFRAN® was significantly reduced and the serum half-life significantly prolonged in subjects with severe impairment of hepatic function. In patients with moderate or severe impairment of hepatic function, reductions in dosage are therefore recommended and a total daily dose of 8 ...
... intravenous dose of ZOFRAN® was significantly reduced and the serum half-life significantly prolonged in subjects with severe impairment of hepatic function. In patients with moderate or severe impairment of hepatic function, reductions in dosage are therefore recommended and a total daily dose of 8 ...
CURRICULUM VITAE
... to contain allosteric binding sites for endogenous/synthetic ligands which are discrete from the agonist binding (orthosteric) site. The binding of allosteric modulators leads to a conformational change which affects the affinity and/or efficacy of the orthosteric (endogenous) ligands, thereby fine- ...
... to contain allosteric binding sites for endogenous/synthetic ligands which are discrete from the agonist binding (orthosteric) site. The binding of allosteric modulators leads to a conformational change which affects the affinity and/or efficacy of the orthosteric (endogenous) ligands, thereby fine- ...
Oculocardiac reflex as a predictive sign of postoperative nausea and
... strategies been used for prediction as well as treatment. Contrary to previous studies we concluded that oculocardiac reflex (OCR) can not be used as a predictor of PONV as previously reported. Hence administration of more than one anti-emetic, including dexamethasone or anti-cholinergics is not jus ...
... strategies been used for prediction as well as treatment. Contrary to previous studies we concluded that oculocardiac reflex (OCR) can not be used as a predictor of PONV as previously reported. Hence administration of more than one anti-emetic, including dexamethasone or anti-cholinergics is not jus ...
3,4-Methylenedioxymethamphetamine Produces Glycogenolysis
... bation, 1.33 ml of Tris buffer (pH ⫽ 7.8), 0.66 ml of MgCl2 (10 mM), 100 l of ATP (2 mg/ml), and 10 l of NADP (10 mg/ml) were added to each tube. The tubes were vortexed and subjected to centrifugation at 10,000g for 5 min. The supernatants were transferred to other tubes, and the fluorescence (ex ...
... bation, 1.33 ml of Tris buffer (pH ⫽ 7.8), 0.66 ml of MgCl2 (10 mM), 100 l of ATP (2 mg/ml), and 10 l of NADP (10 mg/ml) were added to each tube. The tubes were vortexed and subjected to centrifugation at 10,000g for 5 min. The supernatants were transferred to other tubes, and the fluorescence (ex ...
3,4-Methylenedioxymethamphetamine Produces Glycogenolysis
... bation, 1.33 ml of Tris buffer (pH ⫽ 7.8), 0.66 ml of MgCl2 (10 mM), 100 l of ATP (2 mg/ml), and 10 l of NADP (10 mg/ml) were added to each tube. The tubes were vortexed and subjected to centrifugation at 10,000g for 5 min. The supernatants were transferred to other tubes, and the fluorescence (ex ...
... bation, 1.33 ml of Tris buffer (pH ⫽ 7.8), 0.66 ml of MgCl2 (10 mM), 100 l of ATP (2 mg/ml), and 10 l of NADP (10 mg/ml) were added to each tube. The tubes were vortexed and subjected to centrifugation at 10,000g for 5 min. The supernatants were transferred to other tubes, and the fluorescence (ex ...
The Magic Mint - Stephanie Nichole Halbleib
... • Activated endogenous by peptides (like endorphins), or exogenously by alkaloid opiates (such as morphine) • Signal transduction is theorized as follows: – Activation is coupled to the G protein which increases phosphodiesterase activity – Breaks down cAMP, producing an inhibitory effect in neurons ...
... • Activated endogenous by peptides (like endorphins), or exogenously by alkaloid opiates (such as morphine) • Signal transduction is theorized as follows: – Activation is coupled to the G protein which increases phosphodiesterase activity – Breaks down cAMP, producing an inhibitory effect in neurons ...
PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT
... fatal cases. These reports include toxic skin eruptions such as Stevens-Johnson syndrome and toxic epidermal necrolysis, and have occurred in patients taking other medications that can be associated with bullous skin and mucosal reactions. ...
... fatal cases. These reports include toxic skin eruptions such as Stevens-Johnson syndrome and toxic epidermal necrolysis, and have occurred in patients taking other medications that can be associated with bullous skin and mucosal reactions. ...
Reward Processing by the Opioid System in the Brain
... and endopiriform cortex (En), olfactory tubercle (Tu), striatum (caudate putamen and nucleus accumbens), preoptic area (POA), hypothalamus, and pituitary. The delta receptor is the most abundant receptor in the olfactory tract (olfactory bulbs, anterior olfactory nucleus, Tu, medial amygdala) and in ...
... and endopiriform cortex (En), olfactory tubercle (Tu), striatum (caudate putamen and nucleus accumbens), preoptic area (POA), hypothalamus, and pituitary. The delta receptor is the most abundant receptor in the olfactory tract (olfactory bulbs, anterior olfactory nucleus, Tu, medial amygdala) and in ...
DOCTORAL THESIS
... present different conformers in equilibrium in solution, derived from the rotation of the bonds that joint the three side chains to the triazine ring. Ten of those triazines were particularly active blocking TRPV1 with submicromolar IC50 values. Triazine 46 exhibited a remarkably high activity (IC50 ...
... present different conformers in equilibrium in solution, derived from the rotation of the bonds that joint the three side chains to the triazine ring. Ten of those triazines were particularly active blocking TRPV1 with submicromolar IC50 values. Triazine 46 exhibited a remarkably high activity (IC50 ...
NAUSEA What`s the Problem, and How Do You Diagnose It
... Natural anti-nausea substances. In addition to all the anti-nausea medications discussed below, there are several natural substances that are very often effective. Since they have no side effects, are inexpensive, and are commonly available, they might be the best place to start in seeking help for ...
... Natural anti-nausea substances. In addition to all the anti-nausea medications discussed below, there are several natural substances that are very often effective. Since they have no side effects, are inexpensive, and are commonly available, they might be the best place to start in seeking help for ...
Duloxetine Inhibits Effects of MDMA (``Ecstasy``) In Vitro and in
... effects of 3,4–methylenedioxy-methamphetamine (MDMA, ecstasy) in vitro and in 16 healthy subjects. The clinical study used a double-blind, randomized, placebo-controlled, four-session, crossover design. In vitro, duloxetine blocked the release of both 5-HT and NE by MDMA or by its metabolite 3,4-met ...
... effects of 3,4–methylenedioxy-methamphetamine (MDMA, ecstasy) in vitro and in 16 healthy subjects. The clinical study used a double-blind, randomized, placebo-controlled, four-session, crossover design. In vitro, duloxetine blocked the release of both 5-HT and NE by MDMA or by its metabolite 3,4-met ...
patrick_tb_ch21
... Feedback: The N-substituents that lead to antagonism or increased activity in more complex opiates such as the morphine analogues, the morphinans and the benzomorphans, do not have these effects in the 4phenylpiperidine series. This indicates that the 4-phenylpiperidines are binding to the binding s ...
... Feedback: The N-substituents that lead to antagonism or increased activity in more complex opiates such as the morphine analogues, the morphinans and the benzomorphans, do not have these effects in the 4phenylpiperidine series. This indicates that the 4-phenylpiperidines are binding to the binding s ...
5-HT3 antagonist
The 5-HT3 antagonists, informally known as ""setrons"", are a class of drugs that act as receptor antagonists at the 5-HT3 receptor, a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the brain.With the notable exception of alosetron and cilansetron, which are used in the treatment of irritable bowel syndrome, all 5-HT3 antagonists are antiemetics, used in the prevention and treatment of nausea and vomiting. They are particularly effective in controlling the nausea and vomiting produced by cancer chemotherapy and are considered the gold standard for this purpose.The 5-HT3 antagonists may be identified by the suffix –setron, and are classified under code A04AA of the WHO's Anatomical Therapeutic Chemical Classification System.