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... Overdosage may manifest as hypotension, tachycardia. Bradycardia occurs less often. Viral infection and URTI (cough, pharyngitis, sinusitis, rhinitis) occur rarely. ...
... Overdosage may manifest as hypotension, tachycardia. Bradycardia occurs less often. Viral infection and URTI (cough, pharyngitis, sinusitis, rhinitis) occur rarely. ...
Antiviral chemotherapy
... cell membrane proteins during fusion. • Raltegravir (Integrase Inhibitor) targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV. • Maraviroc It blocks the interaction between chemokine receptor CCR5 and HIV gp12 ...
... cell membrane proteins during fusion. • Raltegravir (Integrase Inhibitor) targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV. • Maraviroc It blocks the interaction between chemokine receptor CCR5 and HIV gp12 ...
Selective Serotonin-Reuptake Inhibitors
... incidence of sexual dysfunction, and increase the risk of seizure at high doses. 2. Mirtazapine This drug enhance serotonin and norepinephrine neurotransmission via mechanism related to it is ability to block presynaptic α2 and 5-HT2receptors. It is sedative because of its potent antihistaminic acti ...
... incidence of sexual dysfunction, and increase the risk of seizure at high doses. 2. Mirtazapine This drug enhance serotonin and norepinephrine neurotransmission via mechanism related to it is ability to block presynaptic α2 and 5-HT2receptors. It is sedative because of its potent antihistaminic acti ...
Wobenzym PS - The Modern Herbalist
... significant energy in order to take place, and therefore need a catalyst to allow the reaction to proceed. The catalyst acts to lower the energy needed for the reaction to move forward. In the body, enzymes play the role of the catalyst and allow reactions to take place that otherwise would not occu ...
... significant energy in order to take place, and therefore need a catalyst to allow the reaction to proceed. The catalyst acts to lower the energy needed for the reaction to move forward. In the body, enzymes play the role of the catalyst and allow reactions to take place that otherwise would not occu ...
Bodybuilding supplement
... Prohormones are precursors to hormones and were most typically sold to bodybuilders as a precursor to the natural hormone testosterone. This conversion requires naturally occurring enzymes in the body. Side effects are not uncommon, as prohormones can also convert further into DHT and estrogen. To d ...
... Prohormones are precursors to hormones and were most typically sold to bodybuilders as a precursor to the natural hormone testosterone. This conversion requires naturally occurring enzymes in the body. Side effects are not uncommon, as prohormones can also convert further into DHT and estrogen. To d ...
Bioisosteres
... Last time we talked about isosteric replacement, which is changing a functional group in a structure to modify certain properties How do I know that a certain functional group is isosteric with another? Both molecules (that are being compared) should have almost identical size\volume(3D shape), and ...
... Last time we talked about isosteric replacement, which is changing a functional group in a structure to modify certain properties How do I know that a certain functional group is isosteric with another? Both molecules (that are being compared) should have almost identical size\volume(3D shape), and ...
EGFR TYROSINE KINASE TARGETED COMPOUNDS: IN VITRO
... aimed at further exploration of the SAR of this novel template, led to the discovery of highly selective compounds that target EGFR. Benzothiazoles act via competing with ATP for binding at the catalytic domain of EGFR-TK (Noolvi et al., 2012). The characteristic features of ATP binding site are; ad ...
... aimed at further exploration of the SAR of this novel template, led to the discovery of highly selective compounds that target EGFR. Benzothiazoles act via competing with ATP for binding at the catalytic domain of EGFR-TK (Noolvi et al., 2012). The characteristic features of ATP binding site are; ad ...
Pharmacology - Cardiovascular drugs II NCLEX MCQs
... Research has shown that when nitrates are administered early to the acute MI client, the effect is reduced mortality, infarct size, infarct extension, and related complications. Hypotension will result from nitrate administration, but it is not the reason for prescribing the drug. Tachycardia rather ...
... Research has shown that when nitrates are administered early to the acute MI client, the effect is reduced mortality, infarct size, infarct extension, and related complications. Hypotension will result from nitrate administration, but it is not the reason for prescribing the drug. Tachycardia rather ...
