Esters and amides of hexanoic acid substituted with
... distillation of the reaction mixture after alkylation of pyrrolidine with ethyl 6-bromohexanoate also gave a small amount of 1,6-bis(pyrrolidin-1-yl)hexan-1-one (2a) as a by-product, probably originating by the direct aminolysis of ethyl 6-(pyrrolidin-1-yl)hexanoate with pyrrolidine. A solution of 0 ...
... distillation of the reaction mixture after alkylation of pyrrolidine with ethyl 6-bromohexanoate also gave a small amount of 1,6-bis(pyrrolidin-1-yl)hexan-1-one (2a) as a by-product, probably originating by the direct aminolysis of ethyl 6-(pyrrolidin-1-yl)hexanoate with pyrrolidine. A solution of 0 ...
Slide 1
... and the density of the lipids and type of protein determines the fate of the particle and its influence on metabolism. ...
... and the density of the lipids and type of protein determines the fate of the particle and its influence on metabolism. ...
Diuretics & Antihypertensives
... • Best blood pressure lowering result is achieved when given with a diuretic agent – Negative inotropic – Negative chronotropic – Negative dromotropic ...
... • Best blood pressure lowering result is achieved when given with a diuretic agent – Negative inotropic – Negative chronotropic – Negative dromotropic ...
Bergamottin and “The Grapefruit Juice Effect”
... during inactivation by using SDS PAGE and the masses of the apoproteins were analyzed by ESI-LC-MS 2. It was found that oxidation of a double bond in the furan ring is responsible for inactivation; the irreversible inactivation of CYP450 3A4 catalytic activity is due to a mono-oxygenated reactive me ...
... during inactivation by using SDS PAGE and the masses of the apoproteins were analyzed by ESI-LC-MS 2. It was found that oxidation of a double bond in the furan ring is responsible for inactivation; the irreversible inactivation of CYP450 3A4 catalytic activity is due to a mono-oxygenated reactive me ...
Print this article - Journal of Applied Pharmaceutical Research
... Columbia Institute of Pharmacy, Tekari, Near Vidhan Sabha, Raipur, C.G., 493111, India The important therapeutic approach for treating type 2 diabetes mellitus is to decrease the post-prandial glucose levels which could be done by decreasing the absorption of glucose through the inhibition of the ca ...
... Columbia Institute of Pharmacy, Tekari, Near Vidhan Sabha, Raipur, C.G., 493111, India The important therapeutic approach for treating type 2 diabetes mellitus is to decrease the post-prandial glucose levels which could be done by decreasing the absorption of glucose through the inhibition of the ca ...
Drug metabolism2
... and liver blood flow are decreased .Metabolic inactivation of drugs is slowed Drugs persist for longer time and in higher concentration the must be lowered e.g. tricyclic ...
... and liver blood flow are decreased .Metabolic inactivation of drugs is slowed Drugs persist for longer time and in higher concentration the must be lowered e.g. tricyclic ...
Antimicrobial Agents (Sulfonamides and Quinolones 1 )
... antiepileptics are among those at most risk. • Patients with sulfonamide-induced toxic epidermal necrolysis have been shown to have a slow acetylator genotype that results in increased production of sulfonamide hydroxylamine . ...
... antiepileptics are among those at most risk. • Patients with sulfonamide-induced toxic epidermal necrolysis have been shown to have a slow acetylator genotype that results in increased production of sulfonamide hydroxylamine . ...
chapter 8 - Lange Textbooks
... ii. Didanosine (ddI, dideoxyinosine) and zalcitabine (ddC, dideoxycytidine) 1. Nucleoside analogs that inhibit HIV replication 2. Serious adverse effects include peripheral neuropathy and pancreatitis 3. Used only in combination with one or two other anti-HIV drugs iii. Stavudine (D4T) 1. Interferes ...
... ii. Didanosine (ddI, dideoxyinosine) and zalcitabine (ddC, dideoxycytidine) 1. Nucleoside analogs that inhibit HIV replication 2. Serious adverse effects include peripheral neuropathy and pancreatitis 3. Used only in combination with one or two other anti-HIV drugs iii. Stavudine (D4T) 1. Interferes ...
S09 Toxicology NSAIDS
... The likelihood of GI bleeding is less with these drugs than with conventional NSAIDs There is limited information regarding overdoses of COX-2 inhibitors……hypertension, acute renal failure, respiratory depression, and coma may occur in overdose Rofecoxib and valdecoxib have been removed from the mar ...
... The likelihood of GI bleeding is less with these drugs than with conventional NSAIDs There is limited information regarding overdoses of COX-2 inhibitors……hypertension, acute renal failure, respiratory depression, and coma may occur in overdose Rofecoxib and valdecoxib have been removed from the mar ...
PowerPoint Presentation - Lecture 9
... aldosterone & Na excreted, but H2O & K retained - Used to treat HTN primarily, - but not a 1st line drug. Also used in heart failure. - SE = hyperkalemia & 1st dose hypotension (more common with comb. Diuretic & ACE inhibitor. ...
... aldosterone & Na excreted, but H2O & K retained - Used to treat HTN primarily, - but not a 1st line drug. Also used in heart failure. - SE = hyperkalemia & 1st dose hypotension (more common with comb. Diuretic & ACE inhibitor. ...
Discovery and development of ACE inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.