Power Point
... Very similar to ACE inhibitors (more specific site of action) and have fewer side effects ...
... Very similar to ACE inhibitors (more specific site of action) and have fewer side effects ...
Anti-viral drugs
... • Both DNA and RNA viruses induce interferon but RNA viruses tend to induce higher levels • Currently grouped into : IFN-α, IFN-β, and IFN-γ • Administered Intralesionally, S.C, and I.V • Distribution in all body tissues, except CNS and eye • Pegylated interferons are modified interferons with impro ...
... • Both DNA and RNA viruses induce interferon but RNA viruses tend to induce higher levels • Currently grouped into : IFN-α, IFN-β, and IFN-γ • Administered Intralesionally, S.C, and I.V • Distribution in all body tissues, except CNS and eye • Pegylated interferons are modified interferons with impro ...
CLin_Pharm_antiinflammatory agents
... When stop taking corticosteroids, the doses will be slowly reduced over a period of days or weeks. Even if patient has only been taking steroids for a few weeks, he will still need to taper off. Corticosteroid withdrawal can be very difficult for body. In many patients, the disease symptoms become w ...
... When stop taking corticosteroids, the doses will be slowly reduced over a period of days or weeks. Even if patient has only been taking steroids for a few weeks, he will still need to taper off. Corticosteroid withdrawal can be very difficult for body. In many patients, the disease symptoms become w ...
Version 1
... Based on the results of in vitro interaction studies with, among other things, simvastatin, metoprolol, diazepam and terfenadine, it is considered unlikely that barnidipine has any effect on the pharmacokinetics of other drugs which are metabolised by cytochrome P450 isoenzymes. An in vivo interacti ...
... Based on the results of in vitro interaction studies with, among other things, simvastatin, metoprolol, diazepam and terfenadine, it is considered unlikely that barnidipine has any effect on the pharmacokinetics of other drugs which are metabolised by cytochrome P450 isoenzymes. An in vivo interacti ...
Anti-viral drugs - Lectures For UG-5
... ◦ chronic Herpes (does not cure but can reduce recurrence) ...
... ◦ chronic Herpes (does not cure but can reduce recurrence) ...
benzoyl benzoic acid based 1,3,4-oxadiazole analogues
... Non-steroidal anti-inflammatory drugs (NSAIDs) form an imperative class of commonly used therapeutic agents due to their anti-inflammatory, analgesic and antipyretic effects. The biological activity of NSAIDs is associated to suppression of prostaglandin biosynthesis by inhibiting the enzyme cycloox ...
... Non-steroidal anti-inflammatory drugs (NSAIDs) form an imperative class of commonly used therapeutic agents due to their anti-inflammatory, analgesic and antipyretic effects. The biological activity of NSAIDs is associated to suppression of prostaglandin biosynthesis by inhibiting the enzyme cycloox ...
Influenza Antiviral Drug Development
... inhibitors. Adamantanes block influenza A virus entry into the host cell but have no activity against influenza B viruses. They are associated with serious side effects, and resistant viruses have emerged. Neuraminidase inhibitors block the release of virions from the host cell. Although they exhibi ...
... inhibitors. Adamantanes block influenza A virus entry into the host cell but have no activity against influenza B viruses. They are associated with serious side effects, and resistant viruses have emerged. Neuraminidase inhibitors block the release of virions from the host cell. Although they exhibi ...
Phylogica - Moodle Lille 2
... 1 phenyl ring with 2 bromo methyls groups they have to be soluble in aqueous solvents It would be preferable to use a non-chiral scaffold ...
... 1 phenyl ring with 2 bromo methyls groups they have to be soluble in aqueous solvents It would be preferable to use a non-chiral scaffold ...
PERTINENT (a substudy of the EUROPA trial): a persistent legacy
... 9–29, P ¼ 0.0003) with the use of perindopril. These results strongly suggested that ACE inhibitors—perindopril specifically—can improve clinical outcome beyond the context of an acute myocardial infarction, as patients in the EUROPA trial were considered to be ‘stable’ and ‘low risk’. Although the ...
... 9–29, P ¼ 0.0003) with the use of perindopril. These results strongly suggested that ACE inhibitors—perindopril specifically—can improve clinical outcome beyond the context of an acute myocardial infarction, as patients in the EUROPA trial were considered to be ‘stable’ and ‘low risk’. Although the ...
Stage 1 hypertension
... The threshold blood pressure for offering drug therapy has changed, partly reflecting the move to ambulatory BP monitoring. Diuretics have moved to third line drugs after ACE inhibitors and calcium channel blockers The thiazide-like diuretic of choice is now indapamide or chlortalidone rather ...
... The threshold blood pressure for offering drug therapy has changed, partly reflecting the move to ambulatory BP monitoring. Diuretics have moved to third line drugs after ACE inhibitors and calcium channel blockers The thiazide-like diuretic of choice is now indapamide or chlortalidone rather ...
Antidepressants and Sedatives David G. Standaert, MD, Ph.D
... Act by inhibition of presynaptic reuptake of serotonin in central synapses. Not as sedating as many of the tricylic compounds Also do not have the anticholinergic side effects of the tricyclics ...
... Act by inhibition of presynaptic reuptake of serotonin in central synapses. Not as sedating as many of the tricylic compounds Also do not have the anticholinergic side effects of the tricyclics ...
What is the primary objective of medicinal chemistry ? Which
... and toxicity but same chemical properties. ...
... and toxicity but same chemical properties. ...
Discovery and development of ACE inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.