2 Non-steroidal anti-inflammatory drugs
... Example: Celecoxib o Example: Celecoxib • Half-life 11 hours (twice/day). • Food decrease its absorption. • Highly bound to plasma proteins. • Clinical uses & Adverse effects: • Discussed before with general uses and general adverse effects of selective COX-2 inhibitors. ...
... Example: Celecoxib o Example: Celecoxib • Half-life 11 hours (twice/day). • Food decrease its absorption. • Highly bound to plasma proteins. • Clinical uses & Adverse effects: • Discussed before with general uses and general adverse effects of selective COX-2 inhibitors. ...
Treatments for Diabetes Mellitus
... acylated derivatives of GLP-1 that have long acting effects. • Liraglutide works by selfassociation and noncovalent binding of plasma albumin fatty acid binding sites • Albumin acts as a buffer reservoir to insure the binding of liraglutide to the active site. • This binding causes a pharmacokinetic ...
... acylated derivatives of GLP-1 that have long acting effects. • Liraglutide works by selfassociation and noncovalent binding of plasma albumin fatty acid binding sites • Albumin acts as a buffer reservoir to insure the binding of liraglutide to the active site. • This binding causes a pharmacokinetic ...
2016 International Symposium on Chemical Biology of the
... target the mTOR kinase and the Ras GTPase, both of which are among the most challenging drug targets in oncology. mTOR can be targeted by the natural product rapamycin and its derivatives (rapalogues), which act as allosteric inhibitors. More recently, ATP-competitive inhibitors that directly target ...
... target the mTOR kinase and the Ras GTPase, both of which are among the most challenging drug targets in oncology. mTOR can be targeted by the natural product rapamycin and its derivatives (rapalogues), which act as allosteric inhibitors. More recently, ATP-competitive inhibitors that directly target ...
Chapter 16. Side Effects of Drugs in Sjögren`s Syndrome
... Side effects of drugs in Sjögren’s syndrome Drugs play an important role in the treatment of diseases, but every drug has its advantages and disadvantages. Use of a drug is only justified if the expected advantages are greater than the disadvantages. In order to be able to evaluate the advantage, ...
... Side effects of drugs in Sjögren’s syndrome Drugs play an important role in the treatment of diseases, but every drug has its advantages and disadvantages. Use of a drug is only justified if the expected advantages are greater than the disadvantages. In order to be able to evaluate the advantage, ...
Medications to Treat Hypertension
... flexibility in the systolic reading if the diastolic was within normal limits. New research suggests that deaths could be avoided by initiating treatment earlier. Third, the use of more than one medication is advisable. “Using more than one drug to treat most patients will be key to improving blood ...
... flexibility in the systolic reading if the diastolic was within normal limits. New research suggests that deaths could be avoided by initiating treatment earlier. Third, the use of more than one medication is advisable. “Using more than one drug to treat most patients will be key to improving blood ...
eprint_1_30658_130
... 3- Food has little effect on absorption (except with sertraline, for which food increases its absorption). 4- Only sertraline undergoes significant first-pass metabolism. 5- All of these agents are well distributed, having volumes of distribution far in excess of body weight (15-30 L/kg). 6- The maj ...
... 3- Food has little effect on absorption (except with sertraline, for which food increases its absorption). 4- Only sertraline undergoes significant first-pass metabolism. 5- All of these agents are well distributed, having volumes of distribution far in excess of body weight (15-30 L/kg). 6- The maj ...
heart failure
... indicated in severe forms of HF in combination with other treatment to improve symptoms of HF and clinical status ...
... indicated in severe forms of HF in combination with other treatment to improve symptoms of HF and clinical status ...
Norepinephrine
... chain on amine. In agonist, as we increase the alkyl chain we make better binding and increase the duration of action. But this property doesn’t convert the agonist to antagonist. So, any change on alkylation can’t convert agonist to antagonist. In general, antagonist needs more hydrophobicity and b ...
... chain on amine. In agonist, as we increase the alkyl chain we make better binding and increase the duration of action. But this property doesn’t convert the agonist to antagonist. So, any change on alkylation can’t convert agonist to antagonist. In general, antagonist needs more hydrophobicity and b ...
Discovery and development of ACE inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.